Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Mus musculus | nuclear receptor subfamily 3, group C, member 1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | Inhibition of tyrosine amino transferase activity in human HepG2 cell line; nd=not determined | ChEMBL. | 15808489 | |
EC50 (binding) | Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cells; nd=not determined | ChEMBL. | 15808489 | |
EC50 (binding) | 0 | Inhibition of tyrosine amino transferase activity in human HepG2 cell line; nd=not determined | ChEMBL. | 15808489 |
EC50 (binding) | 0 | Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cells; nd=not determined | ChEMBL. | 15808489 |
EC50 (functional) | = 38 nM | GR-mediated transrepression of IL-6 in human A549 lung carcinoma cells | ChEMBL. | 15808489 |
EC50 (functional) | = 38 nM | GR-mediated transrepression of IL-6 in human A549 lung carcinoma cells | ChEMBL. | 15808489 |
EC50 (binding) | = 215 nM | GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 mice | ChEMBL. | 15808489 |
EC50 (binding) | = 215 nM | GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 mice | ChEMBL. | 15808489 |
IC50 (binding) | = 23.2 nM | Inhibition of human glucocorticoid receptor alpha by displacement of [3H]-dexamethasone | ChEMBL. | 15808489 |
IC50 (binding) | = 23.2 nM | Inhibition of human glucocorticoid receptor alpha by displacement of [3H]-dexamethasone | ChEMBL. | 15808489 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.