Detailed information for compound 339480

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 260.682 | Formula: C11H9ClN6
  • H donors: 2 H acceptors: 4 LogP: 2.12 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1n[nH]c(c1)Cc1nnn[nH]1
  • InChi: 1S/C11H9ClN6/c12-8-3-1-7(2-4-8)10-5-9(13-14-10)6-11-15-17-18-16-11/h1-5H,6H2,(H,13,14)(H,15,16,17,18)
  • InChiKey: XEJIPDPSNMUYKH-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0074 0.1024
Onchocerca volvulus 0.0201 0.0317 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0042 0.2947
Schistosoma mansoni multidrug resistance protein 0.0023 0.0023 0.0714
Brugia malayi Cathepsin L-like precursor 0.0035 0.0042 0.1313
Entamoeba histolytica cysteine protease, putative 0.0027 0.0028 0.1884
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0023 0.143
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0023 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0201 0.0317 1
Brugia malayi cytochrome P450 0.0011 0.0002 0.006
Chlamydia trachomatis cysteine--tRNA ligase 0.0088 0.013 1
Echinococcus granulosus follistatin 0.0106 0.0159 0.5011
Brugia malayi hypothetical protein 0.0201 0.0317 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0023 0.143
Brugia malayi cathepsin L-like precursor 0.0035 0.0042 0.1313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0028 0.1884
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.007 0.5225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.007 0.5225
Brugia malayi sodium-independent organic anion transporter family protein 0.0201 0.0317 1
Trichomonas vaginalis ABC transporter, putative 0.0023 0.0023 0.143
Entamoeba histolytica cysteine protease, putative 0.0027 0.0028 0.1884
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.1313
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0023 0.143
Echinococcus granulosus multidrug resistance protein 1 0.0016 0.0011 0.0345
Brugia malayi secreted modular calcium-binding protein 1 0.0106 0.0159 0.5011
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0016 0.0503
Brugia malayi Cathepsin L-like precursor 0.0052 0.007 0.2212
Loa Loa (eye worm) CYP4Cod1 0.0029 0.0032 0.1017
Brugia malayi hypothetical protein 0.0019 0.0016 0.0503
Trichomonas vaginalis taga, putative 0.0023 0.0023 0.143
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0088 0.013 1
Trichomonas vaginalis abcb9, putative 0.0023 0.0023 0.143
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0016 0.0011 0.0495
Brugia malayi Cathepsin L-like precursor 0.0035 0.0042 0.1313
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0023 0.0315
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.007 0.2212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.007 0.5225
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0005 0.009
Loa Loa (eye worm) hypothetical protein 0.0201 0.0317 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.005 0.0691
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0503
Onchocerca volvulus Cathepsin L homolog 0.0052 0.007 0.18
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0042 0.2947
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0058 0.1839
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0391
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0074 0.2324
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0023 0.0315
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.007 0.5225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.007 0.5225
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.007 0.0975
Plasmodium falciparum cysteine--tRNA ligase 0.0088 0.013 1
Plasmodium vivax unspecified product 0.0017 0.0012 0.0177
Echinococcus multilocularis ATP binding cassette sub family B 0.0023 0.0022 0.0309
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0033 0.1039
Echinococcus multilocularis pol protein 0.0444 0.072 1
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0201 0.0317 0.4405
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0181 0.0284 0.8953
Loa Loa (eye worm) hypothetical protein 0.0106 0.0159 0.5011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.007 0.5225
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0714
Echinococcus granulosus leucyl tRNA synthetase 0.0088 0.013 0.4097
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0201 0.0317 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0028 0.085
Onchocerca volvulus 0.0201 0.0317 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0023 0.1453
Leishmania major cathepsin L-like protease 0.0052 0.007 0.2197
Echinococcus granulosus cathepsin l1 0.0052 0.007 0.2212
Schistosoma mansoni hypothetical protein 0.0011 0.0002 0.006
Brugia malayi Cathepsin L-like precursor 0.0017 0.0012 0.0391
Leishmania major cathepsin L-like protease 0.0198 0.0313 1
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0106 0.0159 0.5011
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.007 0.0975
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.007 0.2166
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0023 0.0714
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0016 0.0222
Entamoeba histolytica cysteine proteinase 2 0.0027 0.0028 0.1884
