TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 892.939 | Formula: C50H52O15
H donors: 1 H acceptors: 8 LogP: 5.4 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: COc1cccc(c1)C(=O)O[C@H]1[C@H]2[C@@](C)([C@@H](OC(=O)/C=C/c3ccc(cc3)C(=O)c3ccccc3)C[C@@H]3[C@]2(CO3)OC(=O)C)C(=O)[C@@H](C2=C([C@H](C[C@]1(O)C2(C)C)OC(=O)C)C)OC(=O)C
InChi: 1S/C50H52O15/c1-27-36(61-28(2)51)25-50(58)45(64-46(57)34-15-12-16-35(23-34)59-8)43-48(7,44(56)42(62-29(3)52)40(27)47(50,5)6)37(24-38-49(43,26-60-38)65-30(4)53)63-39(54)22-19-31-17-20-33(21-18-31)41(55)32-13-10-9-11-14-32/h9-23,36-38,42-43,45,58H,24-26H2,1-8H3/b22-19+/t36-,37-,38+,42+,43-,45-,48+,49-,50+/m0/s1
InChiKey: ZCYBGXAWGGOIID-XUDNWASPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0303	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0008	0.0085
Brugia malayi	Papain family cysteine protease containing protein	0.0035	0.0029	0.0947
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0102	0.0145	0.4774
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0009	0.0301
Echinococcus granulosus	follistatin	0.0102	0.0145	0.4774
Mycobacterium tuberculosis	Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC	0.5863	1	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0023	0.0008	0.072
Leishmania major	cysteine peptidase A (CPA)	0.0035	0.0029	0.121
Plasmodium vivax	cysteine--tRNA ligase, putative	0.0086	0.0116	1
Brugia malayi	ABC transporter family protein	0.0023	0.0008	0.0275
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0132	0.0195	1
Brugia malayi	secreted modular calcium-binding protein 1	0.0102	0.0145	0.4774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0009	0.0789
Trypanosoma cruzi	cytochrome P450, putative	0.0021	0.0006	0.0191
Brugia malayi	Cytochrome P450 family protein	0.0021	0.0006	0.0191
Onchocerca volvulus		0.0195	0.0303	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0035	0.117
Toxoplasma gondii	cathepsin CPL	0.0035	0.0029	0.0691
Leishmania major	cathepsin L-like protease	0.0035	0.0029	0.121
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0029	0.2479
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0029	0.2479
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0029	0.2479
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0035	0.0029	0.2479
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0023	0.0008	0.072
Brugia malayi	multidrug resistance protein 3	0.0023	0.0008	0.0275
Echinococcus multilocularis	cysteine protease	0.0035	0.0029	0.0406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0009	0.0789
Echinococcus multilocularis	cysteine protease	0.0035	0.0029	0.0406
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0023	0.0008	0.072
Entamoeba histolytica	P-glycoprotein-2	0.0023	0.0008	0.072
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0195	0.0303	1
Entamoeba histolytica	P-glycoprotein-2	0.0023	0.0008	0.072
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0132	0.0195	1
Trypanosoma brucei	cysteinyl-tRNA synthetase, putative	0.0086	0.0116	0.5936
Entamoeba histolytica	cysteine proteinase, putative	0.0035	0.0029	0.2479
Onchocerca volvulus		0.0035	0.0029	0.0691
Entamoeba histolytica	P-glycoprotein-5	0.0023	0.0008	0.072
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0023	0.0008	0.0118
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0029	0.2479
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0132	0.0195	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0132	0.0195	0.6433
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0029	0.0947
Loa Loa (eye worm)	cysteine protease	0.0035	0.0029	0.077
Echinococcus multilocularis	multidrug resistance protein 1	0.0023	0.0008	0.0118
Echinococcus multilocularis	follistatin	0.0102	0.0145	0.2047
Entamoeba histolytica	cysteine protease, putative	0.0035	0.0029	0.2479
Toxoplasma gondii	cysteine-tRNA synthetase (CysRS)	0.0086	0.0116	0.3644
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0035	0.0029	0.0406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0035	0.0029	0.2479
Echinococcus multilocularis	multidrug resistance protein 1	0.0023	0.0008	0.0118
Leishmania major	p-glycoprotein	0.0023	0.0008	0.0134
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0035	0.0029	0.2479
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0145	0.4673
Leishmania major	cathepsin L-like protease	0.0035	0.0029	0.121
Echinococcus multilocularis	pol protein	0.0431	0.0707	1
Brugia malayi	Cytochrome P450 family protein	0.0054	0.0062	0.204
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0023	0.0008	0.072
Leishmania major	cathepsin L-like protease	0.0132	0.0195	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0008	0.0085
Echinococcus multilocularis	pol protein	0.0431	0.0707	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0132	0.0195	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0132	0.0195	0.6433
