Detailed information for compound 341886

Basic information

Technical information
  • TDR Targets ID: 341886
  • Name: [4-[(2S)-2-acetamido-3-[[(2S)-1-[(2S)-2-[[(2S )-5-amino-1-(methylamino)-1,5-dioxopentan-2-y l]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxope ntan-2-yl]amino]-3-oxopropyl]phenyl] dihydrog en phosphate
  • MW: 654.649 | Formula: C28H43N6O10P
  • H donors: 7 H acceptors: 9 LogP: -1.08 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 3
  • SMILES: CNC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccc(cc1)OP(=O)(O)O)NC(=O)C)CC(C)C)CCC(=O)N
  • InChi: 1S/C28H43N6O10P/c1-16(2)14-22(28(40)34-13-5-6-23(34)27(39)32-20(25(37)30-4)11-12-24(29)36)33-26(38)21(31-17(3)35)15-18-7-9-19(10-8-18)44-45(41,42)43/h7-10,16,20-23H,5-6,11-15H2,1-4H3,(H2,29,36)(H,30,37)(H,31,35)(H,32,39)(H,33,38)(H2,41,42,43)/t20-,21-,22-,23-/m0/s1
  • InChiKey: WSKURUMBWYJVSI-MLCQCVOFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-[(2S)-2-acetamido-3-[[(1S)-1-[(2S)-2-[[(1S)-4-amino-1-(methylcarbamoyl)-4-oxo-butyl]carbamoyl]pyrrolidine-1-carbonyl]-3-methyl-butyl]amino]-3-oxo-propyl]phenyl] dihydrogen phosphate
  • [4-[(2S)-2-acetamido-3-[[(1S)-1-[[(2S)-2-[[[(1S)-4-amino-1-(methylcarbamoyl)-4-oxobutyl]amino]-oxomethyl]-1-pyrrolidinyl]-oxomethyl]-3-methylbutyl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate
  • [4-[(2S)-2-acetamido-3-[[(2S)-1-[(2S)-2-[[(2S)-5-azanyl-1-(methylamino)-1,5-dioxo-pentan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxo-pentan-2-yl]amino]-3-oxo-propyl]phenyl] dihydrogen phosphate
  • [4-[(2S)-2-acetamido-3-[[(1S)-1-[(2S)-2-[[(1S)-4-amino-4-keto-1-(methylcarbamoyl)butyl]carbamoyl]pyrrolidine-1-carbonyl]-3-methyl-butyl]amino]-3-keto-propyl]phenyl] dihydrogen phosphate
  • [4-[(2S)-2-acetamido-3-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-1-methylamino-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate
  • [4-[(2S)-2-acetamido-3-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-1-methylamino-1,5-dioxo-pentan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxo-pentan-2-yl]amino]-3-oxo-propyl]phenyl] dihydrogen phosphate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0011
Trypanosoma brucei short-chain dehydrogenase, putative 0.0102 0.0127 0.0307
Echinococcus granulosus GTP binding nuclear protein Ran 0.0019 0.0005 0.0009
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0047 0.0077
Schistosoma mansoni hypothetical protein 0.0032 0.0024 0.0039
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.0127 0.0122
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0489 0.0688 0.1131
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0031 0.0024 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0117 0.1569
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0031 0.0024 0.0039
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0323 0.0447 0.1113
Echinococcus granulosus importin subunit beta 1 0.0026 0.0015 0.0025
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0102 0.0127 0.0654
Toxoplasma gondii hypothetical protein 0.0023 0.0011 0.0028
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0006 0.0009
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0102 0.0127 0.0122
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.025 0.0622
Trypanosoma cruzi hypothetical protein, conserved 0.0102 0.0127 0.0315
Leishmania major hypothetical protein, conserved 0.0102 0.0127 0.0315
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0077
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0101 0.0125 0.0205
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0048 0.0078
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0102 0.0127 0.0122
Loa Loa (eye worm) hypothetical protein 0.0096 0.0117 0.0193
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0122 0.0201
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0102 0.0127 0.0208
Schistosoma mansoni amine GPCR 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.028 0.0385 0.0632
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0026 0.0016 0.0026
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0102 0.0127 0.012
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0358 0.0497 0.1237
Brugia malayi nuclear receptor RXR 0.0053 0.0055 0.0091
Brugia malayi nuclear hormone receptor family member odr-7 0.0048 0.0047 0.0077
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0024 0.0039
Brugia malayi CXXC zinc finger family protein 0.0028 0.0019 0.0031
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0566 0.08 0.1313
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0036 0.006
Schistosoma mansoni hypothetical protein 0.04 0.0558 0.0917
Echinococcus granulosus tachykinin peptides receptor 99D 0.0031 0.0024 0.0039
Toxoplasma gondii exonuclease III APE 0.0022 0.001 0.0024
Leishmania major quinonoid dihydropteridine reductase 0.0102 0.0127 0.0315
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0508 0.0716 0.178
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0031 0.0024 0.0039
Schistosoma mansoni biogenic amine (5HT) receptor 0.0031 0.0024 0.0039
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0426 0.0597 0.098
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0101 0.0125 0.0205
Echinococcus multilocularis expressed conserved protein 0.021 0.0283 0.0464
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0036 0.006
Loa Loa (eye worm) hypothetical protein 0.021 0.0282 0.0464
Onchocerca volvulus 0.0031 0.0024 0.0122
Loa Loa (eye worm) hypothetical protein 0.0049 0.005 0.0082
Echinococcus multilocularis transient receptor potential cation channel 0.0102 0.0127 0.0208
Loa Loa (eye worm) thymidylate synthase 0.0768 0.1093 0.1796
Echinococcus granulosus peptide allatostatin:somatostatin 0.0031 0.0024 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0016 0.001
Schistosoma mansoni short chain dehydrogenase 0.0102 0.0127 0.0208
Loa Loa (eye worm) hypothetical protein 0.0237 0.0322 0.0529
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0186 0.0248 0.3318
Loa Loa (eye worm) hypothetical protein 0.0508 0.0716 0.1175
Schistosoma mansoni vav2 0.0034 0.0028 0.0045
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0048 0.0047 0.0077
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0024 0.0039
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0026
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0358 0.0497 0.0817
Echinococcus multilocularis neuropeptide Y receptor 0.0031 0.0024 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0024 0.0039
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.0047 0.0077
Echinococcus granulosus snurportin 1 0.0275 0.0377 0.0619
Leishmania major phosphoinositide phosphatase 0.0188 0.0251 0.0625
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0016 0.0027
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0102 0.0127 0.1695
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0114 0.0187
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0031 0.0024 0.0039
Onchocerca volvulus Protein ultraspiracle homolog 0.0101 0.0125 0.0643
Schistosoma mansoni aldehyde dehydrogenase 0.0107 0.0133 0.0219
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0067 0.0075 0.0186
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0026
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0019 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0169 0.0223 0.0555
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0102 0.0127 0.012
Echinococcus multilocularis somatostatin receptor 0.0031 0.0024 0.0039
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0102 0.0127 0.012
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0186 0.0248 0.3318
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.004 0.0036 0.006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0101 0.0125 0.0205
