Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | poly (ADP-ribose) polymerase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1658 | 0.1782 |
Schistosoma mansoni | kinase | 0.0055 | 0.1008 | 0.1083 |
Echinococcus granulosus | geminin | 0.0196 | 0.5478 | 1 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.0112 | 0.282 | 0.2911 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0165 | 0.4496 | 1 |
Trichomonas vaginalis | mannose-6-phosphate isomerase, putative | 0.0112 | 0.282 | 0.2716 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0495 | 0.0532 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1076 | 0.1156 |
Schistosoma mansoni | protein phosphatase 2C | 0.0029 | 0.0164 | 0.0176 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0095 | 0.2279 | 0.3062 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.065 | 0.0539 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0495 | 0.0532 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.0112 | 0.282 | 0.2911 |
Loa Loa (eye worm) | glutaminase 2 | 0.0316 | 0.9304 | 1 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0174 | 0.4772 | 0.8693 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0034 | 0.0314 | 0.031 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0174 | 0.4772 | 0.5129 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0034 | 0.0314 | 0.045 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0029 | 0.0164 | 0.0176 |
Trypanosoma brucei | phosphomannose isomerase | 0.0112 | 0.282 | 0.3845 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0314 | 0.0337 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.5478 | 0.5888 |
Brugia malayi | jmjC domain containing protein | 0.0029 | 0.0164 | 0.0007 |
Entamoeba histolytica | mannose-6-phosphate isomerase, putative | 0.0051 | 0.0879 | 0.0788 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.1572 | 0.2777 |
Giardia lamblia | Kinase, PLK | 0.0109 | 0.2718 | 0.2482 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0109 | 0.2718 | 0.2921 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.007 | 0.0076 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.1572 | 0.169 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0338 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0111 | 0.2775 | 0.2983 |
Entamoeba histolytica | phosphomannose isomerase, putative | 0.0112 | 0.282 | 0.2748 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.1572 | 0.169 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0047 | 0.0734 | 0.1227 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0029 | 0.0164 | 0.0174 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0029 | 0.0164 | 0.0176 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0027 | 0.0099 | 0.0054 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.018 | 0.4988 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.2718 | 0.2613 |
Echinococcus multilocularis | poly (ADP ribose) polymerase | 0.004 | 0.051 | 0.0812 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0109 | 0.2718 | 0.3717 |
Schistosoma mansoni | jumonji domain containing protein | 0.0029 | 0.0164 | 0.0176 |
Echinococcus granulosus | mannose 6 phosphate isomerase | 0.0112 | 0.282 | 0.5084 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.1572 | 0.169 |
Schistosoma mansoni | mannose-6-phosphate isomerase | 0.0112 | 0.282 | 0.3031 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.1572 | 0.169 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0029 | 0.0164 | 0.0174 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0109 | 0.2718 | 0.2921 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0029 | 0.0164 | 0.0174 |
Mycobacterium ulcerans | glutaminase | 0.0316 | 0.9304 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0109 | 0.2718 | 0.4895 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0246 | 0.7072 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.0563 | 0.0911 |
Leishmania major | phosphomannose isomerase | 0.0112 | 0.282 | 0.3864 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0165 | 0.4496 | 0.4753 |
Plasmodium falciparum | phd finger protein, putative | 0.0034 | 0.0314 | 0.0563 |
Trypanosoma brucei | polo-like protein kinase | 0.0109 | 0.2718 | 0.3697 |
Echinococcus granulosus | jumonji domain containing protein | 0.0047 | 0.0734 | 0.1227 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.2718 | 0.2613 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0338 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0029 | 0.0164 | 0.0007 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.1572 | 0.2777 |
Plasmodium vivax | hypothetical protein, conserved | 0.0034 | 0.0314 | 0.0563 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.0068 | 0.142 | 0.1527 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1844 | 0.1982 |
Brugia malayi | WGR domain containing protein | 0.0095 | 0.2279 | 0.232 |
Brugia malayi | Bromodomain containing protein | 0.0087 | 0.2001 | 0.2016 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.1456 | 0.1565 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0029 | 0.0164 | 0.0032 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.1572 | 0.169 |
Brugia malayi | RNA binding protein | 0.0073 | 0.1572 | 0.1547 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0165 | 0.4496 | 1 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0031 | 0.0235 | 0.0304 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0029 | 0.0164 | 0.0176 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0164 | 0.0032 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.0112 | 0.282 | 0.3031 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.074 | 0.0795 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.1076 | 0.1156 |
Brugia malayi | jmjC domain containing protein | 0.0029 | 0.0164 | 0.0007 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0338 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0036 | 0.0401 | 0.0266 |
Schistosoma mansoni | phd/f-box containing protein | 0.0029 | 0.0164 | 0.0176 |
Schistosoma mansoni | bromodomain containing protein | 0.0073 | 0.157 | 0.1687 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0174 | 0.4772 | 0.4719 |
Echinococcus granulosus | peregrin | 0.0036 | 0.0401 | 0.0611 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.1438 | 0.2529 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0095 | 0.2279 | 0.245 |
Plasmodium vivax | mannose-6-phosphate isomerase, putative | 0.0112 | 0.282 | 1 |
Mycobacterium ulcerans | mannose-6-phosphate isomerase ManA | 0.0112 | 0.282 | 0.2923 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0034 | 0.0314 | 0.045 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.1572 | 0.1547 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.2279 | 0.245 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.2718 | 0.2613 |