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0029	0.2479
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0023	0.0008	0.072
Onchocerca volvulus	Putative organic anion transporter	0.0195	0.0303	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0023	0.0008	0.072
Loa Loa (eye worm)	multidrug resistance protein 3	0.0023	0.0008	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0303	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0023	0.0008	0.072
Echinococcus granulosus	multidrug resistance protein 1	0.0023	0.0008	0.0275
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0102	0.0145	0.4774
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0132	0.0195	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0029	0.2479
Entamoeba histolytica	P-glycoprotein-2, putative	0.0023	0.0008	0.072
Echinococcus multilocularis	cysteinyl tRNA synthetase	0.0086	0.0116	0.1637
Wolbachia endosymbiont of Brugia malayi	cysteinyl-tRNA synthetase	0.0086	0.0116	0.5
Giardia lamblia	Cysteinyl-tRNA synthetase	0.0086	0.0116	0.5
Onchocerca volvulus	Cathepsin L homolog	0.0035	0.0029	0.0691
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0029	0.2479
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0116	0.3698
Echinococcus multilocularis	cathepsin L cysteine protease	0.0035	0.0029	0.0406
Onchocerca volvulus		0.0035	0.0029	0.0691
Trichomonas vaginalis	ABC transporter, putative	0.0023	0.0008	0.072
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0023	0.0008	0.072
Entamoeba histolytica	cysteinyl-tRNA synthetase, putative	0.0086	0.0116	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0009	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0008	0.0071
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0029	0.0947
Trichomonas vaginalis	cysteinyl-tRNA synthetase, putative	0.0086	0.0116	1
Onchocerca volvulus		0.0035	0.0029	0.0691
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0029	0.2479
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0023	0.0008	0.0275
Leishmania major	cathepsin L-like protease	0.0132	0.0195	1
Onchocerca volvulus		0.0102	0.0145	0.4627
Trichomonas vaginalis	ABC transporter, putative	0.0023	0.0008	0.072
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0303	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0035	0.0029	0.0947
Brugia malayi	cysteinyl tRNA synthetase protein 1	0.0086	0.0116	0.3819
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0102	0.0145	0.4774
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0132	0.0195	1
Entamoeba histolytica	cysteine proteinase, putative	0.0035	0.0029	0.2479
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0023	0.0008	0.072
Trichomonas vaginalis	abcb9, putative	0.0023	0.0008	0.072
Trypanosoma cruzi	cytochrome P450, putative	0.0021	0.0006	0.0191
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0029	0.0947
Schistosoma mansoni	cathepsin F (C01 family)	0.0035	0.0029	0.0947
Onchocerca volvulus		0.0035	0.0029	0.0691
Entamoeba histolytica	P-glycoprotein-1	0.0023	0.0008	0.072
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0022	0.0008	0.0261
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0035	0.0029	0.077
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.0086	0.0116	0.3819
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0029	0.2479
Schistosoma mansoni	multidrug resistance protein	0.0023	0.0008	0.0275
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0029	0.2479
Leishmania major	cathepsin L-like protease	0.0035	0.0029	0.121
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0023	0.0008	0.072
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0102	0.0145	0.4627
Echinococcus granulosus	multidrug resistance protein 1	0.0023	0.0008	0.0275
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.0102	0.0145	0.4673
Schistosoma mansoni	hypothetical protein	0.0039	0.0035	0.117
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0023	0.0008	0.0134
Schistosoma mansoni	agrin	0.0102	0.0145	0.4774
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0303	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0029	0.2479
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0029	0.2479
Toxoplasma gondii	transporter, major facilitator family protein	0.0195	0.0303	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0029	0.2479
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0132	0.0195	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0035	0.0029	0.0406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0029	0.2479
Schistosoma mansoni	cathepsin F (C01 family)	0.0035	0.0029	0.0947
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0023	0.0009	0.0301
Loa Loa (eye worm)	fibroinase	0.0035	0.0029	0.077
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0023	0.0008	0.0118
