Detailed information for compound 341799

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 521.601 | Formula: C30H35NO7
  • H donors: 1 H acceptors: 4 LogP: 3.89 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)O[C@H]1C[C@@H](C(=O)NCCc2ccccc2)[C@]2([C@H](C1=O)[C@@]1(C)C[C@H](OC(=O)[C@@H]1CC2)c1cocc1)C
  • InChi: 1S/C30H35NO7/c1-18(32)37-23-15-22(27(34)31-13-10-19-7-5-4-6-8-19)29(2)12-9-21-28(35)38-24(20-11-14-36-17-20)16-30(21,3)26(29)25(23)33/h4-8,11,14,17,21-24,26H,9-10,12-13,15-16H2,1-3H3,(H,31,34)/t21-,22-,23-,24-,26-,29-,30-/m0/s1
  • InChiKey: IPENZWWLBYJXCB-KLKKBBNASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, kappa 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.2898 0.9224
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.109 0.3475
Loa Loa (eye worm) hypothetical protein 0.0035 0.1048 0.1048
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0021 0.0555 0.0555
Brugia malayi Cathepsin L-like precursor 0.0031 0.0899 0.0899
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0203 0.0645
Loa Loa (eye worm) hypothetical protein 0.0185 0.6527 0.6527
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0555 0.1626
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0203 0.0645
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1943 0.1943
Entamoeba histolytica cysteine protease, putative 0.0021 0.0555 0.1741
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0203 0.0645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0899 0.0895
Plasmodium falciparum cysteine proteinase falcipain 1 0.012 0.4148 1
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0106 0.0337
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1439 0.1434
Schistosoma mansoni inositol monophosphatase 0.0043 0.1342 0.1342
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0253 0.0808
Schistosoma mansoni dishevelled 0.0009 0.0106 0.0106
Entamoeba histolytica cysteine proteinase 2 0.0021 0.0555 0.1741
Loa Loa (eye worm) glutathione reductase 0.0044 0.138 0.138
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.3138 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0899 0.0895
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0106 0.0337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0899 0.0895
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.001 0.001
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.01 0.3439 0.8837
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.033 0.0898
Onchocerca volvulus 0.0031 0.0899 0.1365
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0008 0.0053 0.0048
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0008 0.0053 0.0053
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.2353 0.2092
Echinococcus granulosus Protein son of sevenless 0.0006 0.001 0.0032
Brugia malayi ecdysteroid receptor 0.0012 0.0203 0.0203
Onchocerca volvulus Cathepsin L homolog 0.0031 0.0899 0.1365
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0053 0.0048
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.109 0.1086
Brugia malayi TAR-binding protein 0.0065 0.2143 0.2143
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.033 0.0676
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0899 0.0895
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0031 0.0899 0.0895
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.2143 0.2143
Brugia malayi cathepsin L-like precursor 0.0017 0.0398 0.0398
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0203 0.0645
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0203 0.0645
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1638 0.1638
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.0555 0.1741
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.3138 0.3138
Brugia malayi nuclear hormone receptor 0.0012 0.0203 0.0203
Trypanosoma cruzi cysteine peptidase, putative 0.0085 0.2898 0.9234
Entamoeba histolytica cysteine protease, putative 0.0021 0.0555 0.1741
Brugia malayi RNA binding protein 0.0065 0.2143 0.2143
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0008 0.0053 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0203 0.0203
Trypanosoma cruzi cysteine peptidase, putative 0.0021 0.0555 0.1741
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0006 0.001 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0203 0.0645
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0363 0.1158
Plasmodium falciparum glutathione reductase 0.0015 0.033 0.0676
Schistosoma mansoni cathepsin s 0.0014 0.0275 0.0275
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.1342 0.1338
Echinococcus granulosus GPCR family 2 0.0016 0.0363 0.1158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.2898 0.9224
Echinococcus granulosus cathepsin b 0.0008 0.0053 0.0169
Echinococcus granulosus cathepsin L cysteine protease 0.0021 0.0555 0.1768
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0203 0.0203
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0053 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2143 0.2143
Loa Loa (eye worm) fibroinase 0.0031 0.0899 0.0899
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.109 0.109
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2143 0.2143
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1638 0.1638
Brugia malayi Papain family cysteine protease containing protein 0.0021 0.0555 0.0555
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0008 0.0053 0.0053
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0008 0.0053 0.0137
