Detailed information for compound 33973

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 296.235 | Formula: C16H19Cl2N
  • H donors: 0 H acceptors: 0 LogP: 4.57 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cl/C=C/[C@@H]1C2CCC(N2C)C[C@@H]1c1ccc(cc1)Cl
  • InChi: 1S/C16H19Cl2N/c1-19-13-6-7-16(19)14(8-9-17)15(10-13)11-2-4-12(18)5-3-11/h2-5,8-9,13-16H,6-7,10H2,1H3/b9-8+/t13?,14-,15-,16?/m1/s1
  • InChiKey: TUWFHUVJRFWFJU-GGNRPVDASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Myosin tail family protein 0.0048 0.0032 0.0053
Loa Loa (eye worm) STAT protein 0.0049 0.0036 0.0036
Brugia malayi CHE-14 protein 0.0475 0.1285 0.2134
Echinococcus multilocularis 0.0049 0.0036 0.0036
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0048 0.0032 0.0032
Echinococcus multilocularis geminin 0.0152 0.0338 0.0338
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0049 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0032 0.0108
Schistosoma mansoni sorbin 0.0048 0.0032 0.0033
Echinococcus granulosus tensin 0.0049 0.0036 0.0036
Brugia malayi Protein kinase domain containing protein 0.0063 0.0076 0.0127
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0219 0.0534 0.0887
Schistosoma mansoni tensin 0.0049 0.0036 0.0036
Schistosoma mansoni adapter molecule crk 0.0097 0.0177 0.018
Brugia malayi Spectrin alpha chain 0.0048 0.0032 0.0053
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0049 0.0036 0.0036
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0006 0.0006
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0076 0.0076
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0026 0.0483
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0111 0.0218 0.0218
Schistosoma mansoni SH2A 0.0049 0.0036 0.0036
Echinococcus multilocularis SHC transforming protein 3 0.0049 0.0036 0.0036
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0111 0.0218 0.0218
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.1153 0.3277 0.3277
Schistosoma mansoni GTPase activating protein 0.0049 0.0036 0.0036
Echinococcus granulosus tyrosine protein kinase Lyn 0.0114 0.0227 0.0227
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0541 0.1479 1
Loa Loa (eye worm) hypothetical protein 0.1306 0.3726 0.3726
Loa Loa (eye worm) hypothetical protein 0.0048 0.0032 0.0032
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0032 0.0053
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0049 0.0036 0.0036
Loa Loa (eye worm) serotonin transporter b 0.0219 0.0534 0.0534
Brugia malayi Protein kinase domain containing protein 0.0063 0.0076 0.0127
Echinococcus multilocularis SH2 motif 0.0049 0.0036 0.0036
Onchocerca volvulus 0.0048 0.0032 0.0601
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0063 0.0076 0.0076
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0048 0.0032 0.0033
Entamoeba histolytica BAR/SH3 domain containing protein 0.0048 0.0032 0.3676
Brugia malayi Variant SH3 domain containing protein 0.0049 0.0036 0.0059
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0078 0.012 0.012
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.1153 0.3277 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0033 0.0117
Onchocerca volvulus 0.0063 0.0076 0.143
Loa Loa (eye worm) hypothetical protein 0.0045 0.0022 0.0022
Loa Loa (eye worm) SH2 domain-containing protein 0.0049 0.0036 0.0036
Schistosoma mansoni suppressor of cytokine signaling 0.0049 0.0036 0.0036
Plasmodium falciparum amino acid transporter, putative 0.0037 0 0.5
Echinococcus granulosus growth factor receptor bound protein 2 0.0097 0.0177 0.0177
Echinococcus granulosus SH2 motif 0.0049 0.0036 0.0036
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0049 0.0036 0.0036
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0076 0.0076
Entamoeba histolytica unconventional myosin IB 0.0048 0.0032 0.3676
Schistosoma mansoni tyrosine kinase 0.0111 0.0218 0.0221
Loa Loa (eye worm) protein-tyrosine kinase 0.0048 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0049 0.0036 0.0036
Echinococcus granulosus SH2 domain containing protein 7 0.0049 0.0036 0.0036
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0033 0.0004
Echinococcus granulosus endophilin A3 0.0048 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase Fyn 0.0111 0.0218 0.0218
Loa Loa (eye worm) SH2 domain-containing protein 0.0049 0.0036 0.0036
Loa Loa (eye worm) TK protein kinase 0.0063 0.0076 0.0076
Schistosoma mansoni sodium/chloride dependent transporter 0.0219 0.0534 0.0542
