Detailed information for compound 339472

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 864.929 | Formula: C49H52O14
  • H donors: 1 H acceptors: 7 LogP: 5.29 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)O[C@H]1C[C@@]2(O)[C@@H](OCc3ccccc3)[C@@H]3[C@@]4(CO[C@@H]4C[C@@H]([C@]3(C(=O)[C@@H](C(=C1C)C2(C)C)OC(=O)/C=C/c1ccc(cc1)OC(=O)c1ccccc1)C)OC(=O)C)OC(=O)C
  • InChi: 1S/C49H52O14/c1-28-36(59-29(2)50)25-49(56)44(57-26-33-14-10-8-11-15-33)42-47(7,37(60-30(3)51)24-38-48(42,27-58-38)63-31(4)52)43(54)41(40(28)46(49,5)6)62-39(53)23-20-32-18-21-35(22-19-32)61-45(55)34-16-12-9-13-17-34/h8-23,36-38,41-42,44,56H,24-27H2,1-7H3/b23-20+/t36-,37-,38+,41+,42-,44-,47+,48-,49+/m0/s1
  • InChiKey: NTEBVSLSDIYABU-MNUDITJESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0668 0.8429 0.8423
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0223 0.0284
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.121 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0095 0.1074 0.1266
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0092 0.0262
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0071 0.0774 0.0744
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0097 0.0071
Mycobacterium tuberculosis Carboxylesterase LipT 0.0093 0.1054 0.7703
Loa Loa (eye worm) hypothetical protein 0.0093 0.1054 0.1021
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.12 0.8837
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0097 0.0071
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Toxoplasma gondii hypothetical protein 0.0116 0.1345 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0095 0.1074 0.1234
Onchocerca volvulus 0.0093 0.1054 0.436
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0446 0.3688
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0097 0.0071
Loa Loa (eye worm) hypothetical protein 0.0093 0.1054 0.1021
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0614 0.0686
Onchocerca volvulus Putative endochitinase 0.0082 0.0908 0.3733
Loa Loa (eye worm) hypothetical protein 0.0101 0.1153 0.112
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0053 0.0016
Echinococcus multilocularis acetylcholinesterase 0.0552 0.6935 0.6961
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0196 0.2369 0.2341
Brugia malayi jmjC domain containing protein 0.0015 0.0053 0.0054
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0053 0.0016
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0097 0.006
Onchocerca volvulus 0.0093 0.1054 0.436
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0196 0.2369 0.2775
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0196 0.2369 0.2341
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0196 0.2369 0.2775
Loa Loa (eye worm) hypothetical protein 0.0552 0.6935 0.6923
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0097 0.0105
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0101 0.1153 0.136
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0092 0.0761
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0092 0.0761
Loa Loa (eye worm) hypothetical protein 0.0101 0.1153 0.112
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0223 0.1847
Loa Loa (eye worm) hypothetical protein 0.0101 0.1153 0.112
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0097 0.0071
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0223 0.1318
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0097 0.0105
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0097 0.0071
Echinococcus granulosus phd:f box containing protein 0.0015 0.0053 0.0019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0614 0.4803
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0053 0.044
Echinococcus granulosus BC026374 protein S09 family 0.0093 0.1054 0.121
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0196 0.2369 0.2804
Onchocerca volvulus 0.0116 0.1345 0.5608
Echinococcus granulosus RUN 0.0019 0.0103 0.0079
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.12 0.8837
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0016
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0097 0.0105
Onchocerca volvulus Putative endochitinase 0.0082 0.0908 0.3733
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0196 0.2369 0.2804
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0062 0.0512
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0196 0.2369 0.2804
Echinococcus multilocularis nAChR subunit 0.0196 0.2369 0.2354
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0103 0.0388
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.006
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0614 0.0686
Schistosoma mansoni gliotactin 0.0093 0.1054 0.121
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0053 0.0016
Echinococcus multilocularis carboxylesterase 5A 0.0552 0.6935 0.6961
Loa Loa (eye worm) RecQ helicase 0.0021 0.0124 0.0087
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.006
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0037 0.000000012337
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0196 0.2369 0.2775
