TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 609.575 | Formula: C32H31F3N3O4P
H donors: 1 H acceptors: 4 LogP: 4.71 Rotable bonds: 15
Rule of 5 violations (Lipinski): 2
SMILES: O=C(C1(CCCCP(=O)(OCc2ccccn2)OCc2ccccn2)c2ccccc2c2c1cccc2)NCC(F)(F)F
InChi: 1S/C32H31F3N3O4P/c33-32(34,35)23-38-30(39)31(28-15-3-1-13-26(28)27-14-2-4-16-29(27)31)17-7-10-20-43(40,41-21-24-11-5-8-18-36-24)42-22-25-12-6-9-19-37-25/h1-6,8-9,11-16,18-19H,7,10,17,20-23H2,(H,38,39)
InChiKey: ISWOQHZTAOFRKD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Microsomal triglyceride transfer protein large subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133861	All targets in OG5_133861
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_133861	All targets in OG5_133861
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_133861	All targets in OG5_133861
Echinococcus granulosus	microsomal triglyceride transfer protein large	Get druggable targets OG5_133861	All targets in OG5_133861
Echinococcus multilocularis	microsomal triglyceride transfer protein large	Get druggable targets OG5_133861	All targets in OG5_133861

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Glutaredoxin protein 5	0.0164	0.1042	0.5156
Schistosoma mansoni	cell adhesion molecule	0.0017	0.0004	0.002
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0088	0.0504	0.2491
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0055	0.0273	0.1352
Loa Loa (eye worm)	SRC-1	0.0055	0.0273	0.0269
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0017	0.0004	0.002
Trichomonas vaginalis	AGC family protein kinase	0.0088	0.0504	0.0257
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0088	0.0504	0.2491
Echinococcus granulosus	c src tyrosine kinase	0.0027	0.0069	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0599	0.0595
Brugia malayi	Immunoglobulin I-set domain containing protein	0.003	0.0093	0.0089
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0168	0.1073	0.6441
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0088	0.0504	0.2491
Loa Loa (eye worm)	TK protein kinase	0.0049	0.0224	0.022
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.0245	0.1616	0.7994
Schistosoma mansoni	nephrin	0.0017	0.0004	0.002
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0095	0.0556	0.0553
Echinococcus multilocularis	nervana 2	0.0164	0.1042	0.5156
Echinococcus granulosus	raf serine:threonine protein kinase	0.0225	0.1471	0.7277
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0055	0.0273	0.1352
Echinococcus granulosus	NDR protein kinase	0.0088	0.0504	0.2491
Schistosoma mansoni	hypothetical protein	0.017	0.1081	0.535
Echinococcus multilocularis	c src tyrosine kinase	0.0027	0.0069	0.0341
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.017	0.1081	0.1078
Brugia malayi	Tyrosine-protein kinase abl-1	0.0115	0.0698	0.0695
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0088	0.0504	0.05
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0055	0.0273	0.1352
Brugia malayi	Raf kinase	0.0217	0.1418	0.1415
Entamoeba histolytica	protein kinase 2, putative	0.0168	0.1073	0.6441
Schistosoma mansoni	serine/threonine protein kinase	0.0095	0.0556	0.2752
Echinococcus granulosus	serine/threonine protein kinase	0.0168	0.1073	0.5307
Loa Loa (eye worm)	raf kinase	0.0212	0.1382	0.1379
Echinococcus granulosus	Immunoglobulin	0.0017	0.0004	0.002
Echinococcus granulosus	protein kinase c iota type	0.0095	0.0556	0.2752
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0164	0.1042	0.5156
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0132	0.0818	0.0814
Echinococcus granulosus	Protein kinase C brain isozyme	0.0095	0.0556	0.2752
Leishmania major	protein kinase, putative	0.0017	0	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0252	0.1666	0.1663
Mycobacterium tuberculosis	Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase)	0.0804	0.5575	0.5
Echinococcus granulosus	Lipid transport protein N terminal	0.0171	0.1095	0.5418
Echinococcus multilocularis	MAM	0.017	0.1081	0.535
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.002	0.0016
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0088	0.0504	0.05
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0055	0.0273	0.1352