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0048 0.0032 0.0032
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0097 0.0177 0.0177
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0048 0.0032 0.0032
Brugia malayi Fli-1 protein 0.0237 0.0588 0.0976
Brugia malayi Tensin 0.0049 0.0036 0.0059
Loa Loa (eye worm) hypothetical protein 0.0063 0.0076 0.0076
Schistosoma mansoni dreadlocks/dock 0.0048 0.0032 0.0033
Schistosoma mansoni nck2/grb4 0.0097 0.0177 0.018
Brugia malayi Ets-domain containing protein 0.0078 0.012 0.02
Entamoeba histolytica SH2 domain containing protein 0.0049 0.0036 0.419
Echinococcus granulosus SH2 domain containing adapter protein F 0.0049 0.0036 0.0036
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0049 0.0036 0.0036
Brugia malayi Variant SH3 domain containing protein 0.0097 0.0177 0.0294
Schistosoma mansoni growth factor receptor-bound protein 0.0097 0.0177 0.018
Echinococcus granulosus hypothetical protein 0.0049 0.0036 0.0036
Treponema pallidum sodium- and chloride- dependent transporter 0.0219 0.0534 0.5
Entamoeba histolytica hypothetical protein 0.0048 0.0032 0.3676
Echinococcus granulosus tyrosine protein kinase Fyn 0.0111 0.0218 0.0218
Schistosoma mansoni vav2 0.0049 0.0036 0.0036
Brugia malayi Tyrosine-protein kinase abl-1 0.2087 0.602 1
Onchocerca volvulus 0.0049 0.0036 0.0669
Entamoeba histolytica hypothetical protein 0.0048 0.0032 0.3676
Brugia malayi Variant SH3 domain containing protein 0.0097 0.0177 0.0294
Loa Loa (eye worm) thyroid receptor interactor 0.0048 0.0032 0.0032
Trichomonas vaginalis p67phox protein, putative 0.0048 0.0032 0.0108
Echinococcus granulosus epidermal growth factor receptor kinase 0.0048 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0063 0.0076 0.0076
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0026 0.0065
Echinococcus multilocularis sterol regulatory element binding protein 0.0475 0.1285 0.1285
Echinococcus granulosus suppressor of cytokine signaling 7 0.0049 0.0036 0.0036
Plasmodium vivax hypothetical protein, conserved 0.0037 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0219 0.0534 0.0534
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0048 0.0032 0.0032
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0049 0.0036 0.0036
Schistosoma mansoni ets-related 0.0237 0.0588 0.0596
Brugia malayi Protein kinase domain containing protein 0.0063 0.0076 0.0127
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0475 0.1285 0.1285
Echinococcus granulosus chromobox protein 1 0.0076 0.0115 0.0115
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0033 0.0033
Brugia malayi Variant SH3 domain containing protein 0.0049 0.0036 0.0059
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0032 0.0053
Schistosoma mansoni tyrosine kinase 0.0111 0.0218 0.0221
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0033 0.0004
Schistosoma mansoni dynamin-associated protein 0.0048 0.0032 0.0033
Echinococcus granulosus expressed conserved protein 0.0049 0.0036 0.0036
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0076 0.0076
Echinococcus multilocularis tensin 0.0049 0.0036 0.0036
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0111 0.0218 0.0218
Brugia malayi SRC-1 0.0111 0.0218 0.0362
Loa Loa (eye worm) SRC-1 0.0111 0.0218 0.0218
Schistosoma mansoni run and tbc1 domain containing 0.0048 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0048 0.0032 0.0032
Echinococcus multilocularis protein dispatched 1 0.0475 0.1285 0.1285
Echinococcus granulosus tyrosine kinase 0.0063 0.0076 0.0076
Echinococcus multilocularis tyrosine kinase 0.0063 0.0076 0.0076
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0033 0.0117
Loa Loa (eye worm) hypothetical protein 0.0048 0.0032 0.0032
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0033 0.0117
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0033 0.0033
Echinococcus multilocularis SH2 motif 0.0049 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0043 0.0016 0.0016
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.0009 0.0009
Echinococcus granulosus NCK adaptor protein 0.0097 0.0177 0.0177
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0111 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0049 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.0032 0.0032
Echinococcus multilocularis SH2 domain containing protein 7 0.0049 0.0036 0.0036
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0048 0.0032 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0076 0.0076