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0132	0.0195	1
Loa Loa (eye worm)	agrin synaptic family protein	0.0102	0.0145	0.4673
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0009	0.0112
Trypanosoma cruzi	cysteine peptidase, putative	0.0132	0.0195	0.6433
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0035	0.0029	0.077
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0145	0.4673
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0023	0.0008	0.0118
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0023	0.0008	0.072
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0009	0.0789
Echinococcus granulosus	cathepsin l1	0.0023	0.0009	0.0301
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0029	0.0947
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0195	0.0303	0.4288
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.0086	0.0116	0.3819
Trichomonas vaginalis	ABC transporter, putative	0.0023	0.0008	0.072
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0195	0.0303	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0132	0.0195	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0023	0.0008	0.0118
Brugia malayi	hypothetical protein	0.0039	0.0035	0.117
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0009	0.0112
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0023	0.0008	0.072
Schistosoma mansoni	organic anion transporter	0.0195	0.0303	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0145	0.4673
Leishmania major	cathepsin L-like protease	0.0132	0.0195	1
Brugia malayi	hypothetical protein	0.0195	0.0303	1
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.0086	0.0116	0.3819
Echinococcus multilocularis	ATP binding cassette sub family B	0.0022	0.0008	0.0112
Loa Loa (eye worm)	ctsf protein	0.0035	0.0029	0.077
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0102	0.0145	0.4774
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0023	0.0008	0.072
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0029	0.2479
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0023	0.0008	0.072
Onchocerca volvulus		0.0195	0.0303	1
Schistosoma mansoni	organic anion transporter	0.0195	0.0303	1
Plasmodium falciparum	cysteine--tRNA ligase	0.0086	0.0116	1
Schistosoma mansoni	multidrug resistance protein	0.0023	0.0008	0.0275
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0029	0.2479
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0303	1
Trichomonas vaginalis	ABC transporter, putative	0.0023	0.0008	0.072
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0132	0.0195	1
Echinococcus multilocularis	pol protein	0.0431	0.0707	1
Schistosoma mansoni	multidrug resistance protein	0.0023	0.0008	0.0275
Onchocerca volvulus		0.0035	0.0029	0.0691
Brugia malayi	hypothetical protein	0.0195	0.0303	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0023	0.0008	0.0275
Trichomonas vaginalis	abcb9, putative	0.0023	0.0008	0.072
Onchocerca volvulus		0.0195	0.0303	1
Trichomonas vaginalis	abcb9, putative	0.0023	0.0008	0.072
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0303	1
Brugia malayi	SPARC precursor	0.0102	0.0145	0.4774
Brugia malayi	sodium-independent organic anion transporter family protein	0.0195	0.0303	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0104	0.0147	0.4841
Echinococcus granulosus	cathepsin l1	0.0035	0.0029	0.0947
Plasmodium falciparum	cysteine--tRNA ligase	0.0086	0.0116	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0145	0.4673
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0102	0.0145	0.4627
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.5863	1	1
Leishmania major	cysteinyl-tRNA synthetase, putative	0.0086	0.0116	0.5812
Echinococcus granulosus	cysteinyl tRNA synthetase	0.0086	0.0116	0.3819
Entamoeba histolytica	hypothetical protein	0.0039	0.0035	0.3063
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0029	0.2479
Onchocerca volvulus	Cathepsin F homolog	0.0035	0.0029	0.0691
Brugia malayi	cathepsin L-like precursor	0.0023	0.0009	0.0301
Leishmania major	cathepsin L-like protease	0.0035	0.0029	0.121
Onchocerca volvulus		0.0086	0.0116	0.3644
Trichomonas vaginalis	taga, putative	0.0023	0.0008	0.072
Chlamydia trachomatis	cysteine--tRNA ligase	0.0086	0.0116	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0029	0.2479
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0029	0.2479
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0303	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0035	0.3063
Onchocerca volvulus		0.0035	0.0029	0.0691
Onchocerca volvulus		0.0195	0.0303	1
Entamoeba histolytica	P-glyco protein 6, putative	0.0023	0.0008	0.072
Schistosoma mansoni	follistatin	0.0102	0.0145	0.4774
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0023	0.0008	0.0085
