Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | adenosine kinase, putative | adenosine kinase | 345 aa | 337 aa | 35.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidylate synthase | 0.0106 | 0.1667 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.0105 | 0.165 | 0.4036 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0105 | 0.165 | 0.5567 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0091 | 0.1236 | 0.7415 |
Brugia malayi | Adenosine kinase-like | 0.0105 | 0.165 | 0.9898 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0136 | 0.257 | 0.8675 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0383 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0149 | 0.2963 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0106 | 0.1667 | 0.1667 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0149 | 0.2963 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0091 | 0.1236 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0149 | 0.2963 | 0.1971 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0076 | 0.0761 | 0.2568 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0136 | 0.257 | 0.8217 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0105 | 0.165 | 0.5567 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0149 | 0.2963 | 0.1971 |
Loa Loa (eye worm) | thymidylate synthase | 0.0106 | 0.1667 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0091 | 0.1236 | 0.5 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0136 | 0.257 | 0.8217 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0182 | 0.3975 | 1 |
Schistosoma mansoni | adenosine kinase | 0.0105 | 0.165 | 0.9604 |
Onchocerca volvulus | 0.0106 | 0.1667 | 1 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0106 | 0.1667 | 1 |
Echinococcus granulosus | adenosine kinase | 0.0105 | 0.165 | 0.9604 |
Giardia lamblia | DNA topoisomerase II | 0.0084 | 0.1027 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.0105 | 0.165 | 0.9604 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0091 | 0.1236 | 0.7415 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0383 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0189 | 0.4179 | 0.4179 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0383 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0383 | 1 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0189 | 0.4179 | 0.3358 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0383 | 1 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.0105 | 0.165 | 0.4036 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0105 | 0.165 | 0.0472 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0076 | 0.0761 | 0.2568 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0136 | 0.257 | 0.8675 |
Leishmania major | adenosine kinase, putative | 0.0105 | 0.165 | 0.4036 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0383 | 1 | 1 |
Onchocerca volvulus | 0.0093 | 0.1289 | 0.1241 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.165 | 0.9604 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0189 | 0.4179 | 0.1865 |
Brugia malayi | Probable DNA topoisomerase II | 0.0091 | 0.1236 | 0.7415 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0096 | 0.1375 | 0.0159 |
Brugia malayi | thymidylate synthase | 0.0106 | 0.1667 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0383 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0189 | 0.4179 | 0.3358 |
Echinococcus granulosus | thymidylate synthase | 0.0106 | 0.1667 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0149 | 0.2963 | 0.1971 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0189 | 0.4179 | 0.3015 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0149 | 0.2963 | 1 |
Echinococcus multilocularis | adenosine kinase | 0.0105 | 0.165 | 0.9604 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.3 nM | Inhibitory concentration against human recombinant adenosine kinase using [14C]-AMP as radioligand | ChEMBL. | 16190769 |
IC50 (binding) | = 5.3 nM | Inhibitory concentration against human recombinant adenosine kinase using [14C]-AMP as radioligand | ChEMBL. | 16190769 |
Inhibition (functional) | = 16 % | Percent inhibition of the licking and biting behavior in response to formalin injection at a dose of 20 mg/Kg when given orally in rat by formalin paw assay; (n=6) | ChEMBL. | 16190769 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.