TDR Targets

Basic information

Technical information

TDR Targets ID: 339626
Name: 1-(3,5-diphenyl-3,4-dihydropyrazol-2-yl)ethan one
MW: 264.322 | Formula: C17H16N2O
H donors: 0 H acceptors: 1 LogP: 2.7 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)N1N=C(CC1c1ccccc1)c1ccccc1
InChi: 1S/C17H16N2O/c1-13(20)19-17(15-10-6-3-7-11-15)12-16(18-19)14-8-4-2-5-9-14/h2-11,17H,12H2,1H3
InChiKey: BSTJKGVHQLTINE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(3,5-diphenyl-2-pyrazolin-1-yl)ethanone
1-[3,5-di(phenyl)-4,5-dihydropyrazol-1-yl]ethanone
30693-34-6
STK050480
1-(3,5-Diphenyl-4,5-dihydro-pyrazol-1-yl)-ethanone
BAS 00615590
1-Acetyl-3,5-diphenyl-4,5-dihydropyrazole
1-Acetyl-4,5-dihydro-3,5-diphenyl-1H-pyrazole
1H-Pyrazole, 4,5-dihydro-1-acetyl-3,5-diphenyl-
5-23-09-00010 (Beilstein Handbook Reference)
BRN 0221183

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Capra hircus	Cathepsin H	Starlite/ChEMBL	References
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Capra hircus	Cathepsin B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	serine repeat antigen 1	Cathepsin H	335 aa	287 aa	22.3 %
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Onchocerca volvulus		Cathepsin B	335 aa	327 aa	35.2 %
Toxoplasma gondii	cathepsin CPC2	Cathepsin B	335 aa	269 aa	25.3 %
Giardia lamblia	Dipeptidyl-peptidase I precursor	Cathepsin B	335 aa	281 aa	25.6 %
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Cathepsin H	335 aa	331 aa	34.4 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	35.7 %
Plasmodium yoelii	cathepsin c precursor	Cathepsin B	335 aa	319 aa	25.7 %
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	Cathepsin B	335 aa	275 aa	33.5 %
Trypanosoma cruzi	cysteine peptidase, putative	Cathepsin H	335 aa	332 aa	33.7 %
Onchocerca volvulus		Cathepsin H	335 aa	325 aa	37.2 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	337 aa	25.8 %
Cryptosporidium parvum	preprocathepsin c precursor, putative	Cathepsin B	335 aa	281 aa	28.1 %
Brugia malayi	Cathepsin L-like precursor	Cathepsin B	335 aa	307 aa	26.1 %
Trypanosoma cruzi	cysteine peptidase, putative	Cathepsin H	335 aa	319 aa	34.5 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	296 aa	23.6 %
Loa Loa (eye worm)	ctsf protein	Cathepsin H	335 aa	306 aa	36.6 %
Trypanosoma cruzi	cysteine peptidase, putative	Cathepsin H	335 aa	314 aa	34.1 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Plasmodium knowlesi	knowpain-1	Cathepsin B	335 aa	289 aa	21.8 %
Dictyostelium discoideum	hypothetical protein	Cathepsin B	335 aa	290 aa	25.9 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	306 aa	36.6 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	270 aa	27.4 %
Onchocerca volvulus		Cathepsin B	335 aa	313 aa	23.0 %
Onchocerca volvulus		Cathepsin H	335 aa	328 aa	36.9 %
Echinococcus multilocularis	cysteine protease	Cathepsin H	335 aa	316 aa	40.2 %
Dictyostelium discoideum	cysteine proteinase 3	Cathepsin B	335 aa	275 aa	27.6 %
Giardia lamblia	Cathepsin L-like protease	Cathepsin B	335 aa	284 aa	23.6 %
Leishmania donovani	cysteine peptidase A (CBA)	Cathepsin H	335 aa	334 aa	33.8 %
Giardia lamblia	Cathepsin L-like protease	Cathepsin H	335 aa	276 aa	24.6 %
Plasmodium berghei	berghepain-1	Cathepsin B	335 aa	286 aa	22.4 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin B	335 aa	274 aa	21.5 %
Babesia bovis	papain family cysteine protease containing protein	Cathepsin H	335 aa	311 aa	32.2 %
Theileria parva	cathepsin C, putative	Cathepsin B	335 aa	291 aa	26.8 %
Plasmodium vivax	vivapain-3	Cathepsin B	335 aa	301 aa	23.6 %
Leishmania mexicana	cathepsin L-like protease, putative	Cathepsin H	335 aa	333 aa	35.1 %
Leishmania braziliensis	cathepsin L-like protease	Cathepsin H	335 aa	331 aa	35.0 %
Echinococcus granulosus	cathepsin b	Cathepsin H	335 aa	324 aa	29.6 %
Leishmania infantum	cathepsin L-like protease	Cathepsin H	335 aa	324 aa	34.6 %
Theileria parva	cysteine proteinase, putative	Cathepsin H	335 aa	339 aa	28.3 %
Neospora caninum	Cathepsin L, related	Cathepsin H	335 aa	291 aa	39.2 %
