Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Mus musculus | nuclear receptor subfamily 3, group C, member 1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 22 % | Activity at human glucocorticoid receptor in human HepG2 cells assessed as tyrosine amino transferase activity relative to dexamethasone | ChEMBL. | 17467988 |
Activity (binding) | = 22 % | Activity at human glucocorticoid receptor in human HepG2 cells assessed as tyrosine amino transferase activity relative to dexamethasone | ChEMBL. | 17467988 |
Activity (binding) | = 41 % | Activity at human glucocorticoid receptor in C2C12 cells assessed as mouse glutamine synthetase activity relative to dexamethasone | ChEMBL. | 17467988 |
Activity (binding) | = 41 % | Activity at human glucocorticoid receptor in C2C12 cells assessed as mouse glutamine synthetase activity relative to dexamethasone | ChEMBL. | 17467988 |
Activity (binding) | = 66 % | Activity at human glucocorticoid receptor in human A549 cells assessed as repression of human IL6 relative to dexamethasone | ChEMBL. | 17467988 |
Activity (binding) | = 66 % | Activity at human glucocorticoid receptor in C57BI/6 mouse peritonial exudate cells assessed as repression of mouse IL6 relative to dexamethasone | ChEMBL. | 17467988 |
Activity (binding) | = 66 % | Activity at human glucocorticoid receptor in human A549 cells assessed as repression of human IL6 relative to dexamethasone | ChEMBL. | 17467988 |
Activity (binding) | = 66 % | Activity at human glucocorticoid receptor in C57BI/6 mouse peritonial exudate cells assessed as repression of mouse IL6 relative to dexamethasone | ChEMBL. | 17467988 |
EC50 (binding) | Inhibition of tyrosine amino transferase activity in human HepG2 cell line; nd=not determined | ChEMBL. | 15808489 | |
EC50 (binding) | 0 | Inhibition of tyrosine amino transferase activity in human HepG2 cell line; nd=not determined | ChEMBL. | 15808489 |
EC50 (binding) | 0 | Activity at human glucocorticoid receptor in human HepG2 cells assessed as tyrosine amino transferase activity | ChEMBL. | 17467988 |
EC50 (functional) | = 19 nM | GR-mediated transrepression of IL-6 in human A549 lung carcinoma cells | ChEMBL. | 15808489 |
EC50 (binding) | = 19 nM | Activity at human glucocorticoid receptor in human A549 cells assessed as repression of human IL6 | ChEMBL. | 17467988 |
EC50 (functional) | = 19 nM | GR-mediated transrepression of IL-6 in human A549 lung carcinoma cells | ChEMBL. | 15808489 |
EC50 (binding) | = 19 nM | Activity at human glucocorticoid receptor in human A549 cells assessed as repression of human IL6 | ChEMBL. | 17467988 |
EC50 (binding) | = 42 nM | GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 mice | ChEMBL. | 15808489 |
EC50 (binding) | = 42 nM | Activity at human glucocorticoid receptor in C57BI/6 mouse peritonial exudate cells assessed as repression of mouse IL6 | ChEMBL. | 17467988 |
EC50 (binding) | = 42 nM | GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 mice | ChEMBL. | 15808489 |
EC50 (binding) | = 42 nM | Activity at human glucocorticoid receptor in C57BI/6 mouse peritonial exudate cells assessed as repression of mouse IL6 | ChEMBL. | 17467988 |
EC50 (binding) | = 1209 nM | Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cells | ChEMBL. | 15808489 |
EC50 (binding) | = 1209 nM | Activity at human glucocorticoid receptor in C2C12 cells assessed as mouse glutamine synthetase activity | ChEMBL. | 17467988 |
EC50 (binding) | = 1209 nM | Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cells | ChEMBL. | 15808489 |
EC50 (binding) | = 1209 nM | Activity at human glucocorticoid receptor in C2C12 cells assessed as mouse glutamine synthetase activity | ChEMBL. | 17467988 |
IC50 (binding) | = 29.1 nM | Inhibition of human glucocorticoid receptor alpha by displacement of [3H]-dexamethasone | ChEMBL. | 15808489 |
IC50 (binding) | = 29.1 nM | Displacement of [3H]dexamethasone from human glucocorticoid receptor alpha | ChEMBL. | 17467988 |
IC50 (binding) | = 29.1 nM | Inhibition of human glucocorticoid receptor alpha by displacement of [3H]-dexamethasone | ChEMBL. | 15808489 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.