Brugia malayi Cytochrome P450 family protein 0.0029 0.0032 0.1017
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0017 0.0012 0.0391
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0028 0.085
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0023 0.143
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0016 0.0474
Entamoeba histolytica hypothetical protein 0.004 0.005 0.3594
Brugia malayi ABC transporter family protein 0.0023 0.0023 0.0714
Onchocerca volvulus Putative organic anion transporter 0.0201 0.0317 1
Toxoplasma gondii protease inhibitor PI2 0.0106 0.0159 0.5011
Trypanosoma brucei cytochrome P450, putative 0.0029 0.0032 0.0977
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.007 0.5225
Brugia malayi hypothetical protein 0.0019 0.0016 0.0503
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0016 0.1228
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0028 0.0893
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0106 0.0159 0.5011
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0023 0.143
Onchocerca volvulus 0.0052 0.007 0.18
Leishmania major cysteine peptidase A (CPA) 0.0052 0.007 0.2197
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0058 0.1839
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0106 0.0159 0.5011
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.007 0.0975
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0023 0.143
Echinococcus granulosus cathepsin L cysteine protease 0.0027 0.0028 0.0893
Trypanosoma cruzi cysteine peptidase, putative 0.0198 0.0313 0.9858
Entamoeba histolytica hypothetical protein 0.004 0.005 0.3594
Brugia malayi multidrug resistance protein 3 0.0023 0.0023 0.0714
Schistosoma mansoni organic anion transporter 0.0201 0.0317 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0313 1
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0028 0.0838
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0012 0.0391
Plasmodium vivax cysteine--tRNA ligase, putative 0.0088 0.013 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.0012 0.0391
Toxoplasma gondii transporter, major facilitator family protein 0.0201 0.0317 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0023 0.143
Entamoeba histolytica cysteine protease, putative 0.0027 0.0028 0.1884
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0028 0.1884
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0023 0.0023 0.143
Loa Loa (eye worm) fibroinase 0.0052 0.007 0.2212
Schistosoma mansoni polycystin 1-related 0.0019 0.0016 0.0503
Echinococcus granulosus agrin 0.0106 0.0159 0.5011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0313 1
Brugia malayi Cathepsin L-like precursor 0.0052 0.007 0.2212
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.005 0.1568
Onchocerca volvulus 0.0106 0.0159 0.4746
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.1313
Trichomonas vaginalis ABC transporter, putative 0.0023 0.0023 0.143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0313 1
Onchocerca volvulus 0.0052 0.007 0.18
Loa Loa (eye worm) hypothetical protein 0.0201 0.0317 1
Brugia malayi Cathepsin L-like precursor 0.0052 0.007 0.2212
Entamoeba histolytica hypothetical protein 0.004 0.005 0.3594
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0028 0.0893
Entamoeba histolytica cysteine protease, putative 0.0027 0.0028 0.1884
Schistosoma mansoni transcription factor LCR-F1 0.004 0.005 0.1568
Loa Loa (eye worm) hypothetical protein 0.0201 0.0317 1
Onchocerca volvulus Putative organic anion transporter 0.0201 0.0317 1
Echinococcus granulosus cathepsin L 0.0027 0.0028 0.0893
Entamoeba histolytica P-glycoprotein-2, putative 0.0023 0.0023 0.143
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.001 0.0315
Brugia malayi prostaglandin transporter 0.0201 0.0317 1
Onchocerca volvulus 0.0052 0.007 0.18
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0042 0.2947
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0088 0.013 0.4062
Trypanosoma cruzi cysteine peptidase, putative 0.0198 0.0313 0.9858
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0023 0.143
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0106 0.0159 0.5011
Loa Loa (eye worm) cytochrome P450 0.0011 0.0002 0.006
Echinococcus multilocularis RUN 0.0019 0.0016 0.0222
Loa Loa (eye worm) multidrug resistance protein 3 0.0023 0.0023 0.0714
Brugia malayi Cytochrome P450 family protein 0.0029 0.0032 0.1017
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0106 0.0159 0.5011
Loa Loa (eye worm) ctsf protein 0.0052 0.007 0.2212
Schistosoma mansoni smdr2 0.0023 0.0023 0.0714
Plasmodium vivax vivapain-2 0.0052 0.007 0.5004
Loa Loa (eye worm) RecQ helicase 0.0024 0.0023 0.0723
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0088 0.013 0.4097
Onchocerca volvulus Putative organic anion transporter 0.0201 0.0317 1
Brugia malayi Cytochrome P450 family protein 0.003 0.0033 0.1039
Plasmodium falciparum cysteine proteinase falcipain 1 0.0027 0.0028 0.218
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0016 0.0503
Plasmodium falciparum multidrug resistance protein 1 0.0023 0.0023 0.1743
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0023 0.143