Dictyostelium discoideum	cysteine proteinase	Cathepsin H	335 aa	292 aa	39.4 %
Plasmodium berghei	berghepain-2	Cathepsin H	335 aa	318 aa	33.6 %
Leishmania mexicana		Cathepsin H	335 aa	333 aa	35.1 %
Echinococcus multilocularis	cathepsin L cysteine protease	Cathepsin H	335 aa	316 aa	39.6 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	308 aa	25.3 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	35.7 %
Giardia lamblia	Cathepsin L precursor	Cathepsin B	335 aa	279 aa	25.4 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Babesia bovis	cathepsin C precursor, putative	Cathepsin B	335 aa	307 aa	24.8 %
Dictyostelium discoideum	hypothetical protein	Cathepsin H	335 aa	322 aa	31.7 %
Theileria parva	cysteine proteinase	Cathepsin H	335 aa	323 aa	28.2 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Giardia lamblia	Hypothetical protein	Cathepsin B	335 aa	273 aa	32.6 %
Cryptosporidium hominis	cryptopain precursor	Cathepsin H	335 aa	322 aa	32.9 %
Onchocerca volvulus		Cathepsin H	335 aa	327 aa	36.4 %
Plasmodium knowlesi	dipeptidyl aminopeptidase 2, putative	Cathepsin B	335 aa	286 aa	28.3 %
Brugia malayi	Papain family cysteine protease containing protein	Cathepsin H	335 aa	287 aa	34.1 %
Leishmania mexicana		Cathepsin H	335 aa	333 aa	34.8 %
Dictyostelium discoideum	cysteine protease	Cathepsin B	335 aa	285 aa	24.2 %
Echinococcus granulosus	cysteine protease	Cathepsin H	335 aa	316 aa	39.2 %
Plasmodium berghei	dipeptidyl aminopeptidase 1, putative	Cathepsin B	335 aa	319 aa	25.7 %
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	Cathepsin B	335 aa	301 aa	27.6 %
Brugia malayi	Cathepsin L-like precursor	Cathepsin B	335 aa	307 aa	25.7 %
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Plasmodium falciparum	dipeptidyl aminopeptidase 2	Cathepsin B	335 aa	302 aa	26.5 %
Plasmodium knowlesi	cysteine protease, putative	Cathepsin H	335 aa	271 aa	24.7 %
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	Cathepsin B	335 aa	319 aa	25.1 %
Echinococcus granulosus	cathepsin L cysteine protease	Cathepsin H	335 aa	316 aa	38.9 %
Echinococcus multilocularis	cysteine protease	Cathepsin H	335 aa	316 aa	40.2 %
Theileria parva	cathepsin C, putative	Cathepsin B	335 aa	282 aa	29.4 %
Leishmania major	cysteine peptidase A (CPA)	Cathepsin H	335 aa	338 aa	33.7 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Schistosoma mansoni	cathepsin S (C01 family)	Cathepsin H	335 aa	307 aa	30.3 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	308 aa	37.7 %
Leishmania braziliensis	cathepsin L-like protease	Cathepsin H	335 aa	331 aa	35.0 %
Schistosoma japonicum	Disco-interacting protein 2 homolog B, putative	Cathepsin H	335 aa	350 aa	36.0 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	314 aa	23.6 %
Loa Loa (eye worm)	cysteine protease	Cathepsin H	335 aa	333 aa	35.1 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	270 aa	27.4 %
Dictyostelium discoideum	cysteine proteinase 1	Cathepsin B	335 aa	270 aa	25.2 %
Onchocerca volvulus	Cathepsin L homolog	Cathepsin H	335 aa	325 aa	36.9 %
Echinococcus multilocularis	cathepsin L	Cathepsin H	335 aa	300 aa	41.7 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Theileria parva	cysteine proteinase, putative	Cathepsin H	335 aa	330 aa	26.4 %
Dictyostelium discoideum	cathepsin L-like proteinase	Cathepsin B	335 aa	318 aa	25.5 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	Cathepsin B	335 aa	371 aa	25.3 %
Leishmania infantum	cysteine peptidase A (CPA)	Cathepsin H	335 aa	335 aa	33.7 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	337 aa	27.0 %
Giardia lamblia	Cathepsin L precursor	Cathepsin H	335 aa	282 aa	22.7 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	339 aa	26.8 %
Cryptosporidium hominis	preprocathepsin c precursor	Cathepsin B	335 aa	278 aa	29.5 %
Giardia lamblia	Cathepsin L precursor	Cathepsin B	335 aa	280 aa	25.4 %
Dictyostelium discoideum	hypothetical protein	Cathepsin H	335 aa	348 aa	38.5 %
Echinococcus multilocularis	cathepsin l cysteine peptidase	Cathepsin H	335 aa	327 aa	44.3 %
Toxoplasma gondii	cathepsin B	Cathepsin H	335 aa	274 aa	26.3 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	297 aa	23.9 %