Leishmania major cathepsin L-like protease 0.0031 0.0899 0.2744
Schistosoma mansoni coup transcription factor 0.0012 0.0203 0.0203
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.2353 1
Brugia malayi N-terminal motif family protein 0.0185 0.6527 0.6527
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0899 0.0895
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.2898 0.9224
Plasmodium vivax unspecified product 0.012 0.4148 1
Schistosoma mansoni cathepsin F (C01 family) 0.0031 0.0899 0.0899
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.109 0.109
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.2353 0.2353
Loa Loa (eye worm) histone methyltransferase 0.0009 0.009 0.009
Brugia malayi hypothetical protein 0.0142 0.4977 0.4977
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0008 0.0053 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.109 0.1086
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.01 0.3439 0.8468
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.009 0.0286
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.1048 0.1048
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0182 0.0182
Brugia malayi steroid hormone receptor 0.0012 0.0203 0.0203
Schistosoma mansoni kinase 0.0047 0.1483 0.1483
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.1342 0.1047
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.0555 0.1741
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.2898 0.9224
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2143 0.2143
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2143 0.2143
Echinococcus granulosus ras GTP exchange factor 0.0006 0.001 0.0032
Loa Loa (eye worm) hypothetical protein 0.0008 0.0053 0.0053
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0899 0.2844
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0203 0.0203
Echinococcus multilocularis cathepsin b 0.0008 0.0053 0.0169
Loa Loa (eye worm) hypothetical protein 0.0008 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0899 0.0895
Echinococcus multilocularis cathepsin L 0.0008 0.0053 0.0169
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.033 0.0898
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0031 0.0899 0.0895
Schistosoma mansoni glutaminase 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0051 0.1638 0.1638
Trypanosoma cruzi cysteine protease, putative 0.0021 0.0555 0.1741
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0031 0.0899 0.0899
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0008 0.0053 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0203 0.0203
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3138 0.3134
Toxoplasma gondii hypothetical protein 0.0009 0.0106 0.0228
Leishmania major cathepsin L-like protease 0.0031 0.0899 0.2744
Leishmania major trypanothione reductase 0.0044 0.138 0.4302
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0008 0.0053 0.0048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0899 0.0895
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0106 0.0337
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0106 0.0337
Loa Loa (eye worm) hypothetical protein 0.0012 0.0203 0.0203
Mycobacterium tuberculosis Putative ferredoxin reductase 0.01 0.3439 0.8837
Onchocerca volvulus 0.0028 0.0796 0.1206
Onchocerca volvulus 0.0031 0.0899 0.1365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0555 0.055
Brugia malayi cathepsin F-like cysteine proteinase 0.0014 0.0275 0.0275
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0203 0.0203
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.2353 0.7455
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.1342 0.4259
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0203 0.0645
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1402 0.447
Echinococcus multilocularis Protein son of sevenless 0.0006 0.001 0.0032
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.033 0.0898
Brugia malayi Cathepsin L-like precursor 0.0031 0.0899 0.0899
Trypanosoma cruzi cysteine proteinase, putative 0.0021 0.0555 0.1741
Plasmodium falciparum thioredoxin reductase 0.0044 0.138 0.324
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1402 0.447
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3138 0.3134
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0106 0.0106
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0203 0.0645
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0363 0.1158
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0844 0.3439
Schistosoma mansoni cpg binding protein 0.003 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0008 0.0053 0.0053
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.033 0.0898
Trichomonas vaginalis glutaminase, putative 0.028 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0031 0.0899 0.0899
Trypanosoma brucei trypanothione reductase 0.0044 0.138 0.4302
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0203 0.0203
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.1342 0.4179
Trypanosoma cruzi cysteine proteinase, putative 0.0021 0.0555 0.1741
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0844 0.1931
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0363 0.0363
Onchocerca volvulus 0.0031 0.0899 0.1365
Echinococcus granulosus cathepsin L 0.0021 0.0555 0.1768
Trypanosoma cruzi major cysteine proteinase, putative 0.0062 0.2052 0.6528
Onchocerca volvulus 0.0031 0.0899 0.1365
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0106 0.0146