Brugia malayi hypothetical protein 0.0031 0.0024 0.0039
Brugia malayi hypothetical protein 0.0031 0.0024 0.0039
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0492 0.0693 0.1137
Leishmania major oxidoreductase-like protein 0.0102 0.0127 0.0315
Giardia lamblia Hypothetical protein 0.0187 0.025 0.3443
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Schistosoma mansoni biogenic amine (5HT) receptor 0.0031 0.0024 0.0039
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.025 0.0622
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0026
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0067 0.0075 0.0123
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0061 0.0152
Echinococcus granulosus Niemann Pick C1 protein 0.032 0.0442 0.0726
Leishmania major pteridine reductase 1 0.0102 0.0127 0.0315
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0492 0.0693 0.9268
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0102 0.0127 0.0122
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0295 0.0406 0.0666
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0102 0.0127 0.1695
Schistosoma mansoni protein kinase C 0.0026 0.0016 0.0026
Leishmania major cathepsin L-like protease 0.0058 0.0062 0.0154
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0019 0.0005 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0187 0.025 0.3345
Leishmania major quinonoid dihydropteridine reductase 0.0102 0.0127 0.0315
Echinococcus multilocularis retinol dehydrogenase 11 0.0102 0.0127 0.0208
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0003 0.0008
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0102 0.0127 0.0315
Leishmania major cathepsin L-like protease 0.0058 0.0062 0.0154
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Entamoeba histolytica phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative 0.0054 0.0057 0.1868
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0101 0.0125 0.0205
Onchocerca volvulus 0.0031 0.0024 0.0122
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0102 0.0127 0.0122
Loa Loa (eye worm) hypothetical protein 0.0102 0.0127 0.0208
Echinococcus granulosus carbonyl reductase 1 0.0102 0.0127 0.0208
Brugia malayi Nuclear hormone receptor-like 1 0.0053 0.0055 0.0091
Brugia malayi protein kinase C II. 0.0026 0.0016 0.0026
Brugia malayi RhoGAP domain containing protein 0.0034 0.0028 0.0045
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0315
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0508 0.0716 0.1175
Brugia malayi protein kinase C3,putative 0.0026 0.0016 0.0026
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0102 0.0127 0.019
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0036 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0101 0.0125 0.0205
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0077
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0031 0.0024 0.0039
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0031 0.0024 0.0039
Loa Loa (eye worm) neuropeptide F receptor 0.0031 0.0024 0.0039
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.0015 0.003
Echinococcus granulosus neuropeptide receptor 0.0031 0.0024 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0075 0.0124
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0031 0.0024 0.0039
Brugia malayi Melatonin receptor type 1A 0.0031 0.0024 0.0039
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0026 0.0016 0.0026
Onchocerca volvulus 0.0031 0.0024 0.0122
Echinococcus multilocularis neuropeptide FF receptor 2 0.0031 0.0024 0.0039
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0321 0.0444 0.0729
Loa Loa (eye worm) hypothetical protein 0.0101 0.0125 0.0205
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0048 0.0047 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0187 0.025 0.3345
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0186 0.0248 0.0242
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0295 0.0406 0.0666
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0187 0.025 0.0622
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0102 0.0127 0.0315
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0102 0.0127 0.1707
Loa Loa (eye worm) hypothetical protein 0.1006 0.1438 0.2361
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0024 0.0039
Echinococcus granulosus raf serine:threonine protein kinase 0.0752 0.1069 0.1756
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0102 0.0127 0.0122
Schistosoma mansoni coup transcription factor 0.0101 0.0125 0.0205
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0077
Brugia malayi Importin beta-1 subunit 0.0026 0.0015 0.0025
Onchocerca volvulus 0.011 0.0138 0.0712
Schistosoma mansoni steroid dehydrogenase 0.0102 0.0127 0.0208
Echinococcus multilocularis neuropeptide receptor 0.0031 0.0024 0.0039
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.2785 0.402 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0101 0.0125 0.0205
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0024 0.0039
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0036 0.006
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0102 0.0127 0.0122
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0102 0.0127 0.1695
Schistosoma mansoni short chain dehydrogenase 0.0102 0.0127 0.0208
Echinococcus multilocularis FTZ F1 alpha 0.0101 0.0125 0.0205
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0048 0.0047 0.0077
Echinococcus granulosus geminin 0.0495 0.0696 0.1143
Loa Loa (eye worm) hypothetical protein 0.0072 0.0083 0.0136
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0016 0.001
Entamoeba histolytica Ran family GTPase 0.0019 0.0005 0.0179
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.005 0.0124
Schistosoma mansoni steroid dehydrogenase 0.0102 0.0127 0.0208
Mycobacterium ulcerans aldehyde dehydrogenase 0.0107 0.0133 0.0127
Loa Loa (eye worm) hypothetical protein 0.0102 0.0127 0.0208
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0018 0.003
Schistosoma mansoni ran 0.0019 0.0005 0.0009
Leishmania major hypothetical protein, conserved 0.0057 0.006 0.0149
Mycobacterium ulcerans putative regulatory protein 0.0169 0.0223 0.0217
Loa Loa (eye worm) hypothetical protein 0.01 0.0122 0.0201
Echinococcus granulosus g protein coupled receptor 0.0031 0.0024 0.0039
Brugia malayi RNA, U transporter 1 0.0073 0.0084 0.0138
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0356 0.0495 0.6625
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.001 0.0017
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Brugia malayi nuclear hormone receptor 0.1297 0.1861 0.3056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0101 0.0125 0.0205
Echinococcus multilocularis N chimaerin 0.0034 0.0028 0.0045
Onchocerca volvulus 0.0102 0.0127 0.0654
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0062 0.0154
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0008 0.011
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.1351 0.1938 1
Schistosoma mansoni adenoreceptor 0.0031 0.0024 0.0039
Entamoeba histolytica hypothetical protein, conserved 0.0102 0.0127 0.4188
Brugia malayi orphan nuclear receptor NR2E1 0.0048 0.0047 0.0077
Schistosoma mansoni steroid dehydrogenase 0.0102 0.0127 0.0208
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0102 0.0127 0.0208
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0102 0.0127 0.0122
Schistosoma mansoni diacylglycerol kinase theta 0.0026 0.0016 0.0026
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0024 0.0039
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.025 0.0622
Schistosoma mansoni amine GPCR 0.0031 0.0024 0.0039
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0075 0.0124
