Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 8 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 9 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 7 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | serine carboxypeptidase S28, putative | dipeptidyl-peptidase 7 | 492 aa | 471 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Aldose reductase | 0.0411 | 0.8473 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0411 | 0.8473 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.035 | 0.6392 | 0.7544 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0411 | 0.8473 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0411 | 0.8473 | 0.7255 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0411 | 0.8473 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0411 | 0.8473 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0345 | 0.6241 | 0.7366 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0345 | 0.6241 | 0.3244 |
Onchocerca volvulus | 0.0411 | 0.8473 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0411 | 0.8473 | 0.7255 |
Loa Loa (eye worm) | oxidoreductase | 0.0411 | 0.8473 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0411 | 0.8473 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 0.8473 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0411 | 0.8473 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0411 | 0.8473 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.0411 | 0.8473 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0411 | 0.8473 | 0.7255 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0411 | 0.8473 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0411 | 0.8473 | 0.7255 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0411 | 0.8473 | 0.7255 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0776 | 0.0916 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.035 | 0.6392 | 0.3515 |
Entamoeba histolytica | aldose reductase, putative | 0.0411 | 0.8473 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0411 | 0.8473 | 0.7255 |
Onchocerca volvulus | 0.0411 | 0.8473 | 1 | |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0456 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0411 | 0.8473 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0411 | 0.8473 | 0.7255 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0411 | 0.8473 | 0.7255 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0411 | 0.8473 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0411 | 0.8473 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0411 | 0.8473 | 0.7255 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0411 | 0.8473 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0411 | 0.8473 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0411 | 0.8473 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0411 | 0.8473 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0411 | 0.8473 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0411 | 0.8473 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0411 | 0.8473 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.035 | 0.6392 | 0.7544 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0411 | 0.8473 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0411 | 0.8473 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0411 | 0.8473 | 0.7255 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0411 | 0.8473 | 1 |
Onchocerca volvulus | 0.0411 | 0.8473 | 1 | |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.035 | 0.6392 | 0.3515 |
Echinococcus multilocularis | aldo keto reductase | 0.0411 | 0.8473 | 0.7255 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0411 | 0.8473 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0411 | 0.8473 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0411 | 0.8473 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0411 | 0.8473 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0411 | 0.8473 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0411 | 0.8473 | 0.7255 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0411 | 0.8473 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0411 | 0.8473 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0411 | 0.8473 | 0.7255 |
Echinococcus granulosus | hypothetical protein | 0.0411 | 0.8473 | 0.7255 |
Trypanosoma cruzi | aldo-keto reductase | 0.0411 | 0.8473 | 1 |
Onchocerca volvulus | 0.0411 | 0.8473 | 1 | |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0456 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0411 | 0.8473 | 0.7255 |
Loa Loa (eye worm) | oxidoreductase | 0.0411 | 0.8473 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0411 | 0.8473 | 0.7255 |
Echinococcus multilocularis | aldo keto reductase | 0.0411 | 0.8473 | 0.7255 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0411 | 0.8473 | 0.7255 |
Schistosoma mansoni | aldo-keto reductase | 0.0411 | 0.8473 | 0.5937 |
Mycobacterium ulcerans | oxidoreductase | 0.0411 | 0.8473 | 0.5 |
Schistosoma mansoni | pol-related | 0.0411 | 0.8473 | 0.5937 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0345 | 0.6241 | 0.3244 |
Echinococcus multilocularis | aldo keto reductase | 0.0411 | 0.8473 | 0.7255 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0411 | 0.8473 | 0.7255 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0411 | 0.8473 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0411 | 0.8473 | 0.7255 |
Onchocerca volvulus | 0.0411 | 0.8473 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0411 | 0.8473 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0411 | 0.8473 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0411 | 0.8473 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0411 | 0.8473 | 0.7255 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0411 | 0.8473 | 0.7255 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.035 | 0.6392 | 0.0401 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0411 | 0.8473 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0411 | 0.8473 | 0.5937 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0411 | 0.8473 | 0.7255 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0411 | 0.8473 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0411 | 0.8473 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0411 | 0.8473 | 1 |