Loa Loa (eye worm) glutaminase 0.028 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0203 0.0203
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0203 0.0645
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0106 0.0337
Trypanosoma cruzi cruzipain precursor, putative 0.0014 0.0275 0.0846
Brugia malayi cathepsin Z-like cysteine proteinase 0.0008 0.0053 0.0053
Brugia malayi cathepsin Z-like cysteine proteinase 0.0008 0.0053 0.0053
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0203 0.0203
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.033 0.1023
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2143 0.2143
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0111 0.3848 1
Plasmodium vivax unspecified product 0.0014 0.0275 0.0541
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.001 0.001
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.3138 0.4799
Loa Loa (eye worm) hypothetical protein 0.0012 0.0203 0.0203
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0072 0.2397 0.7631
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.001 0.001
Brugia malayi Cathepsin L-like precursor 0.0017 0.0398 0.0398
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0203 0.0203
Plasmodium vivax vivapain-2 0.0031 0.0899 0.2067
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0008 0.0053 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0203 0.0203
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.033 0.0898
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0203 0.0203
Entamoeba histolytica cysteine protease, putative 0.0008 0.0053 0.0137
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0053 0.0053
Loa Loa (eye worm) cathepsin B 0.0008 0.0053 0.0053
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0398 0.124
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0203 0.0203
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.2353 0.2092
Leishmania major cysteine peptidase A (CPA) 0.0031 0.0899 0.2744
Mycobacterium tuberculosis Probable dehydrogenase 0.01 0.3439 0.8837
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.138 0.138
Brugia malayi cathepsin L precursor 0.0008 0.0053 0.0053
Onchocerca volvulus Huntingtin homolog 0.0142 0.4977 0.7622
Loa Loa (eye worm) hypothetical protein 0.0008 0.0053 0.0053
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0203 0.0203
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0203 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0053 0.0048
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.2353 0.575
Loa Loa (eye worm) hypothetical protein 0.0014 0.0275 0.0275
Echinococcus multilocularis cysteine protease 0.0031 0.0899 0.2867
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0555 0.1626
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0203 0.0203
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0021 0.0555 0.1741
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0899 0.0895
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0106 0.0106
Brugia malayi nuclear receptor NHR-88 0.0012 0.0203 0.0203
Entamoeba histolytica cysteine protease, putative 0.0021 0.0555 0.1741
Loa Loa (eye worm) RNA binding protein 0.0065 0.2143 0.2143
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.138 0.438
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.001 0.001
Loa Loa (eye worm) cysteine protease 0.0031 0.0899 0.0899
Brugia malayi Thioredoxin reductase 0.0044 0.138 0.138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0899 0.0895
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1402 0.1402
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0027 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.2898 0.9224
Echinococcus multilocularis cathepsin L cysteine protease 0.0031 0.0899 0.2867
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.1342 0.1338
Brugia malayi cathepsin F-like cysteine proteinase 0.0008 0.0053 0.0053
Echinococcus granulosus cathepsin L 0.0008 0.0053 0.0169
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0021 0.0555 0.0555
Echinococcus granulosus tar DNA binding protein 0.0065 0.2143 0.683
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0203 0.0203
Leishmania major hypothetical protein, conserved 0.0029 0.0844 0.2564
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0203 0.0203
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.2143 0.2143
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.033 0.1023
Brugia malayi Cathepsin L-like precursor 0.0017 0.0398 0.0398
Plasmodium vivax vivapain-2 0.0031 0.0899 0.2067
Plasmodium falciparum thioredoxin reductase 0.0015 0.033 0.0676
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0053 0.0048
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.033 0.1052
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0008 0.0053 0.0053
Echinococcus multilocularis cathepsin L 0.0021 0.0555 0.1768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0053 0.0048
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0796 0.0796
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0203 0.0203
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.109 0.3475
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.033 0.1052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0203 0.0203
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0111 0.3848 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0008 0.0053 0.0048
Loa Loa (eye worm) hypothetical protein 0.0142 0.4977 0.4977
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0899 0.0895
