TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 231.594 | Formula: C5H13ClN2O4P-
H donors: 4 H acceptors: 4 LogP: -6.67 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: NCP(=O)(CC[C@H](C(=O)O)N)O.[Cl-]
InChi: 1S/C5H13N2O4P.ClH/c6-3-12(10,11)2-1-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9)(H,10,11);1H/p-1/t4-;/m0./s1
InChiKey: HLAOQSRGESKVDI-WCCKRBBISA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neuropeptides capa receptor	0.0897	0.9983	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0897	0.9983	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0897	0.9983	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0897	0.9983	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0897	0.9983	1
Echinococcus granulosus	somatostatin receptor	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Echinococcus granulosus	g-protein coupled receptor	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Brugia malayi	G-protein coupled receptor	0.0897	0.9983	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0897	0.9983	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0897	0.9983	1
Brugia malayi	Dopamine receptor protein 1	0.0897	0.9983	0.5
Brugia malayi	ORL1-like opioid receptor	0.0897	0.9983	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0897	0.9983	1
Echinococcus multilocularis	g-protein coupled receptor	0.0897	0.9983	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0897	0.9983	1
Echinococcus granulosus	g protein coupled receptor	0.0897	0.9983	1
Schistosoma mansoni	amine GPCR	0.0897	0.9983	1
Echinococcus granulosus	neuropeptides capa receptor	0.0897	0.9983	1
Echinococcus granulosus	orexin receptor type 2	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Echinococcus granulosus	g protein coupled receptor	0.0897	0.9983	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0897	0.9983	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Echinococcus granulosus	sex peptide receptor	0.0897	0.9983	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0897	0.9983	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0897	0.9983	1
Echinococcus multilocularis	neuropeptide receptor	0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0897	0.9983	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0897	0.9983	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0897	0.9983	1
Echinococcus multilocularis	g protein coupled receptor	0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0897	0.9983	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0897	0.9983	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0897	0.9983	1
Echinococcus granulosus	serotonin receptor	0.0897	0.9983	1
Brugia malayi	hypothetical protein	0.0897	0.9983	0.5
Brugia malayi	neuropeptide F receptor	0.0897	0.9983	0.5
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0897	0.9983	1
Echinococcus granulosus	fmrfamide receptor	0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0897	0.9983	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0897	0.9983	1
Echinococcus multilocularis	serotonin receptor	0.0897	0.9983	1
Echinococcus granulosus	neuropeptide Y receptor	0.0897	0.9983	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0897	0.9983	1
Schistosoma mansoni	biogenic amine receptor	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0897	0.9983	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0897	0.9983	1
Echinococcus granulosus	neuropeptide receptor	0.0897	0.9983	1
Loa Loa (eye worm)	TYRA-2 protein	0.0897	0.9983	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0897	0.9983	1
Schistosoma mansoni	amine GPCR	0.0897	0.9983	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0897	0.9983	1
Brugia malayi	putative neuropeptide receptor	0.0897	0.9983	0.5
Brugia malayi	AKH receptor	0.0897	0.9983	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0897	0.9983	1
Leishmania major	glutamine synthetase, putative	0.0089	0	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0897	0.9983	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Mycobacterium ulcerans	secreted antigen 85-C FbpC	0.0898	1	1
Schistosoma mansoni	amine GPCR	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0897	0.9983	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0897	0.9983	1
Brugia malayi	hypothetical protein	0.0897	0.9983	0.5
Echinococcus multilocularis	somatostatin receptor	0.0897	0.9983	1
Brugia malayi	hypothetical protein	0.0897	0.9983	0.5
Echinococcus multilocularis	G protein coupled receptor 139	0.0897	0.9983	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0897	0.9983	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0897	0.9983	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0897	0.9983	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0897	0.9983	1
Schistosoma mansoni	opsin-like receptor	0.0897	0.9983	1
Wolbachia endosymbiont of Brugia malayi	glutamine synthetase	0.0104	0.0189	0.5
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0897	0.9983	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0897	0.9983	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0897	0.9983	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0897	0.9983	1
Echinococcus multilocularis	neuropeptide receptor	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Echinococcus multilocularis	fmrfamide receptor	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Trypanosoma brucei	glutamine synthetase, putative	0.0089	0	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0897	0.9983	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0897	0.9983	0.5
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Echinococcus granulosus	neuropeptide receptor A26	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Brugia malayi	GnHR receptor homolog	0.0897	0.9983	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0897	0.9983	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0897	0.9983	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0897	0.9983	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Brugia malayi	hypothetical protein	0.0897	0.9983	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0897	0.9983	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0897	0.9983	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Schistosoma mansoni	hypothetical protein	0.0897	0.9983	1
Brugia malayi	G-protein coupled receptor	0.0897	0.9983	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0897	0.9983	1
Echinococcus multilocularis	orexin receptor type 2	0.0897	0.9983	1
Brugia malayi	larval opioid receptor	0.0897	0.9983	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0897	0.9983	1
Trypanosoma cruzi	glutamine synthetase, putative	0.0089	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0897	0.9983	1