Onchocerca volvulus | 0.0411 | 0.8473 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0411 | 0.8473 | 0.7255 |
Echinococcus granulosus | aldo keto reductase | 0.0411 | 0.8473 | 0.7255 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0411 | 0.8473 | 0.7255 |
Toxoplasma gondii | aldose reductase, putative | 0.0411 | 0.8473 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0411 | 0.8473 | 0.7255 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.89 nM | Inhibitory concentration against human dipeptidylpeptidase 4 | ChEMBL. | 16084722 |
IC50 (binding) | = 0.89 nM | Inhibitory concentration against human dipeptidylpeptidase 4 | ChEMBL. | 16084722 |
IC50 (binding) | = 3.5 nM | BindingDB_Patents: Inhibition Assay. The inhibitor solution is prepared by dissolving 3-5 mg of inhibitor in pH 2 solution (0.01 N HCl), such that the concentration of the solution is equal to 1 mg/10 mL. A 10 µL sample of this solution is then added to 990 µL of pH 8 buffer (0.1 M HEPES, 0.14 M NaCl), and the solution is allowed to stand at room temperature overnight.The enzyme solution is prepared by diluting 20 µL of DPIV (concentration 2.5 nM) into 40 mL of pH 8 buffer.The substrate solution is prepared by dissolving 2.0 mg of L-alanyl-L-proline-para-nitroanilide into 20 mL of pH 8 buffer.250 µL of enzyme solution is added to well #B1 to #H1, #A2 to #H2, and #A3 to #H3 of a 96 well plate, while well #A1 receives 250 µL of pH 8 buffer instead of enzyme solution. 904 of pH 8 buffer is then added to column 5 (from well #A5 to #H5). | ChEMBL. | No reference |
IC50 (binding) | = 3.5 nM | BindingDB_Patents: Inhibition Assay. The inhibitor solution is prepared by dissolving 3-5 mg of inhibitor in pH 2 solution (0.01 N HCl), such that the concentration of the solution is equal to 1 mg/10 mL. A 10 µL sample of this solution is then added to 990 µL of pH 8 buffer (0.1 M HEPES, 0.14 M NaCl), and the solution is allowed to stand at room temperature overnight.The enzyme solution is prepared by diluting 20 µL of DPIV (concentration 2.5 nM) into 40 mL of pH 8 buffer.The substrate solution is prepared by dissolving 2.0 mg of L-alanyl-L-proline-para-nitroanilide into 20 mL of pH 8 buffer.250 µL of enzyme solution is added to well #B1 to #H1, #A2 to #H2, and #A3 to #H3 of a 96 well plate, while well #A1 receives 250 µL of pH 8 buffer instead of enzyme solution. 904 of pH 8 buffer is then added to column 5 (from well #A5 to #H5). | ChEMBL. | No reference |
IC50 (binding) | = 9 nM | BindingDB_Patents: Inhibition Assay. The inhibitor solution is prepared by dissolving 3-5 mg of inhibitor in pH 2 solution (0.01 N HCl), such that the concentration of the solution is equal to 1 mg/10 mL. A 10 µL sample of this solution is then added to 990 µL of pH 8 buffer (0.1 M HEPES, 0.14 M NaCl), and the solution is allowed to stand at room temperature overnight.The enzyme solution is prepared by diluting 20 µL of DPIV (concentration 2.5 nM) into 40 mL of pH 8 buffer.The substrate solution is prepared by dissolving 2.0 mg of L-alanyl-L-proline-para-nitroanilide into 20 mL of pH 8 buffer.250 µL of enzyme solution is added to well #B1 to #H1, #A2 to #H2, and #A3 to #H3 of a 96 well plate, while well #A1 receives 250 µL of pH 8 buffer instead of enzyme solution. 904 of pH 8 buffer is then added to column 5 (from well #A5 to #H5). | ChEMBL. | No reference |
IC50 (binding) | = 9 nM | BindingDB_Patents: Inhibition Assay. The inhibitor solution is prepared by dissolving 3-5 mg of inhibitor in pH 2 solution (0.01 N HCl), such that the concentration of the solution is equal to 1 mg/10 mL. A 10 µL sample of this solution is then added to 990 µL of pH 8 buffer (0.1 M HEPES, 0.14 M NaCl), and the solution is allowed to stand at room temperature overnight.The enzyme solution is prepared by diluting 20 µL of DPIV (concentration 2.5 nM) into 40 mL of pH 8 buffer.The substrate solution is prepared by dissolving 2.0 mg of L-alanyl-L-proline-para-nitroanilide into 20 mL of pH 8 buffer.250 µL of enzyme solution is added to well #B1 to #H1, #A2 to #H2, and #A3 to #H3 of a 96 well plate, while well #A1 receives 250 µL of pH 8 buffer instead of enzyme solution. 904 of pH 8 buffer is then added to column 5 (from well #A5 to #H5). | ChEMBL. | No reference |
IC50 (binding) | = 160 nM | Inhibitory concentration against human dipeptidylpeptidase 7 | ChEMBL. | 16084722 |
IC50 (binding) | = 160 nM | Inhibitory concentration against human dipeptidylpeptidase 7 | ChEMBL. | 16084722 |
IC50 (binding) | = 670 nM | Inhibitory concentration against human dipeptidylpeptidase 8 using FP-TAMRA incubated for 30 min | ChEMBL. | 16084722 |
IC50 (binding) | = 670 nM | Inhibitory concentration against human dipeptidylpeptidase 8 using FP-TAMRA incubated for 30 min | ChEMBL. | 16084722 |
IC50 (binding) | = 3200 nM | Inhibitory concentration against human dipeptidylpeptidase 9 using FP-TAMRA incubated for 30 min | ChEMBL. | 16084722 |
IC50 (binding) | = 3200 nM | Inhibitory concentration against human dipeptidylpeptidase 9 using FP-TAMRA incubated for 30 min | ChEMBL. | 16084722 |
IC50 (binding) | = 22000 nM | Inhibitory concentration against human fibroblast activation protein alpha | ChEMBL. | 16084722 |
IC50 (binding) | = 22000 nM | Inhibitory concentration against human fibroblast activation protein alpha | ChEMBL. | 16084722 |
Ki (binding) | = 3.9 nM | Inhibition of human placental DPP4 | ChEMBL. | 18783201 |
Ki (binding) | = 50 nM | Inhibition of human recombinant DPP9 expressed in HEK293T cells | ChEMBL. | 18783201 |
Ki (binding) | = 96 nM | Inhibition of human recombinant DPP8 expressed in HEK293T cells | ChEMBL. | 18783201 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.