Dictyostelium discoideum	cysteine proteinase 5 precursor	Cathepsin B	335 aa	369 aa	21.4 %
Leishmania major	cathepsin L-like protease	Cathepsin H	335 aa	342 aa	36.5 %
Plasmodium yoelii	berghepain-2	Cathepsin H	335 aa	318 aa	33.0 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Dictyostelium discoideum	hypothetical protein	Cathepsin H	335 aa	281 aa	27.8 %
Theileria parva	cysteine proteinase, putative	Cathepsin B	335 aa	322 aa	23.3 %
Leishmania braziliensis	cysteine peptidase A (CPA)	Cathepsin H	335 aa	300 aa	33.7 %
Plasmodium knowlesi	knowpain-2	Cathepsin B	335 aa	304 aa	26.0 %
Leishmania major	cathepsin L-like protease	Cathepsin H	335 aa	332 aa	36.7 %
Dictyostelium discoideum	cysteine protease	Cathepsin B	335 aa	283 aa	25.8 %
Brugia malayi	cathepsin B-like cysteine proteinase	Cathepsin H	335 aa	342 aa	24.6 %
Plasmodium berghei	dipeptidyl aminopeptidase 2	Cathepsin B	335 aa	315 aa	25.1 %
Trypanosoma cruzi	cysteine proteinase, putative	Cathepsin B	335 aa	278 aa	26.3 %
Trypanosoma cruzi	cysteine protease, putative	Cathepsin H	335 aa	341 aa	32.3 %
Plasmodium vivax	vivapain-2	Cathepsin B	335 aa	309 aa	25.9 %
Plasmodium knowlesi	dipeptidyl aminopeptidase 1, putative	Cathepsin B	335 aa	314 aa	24.5 %
Leishmania major	cathepsin L-like protease	Cathepsin H	335 aa	342 aa	36.5 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	343 aa	28.3 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	376 aa	24.7 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	271 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 2a	Cathepsin H	335 aa	329 aa	34.6 %
Schistosoma mansoni	cathepsin F (C01 family)	Cathepsin H	335 aa	325 aa	36.9 %
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Cathepsin H	335 aa	322 aa	33.2 %
Babesia bovis	cysteine protease 2	Cathepsin H	335 aa	339 aa	31.0 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	270 aa	27.0 %
Echinococcus granulosus	cathepsin L	Cathepsin H	335 aa	312 aa	32.7 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Toxoplasma gondii	cathepsin CPC1	Cathepsin B	335 aa	304 aa	28.6 %
Schistosoma japonicum	ko:K01275 cathepsin C [EC3.4.14.1], putative	Cathepsin B	335 aa	327 aa	30.9 %
Echinococcus granulosus	cathepsin L cysteine proteinase	Cathepsin H	335 aa	321 aa	39.9 %
Echinococcus multilocularis	cathepsin L	Cathepsin H	335 aa	312 aa	32.4 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	322 aa	35.4 %
Theileria parva	cysteine protease, putative	Cathepsin H	335 aa	306 aa	34.0 %
Echinococcus multilocularis	cathepsin l cysteine peptidase	Cathepsin H	335 aa	316 aa	39.6 %
Echinococcus granulosus	cathepsin L	Cathepsin H	335 aa	300 aa	41.3 %
Theileria parva	cysteine proteinase, putative	Cathepsin H	335 aa	337 aa	29.1 %
Leishmania braziliensis	cathepsin L-like protease	Cathepsin H	335 aa	331 aa	35.3 %
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Plasmodium vivax	vivapain-1	Cathepsin B	335 aa	288 aa	21.9 %
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	Cathepsin B	335 aa	286 aa	27.6 %
Giardia lamblia	Cathepsin L precursor	Cathepsin H	335 aa	270 aa	25.2 %
Leishmania major	cathepsin L-like protease	Cathepsin H	335 aa	342 aa	36.3 %
Schistosoma mansoni	cathepsin F (C01 family)	Cathepsin H	335 aa	300 aa	38.3 %
Drosophila melanogaster	Cathepsin B1	Cathepsin H	335 aa	318 aa	26.4 %
Plasmodium knowlesi	knowpain-3	Cathepsin H	335 aa	336 aa	35.7 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	337 aa	25.8 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	322 aa	35.4 %
Leishmania mexicana		Cathepsin H	335 aa	272 aa	36.4 %
Leishmania major	cathepsin L-like protease	Cathepsin H	335 aa	342 aa	36.5 %
Dictyostelium discoideum	hypothetical protein	Cathepsin H	335 aa	325 aa	33.5 %
Onchocerca volvulus	Protein MCM10 homolog	Cathepsin H	335 aa	313 aa	36.1 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	331 aa	25.1 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin B	335 aa	276 aa	23.2 %
Echinococcus multilocularis	cathepsin b	Cathepsin H	335 aa	311 aa	31.5 %