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.109 0.3454
Echinococcus granulosus cpg binding protein 0.003 0.0854 0.2723
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.2353 0.7498
Entamoeba histolytica cysteine protease, putative 0.0008 0.0053 0.0137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1402 0.1402
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0203 0.0645
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0006 0.001 0.0005
Plasmodium vivax vivapain-1 0.012 0.4148 1
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0899 0.2844
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0027 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0203 0.0203
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3138 0.3134
Echinococcus granulosus cathepsin l1 0.0017 0.0398 0.1268
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.033 0.033
Brugia malayi DIX domain containing protein 0.0009 0.0106 0.0106
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0008 0.0053 0.0137
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.033 0.1204
Brugia malayi fibroinase precursor 0.0008 0.0053 0.0053
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.2353 0.2353
Loa Loa (eye worm) TAR-binding protein 0.0065 0.2143 0.2143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0899 0.0895
Echinococcus multilocularis ras GTP exchange factor 0.0006 0.001 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0008 0.0053 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.2898 0.9224
Schistosoma mansoni cpg binding protein 0.003 0.0854 0.0854
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0009 0.0106 0.0106
Echinococcus granulosus cathepsin L cysteine proteinase 0.0031 0.0899 0.2867
Toxoplasma gondii thioredoxin reductase 0.0044 0.138 0.5771
Loa Loa (eye worm) hypothetical protein 0.0036 0.109 0.109
Brugia malayi cathepsin L-like cysteine proteinase 0.0008 0.0053 0.0053
Schistosoma mansoni dishevelled 0.0009 0.0106 0.0106
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0008 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0016 0.0363 0.0363
Echinococcus multilocularis cysteine protease 0.0031 0.0899 0.2867
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0006 0.001 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0899 0.0895
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.3138 1
Brugia malayi Cathepsin L-like precursor 0.0014 0.0275 0.0275
Schistosoma mansoni cathepsin S (C01 family) 0.0008 0.0053 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.033 0.1023
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.3138 0.3138
Loa Loa (eye worm) hypothetical protein 0.0017 0.0398 0.0398
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.033 0.1023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0203 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0053 0.0048
Plasmodium falciparum glutathione reductase 0.0044 0.138 0.324
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.033 0.1204
Plasmodium vivax unspecified product 0.0106 0.3647 0.8775
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0008 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0012 0.0203 0.0203
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0008 0.0053 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.2898 0.9224
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0008 0.0053 0.0048
Entamoeba histolytica cysteine protease, putative 0.0008 0.0053 0.0137
Onchocerca volvulus 0.0009 0.0106 0.0146
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0008 0.0053 0.0053
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0008 0.0053 0.0053
Trichomonas vaginalis ras GTP exchange factor, putative 0.0006 0.001 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0203 0.0203
Leishmania major cathepsin L-like protease 0.0031 0.0899 0.2744
Schistosoma mansoni cathepsin F (C01 family) 0.0031 0.0899 0.0899
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.109 0.3363
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0253 0.0808
Echinococcus multilocularis cpg binding protein 0.003 0.0854 0.2723
Brugia malayi N-terminal motif family protein 0.0006 0.001 0.001
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.033 0.0898
Trypanosoma cruzi cysteine peptidase, putative 0.0085 0.2898 0.9234
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.033 0.1023
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.001 0.001
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.0555 0.1741
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.033 0.0676
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0008 0.0053 0.0137
Brugia malayi cathepsin B-like cysteine proteinase 0.0008 0.0053 0.0053
Onchocerca volvulus 0.0031 0.0899 0.1365
Onchocerca volvulus Huntingtin homolog 0.0142 0.4977 0.7622
Trypanosoma cruzi cysteine peptidase, putative 0.0085 0.2898 0.9234
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0203 0.0645
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0203 0.0203
Entamoeba histolytica cysteine protease, putative 0.0008 0.0053 0.0137
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0844 0.2666
Mycobacterium ulcerans glutaminase 0.028 1 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0008 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0012 0.0203 0.0203
Schistosoma mansoni cathepsin B (C01 family) 0.0008 0.0053 0.0053
Trichomonas vaginalis ras GTP exchange factor, putative 0.0006 0.001 0.0005