Onchocerca volvulus 0.004 0.0036 0.0187
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0102 0.0127 0.019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0062 0.0146
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.025 0.0622
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0036 0.009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0114 0.0187
Echinococcus granulosus allatostatin A receptor 0.0031 0.0024 0.0039
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0102 0.0127 0.0208
Brugia malayi Pre-SET motif family protein 0.019 0.0253 0.0416
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0019 0.0005 0.0009
Echinococcus multilocularis conserved hypothetical protein 0.0102 0.0127 0.0208
Echinococcus multilocularis cpg binding protein 0.003 0.0021 0.0035
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0186 0.0248 0.8197
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0024 0.0039
Brugia malayi jmjC domain containing protein 0.0067 0.0075 0.0124
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0026 0.0016 0.0026
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.0036 0.006
Schistosoma mansoni steroid dehydrogenase 0.0102 0.0127 0.0208
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0102 0.0127 0.0122
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.001 0.0316
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0102 0.0127 0.0315
Schistosoma mansoni neuropeptide F-like receptor 0.0031 0.0024 0.0039
Mycobacterium leprae conserved hypothetical protein 0.0169 0.0223 0.0348
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0031 0.0024 0.0039
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0768 0.1093 0.178
Echinococcus multilocularis g-protein coupled receptor 0.0031 0.0024 0.0039
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0036 0.0059
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0067 0.0075 0.2092
Leishmania major hypothetical protein, conserved 0.0102 0.0127 0.0315
Brugia malayi ORL1-like opioid receptor 0.0031 0.0024 0.0039
Schistosoma mansoni thyroid hormone receptor 0.0101 0.0125 0.0205
Onchocerca volvulus 0.0031 0.0024 0.0122
Mycobacterium ulcerans short-chain dehydrogenase 0.0102 0.0127 0.012
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0356 0.0495 0.6625
Mycobacterium ulcerans thymidylate synthase 0.0768 0.1093 0.1087
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0358 0.0497 0.1237
Echinococcus granulosus phd:f box containing protein 0.0017 0.0003 0.0005
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0187 0.025 0.0622
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0024 0.0039
Echinococcus multilocularis neuropeptide receptor A26 0.0424 0.0594 0.0976
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.001 0.0016
Plasmodium falciparum GAF domain-related protein, putative 0.0169 0.0223 0.0555
Schistosoma mansoni carbonyl reductase 0.0102 0.0127 0.0208
Schistosoma mansoni short chain dehydrogenase 0.0102 0.0127 0.0208
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0019 0.0005 0.0013
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0102 0.0127 0.0315
Onchocerca volvulus 0.0031 0.0024 0.0122
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.0319 0.0524
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0492 0.0693 0.1723
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0356 0.0495 0.6625
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0036 0.009
Echinococcus granulosus neuropeptide Y receptor 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0011
Onchocerca volvulus 0.0102 0.0127 0.0654
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0027
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0102 0.0127 0.1695
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0003 0.0008
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0102 0.0127 0.0208
Brugia malayi Protein kinase c protein 2 0.0026 0.0016 0.0026
Brugia malayi hypothetical protein 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Onchocerca volvulus 0.0102 0.0127 0.0654
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0768 0.1093 0.1796
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Mycobacterium ulcerans putative regulatory protein 0.0169 0.0223 0.0217
Echinococcus multilocularis protein patched 0.0096 0.0117 0.0193
Entamoeba histolytica hypothetical protein 0.004 0.0036 0.1192
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0101 0.0125 0.0205
Schistosoma mansoni carbonyl reductase 0.0102 0.0127 0.0208
Schistosoma mansoni sodium/chloride dependent transporter 0.0237 0.0322 0.0529
Echinococcus granulosus retinol dehydrogenase 11 0.0102 0.0127 0.0208
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.005 0.0124
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0187 0.025 0.3345
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0024 0.0039
Loa Loa (eye worm) serotonin transporter b 0.0237 0.0322 0.0529
Schistosoma mansoni steroid dehydrogenase 0.0102 0.0127 0.0208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0114 0.0187
Plasmodium vivax importin-beta 2, putative 0.0026 0.0015 0.0038
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0019 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0092 0.0112 0.0184
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0044 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0101 0.0125 0.0205
Echinococcus granulosus Rac GTPase activating protein 1 0.0026 0.0016 0.0026
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0442 0.0619 0.1016
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0102 0.0127 0.0307
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.025 0.3345
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0067 0.0075 0.0068
Echinococcus granulosus retinol dehydrogenase 11 0.0102 0.0127 0.0208
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Echinococcus multilocularis protein kinase c eta type 0.0026 0.0016 0.0026
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0102 0.0127 0.0315
Echinococcus multilocularis G protein coupled receptor 139 0.0031 0.0024 0.0039
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0768 0.1093 0.1089
Trypanosoma brucei short-chain dehydrogenase, putative 0.0102 0.0127 0.0307
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0003 0.0005
Brugia malayi hypothetical protein 0.0031 0.0024 0.0039
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0102 0.0127 0.0208
Entamoeba histolytica short chain dehydrogenase family protein 0.0102 0.0127 0.4188
Echinococcus granulosus oxidoreductase 0.0102 0.0127 0.0208
Loa Loa (eye worm) nuclear receptor nhr-7B 0.1297 0.1861 0.3056
Loa Loa (eye worm) dehydrogenase 0.0102 0.0127 0.0208
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0102 0.0127 1
Mycobacterium ulcerans oxidoreductase 0.0102 0.0127 0.012
Treponema pallidum sodium- and chloride- dependent transporter 0.0237 0.0322 1
Loa Loa (eye worm) oxidoreductase 0.0102 0.0127 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.042 0.5627
Loa Loa (eye worm) nuclear hormone receptor 0.0048 0.0047 0.0077
Brugia malayi Pleckstrin Homology Domain 0.0026 0.0016 0.0026
Echinococcus multilocularis Diacylglycerol kinase theta 0.0026 0.0016 0.0026
Onchocerca volvulus 0.0102 0.0127 0.0654
Schistosoma mansoni RAR-like nuclear receptor 0.0101 0.0125 0.0205
Trypanosoma cruzi tyrosine phosphatase, putative 0.0054 0.0057 0.0141
Loa Loa (eye worm) hypothetical protein 0.0101 0.0125 0.0205
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.053 0.0747 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0091 0.0149
Leishmania major dehydrogenase-like protein 0.0102 0.0127 0.0315
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.0047 0.0077
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0102 0.0127 0.012