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	Cathepsin B	335 aa	273 aa	31.9 %
Plasmodium falciparum	cysteine proteinase falcipain 2b	Cathepsin H	335 aa	340 aa	33.2 %
Plasmodium falciparum	cysteine proteinase falcipain 3	Cathepsin H	335 aa	343 aa	32.9 %
Echinococcus multilocularis	cathepsin L cysteine protease	Cathepsin H	335 aa	316 aa	39.2 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	273 aa	26.4 %
Onchocerca volvulus	Cathepsin B-like cysteine proteinase 6 homolog	Cathepsin B	335 aa	315 aa	50.2 %
Schistosoma mansoni	cathepsin F (C01 family)	Cathepsin H	335 aa	296 aa	37.8 %
Leishmania major	cathepsin L-like protease	Cathepsin H	335 aa	342 aa	36.3 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	322 aa	20.5 %
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Cathepsin B	335 aa	286 aa	26.9 %
Toxoplasma gondii	cathepsin CPL	Cathepsin H	335 aa	311 aa	38.6 %
Leishmania mexicana	cysteine peptidase A (CBA)	Cathepsin H	335 aa	308 aa	34.1 %
Drosophila melanogaster	CG6347 gene product from transcript CG6347-RA	Cathepsin H	335 aa	353 aa	35.7 %
Plasmodium vivax	vivapain-2	Cathepsin H	335 aa	327 aa	36.1 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	324 aa	34.6 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	298 aa	28.2 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	337 aa	25.8 %
Dictyostelium discoideum	cysteine proteinase	Cathepsin H	335 aa	297 aa	38.7 %
Trypanosoma cruzi	cysteine proteinase, putative	Cathepsin B	335 aa	275 aa	25.8 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	270 aa	26.7 %
Leishmania mexicana	cathepsin L-like protease, putative	Cathepsin H	335 aa	333 aa	34.8 %
Plasmodium yoelii	cysteine proteinase precursor	Cathepsin H	335 aa	358 aa	27.7 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	271 aa	26.6 %
Theileria parva	cysteine proteinase, putative	Cathepsin H	335 aa	316 aa	27.5 %
Leishmania infantum	cathepsin L-like protease	Cathepsin H	335 aa	333 aa	37.2 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Leishmania mexicana		Cathepsin H	335 aa	333 aa	34.8 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	308 aa	37.0 %
Toxoplasma gondii	preprocathepsin c precursor, putative	Cathepsin B	335 aa	274 aa	24.5 %
Schistosoma japonicum	Cathepsin C precursor, putative	Cathepsin B	335 aa	333 aa	26.7 %
Neospora caninum	hypothetical protein	Cathepsin B	335 aa	306 aa	28.1 %
Plasmodium vivax	unspecified product	Cathepsin B	335 aa	288 aa	21.9 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	322 aa	34.8 %
Trypanosoma cruzi	cruzipain precursor, putative	Cathepsin H	335 aa	332 aa	33.7 %
Trypanosoma cruzi	cysteine peptidase, putative	Cathepsin H	335 aa	332 aa	33.7 %
Plasmodium falciparum	cysteine proteinase falcipain 1	Cathepsin B	335 aa	297 aa	22.9 %
Plasmodium knowlesi	knowpain-4	Cathepsin B	335 aa	300 aa	26.0 %
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	Cathepsin H	335 aa	315 aa	32.7 %
Onchocerca volvulus		Cathepsin H	335 aa	309 aa	36.9 %
Leishmania major	cathepsin L-like protease	Cathepsin H	335 aa	342 aa	36.5 %
Leishmania major	cathepsin L-like protease	Cathepsin H	335 aa	342 aa	36.3 %
Theileria parva	cysteine proteinase, putative	Cathepsin H	335 aa	334 aa	32.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tubulin epsilon chain	0.0029	0.0373	0.0636
Trypanosoma cruzi	beta tubulin, putative	0.0058	0.1528	0.2604
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0037	0.0688	0.1172
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0951	0.5
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Onchocerca volvulus		0.0043	0.0951	1
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0951	0.6027
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0058	0.1528	0.2604
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0951	0.6027
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.5869	1
Echinococcus multilocularis	tubulin alpha chain	0.0037	0.0688	0.1172
Leishmania major	alpha tubulin	0.0037	0.0688	0.436
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Trichomonas vaginalis	tubulin gamma chain, putative	0.0058	0.1528	0.9689