Trypanosoma cruzi major cysteine proteinase, putative 0.0008 0.0053 0.0137
Entamoeba histolytica cysteine protease, putative 0.0021 0.0555 0.1741
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0106 0.0106
Trypanosoma cruzi cruzipain precursor, putative 0.0085 0.2898 0.9234
Loa Loa (eye worm) hypothetical protein 0.0012 0.0203 0.0203
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.3138 0.3138
Brugia malayi hypothetical protein 0.0009 0.0106 0.0106
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0106 0.0337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0899 0.0895
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0035 0.1048 0.1048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0203 0.0203
Brugia malayi CXXC zinc finger family protein 0.0028 0.0796 0.0796
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.109 0.3475
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0008 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0899 0.0895
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0203 0.0295
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0844 0.2666
Loa Loa (eye worm) hypothetical protein 0.0008 0.0053 0.0053
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0203 0.0645
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.033 0.033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1402 0.1402
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0008 0.0053 0.0053
Giardia lamblia Kinase, PLK 0.0092 0.3138 1
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0844 0.2564
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.3138 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.1178 0.241
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0014 0.0275 0.0275
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0031 0.0899 0.2067
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.1342 0.4278
Leishmania major cathepsin L-like protease 0.0031 0.0899 0.2744
Schistosoma mansoni hypothetical protein 0.0016 0.0363 0.0363
Schistosoma mansoni ras GTP exchange factor 0.0006 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0016 0.0363 0.0363
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0203 0.0203
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0031 0.0899 0.2867
Mycobacterium tuberculosis Probable reductase 0.01 0.3439 0.8837
Echinococcus granulosus son of sevenless 1 0.0006 0.001 0.0032
Onchocerca volvulus 0.0031 0.0899 0.1365
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0203 0.0645
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0203 0.0203
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.109 0.3475
Entamoeba histolytica cysteine protease, putative 0.0021 0.0555 0.1741
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0106 0.0337
Echinococcus granulosus cysteine protease 0.0021 0.0555 0.1768
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0203 0.0203
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1711 0.721
Brugia malayi glutathione reductase 0.0044 0.138 0.138
Echinococcus multilocularis GPCR, family 2 0.0016 0.0363 0.1158
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.033 0.0898
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3138 0.3134
Loa Loa (eye worm) hypothetical protein 0.0017 0.0398 0.0398
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.1342 0.5606
Brugia malayi N-terminal motif family protein 0.0006 0.001 0.001
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.138 0.2985
Entamoeba histolytica cysteine protease, putative 0.0021 0.0555 0.1741
Echinococcus multilocularis tar DNA binding protein 0.0065 0.2143 0.683
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.033 0.0898
Entamoeba histolytica cysteine protease, putative 0.0021 0.0555 0.1741
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.033 0.0325
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.3138 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.1342 0.4259
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3138 0.3134
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1402 0.447
Brugia malayi Cathepsin L-like precursor 0.0031 0.0899 0.0899
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0031 0.0899 0.2067
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.2353 0.7498
Trypanosoma cruzi cysteine peptidase, putative 0.0014 0.0275 0.0846
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.1342 0.4278
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0106 0.0337
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0203 0.0295
Brugia malayi Cathepsin L-like precursor 0.0031 0.0899 0.0899
Plasmodium falciparum cysteine proteinase falcipain 3 0.0031 0.0899 0.2067
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0899 0.2844
Loa Loa (eye worm) hypothetical protein 0.0009 0.0106 0.0106
Entamoeba histolytica cysteine protease, putative 0.0031 0.0899 0.2844
Schistosoma mansoni cathepsin C 0.0008 0.0053 0.0053
Onchocerca volvulus 0.0017 0.0398 0.0595
Plasmodium vivax vivapain-3 0.0021 0.0555 0.1225
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.2898 0.9224
Entamoeba histolytica hypothetical protein 0.0008 0.0053 0.0137
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0053 0.0053
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0203 0.0203
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0053 0.0053
Onchocerca volvulus Cathepsin F homolog 0.0031 0.0899 0.1365
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0398 0.0398
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0844 0.1931