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0122 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0127 0.0208
Leishmania major quinonoid dihydropteridine reductase 0.0102 0.0127 0.0315
Echinococcus multilocularis myotubularin protein 13 0.0026 0.0016 0.0026
Loa Loa (eye worm) hypothetical protein 0.0101 0.0125 0.0205
Onchocerca volvulus 0.0026 0.0016 0.0084
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0508 0.0716 0.1175
Brugia malayi Dehydrogenases, short chain protein 30 0.0102 0.0127 0.0208
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0031 0.0024 0.0039
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0101 0.0125 0.0205
Echinococcus granulosus 7tm_1 domain containing protein 0.0031 0.0024 0.0039
Loa Loa (eye worm) dihydrofolate reductase 0.421 0.6088 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0187 0.025 0.0622
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0068 0.0077 0.0126
Echinococcus granulosus biogenic amine 5HT receptor 0.0031 0.0024 0.0039
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0107 0.0133 0.0219
Entamoeba histolytica hypothetical protein 0.004 0.0036 0.1192
Trypanosoma brucei oxidoreductase-like protein 0.0102 0.0127 0.0307
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0031 0.0024 0.0039
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0492 0.0693 0.1137
Loa Loa (eye worm) oxidoreductase 0.0102 0.0127 0.0208
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0101 0.0125 0.0205
Brugia malayi Nuclear hormone receptor E75 0.0048 0.0047 0.0077
Leishmania major hypothetical protein, conserved 0.0187 0.025 0.0622
Mycobacterium ulcerans ketoacyl reductase 0.0102 0.0127 0.012
Loa Loa (eye worm) hypothetical protein 0.004 0.0036 0.006
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0102 0.0127 0.012
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0067 0.0075 0.0105
Schistosoma mansoni neuropeptide receptor 0.0031 0.0024 0.0039
Echinococcus multilocularis fmrfamide receptor 0.0031 0.0024 0.0039
Schistosoma mansoni opsin-like receptor 0.0031 0.0024 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0062 0.0146
Echinococcus granulosus carbonyl reductase 1 0.0102 0.0127 0.0208
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.025 0.0622
Echinococcus multilocularis raf serine:threonine protein kinase 0.0752 0.1069 0.1756
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Giardia lamblia Reductase, putative 0.0102 0.0127 0.1707
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.003
Mycobacterium ulcerans short-chain dehydrogenase 0.0102 0.0127 0.012
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0366 0.0509 0.6805
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0102 0.0127 0.0307
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0038 0.0033 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0062 0.0146
Leishmania major short chain dehydrogenase-like protein 0.0102 0.0127 0.0315
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0067 0.0075 0.0186
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0107 0.0133 0.0219
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0101 0.0125 0.0205
Plasmodium vivax SET domain protein, putative 0.0028 0.0018 0.0045
Brugia malayi Nuclear hormone receptor E75 0.0048 0.0047 0.0077
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0187 0.025 0.3345
Brugia malayi Nuclear hormone receptor-like 1 0.0101 0.0125 0.0205
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0011
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0003 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.0047 0.0077
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0187 0.025 0.0622
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0053 0.0055 0.0091
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0024 0.0039
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0031 0.0024 0.0039
Brugia malayi jmjC domain containing protein 0.0017 0.0003 0.0005
Onchocerca volvulus Bile acid receptor homolog 0.0101 0.0125 0.0643
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0186 0.0248 0.8197
Brugia malayi G-protein coupled receptor 0.0031 0.0024 0.0039
Schistosoma mansoni hypothetical protein 0.0092 0.0112 0.0184
Echinococcus granulosus uncharacterized sodium dependent transporter 0.004 0.0036 0.006
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0016 0.0011
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0102 0.0127 0.0208
Toxoplasma gondii hypothetical protein 0.0305 0.042 0.1046
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1842 0.2651 0.4354
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0187 0.025 0.0614
Onchocerca volvulus 0.0031 0.0024 0.0122
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.0047 0.0077
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.001 0.0024
Plasmodium vivax steroid dehydrogenase, putative 0.0102 0.0127 0.0315
Schistosoma mansoni thyroid hormone receptor 0.0101 0.0125 0.0205
Loa Loa (eye worm) hypothetical protein 0.0053 0.0055 0.0091
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0102 0.0127 0.1695
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0102 0.0127 0.019
Schistosoma mansoni biogenic amine receptor 0.0031 0.0024 0.0039
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0047 0.0116
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0436 0.0611 0.1003
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.001 0.0128
Trichomonas vaginalis retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase, putative 0.028 0.0385 0.5147
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0024 0.0039
Brugia malayi dehydrogenases, short chain protein 2 0.0102 0.0127 0.0208
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.073 0.1037 0.1704
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0101 0.0125 0.0205
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0016 0.0011
Brugia malayi RE15519p 0.0031 0.0024 0.0039
Brugia malayi Protein-tyrosine phosphatase 0.0082 0.0098 0.016
Loa Loa (eye worm) norepinephrine transporter 0.0237 0.0322 0.0529
Brugia malayi Dehydrogenases, short chain protein 2 0.0102 0.0127 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0062 0.0146
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.421 0.6088 0.6086
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.005 0.0124
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0102 0.0127 0.012
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.0073 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0061 0.0152
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.004 0.0036 0.006
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0101 0.0125 0.0205
Echinococcus multilocularis protein dispatched 1 0.011 0.0137 0.0225
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0031 0.0024 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0223 0.2984
Echinococcus granulosus expressed conserved protein 0.021 0.0283 0.0464
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0101 0.0125 0.0205
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0016 0.0027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0026
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0187 0.025 0.0622
Echinococcus granulosus peptidase Clp S14 family 0.0044 0.0041 0.0068
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0003 0.0005
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0102 0.0127 0.0315
Toxoplasma gondii hypothetical protein 0.0169 0.0223 0.0555
Schistosoma mansoni hypothetical protein 0.0068 0.0077 0.0126
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0492 0.0693 0.9268
Mycobacterium tuberculosis Probable dehydrogenase 0.0102 0.0127 0.0122
Loa Loa (eye worm) hypothetical protein 0.0442 0.0619 0.1016