Onchocerca volvulus 0.0201 0.0317 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.007 0.5225
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.1313
Echinococcus multilocularis pol protein 0.0444 0.072 1
Onchocerca volvulus 0.0088 0.013 0.3785
Brugia malayi Cathepsin L-like precursor 0.0052 0.007 0.2212
Trypanosoma cruzi MFS transporter, putative 0.0201 0.0317 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0023 0.143
Brugia malayi hypothetical protein 0.0201 0.0317 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0156 0.0242 0.7625
Loa Loa (eye worm) hypothetical protein 0.0106 0.0159 0.5011
Echinococcus granulosus cysteine protease 0.0027 0.0028 0.0893
Onchocerca volvulus 0.0201 0.0317 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0023 0.0023 0.0714
Entamoeba histolytica P-glycoprotein-1 0.0023 0.0023 0.143
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0028 0.0838
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0018 0.14
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0023 0.0023 0.0714
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0023 0.143
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0023 0.0315
Trypanosoma cruzi cruzipain precursor, putative 0.0198 0.0313 0.9858
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0023 0.143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.007 0.5225
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0023 0.143
Loa Loa (eye worm) hypothetical protein 0.0201 0.0317 1
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.007 0.5225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0058 0.1839
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0088 0.013 1
Plasmodium vivax vivapain-1 0.0027 0.0028 0.1508
Leishmania major cysteinyl-tRNA synthetase, putative 0.0088 0.013 0.4121
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.007 0.54
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0106 0.0159 0.5011
Entamoeba histolytica cysteine protease, putative 0.0027 0.0028 0.1884
Loa Loa (eye worm) hypothetical protein 0.0201 0.0317 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.007 0.5225
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0023 0.143
Schistosoma mansoni rab6-interacting 0.0019 0.0016 0.0503
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0088 0.013 0.4097
Echinococcus granulosus cysteinyl tRNA synthetase 0.0088 0.013 0.4097
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0023 0.143
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0005 0.0092
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.6047 1 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0015 0.0464
Loa Loa (eye worm) hypothetical protein 0.0106 0.0159 0.5011
Loa Loa (eye worm) agrin synaptic family protein 0.0106 0.0159 0.5011
Entamoeba histolytica cysteine protease, putative 0.0027 0.0028 0.1884
Trichomonas vaginalis ABC transporter, putative 0.0023 0.0023 0.143
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0016 0.0222
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0023 0.143
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.007 0.5225
Onchocerca volvulus 0.0052 0.007 0.18
Schistosoma mansoni lipoxygenase 0.0054 0.0074 0.2324
Onchocerca volvulus 0.0023 0.0023 0.0222
Treponema pallidum cysteinyl-tRNA synthetase 0.0088 0.013 0.5
Schistosoma mansoni hypothetical protein 0.004 0.005 0.1568
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.007 0.54
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0002 0.006
Plasmodium falciparum cysteine--tRNA ligase 0.0088 0.013 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.007 0.5225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.007 0.5225
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0088 0.013 0.4097
Giardia lamblia Cysteinyl-tRNA synthetase 0.0088 0.013 1
Entamoeba histolytica P-glycoprotein-2 0.0023 0.0023 0.143
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0028 0.0893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.007 0.5225
Leishmania major p-glycoprotein 0.0023 0.0023 0.0668
Echinococcus multilocularis multidrug resistance protein 1 0.0023 0.0023 0.0315
Leishmania major cathepsin L-like protease 0.0198 0.0313 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0313 1
Brugia malayi Cytochrome P450 family protein 0.0011 0.0002 0.006
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0023 0.0714
Entamoeba histolytica P-glycoprotein-5 0.0023 0.0023 0.143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0313 1
Echinococcus multilocularis follistatin 0.0106 0.0159 0.2207
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0032 0.0963
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0028 0.0893
Entamoeba histolytica P-glyco protein 6, putative 0.0023 0.0023 0.143
Loa Loa (eye worm) hypothetical protein 0.0201 0.0317 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0023 0.0023 0.0714
Brugia malayi sodium-independent organic anion transporter family protein 0.0201 0.0317 1
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0028 0.1884
Entamoeba histolytica cysteine protease, putative 0.0027 0.0028 0.1884
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0313 1
