Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 50.1 nM | Inhibitory concentration of the compound against TNF-alpha production in THP-1 cells | ChEMBL. | 15837335 |
IC50 (functional) | = 50.1 nM | Inhibitory concentration of the compound against TNF-alpha production in THP-1 cells | ChEMBL. | 15837335 |
IC50 (functional) | = 165 nM | Inhibitory concentration of the compound against LPS-induced release of TNF-alpha in human whole blood | ChEMBL. | 15837335 |
IC50 (functional) | = 165 nM | Inhibitory concentration of the compound against LPS-induced release of TNF-alpha in human whole blood | ChEMBL. | 15837335 |
IC50 (functional) | = 454 nM | Inhibitory concentration of the compound against LPS-induced release of IL-1 beta in human whole blood | ChEMBL. | 15837335 |
IC50 (functional) | = 454 nM | Inhibitory concentration of the compound against LPS-induced release of IL-1 beta in human whole blood | ChEMBL. | 15837335 |
Ki (binding) | = 7 nM | Inhibitory activity against mitogen-activated protein kinase p38 | ChEMBL. | 15837335 |
Ki (binding) | = 735 nM | Inhibitory activity against c-Jun N-terminal kinase 3 (JNK3) | ChEMBL. | 15837335 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15837335 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.