Schistosoma mansoni tyrosine kinase 0.3393 0.9855 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0049 0.0036 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0073 0.0074
Echinococcus granulosus Niemann Pick C1 protein 0.0475 0.1285 0.1285
Brugia malayi hypothetical protein 0.0049 0.0036 0.0059
Brugia malayi chromobox protein homolog 3 0.0043 0.0016 0.0027
Entamoeba histolytica protein kinase, putative 0.0052 0.0045 0.5493
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0049 0.0036 0.0036
Echinococcus granulosus tyrosine protein kinase Fyn 0.0111 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0475 0.1285 0.1285
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.1153 0.3277 0.3277
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.1153 0.3277 1
Schistosoma mansoni C-fyn 0.0048 0.0032 0.0033
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0049 0.0036 0.0036
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0045 0.0022 0.0037
Schistosoma mansoni sorting nexin 0.0048 0.0032 0.0033
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0033 1
Brugia malayi Tyrosine-protein kinase abl-1 0.1403 0.4012 0.6664
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0111 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0049 0.0036 0.0036
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0152 0.0338 0.0343
Loa Loa (eye worm) hypothetical protein 0.0049 0.0036 0.0036
Echinococcus multilocularis NCK adaptor protein 0.0097 0.0177 0.0177
Echinococcus granulosus chromobox protein 1 0.0076 0.0115 0.0115
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0097 0.0177 0.018
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0048 0.0032 0.0032
Schistosoma mansoni signal transduction protein lnk-related 0.0049 0.0036 0.0036
Onchocerca volvulus 0.0051 0.0041 0.0772
Echinococcus multilocularis tyrosine protein kinase Blk 0.0063 0.0076 0.0076
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0033 0.0004
Echinococcus granulosus tyrosine protein kinase Blk 0.0063 0.0076 0.0076
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0115 0.0672
Echinococcus granulosus Protein patched homolog 1 0.0475 0.1285 0.1285
Brugia malayi hypothetical protein 0.0063 0.0076 0.0127
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0045 0.0022 0.0022
Echinococcus multilocularis intersectin 2 0.0048 0.0032 0.0032
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0049 0.0036 0.0036
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0541 0.1479 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.0049 0.0036 0.0059
Brugia malayi MAP kinase sur-1 0.0049 0.0033 0.0055
Echinococcus multilocularis tensin 0.0049 0.0036 0.0036
Brugia malayi Src substrate cortactin 0.0048 0.0032 0.0053
Schistosoma mansoni formin binding protein and related proteins 0.0048 0.0032 0.0033
Brugia malayi Heterochromatin protein 1 0.0076 0.0115 0.019
Loa Loa (eye worm) hypothetical protein 0.0049 0.0036 0.0036
Onchocerca volvulus 0.0063 0.0076 0.143
Echinococcus multilocularis Spectrin alpha actinin 0.0048 0.0032 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0076 0.0076
Echinococcus multilocularis endophilin A3 0.0048 0.0032 0.0032
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0033 0.0004
Echinococcus granulosus Spectrin alpha actinin 0.0048 0.0032 0.0032
Brugia malayi SH2 domain containing protein 0.0049 0.0036 0.0059
Loa Loa (eye worm) TK/ABL protein kinase 0.3442 1 1
Echinococcus multilocularis SH2 motif 0.0049 0.0036 0.0036
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0033 0.0004
Brugia malayi SH2 domain containing protein 0.0063 0.0076 0.0127
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.0048 0.0032 0.3676
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0541 0.1479 1
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0049 0.0036 0.0036
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0048 0.0032 0.0032
Echinococcus granulosus src region 0.0048 0.0032 0.0032
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0049 0.0036 0.0669
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0049 0.0036 0.0036
Loa Loa (eye worm) SH2 domain-containing protein 0.0049 0.0036 0.0036
Entamoeba histolytica hypothetical protein 0.0048 0.0032 0.3676
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0033 0.0117
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0049 0.0036 0.0036
Echinococcus multilocularis Niemann Pick C1 protein 0.0475 0.1285 0.1285
Loa Loa (eye worm) hypothetical protein 0.0067 0.0087 0.0087