Brugia malayi hypothetical protein 0.004 0.005 0.1568
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0088 0.013 0.0128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0058 0.1839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.007 0.5225
Loa Loa (eye worm) cysteine protease 0.0052 0.007 0.2212
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0023 0.143
Onchocerca volvulus 0.0052 0.007 0.18
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0088 0.013 0.4097
Schistosoma mansoni organic anion transporter 0.0201 0.0317 1
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0023 0.0023 0.0668
Entamoeba histolytica cysteine protease, putative 0.0027 0.0028 0.1884
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0106 0.0159 0.5011
Loa Loa (eye worm) hypothetical protein 0.0088 0.013 0.4097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0028 0.1884
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0023 0.0023 0.0714
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0027 0.0028 0.0838
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.007 0.2212
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0005 0.0092
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.007 0.5225
Plasmodium vivax multidrug resistance protein 1, putative 0.0023 0.0023 0.1033
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0023 0.0319
Entamoeba histolytica cysteine protease, putative 0.0027 0.0028 0.1884
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0012 0.0333
Trichomonas vaginalis ABC transporter, putative 0.0023 0.0023 0.143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.007 0.5225
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0023 0.1453
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0028 0.1884
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.007 0.5225
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.007 0.2212
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0042 0.1313
Trypanosoma cruzi cruzipain precursor, putative 0.0017 0.0012 0.0333
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0058 0.081
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0088 0.013 0.4097
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0028 0.0893
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0028 0.1884
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0058 0.081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0313 1
Echinococcus multilocularis expressed protein 0.0106 0.0159 0.2207
Leishmania major cathepsin L-like protease 0.0052 0.007 0.2197
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0000000000073433 0.00000000023157
Onchocerca volvulus Cathepsin L homolog 0.0052 0.007 0.18
Echinococcus granulosus bloom syndrome protein 0.0024 0.0023 0.0723
Echinococcus multilocularis cysteine protease 0.0052 0.007 0.0975
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.007 0.5225
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0023 0.143
Onchocerca volvulus Cathepsin F homolog 0.0052 0.007 0.18
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0313 1
Trichomonas vaginalis abcb9, putative 0.0023 0.0023 0.143
Echinococcus multilocularis multidrug resistance protein 1 0.0016 0.0011 0.0152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.007 0.5225
Schistosoma mansoni multidrug resistance protein 0.0023 0.0023 0.0714
Schistosoma mansoni lipoxygenase 0.0019 0.0016 0.0503
Onchocerca volvulus 0.0035 0.0042 0.0853
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0503
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.007 0.5225
Loa Loa (eye worm) hypothetical protein 0.0119 0.018 0.5692
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0391
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0029 0.0032 0.003
Brugia malayi SPARC precursor 0.0106 0.0159 0.5011
Schistosoma mansoni hypothetical protein 0.0019 0.0016 0.0503
Echinococcus multilocularis cathepsin L 0.0027 0.0028 0.0393
Leishmania major cathepsin L-like protease 0.0052 0.007 0.2197
Echinococcus multilocularis 0.0011 0.0002 0.0026
Echinococcus multilocularis multidrug resistance protein 1 0.0023 0.0023 0.0315
Onchocerca volvulus 0.0201 0.0317 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0016 0.0222
Brugia malayi sodium-independent organic anion transporter family protein 0.0201 0.0317 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.007 0.2212
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0106 0.0159 0.5011
Brugia malayi Cathepsin L-like precursor 0.0052 0.007 0.2212
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0058 0.1839
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0016 0.0503
Loa Loa (eye worm) hypothetical protein 0.0106 0.0159 0.5011
Schistosoma mansoni cathepsin s 0.0017 0.0012 0.0391
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0714
Entamoeba histolytica cysteine protease, putative 0.0027 0.0028 0.1884
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0391
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.6047 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0023 0.0023 0.0714
Schistosoma mansoni agrin 0.0106 0.0159 0.5011
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0023 0.0723