Brugia malayi Cytochrome P450 family protein 0.0019 0.0099 0.0108
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0787 0.9946 1
Brugia malayi glutathione reductase 0.0046 0.0446 0.0521
Loa Loa (eye worm) hypothetical protein 0.0095 0.1074 0.1041
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0097 0.0071
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0092 0.0056
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0223 0.1435
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0097 0.0798
Loa Loa (eye worm) cuticular endochitinase 0.0073 0.0795 0.076
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0092 0.0262
Toxoplasma gondii exonuclease III APE 0.0018 0.0092 0.0432
Echinococcus granulosus glycine receptor subunit alpha 1 0.0196 0.2369 0.2775
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.121 1
Brugia malayi hypothetical protein 0.0095 0.1074 0.1266
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0097 0.0071
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0053 0.044
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.121 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0614 0.4283
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.059 0.0555
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0095 0.1074 0.1041
Onchocerca volvulus 0.0116 0.1345 0.5608
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0223 0.1847
Brugia malayi Carboxylesterase family protein 0.0552 0.6935 0.8225
Brugia malayi jmjC domain containing protein 0.0015 0.0053 0.0054
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0062 0.0512
Onchocerca volvulus 0.0101 0.1153 0.4786
Onchocerca volvulus 0.0095 0.1074 0.4448
Schistosoma mansoni nAChR subunit 0.0196 0.2369 0.2775
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0614 0.4803
Loa Loa (eye worm) hypothetical protein 0.0095 0.1074 0.1041
Loa Loa (eye worm) hypothetical protein 0.0101 0.1153 0.112
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.121 0.1396
Mycobacterium ulcerans chitinase/cellulase 0.0062 0.0657 0.5179
Brugia malayi Thioredoxin reductase 0.0046 0.0446 0.0521
Schistosoma mansoni nAChR subunit 0.0095 0.1074 0.1234
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0053 0.0136
Onchocerca volvulus Putative endochitinase 0.0082 0.0908 0.3733
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.121 0.1396
Onchocerca volvulus 0.0196 0.2369 1
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.0524 0.6583 1
Brugia malayi phosphofructokinase 0.0105 0.121 0.1428
Loa Loa (eye worm) hypothetical protein 0.0101 0.1153 0.112
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0053 0.0136
Plasmodium falciparum conserved protein, unknown function 0.0116 0.1345 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0223 0.1435
Brugia malayi hypothetical protein 0.0019 0.0103 0.0113
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0062 0.0512
Loa Loa (eye worm) hypothetical protein 0.0062 0.0657 0.0622
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0037 0.000000012337
Brugia malayi Carboxylesterase family protein 0.0093 0.1054 0.1242
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0103 0.0079
Schistosoma mansoni nAChR subunit 0.0196 0.2369 0.2775
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0124 0.1021
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0196 0.2369 0.2775
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0053 0.0019
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Brugia malayi Protein kinase domain containing protein 0.0014 0.0037 0.0035
Schistosoma mansoni ap endonuclease 0.0018 0.0092 0.0066
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0524 0.0489
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0093 0.1054 0.121
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.062 0.4332
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0223 0.1435
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0053 0.0016
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0097 0.0071
Onchocerca volvulus 0.0093 0.1054 0.436
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0062 0.003
Echinococcus granulosus carboxylesterase 5A 0.0552 0.6935 0.8206
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0099 0.0062
Plasmodium vivax hypothetical protein, conserved 0.0116 0.1345 0.1997
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.062 0.4858
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.062 0.0693
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.006
Loa Loa (eye worm) hypothetical protein 0.0101 0.1153 0.112
Onchocerca volvulus 0.0093 0.1054 0.436
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0446 0.0413
Loa Loa (eye worm) hypothetical protein 0.0095 0.1074 0.1041
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0097 0.006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0095 0.1074 0.1266
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0062 0.0512
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0092 0.0066
Onchocerca volvulus 0.0196 0.2369 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0092 0.01