Echinococcus granulosus	cathepsin b	0.0171	0.5869	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.006	0.1577	1
Leishmania major	hypothetical protein, conserved	0.0043	0.0951	0.6027
Toxoplasma gondii	beta tubulin	0.0058	0.1528	0.9689
Loa Loa (eye worm)	beta-tubulin	0.0058	0.1528	0.2604
Echinococcus granulosus	tubulin subunit TubB	0.0037	0.0688	0.1172
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0037	0.0688	0.436
Echinococcus granulosus	tubulin alpha chain	0.0037	0.0688	0.1172
Leishmania major	gamma-tubulin	0.0029	0.0373	0.2366
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0951	0.162
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0951	0.162
Trypanosoma brucei	epsilon tubulin	0.0029	0.0373	0.2366
Trypanosoma brucei	tubulin gamma chain	0.0029	0.0373	0.2366
Plasmodium falciparum	tubulin beta chain	0.0058	0.1528	1
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0021	0.0064	0.0408
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0058	0.1528	0.9689
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0064	0.011
Brugia malayi	Tubulin alpha-2 chain	0.0037	0.0688	0.1172
Echinococcus multilocularis	tubulin alpha 1C chain	0.0037	0.0688	0.1172
Loa Loa (eye worm)	tubulin beta chain	0.0058	0.1528	0.2604
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Trypanosoma cruzi	epsilon tubulin, putative	0.0029	0.0373	0.0636
Giardia lamblia	Alpha-tubulin	0.0037	0.0688	0.2611
Leishmania major	alpha tubulin	0.0037	0.0688	0.436
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0951	0.6027
Brugia malayi	beta-lactamase family protein	0.0043	0.0951	0.162
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0951	0.162
Schistosoma mansoni	tubulin subunit beta	0.0058	0.1528	0.2604
Leishmania major	alpha tubulin	0.0037	0.0688	0.436
Echinococcus multilocularis	tubulin alpha 3 chain	0.0037	0.0688	0.1172
Loa Loa (eye worm)	tubulin beta-1 chain	0.0058	0.1528	0.2604
Echinococcus multilocularis	peroxisome assembly protein 26	0.0037	0.0688	0.1172
Trichomonas vaginalis	tubulin beta chain, putative	0.0037	0.0688	0.436
Trichomonas vaginalis	tubulin alpha chain, putative	0.0058	0.1528	0.9689
Entamoeba histolytica	tubulin alpha-1 chain	0.0037	0.0688	0.45
Leishmania major	alpha tubulin	0.0037	0.0688	0.436
Plasmodium vivax	tubulin gamma chain, putative	0.0029	0.0373	0.2442
Giardia lamblia	Alpha-tubulin	0.0037	0.0688	0.2611
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0951	0.5
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Trichomonas vaginalis	tubulin, putative	0.0058	0.1528	0.9689
Loa Loa (eye worm)	tubulin beta-4 chain	0.0058	0.1528	0.2604
Trypanosoma brucei	epsilon tubulin	0.0029	0.0373	0.2366
Trichomonas vaginalis	tubulin beta chain, putative	0.0037	0.0688	0.436
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0951	0.6027
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0209	0.0357
Loa Loa (eye worm)	alpha-tubulin	0.0037	0.0688	0.1172
Loa Loa (eye worm)	tubulin gamma chain	0.0029	0.0373	0.0636
Leishmania major	alpha tubulin	0.0037	0.0688	0.436
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0951	0.5
Echinococcus multilocularis	tubulin alpha 1C chain	0.0037	0.0688	0.1172
Echinococcus granulosus	beta tubulin	0.0058	0.1528	0.2604
Entamoeba histolytica	tubulin family protein	0.0058	0.1528	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0058	0.1528	0.2604
Echinococcus granulosus	Tubulin alpha 1 chain	0.0037	0.0688	0.1172
Echinococcus granulosus	tubulin beta 1 chain	0.0058	0.1528	0.2604
Loa Loa (eye worm)	tubulin alpha 2	0.0024	0.0209	0.0357
Echinococcus granulosus	Tubulin beta 2C chain	0.0058	0.1528	0.2604
Brugia malayi	beta-lactamase family protein	0.0043	0.0951	0.162
Trypanosoma brucei	beta tubulin	0.0058	0.1528	0.9689
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Echinococcus multilocularis	tubulin beta 1 chain	0.0058	0.1528	0.2604
Leishmania major	alpha tubulin	0.0037	0.0688	0.436
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0951	0.6027
Mycobacterium ulcerans	lipase LipD	0.0043	0.0951	0.5