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0203 0.0203
Entamoeba histolytica cysteine protease, putative 0.0021 0.0555 0.1741
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0899 0.0899
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0203 0.0203
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0203 0.0645
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0006 0.001 0.0032
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0106 0.0106
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0182 0.0182
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0111 0.3848 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0899 0.0895
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0053 0.0048
Echinococcus granulosus cathepsin b 0.0008 0.0053 0.0169
Loa Loa (eye worm) inositol-1 0.0043 0.1342 0.1342
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0053 0.0048
Mycobacterium tuberculosis Probable oxidoreductase 0.0111 0.3848 1
Entamoeba histolytica cysteine protease, putative 0.0008 0.0053 0.0137
Loa Loa (eye worm) hypothetical protein 0.0029 0.0844 0.0844
Schistosoma mansoni hypothetical protein 0.0013 0.0253 0.0253
Onchocerca volvulus Cathepsin L homolog 0.0008 0.0053 0.0066
Loa Loa (eye worm) hypothetical protein 0.0009 0.0106 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1402 0.1402
Schistosoma mansoni dep domain containing protein 0.0009 0.0106 0.0106
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.1342 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.001 0.001
Leishmania major cathepsin L-like protease 0.0085 0.2898 0.9224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0899 0.0895
Brugia malayi hypothetical protein 0.0009 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0014 0.0275 0.0275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0398 0.0393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0899 0.0895
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0203 0.0645
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0008 0.0053 0.0048
Echinococcus multilocularis cathepsin L cysteine protease 0.0031 0.0899 0.2867
Brugia malayi Cathepsin L-like precursor 0.0031 0.0899 0.0899
Echinococcus multilocularis cathepsin b 0.0008 0.0053 0.0169
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.109 0.109
Onchocerca volvulus 0.0031 0.0899 0.1365
Schistosoma mansoni cpg binding protein 0.0028 0.0796 0.0796
Entamoeba histolytica cysteine protease, putative 0.0021 0.0555 0.1741
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.109 0.3363
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.033 0.1023
Leishmania major cathepsin L-like protease 0.0031 0.0899 0.2744
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.01 0.3439 0.8837
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0008 0.0053 0.0053
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.033 0.0676
Loa Loa (eye worm) hypothetical protein 0.0012 0.0203 0.0203
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0006 0.001 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0398 0.0393
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0106 0.0106
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3138 0.3134
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0142 0.4977 0.4977
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0203 0.0203
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.1342 0.4179
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0106 0.0337
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.009 0.0286
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0021 0.0555 0.0555
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0027 0.0087
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1402 0.1402
Trypanosoma brucei polo-like protein kinase 0.0092 0.3138 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0021 0.0555 0.1741
Entamoeba histolytica cysteine protease, putative 0.0021 0.0555 0.1741
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0844 0.1931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0899 0.0895
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1439 0.1434
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.2353 0.2092
Onchocerca volvulus Cathepsin L homolog 0.0031 0.0899 0.1365
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.3138 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0014 0.0275 0.0275
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.109 0.3475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0899 0.0895
Loa Loa (eye worm) hypothetical protein 0.0017 0.0398 0.0398
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0203 0.0645
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0008 0.0053 0.0053
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0363 0.1158
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0106 0.0106
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1638 0.1638
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.033 0.0898
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0185 0.6527 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0053 0.0048
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.109 0.3475
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.109 0.3363
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.033 0.1023
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.001
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.033 0.5
Brugia malayi hypothetical protein 0.0029 0.0844 0.0844