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.025 0.0622
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0102 0.0127 0.012
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0187 0.025 0.0411
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.0047 0.0243
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0036 0.006
Schistosoma mansoni unc-13 (munc13) 0.0026 0.0016 0.0026
Brugia malayi diacylglycerol kinase 0.0026 0.0016 0.0026
Echinococcus multilocularis serotonin transporter 0.0237 0.0322 0.0529
Echinococcus granulosus hypothetical protein 0.0031 0.0024 0.0039
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0358 0.0497 0.1237
Schistosoma mansoni steroid dehydrogenase 0.0102 0.0127 0.0208
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0016 0.001
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0102 0.0127 0.1695
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.0209 0.0519
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0492 0.0693 0.9268
Echinococcus granulosus myotubularin protein 13 0.0026 0.0016 0.0026
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.421 0.6088 0.6087
Loa Loa (eye worm) oxidoreductase 0.0102 0.0127 0.0208
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0102 0.0127 0.0208
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0003 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0114 0.0187
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0315
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.004 0.0036 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0102 0.0127 0.0315
Echinococcus granulosus neuropeptides capa receptor 0.0031 0.0024 0.0039
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0492 0.0693 0.9268
Brugia malayi C1-like domain containing protein 0.0026 0.0016 0.0026
Brugia malayi hypothetical protein 0.0049 0.005 0.0082
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0031 0.0024 0.0039
Mycobacterium ulcerans short-chain dehydrogenase 0.0102 0.0127 0.012
Onchocerca volvulus 0.0026 0.0016 0.0083
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.025 0.0622
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0024 0.0039
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0102 0.0127 0.0208
Toxoplasma gondii HEAT repeat-containing protein 0.0026 0.0015 0.0038
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0102 0.0127 0.0315
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Loa Loa (eye worm) hypothetical protein 0.0067 0.0075 0.0123
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0026 0.0016 0.0026
Schistosoma mansoni protein kinase C mu 0.0026 0.0016 0.0026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0114 0.0187
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0102 0.0127 0.0315
Loa Loa (eye worm) hypothetical protein 0.0102 0.0127 0.0208
Brugia malayi hypothetical protein 0.0031 0.0024 0.0039
Echinococcus granulosus N chimaerin 0.0034 0.0028 0.0045
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0492 0.0693 0.1723
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0102 0.0127 0.0208
Schistosoma mansoni aldehyde dehydrogenase 0.0107 0.0133 0.0219
Plasmodium falciparum importin beta, putative 0.0026 0.0015 0.0038
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0358 0.0497 0.123
Loa Loa (eye worm) hypothetical protein 0.0101 0.0125 0.0205
Brugia malayi hypothetical protein 0.0032 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0102 0.0127 0.0208
Toxoplasma gondii hypothetical protein 0.0054 0.0057 0.0141
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpB 0.0188 0.0251 0.0245
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0101 0.0125 0.0205
Brugia malayi putative neuropeptide receptor NPR1 0.0031 0.0024 0.0039
Schistosoma mansoni histamine h1 receptor 0.0031 0.0024 0.0039
Echinococcus multilocularis thymidylate synthase 0.0768 0.1093 0.1796
Schistosoma mansoni steroid dehydrogenase 0.0102 0.0127 0.0208
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0227 0.0307 0.0505
Loa Loa (eye worm) hypothetical protein 0.0818 0.1165 0.1914
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0102 0.0127 0.0208
Echinococcus granulosus carbonyl reductase 1 0.0102 0.0127 0.0208
Onchocerca volvulus 0.0031 0.0024 0.0122
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0336 0.0466 0.1159
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0101 0.0125 0.0205
Echinococcus granulosus protein kinase c eta type 0.0026 0.0016 0.0026
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0492 0.0693 0.1137
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Schistosoma mansoni retinal dehydrogenase 0.0102 0.0127 0.0208
Echinococcus granulosus GPCR family 2 0.0032 0.0024 0.0039
Brugia malayi neuropeptide F receptor 0.0031 0.0024 0.0039
Echinococcus multilocularis nuclear receptor nhr 48 0.0048 0.0047 0.0077
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.004 0.0036 0.006
Brugia malayi nuclear receptor RXR 0.0048 0.0047 0.0077
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0102 0.0127 0.0307
Echinococcus multilocularis neuropeptide s receptor 0.0424 0.0594 0.0976
Brugia malayi ecdysteroid receptor 0.0101 0.0125 0.0205
Mycobacterium tuberculosis Hypothetical protein 0.0366 0.0509 0.0504
Brugia malayi MH2 domain containing protein 0.0107 0.0133 0.0218
Echinococcus multilocularis neuropeptide receptor 0.0031 0.0024 0.0039
Brugia malayi nuclear receptor NHR-88 0.0101 0.0125 0.0205
Mycobacterium ulcerans short chain dehydrogenase 0.6905 1 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0187 0.025 0.0622
Mycobacterium ulcerans short-chain dehydrogenase 0.0102 0.0127 0.012
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0187 0.025 0.0411
Brugia malayi Retinol dehydrogenase 12 0.0102 0.0127 0.0208
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Brugia malayi Tachykinin-like peptides receptor 99D 0.0031 0.0024 0.0039
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0067 0.0075 0.0068
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0036 0.0059
Giardia lamblia hypothetical protein 0.0187 0.025 0.3443
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0102 0.0127 0.0122
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0102 0.0127 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0114 0.0187
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0321 0.0444 0.0729
Echinococcus multilocularis sterol regulatory element binding protein 0.0096 0.0117 0.0193
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0107 0.0133 0.0128
Leishmania major dihydrofolate reductase-thymidylate synthase 0.2785 0.402 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0114 0.0187
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0016 0.0537
Onchocerca volvulus 0.0216 0.0291 0.1501
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0016 0.004
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0207 0.0278 0.0273
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0061 0.0819
Schistosoma mansoni dihydrofolate reductase 0.421 0.6088 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0492 0.0693 0.9268
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.053 0.0747 1
Schistosoma mansoni hypothetical protein 0.0275 0.0377 0.0619
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0026 0.0016 0.0026
Echinococcus granulosus hypothetical protein 0.0102 0.0127 0.0208
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0031 0.0024 0.0039
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0492 0.0693 0.9268
Schistosoma mansoni hypothetical protein 0.0092 0.0112 0.0184
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0275 0.0377 0.0619
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0036 0.006