Loa Loa (eye worm)	tubulin alpha chain	0.0037	0.0688	0.1172
Toxoplasma gondii	beta-tubulin, putative	0.0058	0.1528	0.9689
Giardia lamblia	Cathepsin B precursor	0.006	0.1577	1
Echinococcus multilocularis	tubulin alpha chain	0.0037	0.0688	0.1172
Schistosoma mansoni	alpha tubulin	0.0037	0.0688	0.1172
Onchocerca volvulus		0.0043	0.0951	1
Trypanosoma brucei	alpha tubulin	0.0037	0.0688	0.436
Echinococcus multilocularis	tubulin subunit beta	0.0058	0.1528	0.2604
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Echinococcus granulosus	tubulin alpha 1C chain	0.0037	0.0688	0.1172
Echinococcus multilocularis	Tubulin beta 2C chain	0.0058	0.1528	0.2604
Echinococcus granulosus	tubulin gamma 1 chain	0.0029	0.0373	0.0636
Plasmodium vivax	tubulin beta chain, putative	0.0058	0.1528	1
Plasmodium vivax	tubulin epsilon chain, putative	0.0029	0.0373	0.2442
Trypanosoma cruzi	tubulin gamma chain	0.0029	0.0373	0.0636
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Giardia lamblia	Cathepsin B precursor	0.006	0.1577	1
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0951	0.6221
Toxoplasma gondii	alpha-tubulin I, putative	0.0037	0.0688	0.436
Trichomonas vaginalis	esterase, putative	0.0043	0.0951	0.6027
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0951	0.162
Schistosoma mansoni	tubulin subunit beta	0.0058	0.1528	0.2604
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0171	0.5869	1
Loa Loa (eye worm)	alpha-tubulin	0.0037	0.0688	0.1172
Echinococcus multilocularis	tubulin alpha	0.0029	0.0373	0.0636
Loa Loa (eye worm)	BEN-1 protein	0.0058	0.1528	0.2604
Echinococcus granulosus	Tubulin beta 2C chain	0.0058	0.1528	0.2604
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0024	0.0209	0.1327
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.1577	1
Schistosoma mansoni	alpha tubulin	0.0037	0.0688	0.1172
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0021	0.0064	0.011
Trypanosoma brucei	alpha tubulin	0.0037	0.0688	0.436
Trichomonas vaginalis	tubulin beta chain, putative	0.0037	0.0688	0.436
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.1577	0.2688
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0951	0.162
Echinococcus granulosus	tubulin alpha chain	0.0037	0.0688	0.1172
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Giardia lamblia	Beta tubulin	0.0058	0.1528	0.9592
Echinococcus granulosus	tubulin alpha 1C chain	0.0037	0.0688	0.1172
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0951	0.162
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.1577	1
Echinococcus granulosus	tubulin alpha chain	0.0037	0.0688	0.1172
Echinococcus multilocularis	tubulin alpha chain	0.0037	0.0688	0.1172
Echinococcus granulosus	tubulin subunit beta	0.0058	0.1528	0.2604
Entamoeba histolytica	tubulin alpha chain, putative	0.0037	0.0688	0.45
Leishmania major	epsilon tubulin, putative	0.0029	0.0373	0.2366
Trypanosoma brucei	beta tubulin	0.0058	0.1528	0.9689
Trichomonas vaginalis	tubulin beta chain, putative	0.0037	0.0688	0.436
Loa Loa (eye worm)	tubulin beta-2A chain	0.0058	0.1528	0.2604
Echinococcus multilocularis	beta tubulin	0.0058	0.1528	0.2604
Leishmania major	alpha tubulin	0.0037	0.0688	0.436
Echinococcus multilocularis	beta tubulin	0.0058	0.1528	0.2604
Trypanosoma cruzi	alpha tubulin, putative	0.0037	0.0688	0.1172
Brugia malayi	Tubulin beta-1 chain	0.0058	0.1528	0.2604
Brugia malayi	cathepsin B-like cysteine proteinase	0.0171	0.5869	1
Brugia malayi	tubulin alpha-2 chain	0.0037	0.0688	0.1172
Leishmania major	alpha tubulin	0.0037	0.0688	0.436
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0037	0.0688	0.1172
Echinococcus granulosus	Tubulin alpha 1 chain	0.0037	0.0688	0.1172
Plasmodium falciparum	alpha tubulin 1	0.0037	0.0688	0.45
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0029	0.0373	0.2366
Leishmania major	alpha tubulin	0.0037	0.0688	0.436
Trypanosoma brucei	beta tubulin	0.0058	0.1528	0.9689
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0951	0.162
Echinococcus granulosus	peroxisome assembly protein 26	0.0037	0.0688	0.1172
Leishmania major	alpha tubulin	0.0037	0.0688	0.436