Onchocerca volvulus	Putative organic anion transporter	0.0195	0.0303	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0035	0.0029	0.2479
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0023	0.0008	0.072
Onchocerca volvulus		0.0035	0.0029	0.0691
Plasmodium vivax	multidrug resistance protein 1, putative	0.0023	0.0008	0.072
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0102	0.0145	0.4627
Plasmodium falciparum	multidrug resistance protein 1	0.0023	0.0008	0.072
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0009	0.0301
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0023	0.0008	0.0275
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0195	0.0303	0.4288
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0035	0.117
Brugia malayi	prostaglandin transporter	0.0195	0.0303	1
Echinococcus granulosus	agrin	0.0102	0.0145	0.4774
Loa Loa (eye worm)	cysteinyl tRNA synthetase 1	0.0086	0.0116	0.3698
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0195	0.0303	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0023	0.0008	0.072
Plasmodium vivax	vivapain-2	0.0035	0.0029	0.2479
Onchocerca volvulus		0.0023	0.0009	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0029	0.2479
Entamoeba histolytica	P-glycoprotein 5, putative	0.0023	0.0008	0.072
Brugia malayi	sodium-independent organic anion transporter family protein	0.0195	0.0303	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0035	0.3063
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.0086	0.0116	0.3819
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0029	0.2479
Onchocerca volvulus	Cathepsin L homolog	0.0035	0.0029	0.0691
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0035	0.0502
Loa Loa (eye worm)	cytochrome P450 family protein	0.0054	0.0062	0.1885
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0023	0.0008	0.0275
Entamoeba histolytica	hypothetical protein	0.0039	0.0035	0.3063
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0029	0.0947
Schistosoma mansoni	smdr2	0.0023	0.0008	0.0275
Echinococcus granulosus	leucyl tRNA synthetase	0.0086	0.0116	0.3819
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0132	0.0195	1
Echinococcus multilocularis	expressed protein	0.0102	0.0145	0.2047
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0029	0.2479
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0035	0.0029	0.0947
Onchocerca volvulus		0.0195	0.0303	1
Brugia malayi	Cytochrome P450 family protein	0.0021	0.0006	0.0191
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0029	0.2479
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0029	0.077
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.012	0.0175	0.5787
Trypanosoma cruzi	MFS transporter, putative	0.0195	0.0303	1
Echinococcus multilocularis	pol protein	0.0431	0.0707	1
Echinococcus granulosus	multidrug resistance protein 1	0.0023	0.0008	0.0275
Trypanosoma brucei	cytochrome P450, putative	0.0021	0.0006	0.0297
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0023	0.0008	0.072
Brugia malayi	sodium-independent organic anion transporter family protein	0.0195	0.0303	1
Treponema pallidum	cysteinyl-tRNA synthetase	0.0086	0.0116	0.5
Leishmania major	cathepsin L-like protease	0.0035	0.0029	0.121
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0102	0.0145	0.4627
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0035	0.0029	0.2479
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0023	0.0008	0.072
Echinococcus multilocularis	agrin	0.0102	0.0145	0.2047
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0035	0.0029	0.0947
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0023	0.0008	0.072
Trypanosoma cruzi	cysteine peptidase, putative	0.0132	0.0195	0.6433
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0023	0.0008	0.072
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0035	0.0029	0.0406
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0029	0.0947
Toxoplasma gondii	protease inhibitor PI2	0.0102	0.0145	0.4627
Plasmodium vivax	vivapain-2	0.0035	0.0029	0.2479
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0023	0.0008	0.072
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0009	0.0301
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0023	0.0008	0.072
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.0086	0.0116	0.011
Onchocerca volvulus	Putative organic anion transporter	0.0195	0.0303	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0023	0.0008	0.0118

Activities

Activity type	Activity value	Assay description	Source	Reference
Reduction (functional)	= 95 %	MDR-reversal activity evaluated against the resistant human breast tumor cell line MDA-435/LCC6-MDR	ChEMBL.	15771464
Reduction (functional)	= 95 %	MDR-reversal activity evaluated against the resistant human breast tumor cell line MDA-435/LCC6-MDR	ChEMBL.	15771464

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 339265