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0203 0.0203
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.1342 0.4259
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0363 0.1158
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.1402 0.4467
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0027 0.0087
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0203 0.0295
Leishmania major cathepsin L-like protease 0.0085 0.2898 0.9224
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0203 0.0645
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0008 0.0053 0.0137
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0106 0.0106
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0008 0.0053 0.0053
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0203 0.0203
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.033 0.1023
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0008 0.0053 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0899 0.0895
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0053 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.2898 0.9224
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.109 0.3454
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.1402 0.4467
Treponema pallidum NADH oxidase 0.0015 0.033 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0053 0.0053
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.01 0.3439 0.8837
Echinococcus granulosus cathepsin l cysteine peptidase 0.0031 0.0899 0.2867
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0203 0.0645
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3138 0.3134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0899 0.0895
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0031 0.0899 0.2867
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0106 0.0337
Loa Loa (eye worm) ctsf protein 0.0031 0.0899 0.0899
Entamoeba histolytica cysteine protease, putative 0.0021 0.0555 0.1741
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.033 0.0325
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0006 0.001 0.0032
Onchocerca volvulus 0.0008 0.0053 0.0066
Brugia malayi Inositol-1 0.0043 0.1342 0.1342
Leishmania major cathepsin L-like protease 0.0085 0.2898 0.9224
Entamoeba histolytica cysteine protease, putative 0.0021 0.0555 0.1741
Brugia malayi Cathepsin L-like cysteine proteinase 0.0017 0.0398 0.0398
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0008 0.0053 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0203 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0899 0.0895
Loa Loa (eye worm) glutaminase 2 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0899 0.0899
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.3138 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.109 0.1086
Entamoeba histolytica cysteine protease, putative 0.0008 0.0053 0.0137
Brugia malayi hypothetical protein 0.0019 0.0464 0.0464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.2898 0.9224
Loa Loa (eye worm) hypothetical protein 0.0014 0.0275 0.0275
Brugia malayi RasGEF domain containing protein 0.0006 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0053 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0555 0.055
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0008 0.0053 0.0053
Entamoeba histolytica cysteine protease, putative 0.0021 0.0555 0.1741
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0027 0.0087
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.033 0.0676
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1402 0.447
Toxoplasma gondii cathepsin CPL 0.0031 0.0899 0.3681
Brugia malayi Papain family cysteine protease containing protein 0.0021 0.0555 0.0555
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0363 0.0363
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.1342 0.1338
Schistosoma mansoni inositol monophosphatase 0.0043 0.1342 0.1342
Onchocerca volvulus 0.0012 0.0203 0.0295
Schistosoma mansoni hypothetical protein 0.0016 0.0363 0.0363
Brugia malayi RasGEF domain containing protein 0.0006 0.001 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.033 0.1023
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0203 0.0203
Brugia malayi Cathepsin L-like precursor 0.0031 0.0899 0.0899
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0008 0.0053 0.0048
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.0555 0.1741
Brugia malayi RasGEF domain containing protein 0.0006 0.001 0.001
Echinococcus multilocularis son of sevenless 1 0.0006 0.001 0.0032
Loa Loa (eye worm) hypothetical protein 0.0016 0.0363 0.0363
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.109 0.3454
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0899 0.0895
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.138 0.324
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0203 0.0203
Plasmodium vivax glutathione reductase, putative 0.0044 0.138 0.324
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.2898 0.9224
Echinococcus granulosus cathepsin l1 0.0031 0.0899 0.2867

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 1000 nM Binding affinity for 1 uM [3H]-diprenorphine against human Opioid receptor kappa expressed in chinese hamster ovary cells (CHO cells) ChEMBL. 16051487
Ki (binding) > 1000 nM Binding affinity for 1 uM [3H]-diprenorphine against human Opioid receptor kappa expressed in chinese hamster ovary cells (CHO cells) ChEMBL. 16051487

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.