Trypanosoma brucei	beta tubulin	0.0029	0.0373	0.2366
Entamoeba histolytica	tubulin family protein	0.0058	0.1528	1
Leishmania major	alpha tubulin	0.0037	0.0688	0.436
Schistosoma mansoni	tubulin subunit alpha	0.0037	0.0688	0.1172
Schistosoma mansoni	tubulin subunit alpha	0.0037	0.0688	0.1172
Plasmodium falciparum	tubulin epsilon chain, putative	0.0029	0.0373	0.2442
Toxoplasma gondii	alpha tubulin TUBA1	0.0037	0.0688	0.436
Brugia malayi	Tubulin gamma chain	0.0029	0.0373	0.0636
Schistosoma mansoni	tubulin subunit beta	0.0058	0.1528	0.2604
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Echinococcus granulosus	tubulin alpha chain	0.0037	0.0688	0.1172
Schistosoma mansoni	tubulin subunit alpha	0.0037	0.0688	0.1172
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0037	0.0688	0.1172
Schistosoma mansoni	tubulin subunit beta	0.0058	0.1528	0.2604
Echinococcus granulosus	tubulin alpha	0.0029	0.0373	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0951	0.162
Plasmodium falciparum	alpha tubulin 2	0.0037	0.0688	0.45
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0951	0.162
Trypanosoma brucei	epsilon tubulin	0.0029	0.0373	0.2366
Brugia malayi	beta-tubulin, identical	0.0058	0.1528	0.2604
Trypanosoma brucei	beta tubulin	0.0058	0.1528	0.9689
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0024	0.0209	0.0357
Toxoplasma gondii	ABC1 family protein	0.0043	0.0951	0.6027
Echinococcus multilocularis	tubulin alpha chain	0.0037	0.0688	0.1172
Toxoplasma gondii	cathepsin B	0.006	0.1577	1
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Brugia malayi	Tubulin alpha-2 chain	0.0037	0.0688	0.1172
Trichomonas vaginalis	tubulin gamma chain, putative	0.0029	0.0373	0.2366
Echinococcus multilocularis	cathepsin b	0.0171	0.5869	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.5869	1
Loa Loa (eye worm)	BEN-1 protein	0.0058	0.1528	0.2604
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0951	0.162
Trypanosoma cruzi	epsilon tubulin, putative	0.0029	0.0373	0.0636
Loa Loa (eye worm)	tubulin alpha chain	0.0037	0.0688	0.1172
Entamoeba histolytica	tubulin gamma chain	0.0029	0.0373	0.2442
Echinococcus multilocularis	Tubulin beta 2C chain	0.0058	0.1528	0.2604
Echinococcus granulosus	tubulin alpha 3 chain	0.0037	0.0688	0.1172
Trypanosoma brucei	alpha tubulin	0.0037	0.0688	0.436
Plasmodium vivax	tubulin alpha chain, putative	0.0037	0.0688	0.45
Echinococcus granulosus	Tubulin beta 2C chain	0.0058	0.1528	0.2604
Giardia lamblia	Beta tubulin	0.0058	0.1528	0.9592
Giardia lamblia	Cathepsin B precursor	0.006	0.1577	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0171	0.5869	1
Schistosoma mansoni	tubulin subunit beta	0.0058	0.1528	0.2604
Trypanosoma brucei	alpha tubulin	0.0037	0.0688	0.436
Trichomonas vaginalis	tubulin beta chain, putative	0.0037	0.0688	0.436
Echinococcus multilocularis	tubulin alpha chain	0.0037	0.0688	0.1172
Echinococcus multilocularis	tubulin epsilon chain	0.0029	0.0373	0.0636
Echinococcus granulosus	Tubulin beta 2C chain	0.0058	0.1528	0.2604
Echinococcus granulosus	tubulin alpha 3 chain	0.0037	0.0688	0.1172
Echinococcus multilocularis	Tubulin beta 2C chain	0.0058	0.1528	0.2604
Echinococcus multilocularis	tubulin subunit TubB	0.0037	0.0688	0.1172
Brugia malayi	beta-lactamase	0.0043	0.0951	0.162
Echinococcus multilocularis	tubulin alpha 3 chain	0.0037	0.0688	0.1172
Echinococcus granulosus	Tubulin beta 2C chain	0.0058	0.1528	0.2604
Echinococcus multilocularis	tubulin gamma 1 chain	0.0029	0.0373	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0951	0.162
Brugia malayi	alpha-tubulin	0.0037	0.0688	0.1172
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0951	0.5
Toxoplasma gondii	beta-1 tubulin, putative	0.0058	0.1528	0.9689
Brugia malayi	Tubulin alpha chain	0.0037	0.0688	0.1172
Trichomonas vaginalis	tubulin gamma chain, putative	0.0029	0.0373	0.2366
Schistosoma mansoni	alpha tubulin	0.0037	0.0688	0.1172
Trichomonas vaginalis	tubulin beta chain, putative	0.0037	0.0688	0.436
Echinococcus granulosus	cathepsin b	0.0171	0.5869	1