Schistosoma mansoni steroid dehydrogenase 0.0102 0.0127 0.0208
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0057 0.0141
Echinococcus multilocularis dihydrofolate reductase 0.421 0.6088 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.005 0.0124
Echinococcus multilocularis snurportin 1 0.0275 0.0377 0.0619
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0492 0.0693 0.9268
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.0036 0.006
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0023 0.0011 0.0028
Toxoplasma gondii oxidoreductase, putative 0.0102 0.0127 0.0315
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0003 0.0005
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0101 0.0125 0.0205
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0358 0.0497 0.0817
Schistosoma mansoni hypothetical protein 0.0495 0.0696 0.1143
Schistosoma mansoni hypothetical protein 0.0048 0.0048 0.0078
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0187 0.025 0.0411
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.001 0.0016
Echinococcus multilocularis steroid dehydrogenase 0.0102 0.0127 0.0208
Entamoeba histolytica short chain dehydrogenase family protein 0.0102 0.0127 0.4188
Onchocerca volvulus 0.0031 0.0024 0.0122
Loa Loa (eye worm) hypothetical protein 0.0237 0.0322 0.0529
Loa Loa (eye worm) solute carrier family 6 member 4 0.0237 0.0322 0.0529
Entamoeba histolytica hypothetical protein, conserved 0.0102 0.0127 0.4188
Schistosoma mansoni cpg binding protein 0.0028 0.0019 0.0031
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Brugia malayi jmjC domain containing protein 0.0017 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.004 0.0036 0.006
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.0209 0.0519
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.0319 0.0524
Schistosoma mansoni biogenic amine receptor 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0005
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.025 0.0622
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0062 0.0146
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0492 0.0693 0.9268
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0102 0.0127 0.0122
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0006 0.0009
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0102 0.0127 0.0654
Plasmodium vivax phosphodiesterase gamma, putative 0.0187 0.025 0.0622
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0492 0.0693 0.9268
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0075 0.0124
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0048 0.0047 0.0077
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0187 0.025 0.0411
Toxoplasma gondii hypothetical protein 0.004 0.0036 0.009
Echinococcus granulosus neuropeptide Y receptor 0.0031 0.0024 0.0039
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0186 0.0248 0.3414
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0026
Echinococcus multilocularis geminin 0.0495 0.0696 0.1143
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.073 0.1037 0.1704
Loa Loa (eye worm) hypothetical protein 0.0057 0.006 0.0099
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0102 0.0127 0.0208
Loa Loa (eye worm) hypothetical protein 0.0187 0.025 0.0411
Mycobacterium ulcerans dehydrogenase/reductase 0.0102 0.0127 0.012
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0102 0.0127 0.0122
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0031 0.0024 0.0039
Leishmania major quinonoid dihydropteridine reductase 0.0102 0.0127 0.0315
Onchocerca volvulus 0.0102 0.0127 0.0654
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0026
Echinococcus granulosus g protein coupled receptor 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0026 0.0016 0.0026
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0102 0.0127 0.0122
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0024 0.0039
Toxoplasma gondii hypothetical protein 0.0169 0.0223 0.0555
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0102 0.0127 0.0122
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0016 0.001
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0102 0.0127 0.1695
Schistosoma mansoni biogenic amine receptor 0.0031 0.0024 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0024 0.0039
Echinococcus granulosus ecdysone induced protein 78C 0.0101 0.0125 0.0205
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0102 0.0127 0.0315
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0492 0.0693 0.9268
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0295 0.0406 0.0666
Echinococcus multilocularis serotonin receptor 0.0031 0.0024 0.0039
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0034 0.0028 0.0045
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Onchocerca volvulus 0.0102 0.0127 0.0654
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0077
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.001 0.0017
Plasmodium vivax JmjC domain containing protein 0.0017 0.0003 0.0008
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.001 0.0024
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.001 0.0058
Trypanosoma brucei hypothetical protein, conserved 0.0187 0.025 0.0614
Echinococcus granulosus Protein kinase C brain isozyme 0.0026 0.0016 0.0026
Echinococcus multilocularis G-protein coupled receptor, putative 0.0031 0.0024 0.0039
Echinococcus multilocularis protein kinase c epsilon type 0.0026 0.0016 0.0026
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0566 0.08 0.1313
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0159 0.0209 0.0512
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0186 0.0248 0.3318
Onchocerca volvulus 0.0102 0.0127 0.0654
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0024 0.0039
Onchocerca volvulus 0.0031 0.0024 0.0122
Onchocerca volvulus 0.0102 0.0127 0.0654
Loa Loa (eye worm) G-protein coupled receptor 0.0031 0.0024 0.0039
Loa Loa (eye worm) G-protein coupled receptor 0.0031 0.0024 0.0039
Trypanosoma cruzi importin beta-1 subunit, putative 0.0021 0.0008 0.002
Trichomonas vaginalis importin beta-1, putative 0.0021 0.0008 0.011
Mycobacterium ulcerans hypothetical protein 0.0177 0.0235 0.0228
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0024 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0102 0.0127 0.0315
Onchocerca volvulus 0.0026 0.0016 0.0083
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.2785 0.402 1
Schistosoma mansoni short chain dehydrogenase 0.0102 0.0127 0.0208
Schistosoma mansoni neuropeptide receptor 0.0031 0.0024 0.0039
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0323 0.0447 0.5988
Onchocerca volvulus 0.0102 0.0127 0.0654
Brugia malayi photoreceptor-specific nuclear receptor 0.0101 0.0125 0.0205
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0034 0.0028 0.0045
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Brugia malayi hypothetical protein 0.0366 0.0509 0.0835
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.001 0.0128
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Echinococcus granulosus alpha 1A adrenergic receptor 0.0031 0.0024 0.0039
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.004 0.0036 0.006
Schistosoma mansoni short chain dehydrogenase 0.0102 0.0127 0.0208
Trypanosoma brucei short-chain dehydrogenase, putative 0.0102 0.0127 0.0307
Loa Loa (eye worm) hypothetical protein 0.0101 0.0125 0.0205
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0101 0.0125 0.0205
Echinococcus multilocularis oxidoreductase 0.0102 0.0127 0.0208
Brugia malayi hypothetical protein 0.0053 0.0055 0.0091
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Onchocerca volvulus 0.0031 0.0024 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.025 0.0622