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0055	0.0273	0.1352
Trichomonas vaginalis	AGC family protein kinase	0.0245	0.1616	0.9584
Schistosoma mansoni	serine/threonine protein kinase	0.0095	0.0556	0.2752
Echinococcus granulosus	microsomal triglyceride transfer protein large	0.0302	0.2021	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0055	0.0273	0.1352
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.002	0.002	0.0098
Echinococcus granulosus	tyrosine protein kinase shark	0.002	0.002	0.0098
Trichomonas vaginalis	AGC family protein kinase	0.0252	0.1665	1
Trichomonas vaginalis	AGC family protein kinase	0.0252	0.1665	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0041	0.0174	0.086
Brugia malayi	hypothetical protein	0.002	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0001
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0088	0.0504	0.2491
Onchocerca volvulus	Apolipophorins homolog	0.0171	0.1095	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0055	0.0273	0.1352
Brugia malayi	hypothetical protein	0.017	0.1081	0.1078
Echinococcus multilocularis	neuroglian	0.0017	0.0004	0.002
Echinococcus granulosus	roundabout 2	0.0017	0.0004	0.002
Schistosoma mansoni	tyrosine kinase	0.0055	0.0273	0.1352
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0252	0.1665	0.1662
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.002	0.0016
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.0072	0.0387	0.1915
Echinococcus granulosus	serine:threonine protein kinase N2	0.0088	0.0504	0.2491
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0252	0.1666	0.8242
Brugia malayi	Tyrosine-protein kinase abl-1	0.0144	0.0897	0.0893
Brugia malayi	Protein kinase domain containing protein	0.0088	0.0504	0.05
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0168	0.1073	1
Toxoplasma gondii	AGC kinase	0.0252	0.1665	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.002	0.0016
Schistosoma mansoni	serine/threonine-protein kinase	0.0168	0.1073	0.5307
Schistosoma mansoni	tyrosine kinase	0.002	0.002	0.0098
Entamoeba histolytica	protein kinase, putative	0.0245	0.1616	0.9702
Echinococcus granulosus	serine threonine protein kinase nrc	0.0168	0.1073	0.5307
Trichomonas vaginalis	AGC family protein kinase	0.0252	0.1665	1
Echinococcus multilocularis	microsomal triglyceride transfer protein large	0.0302	0.2021	1
Onchocerca volvulus		0.017	0.1081	0.9872
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0049	0.0224	0.1109
Schistosoma mansoni	hypothetical protein	0.017	0.1081	0.535
Brugia malayi	Protein kinase domain containing protein	0.002	0.002	0.0016
Echinococcus multilocularis	protein kinase c epsilon type	0.0095	0.0556	0.2752
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0055	0.0273	0.1352
Brugia malayi	SH2 domain containing protein	0.002	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.1246	0.8706	0.8709
Loa Loa (eye worm)	hypothetical protein	0.017	0.1081	0.1078
Echinococcus granulosus	neuroglian	0.0017	0.0004	0.002
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.0273	0.1352
Echinococcus granulosus	protein kinase c epsilon type	0.0095	0.0556	0.2752
Echinococcus multilocularis	tyrosine protein kinase shark	0.002	0.002	0.0098
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0252	0.1665	0.1662
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.002	0.002	0.0098
Schistosoma mansoni	tyrosine kinase	0.002	0.002	0.0098
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0055	0.0273	0.1352
Echinococcus multilocularis	Lipid transport protein, N terminal	0.0171	0.1095	0.5418
Giardia lamblia	Kinase, AGC PKA	0.0168	0.1073	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.0273	0.1352
Echinococcus granulosus	nervana 2	0.0164	0.1042	0.5156
Schistosoma mansoni	serine/threonine protein kinase	0.0095	0.0556	0.2752
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.002	0.002	0.0119
Echinococcus granulosus	tyrosine protein kinase HCK	0.0041	0.0174	0.086
Trichomonas vaginalis	AGC family protein kinase	0.0252	0.1665	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0252	0.1666	0.8242
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.002	0.0016
