Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | 0 % | Inhibition of fructose accumulation in diabetic rat after oral gavage administration incubated at RT for 60 minutes in pH 4.5 by acute test; Not measured | ChEMBL. | 16190759 |
Inhibition (functional) | 0 % | Inhibition of fructose accumulation in diabetic rat after oral gavage administration, pH 4.5 by chronic test; Not measured | ChEMBL. | 16190759 |
Inhibition (functional) | = 50 % | Inhibition of sorbitol accumulation in diabetic rat by chronic test | ChEMBL. | 16190759 |
Inhibition (functional) | = 58 % | Inhibition of sorbitol accumulation in diabetic rat by acute test | ChEMBL. | 16190759 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.