Brugia malayi	hypothetical protein	0.0897	0.9983	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0897	0.9983	1
Brugia malayi	Dopamine receptor	0.0897	0.9983	0.5
Echinococcus granulosus	neuropeptide receptor	0.0897	0.9983	1
Brugia malayi	hypothetical protein	0.0897	0.9983	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0897	0.9983	1
Schistosoma mansoni	adenoreceptor	0.0897	0.9983	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0897	0.9983	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0897	0.9983	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0897	0.9983	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0897	0.9983	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0897	0.9983	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0897	0.9983	1
Echinococcus granulosus	neuropeptide s receptor	0.0897	0.9983	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0897	0.9983	1
Brugia malayi	hypothetical protein	0.0897	0.9983	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0897	0.9983	1
Schistosoma mansoni	amine GPCR	0.0897	0.9983	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0897	0.9983	1
Schistosoma mansoni	glutamine synthetase bacteria	0.0104	0.0189	0.019
Schistosoma mansoni	histamine h1 receptor	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Echinococcus granulosus	G protein coupled receptor 139	0.0897	0.9983	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0897	0.9983	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0897	0.9983	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0897	0.9983	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Trypanosoma cruzi	glutamine synthetase, putative	0.0089	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Echinococcus multilocularis	neuropeptide s receptor	0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Brugia malayi	Serotonin receptor	0.0897	0.9983	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0897	0.9983	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0897	0.9983	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0897	0.9983	1
Schistosoma mansoni	hypothetical protein	0.0897	0.9983	1
Brugia malayi	Serotonin receptor	0.0897	0.9983	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0897	0.9983	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0897	0.9983	1
Schistosoma mansoni	neuropeptide receptor	0.0897	0.9983	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Schistosoma mansoni	neuropeptide receptor	0.0897	0.9983	1
Schistosoma mansoni	myosin xvIII	0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Echinococcus multilocularis	g protein coupled receptor	0.0897	0.9983	1
Echinococcus granulosus	g protein coupled receptor	0.0897	0.9983	1
Brugia malayi	hypothetical protein	0.0897	0.9983	0.5
Schistosoma mansoni	opsin-like receptor	0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0897	0.9983	1
Plasmodium falciparum	glutamine synthetase, putative	0.0158	0.0855	0.5
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Mycobacterium tuberculosis	Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II)	0.0158	0.0855	0.0678
Echinococcus multilocularis	neuropeptides capa receptor	0.0897	0.9983	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0897	0.9983	1
Plasmodium vivax	glutamine synthetase, putative	0.0158	0.0855	0.5
Brugia malayi	G protein-coupled receptor	0.0897	0.9983	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0897	0.9983	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0897	0.9983	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0897	0.9983	0.5
Brugia malayi	neuropeptide F receptor	0.0897	0.9983	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0897	0.9983	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0897	0.9983	1
Brugia malayi	hypothetical protein	0.0897	0.9983	0.5
Brugia malayi	sulfakinin receptor protein	0.0897	0.9983	0.5
Brugia malayi	RE15519p	0.0897	0.9983	0.5
Schistosoma mansoni	neuropeptide receptor	0.0897	0.9983	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Brugia malayi	hypothetical protein	0.0897	0.9983	0.5
Schistosoma mansoni	hypothetical protein	0.0897	0.9983	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0897	0.9983	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0897	0.9983	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0897	0.9983	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Toxoplasma gondii	glutamine synthetase, type I, putative	0.0158	0.0855	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0897	0.9983	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0897	0.9983	1
Brugia malayi	Melatonin receptor type 1A	0.0897	0.9983	0.5
Schistosoma mansoni	biogenic amine receptor	0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Schistosoma mansoni	neuropeptide receptor	0.0897	0.9983	1
Echinococcus granulosus	neuropeptides capa receptor	0.0897	0.9983	1
Echinococcus granulosus	hypothetical protein	0.0897	0.9983	1
Brugia malayi	follicle stimulating hormone receptor	0.0897	0.9983	0.5
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Schistosoma mansoni	opsin-like receptor	0.0897	0.9983	1
Onchocerca volvulus		0.0897	0.9983	1
Mycobacterium tuberculosis	Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C)	0.0898	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0897	0.9983	1
Schistosoma mansoni	glutamine synthetase bacteria	0.0104	0.0189	0.019
Echinococcus multilocularis	sex peptide receptor	0.0897	0.9983	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0897	0.9983	1
Schistosoma mansoni	biogenic amine receptor	0.0897	0.9983	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0897	0.9983	1
Echinococcus multilocularis	serotonin receptor	0.0897	0.9983	1
Schistosoma mansoni	hypothetical protein	0.0897	0.9983	1
Echinococcus multilocularis	allatostatin A receptor	0.0897	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0897	0.9983	1
Brugia malayi	Dopamine receptor protein 2	0.0897	0.9983	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0897	0.9983	1
Schistosoma mansoni	amine GPCR	0.0897	0.9983	1
Echinococcus granulosus	allatostatin A receptor	0.0897	0.9983	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0897	0.9983	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1 uM	Inhibitory concentration against glutamine synthetase incubated at 37 degree C for 20 minutes in pH 7.4	ChEMBL.	16190760
Ki (binding)	= 0.59 uM	Binding affinity towards glutamine synthetase	ChEMBL.	16190760
Log Ki (binding)	= 6.229	Binding affinity towards glutamine synthetase	ChEMBL.	16190760

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 429807

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 340337