Schistosoma mansoni patched 1 0.0475 0.1285 0.1304
Loa Loa (eye worm) hypothetical protein 0.0049 0.0036 0.0036
Echinococcus multilocularis chromobox protein 1 0.0076 0.0115 0.0115
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0049 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0049 0.0036 0.0036
Loa Loa (eye worm) guanylate kinase 0.0048 0.0032 0.0032
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0063 0.0076 1
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0048 0.0032 0.0032
Echinococcus granulosus c src tyrosine kinase 0.0111 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0048 0.0032 0.0032
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0026 0.0065
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0111 0.0218 0.0218
Brugia malayi Fes/CIP4 homology domain containing protein 0.0048 0.0032 0.0053
Entamoeba histolytica hypothetical protein 0.0048 0.0032 0.3676
Brugia malayi protein-tyrosine kinase 0.0048 0.0032 0.0053
Brugia malayi SH2 domain containing protein 0.0049 0.0036 0.0059
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0475 0.1285 0.1304
Brugia malayi Calcitonin receptor-like protein seb-1 0.0045 0.0022 0.0037
Schistosoma mansoni tensin-related 0.0049 0.0036 0.0036
Schistosoma mansoni tyrosine kinase 0.0063 0.0076 0.0078
Echinococcus granulosus suppressor of cytokine signaling 6 0.0049 0.0036 0.0036
Plasmodium vivax amine transporter, putative 0.0037 0 0.5
Brugia malayi SH2 domain containing protein 0.0049 0.0036 0.0059
Schistosoma mansoni eps8-related protein 0.0048 0.0032 0.0033
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0006 0.0006
Brugia malayi SH2 domain containing protein 0.0049 0.0036 0.0059
Echinococcus multilocularis nostrin 0.0048 0.0032 0.0032
Echinococcus granulosus sterol regulatory element binding protein 0.0475 0.1285 0.1285
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0063 0.0076 0.0076
Echinococcus multilocularis transfer RNA-Ala 0.0048 0.0032 0.0032
Schistosoma mansoni chromobox protein 0.0076 0.0115 0.0116
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.1153 0.3277 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0049 0.0036 0.0036
Echinococcus multilocularis tyrosine protein kinase Srms 0.0063 0.0076 0.0076
Echinococcus granulosus serotonin transporter 0.0219 0.0534 0.0534
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0111 0.0218 0.0218
Echinococcus granulosus intersectin 2 0.0048 0.0032 0.0032
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0048 0.0032 0.0032
Onchocerca volvulus 0.0048 0.0032 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0032 0.0108
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0016 0.0304
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0048 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase Src42A 0.0111 0.0218 0.0218
Schistosoma mansoni tensin-related 0.0049 0.0036 0.0036
Echinococcus multilocularis tyrosine protein kinase ABL1 0.3442 1 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0097 0.0177 0.0177
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0049 0.0036 0.0036
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0037 0 0.5
Onchocerca volvulus 0.0219 0.0534 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0111 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0048 0.0032 0.3676
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0049 0.0036 0.0036
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0076 0.0076
Schistosoma mansoni tensin 0.0049 0.0036 0.0036
Brugia malayi RhoGAP domain containing protein 0.0049 0.0036 0.0059
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.1153 0.3277 0.5
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0048 0.0032 0.0032
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0048 0.0032 0.0601
Brugia malayi Peripheral plasma membrane protein CASK 0.0048 0.0032 0.0053
Schistosoma mansoni tyrosine kinase 0.0111 0.0218 0.0221
Echinococcus granulosus tyrosine kinase 0.0063 0.0076 0.0076
Schistosoma mansoni suppressor of cytokine signaling 0.0049 0.0036 0.0036
Brugia malayi Ets-domain containing protein 0.0078 0.012 0.02
Entamoeba histolytica BAR/SH3 domain containing protein 0.0048 0.0032 0.3676
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0076 0.0076
Echinococcus granulosus expressed protein 0.0048 0.0032 0.0032
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0049 0.0036 0.0669
Echinococcus multilocularis GA binding protein alpha chain 0.0078 0.012 0.012
