Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0777 | 0.3842 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1989 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0777 | 0.3842 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1989 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0777 | 0.3842 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0777 | 0.3842 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1989 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1989 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1989 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0777 | 0.3842 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0777 | 0.3842 | 0.3842 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0777 | 0.3842 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1989 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0777 | 0.3842 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1989 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0777 | 0.3842 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0052 | 0.016 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0777 | 0.3842 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.1989 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0777 | 0.3842 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0777 | 0.3842 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0777 | 0.3842 | 0.3842 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1989 | 1 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1989 | 1 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1989 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1989 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1989 | 1 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0052 | 0.016 | 0.016 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1989 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction (functional) | = 6 % | MDR-reversal activity evaluated against the resistant human breast tumor cell line MDA-435/LCC6-MDR | ChEMBL. | 15771464 |
Reduction (functional) | = 6 % | MDR-reversal activity evaluated against the resistant human breast tumor cell line MDA-435/LCC6-MDR | ChEMBL. | 15771464 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.