Echinococcus multilocularis	serine threonine protein kinase	0.0088	0.0504	0.2491
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0245	0.1616	0.1613
Echinococcus granulosus	tyrosine protein kinase Blk	0.0049	0.0224	0.1109
Echinococcus granulosus	twitchin	0.0022	0.0035	0.0172
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.0245	0.1616	0.7994
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0017	0.0004	0.002
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0088	0.0504	0.2491
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0088	0.0504	0.2491
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0017	0.0004	0.002
Echinococcus granulosus	protein kinase C gamma type	0.0088	0.0504	0.2491
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0055	0.0273	0.1352
Brugia malayi	Hr1 repeat family protein	0.0088	0.0504	0.05
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.0072	0.0387	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1095	0.1092
Trichomonas vaginalis	AGC family protein kinase	0.0088	0.0504	0.0257
Echinococcus granulosus	tyrosine protein kinase Srms	0.002	0.002	0.0098
Schistosoma mansoni	tyrosine kinase	0.0245	0.1616	0.7993
Trichomonas vaginalis	AGC family protein kinase	0.0252	0.1665	1
Schistosoma mansoni	serine/threonine kinase	0.0088	0.0504	0.2491
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0088	0.0504	0.2491
Brugia malayi	Protein kinase domain containing protein	0.002	0.002	0.0016
Loa Loa (eye worm)	TK/ALK protein kinase	0.1428	0.9997	1
Brugia malayi	Protein kinase domain containing protein	0.002	0.002	0.0016
Trichomonas vaginalis	AGC family protein kinase	0.0252	0.1665	1
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0088	0.0504	0.05
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0027	0.0069	0.0341
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0168	0.1073	1
Echinococcus granulosus	defective proboscis extension response	0.0017	0.0004	0.002
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0095	0.0556	0.2752
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0245	0.1616	0.1613
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0027	0.0069	0.0341
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.0504	0.2491
Trichomonas vaginalis	AGC family protein kinase	0.0088	0.0504	0.0257
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0036	0.0135	0.0669
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0055	0.0273	0.1352
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.002	0.0016
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0088	0.0504	0.05
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0168	0.1073	1
Trypanosoma cruzi	Protein kinase B	0.0168	0.1073	1
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.002	0.0016
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0168	0.1073	0.5307
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.0072	0.039	0.1931
Echinococcus granulosus	tyrosine protein kinase Lyn	0.006	0.0304	0.1504
Brugia malayi	Protein kinase domain containing protein	0.0072	0.0387	0.0383
Echinococcus multilocularis	Immunoglobulin	0.0017	0.0004	0.002
Echinococcus granulosus	nervana 2	0.0164	0.1042	0.5156
Schistosoma mansoni	vesicular amine transporter	0.0017	0.0004	0.002
Trichomonas vaginalis	AGC family protein kinase	0.0088	0.0504	0.0257
Brugia malayi	SH2 domain containing protein	0.002	0.002	0.0016
Schistosoma mansoni	hypothetical protein	0.0302	0.2021	1
Schistosoma mansoni	serine/threonine protein kinase	0.0245	0.1616	0.7994
Entamoeba histolytica	protein kinase, putative	0.0252	0.1665	1
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0088	0.0504	0.2491
Schistosoma mansoni	serine/threonine protein kinase	0.0225	0.1471	0.7277
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.002	0.0016
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0049	0.0224	0.1109
Brugia malayi	Protein kinase domain containing protein	0.0252	0.1665	0.1662
Brugia malayi	Protein kinase domain containing protein	0.0245	0.1616	0.1612
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0088	0.0504	0.2491
Brugia malayi	Protein kinase domain containing protein	0.0088	0.0504	0.05