Echinococcus multilocularis	cathepsin b	0.0171	0.5869	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0951	0.162
Plasmodium vivax	tubulin alpha chain, putative	0.0037	0.0688	0.45
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0951	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0058	0.1528	0.9689
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0058	0.1528	0.9689
Echinococcus multilocularis	Tubulin beta 2C chain	0.0058	0.1528	0.2604
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0951	0.6027
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.1577	0.2688
Schistosoma mansoni	tubulin subunit epsilon	0.0029	0.0373	0.0636
Loa Loa (eye worm)	cathepsin B	0.006	0.1577	0.2688
Plasmodium falciparum	tubulin gamma chain	0.0029	0.0373	0.2442
Echinococcus multilocularis	hypothetical protein	0.0037	0.0688	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0171	0.5869	1
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Echinococcus granulosus	alpha tubulin	0.0037	0.0688	0.1172
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0951	0.5
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0951	0.162
Brugia malayi	tubulin alpha chain - mouse	0.0037	0.0688	0.1172
Giardia lamblia	Beta tubulin	0.0058	0.1528	0.9592
Trichomonas vaginalis	tubulin alpha chain, putative	0.0029	0.0373	0.2366
Echinococcus granulosus	beta tubulin	0.0058	0.1528	0.2604
Echinococcus granulosus	tubulin alpha chain	0.0037	0.0688	0.1172
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Schistosoma mansoni	tubulin subunit beta	0.0058	0.1528	0.2604
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0037	0.0688	0.436
Onchocerca volvulus		0.0043	0.0951	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0951	0.162
Echinococcus granulosus	tubulin beta 4A class IVa	0.0058	0.1528	0.2604
Loa Loa (eye worm)	tubulin alpha 2	0.0024	0.0209	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0688	0.1172
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.5869	1
Schistosoma mansoni	tubulin subunit gamma	0.0029	0.0373	0.0636
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0037	0.0688	0.436
Leishmania major	beta tubulin	0.0058	0.1528	0.9689
Leishmania major	alpha tubulin	0.0037	0.0688	0.436
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0037	0.0688	0.1172
Echinococcus granulosus	Tubulin alpha 1 chain	0.0037	0.0688	0.1172
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0951	0.162

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 2.11 nmol/min/ml	Inhibition of goat liver cathepsin B assessed as enzyme activity at 10 uM using BANA substrate pre-incubated 30 mins before substrate addition by colorimetry (Rvb = 5.65 +/- 0.0276 nmol/min/ml)	ChEMBL.	24913985
Activity (binding)	= 2.33 nmol/min/ml	Inhibition of goat liver cathepsin H assessed as enzyme activity at 10 uM using BANA substrate pre-incubated 30 mins before substrate addition by colorimetry (Rvb = 3.70 +/- 0.0387 nmol/min/ml)	ChEMBL.	24913985
IC50 (binding)	> 50000 nM	In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay (n=3)	ChEMBL.	15808464
IC50 (binding)	> 50000 nM	In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay (n=3)	ChEMBL.	15808464
IC50 (functional)	= 23.54 uM	Cytotoxicity against Homo sapiens (human) OVCAR cells after 48 hr by SRB assay	ChEMBL.	No reference
IC50 (binding)	= 61.4 uM	Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry	ChEMBL.	21353569
Ki (binding)	= 17.54 uM	Non-competitive inhibition of goat liver cathepsin H using Leu-betaNA substrate by Lineweaver-Burk plot analysis	ChEMBL.	24913985
Ki (binding)	= 17.67 uM	Non-competitive inhibition of goat liver cathepsin B using BANA substrate by Lineweaver-Burk plot analysis	ChEMBL.	24913985
MIC (functional)	= 25 ug ml-1	Antimicrobial activity against Escherichia coli ATCC 35218 by MTT assay	ChEMBL.	20594840
Potency (functional)	0.3162 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	= 1 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL193585
PubChem: 207753
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Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 339626