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0053 0.0019
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0116 0.1345 0.132
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0097 0.0105
Loa Loa (eye worm) hypothetical protein 0.0101 0.1153 0.112
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0062 0.0512
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0067
Brugia malayi 6-phosphofructokinase 0.0105 0.121 0.1428
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0062 0.0025
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0196 0.2369 0.2354
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0062 0.0512
Loa Loa (eye worm) hypothetical protein 0.0095 0.1074 0.1041
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.121 1
Echinococcus granulosus expressed protein 0.0362 0.4502 0.5311
Schistosoma mansoni hypothetical protein 0.0116 0.1345 0.1556
Onchocerca volvulus 0.0196 0.2369 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0062 0.0202
Loa Loa (eye worm) hypothetical protein 0.0093 0.1054 0.1021
Loa Loa (eye worm) carboxylesterase 0.0093 0.1054 0.1021
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0097 0.0105
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0053 0.0019
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0101 0.1153 0.1328
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.121 0.0695
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0097 0.0798
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0196 0.2369 0.2804
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0097 0.006
Schistosoma mansoni rab6-interacting 0.0019 0.0103 0.0079
Plasmodium falciparum glutathione reductase 0.0016 0.0062 0.0068
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0116 0.1345 0.1588
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.135 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0196 0.2369 0.2354
Schistosoma mansoni rab6-interacting 0.0019 0.0103 0.0079
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.121 0.1396
Plasmodium vivax glutathione reductase, putative 0.0046 0.0446 0.0624
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0196 0.2369 0.2341
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.059 0.0658
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0099 0.082
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.135 1
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0446 0.0624
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0097 0.006
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.0033
Echinococcus multilocularis neuropeptide s receptor 0.0449 0.5611 0.5625
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0092 0.0301
Brugia malayi jmjC domain containing protein 0.0015 0.0053 0.0054
Mycobacterium tuberculosis Possible chitinase 0.0062 0.0657 0.4619
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0097 0.0071
Schistosoma mansoni lipoxygenase 0.008 0.0884 0.1007
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0099 0.082
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0093 0.1054 0.121
Brugia malayi PXA domain containing protein 0.0019 0.0097 0.0105
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0223 0.1847
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0093 0.1054 0.1026
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0092 0.0234
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0101 0.1153 0.136
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0103 0.0079
Loa Loa (eye worm) hypothetical protein 0.0116 0.1345 0.1313
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0095 0.1074 0.1234
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.8443 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0196 0.2369 0.2354
Brugia malayi Carboxylesterase family protein 0.0093 0.1054 0.1242
Loa Loa (eye worm) glutathione reductase 0.0046 0.0446 0.0411
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0103 0.0067
Schistosoma mansoni nAChR subunit 0.0196 0.2369 0.2775
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0097 0.006
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0614 0.0582
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0097 0.0798
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0062 0.0512
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0053 0.0019
Schistosoma mansoni acetylcholine receptor-related 0.0095 0.1074 0.1234
Loa Loa (eye worm) hypothetical protein 0.0095 0.1074 0.1041
Brugia malayi jmjC domain containing protein 0.0015 0.0053 0.0054
Echinococcus granulosus neuropeptide receptor A26 0.0449 0.5611 0.6631
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0223 0.1847
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0062 0.0512
Schistosoma mansoni ap endonuclease 0.0018 0.0092 0.0066
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.8443 0.8483
Onchocerca volvulus 0.0019 0.0103 0.0285
Loa Loa (eye worm) hypothetical protein 0.0101 0.1153 0.112
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0068 0.0037
Echinococcus multilocularis neuropeptide receptor A26 0.0449 0.5611 0.5625
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0091 0.0295