Echinococcus multilocularis agrin 0.0106 0.0159 0.2207
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0023 0.0315
Leishmania major cathepsin L-like protease 0.0052 0.007 0.2197
Plasmodium vivax vivapain-3 0.0027 0.0028 0.1508
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0201 0.0317 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0313 1
Echinococcus granulosus cathepsin l1 0.0035 0.0042 0.1313
Schistosoma mansoni multidrug resistance protein 0.0023 0.0023 0.0714
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0088 0.013 0.1805
Onchocerca volvulus 0.0052 0.007 0.18
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0023 0.143
Plasmodium vivax unspecified product 0.0027 0.0028 0.1508
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0032 0.1017
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.007 0.0975
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0023 0.0023 0.0714
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0028 0.0838
Trypanosoma cruzi cysteine protease, putative 0.0027 0.0028 0.0838
Entamoeba histolytica P-glycoprotein 5, putative 0.0023 0.0023 0.143
Schistosoma mansoni cytochrome P450 0.0011 0.0002 0.006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0058 0.1839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.007 0.5225
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0201 0.0317 0.4405
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0023 0.0023 0.0714
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0023 0.0022 0.0701
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0023 0.143
Onchocerca volvulus 0.0052 0.007 0.18
Loa Loa (eye worm) hypothetical protein 0.0052 0.007 0.2212
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0023 0.0023 0.143
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.007 0.5225
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.007 0.2212
Entamoeba histolytica cysteine protease, putative 0.0052 0.007 0.5225
Entamoeba histolytica P-glycoprotein-2 0.0023 0.0023 0.143
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0701
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.007 0.5225
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.007 0.2212
Brugia malayi Cathepsin L-like cysteine proteinase 0.0035 0.0042 0.1313
Plasmodium vivax vivapain-2 0.0052 0.007 0.5004
Entamoeba histolytica hypothetical protein 0.004 0.005 0.3594
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0016 0.0503
Brugia malayi Cathepsin L-like precursor 0.0052 0.007 0.2212
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0023 0.0714
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0088 0.013 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0313 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.0028 0.1884
Echinococcus granulosus Solute carrier organic anion transporter family 0.0201 0.0317 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.0028 0.1884
Entamoeba histolytica cysteine proteinase 1, putative 0.0027 0.0028 0.1884
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.007 0.2212
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0106 0.0159 0.5011
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0032 0.1017
Schistosoma mansoni rab6-interacting 0.0019 0.0016 0.0503
Echinococcus multilocularis pol protein 0.0444 0.072 1
Trichomonas vaginalis abcb9, putative 0.0023 0.0023 0.143
Entamoeba histolytica cysteine protease, putative 0.0027 0.0028 0.1884
Schistosoma mansoni loxhd1 0.0019 0.0016 0.0503
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0032 0.0963
Leishmania major cathepsin L-like protease 0.0198 0.0313 1
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0088 0.013 0.4121
Echinococcus multilocularis pol protein 0.0444 0.072 1
Toxoplasma gondii cathepsin CPL 0.0052 0.007 0.2212
Brugia malayi Doublecortin family protein 0.0019 0.0016 0.0503
Echinococcus granulosus multidrug resistance protein 1 0.0016 0.0011 0.0345
Leishmania major cytochrome p450-like protein 0.0029 0.0032 0.0977
Schistosoma mansoni follistatin 0.0106 0.0159 0.5011
Leishmania major cathepsin L-like protease 0.0052 0.007 0.2197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.007 0.5225
Trypanosoma cruzi cysteine peptidase, putative 0.0198 0.0313 0.9858
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0313 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0002 0.006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0058 0.1839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.007 0.5225
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0023 0.0315
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.007 0.54
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0088 0.013 0.4062
Echinococcus granulosus RUN 0.0019 0.0016 0.0503
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0449
Echinococcus multilocularis cysteine protease 0.0052 0.007 0.0975

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 10.8 % Percent fall in blood glucose level in male Sprague-Dawley rats when at 100 mg/kg dose was calculated by AUC method ChEMBL. 15808480

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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