Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | tubulin alpha chain | 0.001 | 0.1152 | 0.1152 |
Trypanosoma brucei | alpha tubulin | 0.001 | 0.1152 | 0.2166 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.001 | 0.1152 | 0.2166 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Trichomonas vaginalis | tubulin beta chain, putative | 0.001 | 0.1152 | 0.2166 |
Trypanosoma brucei | epsilon tubulin | 0.001 | 0.1152 | 0.2166 |
Echinococcus granulosus | tubulin subunit beta | 0.0026 | 0.5317 | 0.4708 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0026 | 0.5317 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0026 | 0.5317 | 0.5317 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Loa Loa (eye worm) | tubulin alpha chain | 0.001 | 0.1152 | 0.1152 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1152 | 0.1152 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0026 | 0.5317 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.001 | 0.1152 | 0.2166 |
Trypanosoma brucei | epsilon tubulin | 0.001 | 0.1152 | 0.2166 |
Loa Loa (eye worm) | beta-tubulin | 0.0026 | 0.5317 | 0.5317 |
Trypanosoma brucei | alpha tubulin | 0.001 | 0.1152 | 0.2166 |
Entamoeba histolytica | tubulin family protein | 0.0026 | 0.5317 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0026 | 0.5317 | 0.4708 |
Loa Loa (eye worm) | BEN-1 protein | 0.0026 | 0.5317 | 0.5317 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.5317 | 0.4708 |
Echinococcus multilocularis | beta tubulin | 0.0026 | 0.5317 | 0.4708 |
Echinococcus granulosus | beta tubulin | 0.0026 | 0.5317 | 0.4708 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.001 | 0.1152 | 0.2166 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0026 | 0.5317 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0026 | 0.5317 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.001 | 0.1152 | 0.2166 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.5317 | 0.4708 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0026 | 0.5317 | 0.5317 |
Trypanosoma brucei | beta tubulin | 0.0026 | 0.5317 | 1 |
Brugia malayi | Tubulin alpha-2 chain | 0.001 | 0.1152 | 0.1152 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.5317 | 0.4708 |
Trypanosoma brucei | epsilon tubulin | 0.001 | 0.1152 | 0.2166 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.001 | 0.1152 | 0.2166 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0026 | 0.5317 | 0.4708 |
Giardia lamblia | Beta tubulin | 0.0026 | 0.5317 | 1 |
Brugia malayi | Tubulin gamma chain | 0.001 | 0.1152 | 0.1152 |
Trypanosoma brucei | alpha tubulin | 0.001 | 0.1152 | 0.2166 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0026 | 0.5317 | 1 |
Brugia malayi | Tubulin alpha chain | 0.001 | 0.1152 | 0.1152 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.5317 | 0.4708 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Giardia lamblia | Beta tubulin | 0.0026 | 0.5317 | 1 |
Trypanosoma brucei | tubulin gamma chain | 0.001 | 0.1152 | 0.2166 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.001 | 0.1152 | 0.2166 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.5317 | 0.4708 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0026 | 0.5317 | 0.4708 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.5317 | 0.4708 |
Trypanosoma cruzi | beta tubulin, putative | 0.0026 | 0.5317 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.001 | 0.1152 | 0.2166 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.5317 | 0.4708 |
Plasmodium vivax | tubulin beta chain, putative | 0.0026 | 0.5317 | 1 |
Loa Loa (eye worm) | tubulin gamma chain | 0.001 | 0.1152 | 0.1152 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.5317 | 0.4708 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0026 | 0.5317 | 0.4708 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0026 | 0.5317 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0026 | 0.5317 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0026 | 0.5317 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.5317 | 0.4708 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Toxoplasma gondii | beta tubulin | 0.0026 | 0.5317 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.5317 | 0.4708 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0026 | 0.5317 | 0.5317 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0026 | 0.5317 | 0.4708 |
Echinococcus granulosus | beta tubulin | 0.0026 | 0.5317 | 0.4708 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0026 | 0.5317 | 0.5317 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Giardia lamblia | Beta tubulin | 0.0026 | 0.5317 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.001 | 0.1152 | 0.2166 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.001 | 0.1152 | 0.1152 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.5317 | 0.4708 |
Brugia malayi | tubulin alpha chain - mouse | 0.001 | 0.1152 | 0.1152 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.5317 | 0.4708 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.001 | 0.1152 | 0.2166 |
Brugia malayi | tubulin alpha-2 chain | 0.001 | 0.1152 | 0.1152 |
Loa Loa (eye worm) | tubulin beta chain | 0.0026 | 0.5317 | 0.5317 |
Trypanosoma brucei | beta tubulin | 0.0026 | 0.5317 | 1 |
Trypanosoma brucei | beta tubulin | 0.0026 | 0.5317 | 1 |
Loa Loa (eye worm) | alpha-tubulin | 0.001 | 0.1152 | 0.1152 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.5317 | 0.4708 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.5317 | 0.4708 |
Brugia malayi | alpha-tubulin | 0.001 | 0.1152 | 0.1152 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0026 | 0.5317 | 0.5317 |
Brugia malayi | Tubulin alpha-2 chain | 0.001 | 0.1152 | 0.1152 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0026 | 0.5317 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.001 | 0.1152 | 0.2166 |
Trypanosoma brucei | beta tubulin | 0.001 | 0.1152 | 0.2166 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0026 | 0.5317 | 0.5317 |
Trypanosoma brucei | alpha tubulin | 0.001 | 0.1152 | 0.2166 |
Trichomonas vaginalis | tubulin, putative | 0.0026 | 0.5317 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.5317 | 0.4708 |
Echinococcus multilocularis | beta tubulin | 0.0026 | 0.5317 | 0.4708 |
Loa Loa (eye worm) | alpha-tubulin | 0.001 | 0.1152 | 0.1152 |
Trypanosoma brucei | beta tubulin | 0.0026 | 0.5317 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.5317 | 0.4708 |
Leishmania major | beta tubulin | 0.0026 | 0.5317 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.001 | 0.1152 | 0.2166 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 138.2 nM | Inhibition of [125I]-PYY binding to the rat NPY Y5 receptor in C6 cells | ChEMBL. | 15771450 |
Inhibition (functional) | 0 % | Inhibition of PYY effect on forskolin-stimulated cyclic AMP formation in C6 cells expressing rat NPY Y5 receptor; n.d. denotes ''not determined | ChEMBL. | 15771450 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.