Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 0.1028 | 1 | 1 |
Onchocerca volvulus | 0.0285 | 0.0774 | 0.5 | |
Brugia malayi | thymidylate synthase | 0.0285 | 0.0774 | 0.0774 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.075 | 0.6546 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.075 | 0.6546 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0285 | 0.0774 | 0.0774 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1028 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1028 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1028 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.075 | 0.6546 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1028 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.075 | 0.6546 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.075 | 0.6546 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.075 | 0.6546 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0285 | 0.0774 | 0.0774 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1028 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0285 | 0.0774 | 0.0774 |
Schistosoma mansoni | dihydrofolate reductase | 0.1028 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1028 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1028 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0285 | 0.0774 | 0.0774 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.331 uM | Inhibitory concentration against human recombinant I-kappa-B-kinase 2 from 3 experiments | ChEMBL. | 15911271 |
IC50 (binding) | = 0.331 uM | Inhibitory concentration against human recombinant I-kappa-B-kinase 2 from 3 experiments | ChEMBL. | 15911271 |
IC50 (functional) | = 1.65 uM | Inhibitory concentration of the compound against interleukin-8 production in rheumatoid arthritis-derived synovial fibroblasts (RASFs) from 2 experiments | ChEMBL. | 15911271 |
LC50 (functional) | > 30 uM | Lethal concentration towards rheumatoid arthritis-derived synovial fibroblasts using Alamar Blue reagent | ChEMBL. | 15911271 |
Ratio (functional) | = 5 | Ratio of inhibitory concentration of rheumatoid arthritis-derived synovial fibroblasts to human recombinant I-kappa-B-kinase 2 | ChEMBL. | 15911271 |
Ratio (functional) | = 5 | Ratio of inhibitory concentration of rheumatoid arthritis-derived synovial fibroblasts to human recombinant I-kappa-B-kinase 2 | ChEMBL. | 15911271 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.