Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 0.6135 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | aldo keto reductase | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Loa Loa (eye worm) | oxidoreductase | 0.0343 | 0.2548 | 0.5 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 0.6135 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Entamoeba histolytica | aldose reductase, putative | 0.0343 | 0.2548 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Plasmodium falciparum | hypoxanthine-guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 0.5 |
Plasmodium vivax | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0483 | 0.6135 | 0.5 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 1 |
Mycobacterium tuberculosis | Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor | 0.037 | 0.3236 | 1 |
Mycobacterium ulcerans | hypoxanthine-guanine phosphoribosyltransferase Hpt | 0.0483 | 0.6135 | 1 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Loa Loa (eye worm) | oxidoreductase | 0.0343 | 0.2548 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Entamoeba histolytica | aldose reductase, putative | 0.0343 | 0.2548 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Loa Loa (eye worm) | oxidoreductase | 0.0343 | 0.2548 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0483 | 0.6135 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0343 | 0.2548 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus granulosus | hypothetical protein | 0.0343 | 0.2548 | 0.2548 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Mycobacterium leprae | Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho | 0.037 | 0.3236 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0343 | 0.2548 | 0.7876 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Loa Loa (eye worm) | oxidoreductase | 0.0343 | 0.2548 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Toxoplasma gondii | hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT | 0.0483 | 0.6135 | 1 |
Brugia malayi | Phosphoribosyl transferase domain containing protein | 0.0483 | 0.6135 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Entamoeba histolytica | aldose reductase, putative | 0.0343 | 0.2548 | 0.5 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0483 | 0.6135 | 1 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 1 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 0.6135 |
Onchocerca volvulus | 0.0483 | 0.6135 | 1 | |
Giardia lamblia | Guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 1 |
Trichomonas vaginalis | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0483 | 0.6135 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0343 | 0.2548 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 0.6135 |
Echinococcus granulosus | aldo keto reductase | 0.0343 | 0.2548 | 0.2548 |
Echinococcus granulosus | aldo keto reductase | 0.0343 | 0.2548 | 0.2548 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0483 | 0.6135 | 1 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0483 | 0.6135 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0343 | 0.2548 | 0.2548 |
Leishmania major | xanthine phosphoribosyltransferase | 0.0483 | 0.6135 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0634 | 1 | 1 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0483 | 0.6135 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | aldo keto reductase | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | aldo keto reductase | 0.0343 | 0.2548 | 0.2548 |
Leishmania major | hypoxanthine-guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log Ki (binding) | = 6.51 | Binding affinity against Opioid receptor mu 1 from rat brain membranes using [3H]-DAMGO | ChEMBL. | 15743203 |
Log Ki (binding) | = 6.57 | Binding affinity against Opioid receptor kappa 1 from guinea pig brain membranes using [3H]-U-69,593 | ChEMBL. | 15743203 |
Log Ki (binding) | = 7.14 | Binding affinity against Opioid receptor delta 1 from rat brain membranes using [3H]-DADLE | ChEMBL. | 15743203 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.