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.0273	0.1352
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.0504	0.2491
Trichomonas vaginalis	AGC family protein kinase	0.0245	0.1616	0.9584
Echinococcus granulosus	Glutaredoxin protein 5	0.0164	0.1042	0.5156
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0168	0.1073	0.6441
Echinococcus multilocularis	nervana 2	0.0164	0.1042	0.5156
Echinococcus multilocularis	rac serine:threonine kinase	0.0168	0.1073	0.5307
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.0504	0.2491
Entamoeba histolytica	protein kinase, putative	0.0252	0.1665	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0027	0.0069	0.0341
Entamoeba histolytica	protein kinase, putative	0.0041	0.0174	0.1043
Schistosoma mansoni	tyrosine kinase	0.0027	0.0069	0.0341
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0049	0.0224	0.1109
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0225	0.1471	0.7277
Brugia malayi	Protein kinase domain containing protein	0.002	0.002	0.0016
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0168	0.1073	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.0504	0.2491
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.003	0.0093	0.0089
Mycobacterium ulcerans	haloalkane dehalogenase	0.0804	0.5575	0.5
Schistosoma mansoni	tyrosine kinase	0.0027	0.0069	0.0341
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0168	0.1073	0.5307
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0055	0.0273	0.1352
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0036	0.0135	0.0669
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0088	0.0504	0.05
Brugia malayi	protein kinase C II.	0.0095	0.0556	0.0552
Loa Loa (eye worm)	hypothetical protein	0.017	0.1081	0.1078
Trichomonas vaginalis	AGC family protein kinase	0.0245	0.1616	0.9584
Brugia malayi	p70 ribosomal S6 kinase beta	0.0252	0.1665	0.1662
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0049	0.0224	0.1109
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0504	0.05
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0164	0.1042	0.5156
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.002	0.0016
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0252	0.1665	1
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.002	0.0016
Echinococcus granulosus	tyrosine kinase	0.0049	0.0224	0.1109
Trichomonas vaginalis	AGC family protein kinase	0.0252	0.1665	1
Echinococcus multilocularis	roundabout 2	0.0017	0.0004	0.002
Echinococcus multilocularis	Immunoglobulin	0.0017	0.0004	0.002
Echinococcus granulosus	MAM	0.017	0.1081	0.535
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.002	0.0016
Onchocerca volvulus		0.017	0.1081	0.9872
Loa Loa (eye worm)	hypothetical protein	0.0302	0.2021	0.2019
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0115	0.0698	0.3455
Schistosoma mansoni	serine/threonine-protein kinase	0.0168	0.1073	0.5307
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0017	0.0004	0.002
Brugia malayi	Protein kinase domain containing protein	0.002	0.002	0.0016
Brugia malayi	SRC-1	0.0055	0.0273	0.0269
Echinococcus multilocularis	tyrosine kinase	0.002	0.002	0.0098
Entamoeba histolytica	protein kinase, putative	0.0252	0.1665	1
Schistosoma mansoni	tyrosine kinase	0.0055	0.0273	0.1352
Loa Loa (eye worm)	TK protein kinase	0.0041	0.0174	0.017
Echinococcus multilocularis	protein kinase c iota type	0.0095	0.0556	0.2752
Schistosoma mansoni	atypical protein kinase C	0.0095	0.0556	0.2752
Entamoeba histolytica	protein kinase, putative	0.0088	0.0504	0.3024
Brugia malayi	phosphoinositide-dependent protein kinase I	0.0245	0.1616	0.1612
Echinococcus granulosus	tyrosine kinase	0.002	0.002	0.0098
Brugia malayi	protein-tyrosine kinase	0.0049	0.0224	0.022
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0055	0.0273	0.1352
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0019	0.0092

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.027 uM	Inhibitory activity against microsomal triglyceride transfer protein (MTP)	ChEMBL.	12657277
IC50 (binding)	= 0.027 uM	Inhibitory activity against microsomal triglyceride transfer protein (MTP)	ChEMBL.	12657277

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 34012