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0095 0.1074 0.1047
Schistosoma mansoni nAChR subunit 0.0095 0.1074 0.1234
Loa Loa (eye worm) hypothetical protein 0.0095 0.1074 0.1041
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0053 0.0016
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.121 1
Loa Loa (eye worm) ACC-1 protein 0.0196 0.2369 0.2341
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0614 0.4803
Leishmania major chitinase 0.0073 0.0795 0.6566
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.12 0.8837
Trypanosoma brucei trypanothione reductase 0.0046 0.0446 0.3688
Echinococcus granulosus neuroligin 0.0093 0.1054 0.121
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0016
Schistosoma mansoni hypothetical protein 0.0019 0.0103 0.0079
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0103 0.0067
Plasmodium vivax JmjC domain containing protein 0.0015 0.0053 0.0024
Loa Loa (eye worm) LGC-31 protein 0.0196 0.2369 0.2341
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0097 0.0071
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0223 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0092 0.0761
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0062 0.0068
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.121 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1074 0.1041
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0116 0.1345 0.1556
Brugia malayi hypothetical protein 0.0019 0.0097 0.0105
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.059 0.0558
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0097 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0097 0.0798
Echinococcus granulosus para nitrobenzyl esterase 0.0093 0.1054 0.121
Brugia malayi hypothetical protein 0.0095 0.1074 0.1266
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0101 0.1153 0.1328
Echinococcus granulosus glycine receptor subunit alpha 1 0.0196 0.2369 0.2775
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0223 0.0284
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0092 0.0055
Schistosoma mansoni nAChR subunit 0.0196 0.2369 0.2775
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0092 0.0761
Plasmodium falciparum glutathione reductase 0.0046 0.0446 0.3043
Plasmodium falciparum thioredoxin reductase 0.0046 0.0446 0.3043
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0095 0.1074 0.1266
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0097 0.0071
Brugia malayi Carboxylesterase family protein 0.0093 0.1054 0.1242
Brugia malayi jmjC domain containing protein 0.0057 0.059 0.0691
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0101 0.1153 0.136
Brugia malayi hypothetical protein 0.0093 0.1054 0.1242
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0103 0.0067
Entamoeba histolytica hypothetical protein 0.0019 0.0097 0.0798
Brugia malayi Doublecortin family protein 0.0019 0.0103 0.0113
Mycobacterium tuberculosis Probable reductase 0.0105 0.12 0.8837
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0062 0.0512
Brugia malayi hypothetical protein 0.0019 0.0103 0.0113
Loa Loa (eye worm) microfilarial chitinase 0.0071 0.077 0.0735
Loa Loa (eye worm) carboxylesterase 0.0093 0.1054 0.1021
Brugia malayi Carboxylesterase family protein 0.0093 0.1054 0.1242
Loa Loa (eye worm) hypothetical protein 0.0093 0.1054 0.1021
Schistosoma mansoni neuroligin 3 (S09 family) 0.0093 0.1054 0.121
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0223 0.1847
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0062 0.0512
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.121 0.1184
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0196 0.2369 0.2775
Echinococcus granulosus nuclear factor of activated T cells 5 0.0071 0.0774 0.0877
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0039 0.0002
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0614 0.0686
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0196 0.2369 0.2804
Echinococcus granulosus nAChR subunit 0.0101 0.1153 0.1328
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0196 0.2369 0.2775
Onchocerca volvulus Putative endochitinase 0.0073 0.0795 0.3249
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0223 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0103 0.0079
Brugia malayi jmjC domain containing protein 0.0057 0.059 0.0691
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0097 0.006
Loa Loa (eye worm) acetylcholine receptor protein 0.0095 0.1074 0.1041
Echinococcus granulosus glycine receptor subunit beta 0.0196 0.2369 0.2775
Loa Loa (eye worm) hypothetical protein 0.0573 0.7213 0.7202
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0067
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0053 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.006
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0062 0.0512
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0446 0.2985
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.12 0.8837
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.059 0.0558