Schistosoma mansoni chromobox protein 0.0076 0.0115 0.0116
Echinococcus granulosus tyrosine protein kinase Src42A 0.0049 0.0036 0.0036
Brugia malayi SH2 domain containing protein 0.0049 0.0036 0.0059
Schistosoma mansoni growth factor receptor-bound protein 0.0097 0.0177 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0032 0.0108
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0063 0.0076 0.0076
Onchocerca volvulus 0.0048 0.0032 0.0601
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0111 0.0218 0.0218
Schistosoma mansoni hypothetical protein 0.0152 0.0338 0.0343
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0111 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0049 0.0036 0.0036
Echinococcus granulosus GA binding protein alpha chain 0.0078 0.012 0.012
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0111 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0111 0.0218 0.0221
Brugia malayi SH2 domain containing protein 0.0049 0.0036 0.0059
Loa Loa (eye worm) hypothetical protein 0.0219 0.0534 0.0534
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0032 0.0108
Loa Loa (eye worm) hypothetical protein 0.0048 0.0032 0.0032
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0049 0.0036 0.0036
Brugia malayi SH2 domain containing protein 0.0049 0.0036 0.0059
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0032 0.3676
Plasmodium falciparum transporter, putative 0.0037 0 0.5
Echinococcus granulosus SHC transforming protein 3 0.0049 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0049 0.0036 0.0036
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.1153 0.3277 0.5444
Loa Loa (eye worm) hypothetical protein 0.0219 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0097 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.1153 0.3277 0.3277
Schistosoma mansoni hypothetical protein 0.0048 0.0032 0.0033
Onchocerca volvulus 0.0063 0.0076 0.143
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0076 0.0076
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0048 0.0032 0.0033
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0049 0.0036 0.0036
Schistosoma mansoni cell polarity protein 0.0048 0.0032 0.0033
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0049 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.0032 0.0032
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0048 0.0032 0.0032
Brugia malayi SH2 domain containing protein 0.0063 0.0076 0.0127
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0033 0.0004
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.0036 0.0036
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0541 0.1479 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.1403 0.4012 0.4012
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.1153 0.3277 0.3325
Echinococcus multilocularis serotonin transporter 0.0219 0.0534 0.0534
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0052 0.0045 0.5493
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0049 0.0036 0.0036
Schistosoma mansoni tensin 0.0049 0.0036 0.0036
Onchocerca volvulus Putative cortactin 0.0048 0.0032 0.0601
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0032 0.0053
Entamoeba histolytica protein kinase, putative 0.0048 0.0032 0.3676
Schistosoma mansoni hypothetical protein 0.0049 0.0036 0.0036
Echinococcus multilocularis N chimaerin 0.0049 0.0036 0.0036
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0111 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0063 0.0076 0.0127
Brugia malayi Protein kinase domain containing protein 0.0063 0.0076 0.0127
Schistosoma mansoni hypothetical protein 0.0039 0.0006 0.0006
Loa Loa (eye worm) norepinephrine transporter 0.0219 0.0534 0.0534
Echinococcus granulosus signal transduction protein lnk realted 0.0049 0.0036 0.0036
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.1153 0.3277 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0036 0.0036
Echinococcus granulosus N chimaerin 0.0049 0.0036 0.0036
Echinococcus multilocularis chromobox protein 1 0.0076 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0048 0.0032 0.0032
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0111 0.0218 0.0218
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0076 0.0076
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0048 0.0032 0.0032
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0036 0.0059
Echinococcus multilocularis c src tyrosine kinase 0.0111 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0475 0.1285 0.8671