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Echinococcus granulosus Niemann Pick C1 protein 0.0224 0.0302 0.0497
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0016 0.001
Loa Loa (eye worm) oxidoreductase 0.0102 0.0127 0.0208
Onchocerca volvulus Sepiapterin reductase homolog 0.0102 0.0127 0.0654
Schistosoma mansoni nuclear receptor 0.0048 0.0047 0.0077
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0077
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0016 0.0537
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0102 0.0127 0.012
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.001 0.0016
Loa Loa (eye worm) nuclear receptor NHR-67 0.0048 0.0047 0.0077
Onchocerca volvulus 0.0028 0.0019 0.0096
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.025 0.0622
Schistosoma mansoni zinc finger protein 0.0048 0.0047 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0101 0.0125 0.0205
Loa Loa (eye worm) hypothetical protein 0.0118 0.0149 0.0244
Schistosoma mansoni short chain dehydrogenase 0.0102 0.0127 0.0208
Leishmania major mitochondrial DNA polymerase beta 0.0336 0.0466 0.1159
Schistosoma mansoni neuropeptide F-like receptor 0.0031 0.0024 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0024 0.0039
Brugia malayi larval opioid receptor 0.0031 0.0024 0.0039
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0036 0.006
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0062 0.0153
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Brugia malayi nuclear hormone receptor family member nhr-6 0.0048 0.0047 0.0077
Echinococcus granulosus fmrfamide receptor 0.0031 0.0024 0.0039
Onchocerca volvulus 0.0031 0.0024 0.0122
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0024 0.0039
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0016 0.004
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0186 0.0248 0.3318
Schistosoma mansoni cpg binding protein 0.003 0.0021 0.0035
Echinococcus multilocularis sex peptide receptor 0.0031 0.0024 0.0039
Schistosoma mansoni hypothetical protein 0.0031 0.0024 0.0039
Echinococcus granulosus protein kinase c iota type 0.0026 0.0016 0.0026
Loa Loa (eye worm) hypothetical protein 0.0072 0.0083 0.0136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.025 0.0622
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0026 0.0016 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0062 0.0146
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0018 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0062 0.0146
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.025 0.0622
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0026
Echinococcus granulosus Diacylglycerol kinase theta 0.0026 0.0016 0.0026
Echinococcus multilocularis carbonyl reductase 1 0.0102 0.0127 0.0208
Echinococcus multilocularis dro:myosuppressin receptor 0.0031 0.0024 0.0039
Brugia malayi hypothetical protein 0.0102 0.0127 0.0208
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0295 0.0406 0.1009
Brugia malayi Steroid receptor seven-up type 2 0.0101 0.0125 0.0205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0101 0.0125 0.0205
Echinococcus multilocularis allatostatin A receptor 0.0031 0.0024 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.025 0.0622
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0044 0.0041 0.0037
Echinococcus granulosus nuclear receptor nhr 48 0.0048 0.0047 0.0077
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0315
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0931 0.133 0.2184
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase) 0.0188 0.0251 0.0246
Mycobacterium ulcerans carveol-like dehydrogenase 0.0102 0.0127 0.012
Leishmania major hypothetical protein, conserved 0.0102 0.0127 0.0315
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0053 0.0055 0.0091
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0062 0.0154
Entamoeba histolytica hypothetical protein 0.0026 0.0016 0.0529
Loa Loa (eye worm) hypothetical protein 0.0053 0.0055 0.0091
Leishmania major quinonoid dihydropteridine reductase 0.0102 0.0127 0.0315
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0005
Schistosoma mansoni importin beta-1 0.0026 0.0015 0.0025
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0024 0.0039
Echinococcus multilocularis importin subunit beta 1 0.0026 0.0015 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0024 0.0039
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0186 0.0248 0.3318
Schistosoma mansoni diacylglycerol kinase theta 0.0026 0.0016 0.0026
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0096 0.0117 0.0193
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0026 0.0016 0.0026
Onchocerca volvulus Neuropeptide F receptor homolog 0.0031 0.0024 0.0122
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0102 0.0127 0.4188
Echinococcus multilocularis retinol dehydrogenase 13 0.0102 0.0127 0.0208
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0061 0.0819
Echinococcus granulosus 7TM GPCR rhodopsin 0.0031 0.0024 0.0039
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0102 0.0127 0.0654
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.073 0.1037 0.1704
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0007 0.0016
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.421 0.6088 1
Mycobacterium ulcerans ketoacyl reductase 0.0102 0.0127 0.012
Schistosoma mansoni hypothetical protein 0.0031 0.0024 0.0039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0107 0.0133 0.0127
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0187 0.025 0.0622
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0016 0.001
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0047 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0102 0.0127 0.0315
Echinococcus multilocularis serotonin receptor 0.0031 0.0024 0.0039
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0508 0.0716 0.1175
Leishmania major hypothetical protein, conserved 0.0102 0.0127 0.0315
Echinococcus granulosus G protein coupled receptor 139 0.0031 0.0024 0.0039
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0101 0.0125 0.0205
Mycobacterium ulcerans oxidoreductase 0.0102 0.0127 0.012
Loa Loa (eye worm) hypothetical protein 0.0101 0.0125 0.0205
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0102 0.0127 0.012
Brugia malayi Dopamine receptor protein 2 0.0031 0.0024 0.0039
Toxoplasma gondii GAF domain-containing protein 0.0169 0.0223 0.0555
Mycobacterium tuberculosis Possible oxidoreductase 0.0102 0.0127 0.0122
Brugia malayi hypothetical protein 0.0031 0.0024 0.0039
Schistosoma mansoni nuclear receptor 0.0048 0.0047 0.0077
Mycobacterium tuberculosis Conserved hypothetical protein 0.0177 0.0235 0.023
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.073 0.1037 0.1704
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.0015 0.003
Brugia malayi ecdysone receptor 0.0048 0.0047 0.0077
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0031 0.0024 0.0039
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0492 0.0693 0.9268
Loa Loa (eye worm) PDE1B protein 0.073 0.1037 0.1704
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0053 0.0055 0.0091
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.025 0.0622
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0044 0.0041 0.005
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0003 0.0008
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0077
Mycobacterium leprae Probable oxidoreductase 0.0102 0.0127 0.019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0024 0.0039
Brugia malayi Niemann-Pick C1 protein precursor 0.0224 0.0302 0.0497
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0102 0.0127 0.0315
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0016 0.0008