Onchocerca volvulus 0.0196 0.2369 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0196 0.2369 0.2804
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0196 0.2369 0.2775
Echinococcus granulosus neuropeptide s receptor 0.0449 0.5611 0.6631
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.121 0.1178
Loa Loa (eye worm) chitinase I 0.0073 0.0795 0.076
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0037 0.0035
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0062 0.0068
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0196 0.2369 0.2341
Loa Loa (eye worm) hypothetical protein 0.0095 0.1074 0.1041
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0099 0.0324
Echinococcus multilocularis RUN 0.0019 0.0103 0.0067
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0099 0.082
Entamoeba histolytica chitinase, putative 0.0073 0.0795 0.6566
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0097 0.006
Loa Loa (eye worm) hypothetical protein 0.0095 0.1074 0.1041
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0124 0.0137
Onchocerca volvulus Putative endochitinase 0.0073 0.0795 0.3249
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0196 0.2369 0.2775
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0093 0.1054 0.121
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0196 0.2369 0.2354
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0196 0.2369 0.2341
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0093 0.1054 0.7703
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0196 0.2369 0.2354
Loa Loa (eye worm) GABA receptor subunit 0.0101 0.1153 0.112
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0196 0.2369 0.2354
Plasmodium falciparum thioredoxin reductase 0.0016 0.0062 0.0068
Entamoeba histolytica hypothetical protein 0.0101 0.1153 0.9527
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0097 0.006
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0093 0.1054 0.121
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.121 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1074 0.1041
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0092 0.1865
Loa Loa (eye worm) hypothetical protein 0.0093 0.1054 0.1021
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0097 0.0071
Loa Loa (eye worm) hypothetical protein 0.0093 0.1054 0.1021
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0614 0.4414
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0053 0.0019
Schistosoma mansoni BC026374 protein (S09 family) 0.0093 0.1054 0.121
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.062 0.0727
Schistosoma mansoni lipoxygenase 0.0114 0.1325 0.1533
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.062 0.5121
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0196 0.2369 0.2804
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0062 0.0202
Brugia malayi endochitinase 0.0073 0.0795 0.0934
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0196 0.2369 0.2341
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0095 0.1074 0.1266
Echinococcus multilocularis neuroligin 0.0093 0.1054 0.1026
Onchocerca volvulus 0.0019 0.0103 0.0285
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0095 0.1074 0.1234
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0097 0.006
Leishmania major trypanothione reductase 0.0046 0.0446 0.3688
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0097 0.0798
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0103 0.0101
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0223 0.1847
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0095 0.1074 0.1266
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.059 0.0658
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0097 0.0798
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0196 0.2369 0.2804
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0097 0.006
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0196 0.2369 0.2804
Echinococcus multilocularis BC026374 protein (S09 family) 0.0093 0.1054 0.1026
Brugia malayi Cation transporter family protein 0.0196 0.2369 0.2804
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0097 0.006
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0097 0.0071
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0062 0.0037
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0097 0.0071
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0097 0.0071
Schistosoma mansoni nAChR subunit 0.0196 0.2369 0.2775
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.059 0.0658
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0093 0.1054 0.8707
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0062 0.0512
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0062 0.0512
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0092 0.0761
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0062 0.0512
Echinococcus multilocularis nAChR subunit 0.0101 0.1153 0.1126
Echinococcus multilocularis acetylcholinesterase 0.0552 0.6935 0.6961
Onchocerca volvulus Putative nachr subunit 0.0196 0.2369 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0097 0.0798
