Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0709 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.012 | 0.0919 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0919 | 0.0919 |
Onchocerca volvulus | 0.012 | 0.0919 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0709 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0919 | 0.0919 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0709 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0709 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0709 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0709 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0709 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.012 | 0.0919 | 0.0919 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.222 | 0.1433 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.2854 | 0.2854 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0919 | 0.0919 |
Brugia malayi | Carboxylesterase family protein | 0.0709 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0709 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.012 | 0.0919 | 0.0919 |
Echinococcus multilocularis | acetylcholinesterase | 0.0709 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.012 | 0.0919 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0709 | 1 | 1 |
Onchocerca volvulus | 0.012 | 0.0919 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0919 | 0.0919 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.012 | 0.0919 | 0.5 |
Onchocerca volvulus | 0.012 | 0.0919 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.012 | 0.0919 | 0.0919 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.012 | 0.0919 | 0.5 |
Onchocerca volvulus | 0.012 | 0.0919 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0709 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.222 | 0.1433 |
Loa Loa (eye worm) | carboxylesterase | 0.012 | 0.0919 | 0.0919 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0919 | 0.0919 |
Loa Loa (eye worm) | carboxylesterase | 0.012 | 0.0919 | 0.0919 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0919 | 0.0919 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0919 | 0.0919 |
Onchocerca volvulus | 0.012 | 0.0919 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.012 | 0.0919 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0245 | 0.2854 | 0.2854 |
Brugia malayi | hypothetical protein | 0.012 | 0.0919 | 0.0919 |
Brugia malayi | Carboxylesterase family protein | 0.012 | 0.0919 | 0.0919 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.012 | 0.0919 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -7.7 | Binding affinity for human corticotropin releasing factor receptor 1 expressed in LtK- cells using [125I]-sauvagine | ChEMBL. | 16134945 |
Log Ki (binding) | = 7.7 | Binding affinity for human corticotropin releasing factor receptor 1 expressed in LtK- cells using [125I]-sauvagine | ChEMBL. | 16134945 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.