Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 19 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 9 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | Get druggable targets OG5_126582 | All targets in OG5_126582 |
Brugia malayi | Cytochrome P450 family protein | Get druggable targets OG5_126582 | All targets in OG5_126582 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | cytochrome P450, family 2, subfamily C, polypeptide 19 | 490 aa | 411 aa | 23.1 % |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | cytochrome P450, family 2, subfamily C, polypeptide 9 | 490 aa | 441 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1671 | 0.1671 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0139 | 0.3635 | 0.2359 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.5976 | 0.5976 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0287 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0287 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0287 | 1 | 1 |
Brugia malayi | adenosine monophosphate deaminase | 0.0093 | 0.1671 | 0.1671 |
Schistosoma mansoni | adenosine deaminase-related | 0.0287 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.0287 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.0287 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0139 | 0.3635 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0287 | 1 | 1 |
Brugia malayi | Adenosylhomocysteinase | 0.0139 | 0.3635 | 0.3635 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0287 | 1 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0139 | 0.3635 | 0.2359 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0287 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0287 | 1 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0139 | 0.3635 | 0.2359 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0287 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0287 | 1 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0139 | 0.3635 | 0.2359 |
Leishmania major | adenine aminohydrolase | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.5976 | 0.5976 |
Mycobacterium ulcerans | adenosine deaminase | 0.0287 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0139 | 0.3635 | 0.264 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0139 | 0.3635 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.0093 | 0.1671 | 0.1671 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0139 | 0.3635 | 0.2359 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0139 | 0.3635 | 0.2359 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.5976 | 0.5976 |
Schistosoma mansoni | AMP deaminase | 0.0093 | 0.1671 | 0.0368 |
Plasmodium falciparum | adenosine deaminase | 0.0287 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0139 | 0.3635 | 0.3635 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0139 | 0.3635 | 0.2359 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0287 | 1 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0139 | 0.3635 | 0.2359 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0139 | 0.3635 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.5976 | 0.5976 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 8.2 uM | Inhibition against Cytochrome P450 2C19 prepared from baculovirus-infected insect cells using 3-cyano-7-ethoxycoumarin | ChEMBL. | 16061379 |
IC50 (ADMET) | = 8.2 uM | Inhibition against Cytochrome P450 2C19 prepared from baculovirus-infected insect cells using 3-cyano-7-ethoxycoumarin | ChEMBL. | 16061379 |
IC50 (ADMET) | = 16 uM | Inhibition against Cytochrome P450 2C9 prepared from baculovirus-infected insect cells using 7-methoxy-4-trifluoromethylcoumarin | ChEMBL. | 16061379 |
IC50 (ADMET) | = 16 uM | Inhibition against Cytochrome P450 2C9 prepared from baculovirus-infected insect cells using 7-methoxy-4-trifluoromethylcoumarin | ChEMBL. | 16061379 |
IC50 (ADMET) | = 26 uM | Inhibition against Cytochrome P450 3A4 prepared from baculovirus-infected insect cells using 7-benzyloxy- 4-trifluoromethylcoumarin | ChEMBL. | 16061379 |
IC50 (ADMET) | = 26 uM | Inhibition against Cytochrome P450 3A4 prepared from baculovirus-infected insect cells using 7-benzyloxy- 4-trifluoromethylcoumarin | ChEMBL. | 16061379 |
IC50 (ADMET) | = 50 uM | Inhibition against Cytochrome P450 3A4 prepared from baculovirus-infected insect cells using resorufin benzyl ether | ChEMBL. | 16061379 |
IC50 (ADMET) | = 50 uM | Inhibition against Cytochrome P450 3A4 prepared from baculovirus-infected insect cells using resorufin benzyl ether | ChEMBL. | 16061379 |
IC50 (ADMET) | > 100 uM | Inhibition against Cytochrome P450 1A2 prepared from baculovirus-infected insect cells using 3-cyano-7-ethoxycoumarin | ChEMBL. | 16061379 |
IC50 (ADMET) | > 100 uM | Inhibition against Cytochrome P450 2D6 prepared from baculovirus-infected insect cells using 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7- methoxy-4-methylcoumarin | ChEMBL. | 16061379 |
IC50 (ADMET) | > 100 uM | Inhibition against Cytochrome P450 1A2 prepared from baculovirus-infected insect cells using 3-cyano-7-ethoxycoumarin | ChEMBL. | 16061379 |
IC50 (ADMET) | > 100 uM | Inhibition against Cytochrome P450 2D6 prepared from baculovirus-infected insect cells using 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7- methoxy-4-methylcoumarin | ChEMBL. | 16061379 |
Increase (functional) | = 262.5 % | Percent increase of potassium current mediated by large conductance calcium-activated channel expressed in Xenopus laevis oocytes at 20 uM | ChEMBL. | 16061379 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.