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0095 0.1074 0.1047
Onchocerca volvulus 0.0196 0.2369 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0223 1
Schistosoma mansoni loxhd1 0.0019 0.0103 0.0079
Loa Loa (eye worm) ACC-1 protein 0.0196 0.2369 0.2341
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0124 0.0087
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0097 0.0071
Echinococcus multilocularis para nitrobenzyl esterase 0.0093 0.1054 0.1026
Mycobacterium ulcerans carboxylesterase, LipT 0.0093 0.1054 0.8637
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.062 0.0693
Loa Loa (eye worm) hypothetical protein 0.0093 0.1054 0.1021
Brugia malayi Cytochrome P450 family protein 0.0019 0.0099 0.0108
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0053 0.044
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0062 0.003
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0223 0.1318
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0092 0.0761
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0196 0.2369 0.2775
Loa Loa (eye worm) hypothetical protein 0.0095 0.1074 0.1041
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0223 0.1847
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.121 0.1178
Echinococcus granulosus glycine receptor subunit beta 0.0196 0.2369 0.2775
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.1325 0.1533
Entamoeba histolytica hypothetical protein 0.0019 0.0097 0.0798
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0053 0.0019
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0124 0.1021
Mycobacterium ulcerans chitinase/cellulase 0.0062 0.0657 0.5179
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0097 0.0071
Schistosoma mansoni jumonji domain containing protein 0.0057 0.059 0.0658
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0097 0.0071
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0062 0.0512
Leishmania major hypothetical protein, conserved 0.0015 0.0053 0.044
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0062 0.0037
Schistosoma mansoni nAChR subunit 0.0196 0.2369 0.2775
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0446 0.0487
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0196 0.2369 0.2804
Trichomonas vaginalis spcc417.12 protein, putative 0.0093 0.1054 0.8707
Echinococcus granulosus nAChR subunit 0.0196 0.2369 0.2775
Schistosoma mansoni neurotransmitter gated ion channel 0.0095 0.1074 0.1234
Brugia malayi hypothetical protein 0.0095 0.1074 0.1266
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0053 0.0019
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0062 0.0512
Loa Loa (eye worm) acetylcholinesterase 1 0.0552 0.6935 0.6923
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.121 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0062 0.0512
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0196 0.2369 0.2775
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0097 0.006
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0053 0.0019
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0196 0.2369 0.2775
Entamoeba histolytica hypothetical protein 0.0019 0.0097 0.0798
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0093 0.1054 0.7703
Loa Loa (eye worm) phosphofructokinase 0.0105 0.121 0.1178
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0101 0.1153 0.136
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.135 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0062 0.0512
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0196 0.2369 0.2775
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0196 0.2369 0.2804
Echinococcus multilocularis expressed protein 0.0362 0.4502 0.4506
Echinococcus granulosus microtubule associated protein 2 0.0669 0.8443 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.121 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0196 0.2369 0.2775
Schistosoma mansoni acetylcholine receptor subunit beta 0.0095 0.1074 0.1234
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0095 0.1074 0.1041
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.062 0.0588
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0097 0.0071
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0092 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.062 0.4858
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0053 0.0016
Brugia malayi Carboxylesterase family protein 0.0552 0.6935 0.8225
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0095 0.1074 0.1047
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.121 1
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0053 0.0019
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0223 0.1847
Echinococcus multilocularis Ankyrin 0.0014 0.0039 0.0002
Brugia malayi Cation transporter family protein 0.0196 0.2369 0.2804
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Brugia malayi 6-phosphofructokinase 0.0105 0.121 0.1428
Brugia malayi Endochitinase 0.0082 0.0908 0.1068
Brugia malayi hypothetical protein 0.0095 0.1074 0.1266
