Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | No references |
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.1309 | 0.1343 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0016 | 0.0017 |
Brugia malayi | Hexokinase family protein | 0.0096 | 0.1309 | 0.1343 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 0.1309 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0096 | 0.1309 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0016 | 0.0017 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.1309 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.1309 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0096 | 0.1309 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0524 | 0.9746 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 0.1309 | 0.5 |
Onchocerca volvulus | 0.0096 | 0.1309 | 0.0752 | |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.1309 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0096 | 0.1309 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0096 | 0.1309 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0513 | 0.9519 | 0.9767 |
Onchocerca volvulus | 0.0096 | 0.1309 | 0.0752 | |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.1309 | 0.1343 |
Schistosoma mansoni | hexokinase | 0.0096 | 0.1309 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.1309 | 0.1343 |
Loa Loa (eye worm) | hexokinase | 0.006 | 0.0603 | 0.0618 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.1309 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.1309 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 0.1309 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0096 | 0.1309 | 0.5 |
Onchocerca volvulus | 0.0096 | 0.1309 | 0.0752 | |
Leishmania major | hexokinase, putative | 0.0096 | 0.1309 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0524 | 0.9746 | 1 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.1309 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.006 | 0.0603 | 0.0618 |
Trypanosoma brucei | hexokinase | 0.0096 | 0.1309 | 0.5 |
Brugia malayi | hexokinase | 0.0096 | 0.1309 | 0.1343 |
Brugia malayi | hexokinase type II | 0.0031 | 0.0016 | 0.0017 |
Leishmania major | hexokinase, putative | 0.0096 | 0.1309 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0706 | 0.0725 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.1309 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.1309 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0096 | 0.1309 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 0.1309 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.57 uM | Potency in Glucokinase activation assay | ChEMBL. | 15808477 |
EC50 (binding) | = 0.57 uM | Potency in Glucokinase activation assay | ChEMBL. | 15808477 |
IC50 (ADMET) | = 0.01 uM | Inhibition of RAR alpha (unknown origin) | ChEMBL. | No reference |
IC50 (ADMET) | = 0.135 uM | Inhibition of RAR beta (unknown origin) | ChEMBL. | No reference |
IC50 (ADMET) | = 22 uM | Inhibition of RAR gamma (unknown origin) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.