Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0063 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0063 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0063 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0063 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0063 | 1 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0063 | 1 | 0.5 |
Onchocerca volvulus | 0.0063 | 1 | 0.5 | |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0063 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0063 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0063 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0063 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0063 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0063 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0063 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0063 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0063 | 1 | 0.5 |
Onchocerca volvulus | 0.0063 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0063 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0063 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0063 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0063 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0063 | 1 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0063 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0063 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0063 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0063 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0063 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0063 | 1 | 1 |
Onchocerca volvulus | 0.0063 | 1 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0063 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0063 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0063 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0063 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0063 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0063 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0063 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0063 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0063 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0063 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0063 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0063 | 1 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0063 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0063 | 1 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0063 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0063 | 1 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0063 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0063 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0063 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0063 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0063 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0063 | 1 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0063 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0063 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0063 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0063 | 1 | 0.5 |
Onchocerca volvulus | 0.0063 | 1 | 0.5 | |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0063 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0063 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0063 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0063 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0063 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0063 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0063 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0063 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0063 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0063 | 1 | 1 |
Onchocerca volvulus | 0.0063 | 1 | 0.5 | |
Schistosoma mansoni | pol-related | 0.0063 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0063 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0063 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0063 | 1 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0063 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0063 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0063 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0063 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0063 | 1 | 0.5 |
Onchocerca volvulus | 0.0063 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 35 % | Percent inhibition against metabotropic glutamate receptor 5 (mGluR5) at 10 uM | ChEMBL. | 15878659 |
Inhibition (binding) | < 35 % | Percent inhibition against metabotropic glutamate receptor 5 (mGluR5) at 10 uM | ChEMBL. | 15878659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.