Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0415 | 0.3551 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1062 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0415 | 0.3551 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0089 | 0.0305 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0305 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.0305 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.0081 | 0.0229 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.0305 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0415 | 0.3551 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1062 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0415 | 0.3551 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0415 | 0.3551 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0415 | 0.3551 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0415 | 0.3551 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0089 | 0.0305 | 0.0858 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0415 | 0.3551 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0415 | 0.3551 | 0.5 |
Brugia malayi | Probable ClpP-like protease | 0.0089 | 0.0305 | 0.0225 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0089 | 0.0305 | 0.0305 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1062 | 1 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0089 | 0.0305 | 0.0858 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1062 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1062 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1062 | 1 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0415 | 0.3551 | 0.3499 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1062 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.0305 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0415 | 0.3551 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1062 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.1062 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1062 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1062 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1062 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1062 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0415 | 0.3551 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.0081 | 0.0229 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1062 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 7.5 nM | Inhibition constant against human carbonic anhydrase IX | ChEMBL. | 15908204 |
Ki (binding) | = 8.5 nM | Inhibition constant against human carbonic anhydrase XII | ChEMBL. | 15908204 |
Ki (binding) | = 14 nM | Inhibition constant against human carbonic anhydrase II | ChEMBL. | 15908204 |
Ki (binding) | = 62 nM | Inhibition constant against human carbonic anhydrase I | ChEMBL. | 15908204 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.