Toxoplasma gondii | phosphomannose isomerase type I protein | 0.0112 | 0.282 | 0.5506 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0027 | 0.0099 | 0.0054 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0109 | 0.2718 | 0.3717 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.2718 | 0.2613 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0178 | 0.4921 | 0.8969 |
Mycobacterium tuberculosis | Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho | 0.0061 | 0.1181 | 0.2386 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0246 | 0.7072 | 1 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.0028 | 0.0142 | 0.0133 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0109 | 0.2705 | 0.4871 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.0112 | 0.282 | 0.3031 |
Brugia malayi | jmjC domain containing protein | 0.0178 | 0.4921 | 0.5208 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0138 | 0.3635 | 0.3907 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0111 | 0.2775 | 0.2983 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0164 | 0.0176 |
Echinococcus granulosus | phd:f box containing protein | 0.0029 | 0.0164 | 0.0174 |
Echinococcus multilocularis | phd:f box containing protein | 0.0029 | 0.0164 | 0.0174 |
Brugia malayi | glutaminase DH11.1 | 0.0316 | 0.9304 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.2718 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0653 | 0.0702 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.3451 | 0.3709 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0164 | 0.0176 |
Brugia malayi | PHD-finger family protein | 0.0034 | 0.0314 | 0.0171 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0095 | 0.2279 | 0.3084 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0029 | 0.0164 | 0.0174 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0029 | 0.0164 | 0.0174 |
Echinococcus multilocularis | mannose 6 phosphate isomerase | 0.0112 | 0.282 | 0.5084 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.1076 | 0.1004 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.0112 | 0.282 | 0.3864 |
Brugia malayi | MH2 domain containing protein | 0.0138 | 0.3635 | 0.3803 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0338 | 1 | 1 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.0112 | 0.282 | 0.3864 |
Brugia malayi | jmjC domain containing protein | 0.0029 | 0.0164 | 0.0007 |
Schistosoma mansoni | jumonji domain containing protein | 0.0156 | 0.4198 | 0.4512 |
Plasmodium falciparum | mannose-6-phosphate isomerase, putative | 0.0112 | 0.282 | 1 |
Schistosoma mansoni | glutaminase | 0.0316 | 0.9304 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0316 | 0.9304 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.1076 | 0.1004 |
Echinococcus granulosus | WGR domain containing protein | 0.0054 | 0.0959 | 0.1642 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0109 | 0.2718 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0054 | 0.0962 | 0.0831 |
Trichomonas vaginalis | glutaminase, putative | 0.0316 | 0.9304 | 0.9294 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0034 | 0.0314 | 0.0337 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0095 | 0.2279 | 0.4085 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0174 | 0.4772 | 0.8693 |
Brugia malayi | jmjC domain containing protein | 0.0111 | 0.2775 | 0.2862 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0338 | 1 | 1 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0034 | 0.0314 | 0.0337 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0338 | 1 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0095 | 0.2279 | 0.3084 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0178 | 0.4921 | 0.8969 |
Echinococcus multilocularis | peregrin | 0.0036 | 0.0401 | 0.0611 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0034 | 0.0314 | 0.031 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0111 | 0.2775 | 0.2983 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.1438 | 0.2529 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.5478 | 0.5888 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0054 | 0.0962 | 0.0831 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0138 | 0.3635 | 0.3907 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0054 | 0.0959 | 0.1642 |
Leishmania major | hypothetical protein, conserved | 0.0246 | 0.7072 | 1 |
Brugia malayi | WGR domain containing protein | 0.0174 | 0.4772 | 0.5045 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0029 | 0.0164 | 0.0176 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0495 | 0.0369 |
Echinococcus multilocularis | geminin | 0.0196 | 0.5478 | 1 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0029 | 0.0164 | 0.0176 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0109 | 0.2718 | 0.2645 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.1572 | 0.169 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0031 | 0.0235 | 0.0304 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0109 | 0.2718 | 0.3717 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.0563 | 0.0911 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.0028 | 0.0142 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.081 | 0.0871 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.1572 | 0.169 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0246 | 0.7072 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0082 | 0.1869 | 0.2009 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.1572 | 0.169 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.2718 | 0.2613 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0338 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0338 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0338 | 1 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0338 | 1 | 0.5 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0029 | 0.0164 | 0.0174 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0109 | 0.2718 | 0.2799 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0029 | 0.0164 | 0.0032 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0095 | 0.2279 | 0.4085 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0338 | 1 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0111 | 0.2775 | 0.5001 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0027 | 0.0099 | 0.0054 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0314 | 0.0337 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.1572 | 0.1547 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.2718 | 0.2613 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0109 | 0.2718 | 0.4895 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.