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0196 0.2369 0.2354
Echinococcus granulosus glycine receptor subunit alpha 1 0.0196 0.2369 0.2775
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0196 0.2369 0.2804
Brugia malayi Death domain containing protein 0.0014 0.0037 0.0035
Brugia malayi excitatory GABA receptor EXP-1A 0.0196 0.2369 0.2804
Loa Loa (eye worm) hypothetical protein 0.0116 0.1345 0.1313
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.059 0.0658
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0097 0.0071
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0095 0.1074 0.1266
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.121 1
Echinococcus granulosus bloom syndrome protein 0.0021 0.0124 0.0103
Brugia malayi PXA domain containing protein 0.0019 0.0097 0.0105
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0099 0.0062
Brugia malayi endochitinase 0.0082 0.0908 0.1068
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0196 0.2369 0.2354
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0097 0.0105
Schistosoma mansoni polycystin 1-related 0.0019 0.0103 0.0079
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0062 0.0064
Brugia malayi Cation transporter family protein 0.0196 0.2369 0.2804
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0552 0.6935 0.8206
Loa Loa (eye worm) carboxylesterase 0.0552 0.6935 0.6923
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0097 0.0071
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0196 0.2369 0.2804
Toxoplasma gondii thioredoxin reductase 0.0046 0.0446 0.3138
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.135 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0053 0.0016
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0446 0.0411
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0196 0.2369 0.2804
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0097 0.006
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.12 0.8837
Onchocerca volvulus 0.0095 0.1074 0.4448
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0099 0.0062
Onchocerca volvulus 0.0095 0.1074 0.4448
Echinococcus granulosus acetylcholinesterase 0.0552 0.6935 0.8206
Leishmania major cytochrome p450-like protein 0.0019 0.0099 0.082
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.006
Schistosoma mansoni nAChR subunit 0.0196 0.2369 0.2775
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0196 0.2369 0.2775
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0092 0.0761
Schistosoma mansoni acetylcholinesterase 0.0093 0.1054 0.121
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.121 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.1325 0.13
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0196 0.2369 0.2354
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0097 0.006
Brugia malayi hypothetical protein 0.0019 0.0097 0.0105
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0092 0.0083
Echinococcus multilocularis glycine receptor subunit beta 0.0196 0.2369 0.2354
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0196 0.2369 0.2354
Echinococcus granulosus acetylcholinesterase 0.0552 0.6935 0.8206
Loa Loa (eye worm) hypothetical protein 0.0095 0.1074 0.1041
Loa Loa (eye worm) hypothetical protein 0.0095 0.1074 0.1041
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0103 0.0067
Loa Loa (eye worm) hypothetical protein 0.0552 0.6935 0.6923
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0062 0.0512
Schistosoma mansoni neurotransmitter gated ion channel 0.0101 0.1153 0.1328
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0668 0.8429 1
Onchocerca volvulus 0.0101 0.1153 0.4786
Loa Loa (eye worm) hypothetical protein 0.0095 0.1074 0.1041
Onchocerca volvulus 0.0196 0.2369 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0614 0.5069
Loa Loa (eye worm) hypothetical protein 0.0095 0.1074 0.1041
Brugia malayi Uncoordinated protein 44 0.0014 0.0037 0.0035
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0196 0.2369 0.2804
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0097 0.0071
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.121 0.8918
Onchocerca volvulus 0.0093 0.1054 0.436
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.0223 0.1406
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0037 0.000000010465
Loa Loa (eye worm) hypothetical protein 0.0196 0.2369 0.2341
Echinococcus multilocularis glycine receptor subunit beta 0.0196 0.2369 0.2354
Brugia malayi hypothetical protein 0.0095 0.1074 0.1266
Echinococcus granulosus Ankyrin 0.0014 0.0039 0.0002
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0097 0.0071

Activities

Activity type Activity value Assay description Source Reference
Reduction (functional) = 7 % MDR-reversal activity evaluated against the resistant human breast tumor cell line MDA-435/LCC6-MDR ChEMBL. 15771464
Reduction (functional) = 7 % MDR-reversal activity evaluated against the resistant human breast tumor cell line MDA-435/LCC6-MDR ChEMBL. 15771464

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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