Loa Loa (eye worm) hypothetical protein 0.0049 0.0036 0.0036
Brugia malayi STAT protein, DNA binding domain containing protein 0.0049 0.0036 0.0059
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0115 0.0672
Echinococcus granulosus fch and double sh3 domains protein 2 0.0048 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0032 0.0108
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0032 0.0053
Echinococcus multilocularis tyrosine protein kinase shark 0.0063 0.0076 0.0076
Onchocerca volvulus 0.0048 0.0032 0.0601
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0033 0.0004
Brugia malayi hypothetical protein 0.0039 0.0006 0.0011
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0048 0.0032 0.0108
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0097 0.0177 0.0177
Onchocerca volvulus 0.0049 0.0036 0.0669
Echinococcus granulosus geminin 0.0152 0.0338 0.0338
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0032 0.0053
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0049 0.0036 0.0036
Trypanosoma brucei protein kinase, putative 0.0049 0.0033 0.0004
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0049 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0032 0.0108
Echinococcus multilocularis signal transduction protein lnk realted 0.0049 0.0036 0.0036
Echinococcus multilocularis protein patched 0.0475 0.1285 0.1285
Onchocerca volvulus 0.0049 0.0036 0.0669
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0048 0.0032 0.0033
Onchocerca volvulus 0.0063 0.0076 0.143
Loa Loa (eye worm) hypothetical protein 0.0049 0.0036 0.0036
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0219 0.0534 0.0542
Schistosoma mansoni hypothetical protein 0.0048 0.0032 0.0033
Schistosoma mansoni shc transforming protein 0.0049 0.0036 0.0036
Loa Loa (eye worm) solute carrier family 6 member 4 0.0219 0.0534 0.0534
Onchocerca volvulus 0.0049 0.0036 0.0669
Onchocerca volvulus 0.0063 0.0076 0.143
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0032 0.0053
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0032 0.3676
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.0115 0.0115
Echinococcus granulosus tyrosine protein kinase Srms 0.0063 0.0076 0.0076
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0048 0.0032 0.0032
Brugia malayi tRNA modification GTPase TrmE family protein 0.0049 0.0036 0.0059
Loa Loa (eye worm) p53BP2 0.0048 0.0032 0.0032
Schistosoma mansoni apoptosis stimulating of P53 0.0048 0.0032 0.0033
Loa Loa (eye worm) fli-1 protein 0.0237 0.0588 0.0588
Brugia malayi Guanylate kinase family protein 0.0048 0.0032 0.0053
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0111 0.0218 0.0218
Schistosoma mansoni Dab2-interacting protein-like 0.0048 0.0032 0.0033
Brugia malayi Sex muscle abnormal protein 5 0.0097 0.0177 0.0294
Schistosoma mansoni gabp alpha 0.0078 0.012 0.0122
Onchocerca volvulus 0.0049 0.0036 0.0669
Echinococcus multilocularis expressed protein 0.0048 0.0032 0.0032
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0048 0.0032 0.0032
Brugia malayi SH3 domain containing protein 0.0048 0.0032 0.0053
Echinococcus granulosus nostrin 0.0048 0.0032 0.0032
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0048 0.0032 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0032 0.0108
Echinococcus granulosus SH2 motif 0.0049 0.0036 0.0036
Entamoeba histolytica hypothetical protein 0.0048 0.0032 0.3676
Loa Loa (eye worm) hypothetical protein 0.0049 0.0036 0.0036
Echinococcus granulosus tyrosine protein kinase shark 0.0063 0.0076 0.0076
Schistosoma mansoni tyrosine kinase 0.0063 0.0076 0.0078
Brugia malayi protein-tyrosine kinase 0.0063 0.0076 0.0127
Entamoeba histolytica hypothetical protein 0.0048 0.0032 0.3676
Onchocerca volvulus 0.0049 0.0036 0.0669
Onchocerca volvulus 0.0063 0.0076 0.143
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0033 0.0034
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0111 0.0218 0.0221

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 16 nM Inhibitory concentration against [3H]-dopamine uptake ChEMBL. No reference
IC50 (binding) = 18 nM Displacement of [3H]-Mazindol from dopamine transporter ChEMBL. No reference
IC50 (functional) = 19 nM Inhibitory concentration against [3H]-dopamine uptake ChEMBL. No reference
IC50 (binding) = 24 nM Displacement of [3H]-Mazindol from dopamine transporter ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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