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.004 0.0036 0.006
Chlamydia trachomatis dihydrofolate reductase 0.421 0.6088 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0127 0.0208
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0016 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0101 0.0125 0.0205
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Brugia malayi hypothetical protein 0.028 0.0385 0.0632
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0026 0.0016 0.0026
Schistosoma mansoni short chain dehydrogenase 0.0102 0.0127 0.0208
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0102 0.0127 0.0122
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.0036 0.006
Brugia malayi hypothetical protein 0.0031 0.0024 0.0039
Toxoplasma gondii oxidoreductase, putative 0.0102 0.0127 0.0315
Onchocerca volvulus 0.0028 0.0018 0.0094
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0077
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0077
Schistosoma mansoni growth hormone secretagogue receptor 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0011
Echinococcus granulosus uncharacterized sodium dependent transporter 0.004 0.0036 0.006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0026
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0323 0.0447 0.5988
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0442 0.0619 0.1016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0024 0.0039
Brugia malayi Serotonin receptor 0.0031 0.0024 0.0039
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0102 0.0127 0.1695
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0031 0.0024 0.0039
Schistosoma mansoni sodium-dependent amino acid transporter 0.004 0.0036 0.006
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0033 0.0028
Brugia malayi follicle stimulating hormone receptor 0.0031 0.0024 0.0039
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0024 0.0039
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0508 0.0716 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.025 0.0622
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0016 0.0537
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Brugia malayi conserved hypotetical protein 0.0048 0.0047 0.0077
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0047 0.0116
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0053 0.0055 0.0091
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0102 0.0127 0.012
Schistosoma mansoni short chain dehydrogenase 0.0102 0.0127 0.0208
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0102 0.0127 0.0315
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0036 0.006
Brugia malayi Ras association domain family 1 isoform A 0.0026 0.0016 0.0026
Echinococcus granulosus orexin receptor type 2 0.0031 0.0024 0.0039
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0187 0.025 0.0411
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0016 0.001
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0067 0.0075 0.0112
Schistosoma mansoni survival motor neuron protein 0.0048 0.0048 0.0078
Mycobacterium ulcerans aldehyde dehydrogenase 0.0107 0.0133 0.0127
Loa Loa (eye worm) hypothetical protein 0.004 0.0036 0.006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0187 0.025 0.0614
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0102 0.0127 0.4188
Echinococcus multilocularis Niemann Pick C1 protein 0.0224 0.0302 0.0497
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0024 0.0039
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.005 0.0124
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.004 0.0036 0.006
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0031 0.0024 0.0039
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0102 0.0127 0.0307
Echinococcus multilocularis fmrfamide receptor 0.0031 0.0024 0.0039
Brugia malayi hypothetical protein 0.0057 0.006 0.0099
Brugia malayi hypothetical protein 0.0048 0.0047 0.0077
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0102 0.0127 0.0307
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0026 0.0016 0.0026
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.025 0.0622
Echinococcus granulosus unc 13 munc13 0.0026 0.0016 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0018 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0101 0.0125 0.0205
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0024 0.0039
Schistosoma mansoni short chain dehydrogenase 0.0102 0.0127 0.0208
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0003 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0107 0.0133 0.0218
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.0075 0.0124
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0102 0.0127 0.012
Mycobacterium ulcerans ketoacyl reductase 0.0102 0.0127 0.012
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0102 0.0127 0.0208
Schistosoma mansoni opsin-like receptor 0.0031 0.0024 0.0039
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0102 0.0127 0.0208
Echinococcus granulosus neuropeptide s receptor 0.0424 0.0594 0.0976
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0026 0.0016 0.0026
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0336 0.0466 0.1159
Schistosoma mansoni amine GPCR 0.0031 0.0024 0.0039
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0102 0.0127 0.019
Brugia malayi G protein-coupled receptor F59B2.13 0.0031 0.0024 0.0039
Brugia malayi G-protein coupled receptor 0.0031 0.0024 0.0039
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0073 0.012
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0005 0.0013
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0016 0.0008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0025
Schistosoma mansoni unc-13 (munc13) 0.0026 0.0016 0.0026
Brugia malayi sulfakinin receptor protein 0.0031 0.0024 0.0039
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0224 0.0302 1
Brugia malayi hypothetical protein 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Loa Loa (eye worm) oxidoreductase 0.0102 0.0127 0.0208
Trichomonas vaginalis steroid dehydrogenase, putative 0.0102 0.0127 0.1695
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.001 0.0003
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.001 0.0005
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0107 0.0133 0.0332
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0101 0.0125 0.0205
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0003 0.0008
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0067 0.0075 0.0112
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.001 0.0024
Echinococcus multilocularis GPCR, family 2 0.0032 0.0024 0.0039
Echinococcus multilocularis unc 13 (munc13) 0.0026 0.0016 0.0026
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0034 0.0028 0.0045
Onchocerca volvulus 0.0031 0.0024 0.0122
Entamoeba histolytica diacylglycerol kinase, putative 0.0026 0.0016 0.0529
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0187 0.025 0.3345
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0031 0.0024 0.0039
Onchocerca volvulus 0.0031 0.0024 0.0122
Trypanosoma cruzi UNC119 0.0057 0.006 0.0149
Echinococcus granulosus neuropeptide FF receptor 2 0.0031 0.0024 0.0039
Schistosoma mansoni short chain dehydrogenase 0.0102 0.0127 0.0208
Loa Loa (eye worm) hypothetical protein 0.0237 0.0322 0.0529
Loa Loa (eye worm) DR-78 0.0048 0.0047 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.025 0.0622
Onchocerca volvulus 0.0077 0.0089 0.0461
Brugia malayi RhoGEF domain containing protein 0.0026 0.0016 0.0026
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0031 0.0024 0.0039
Brugia malayi GnHR receptor homolog 0.0031 0.0024 0.0039
Entamoeba histolytica hypothetical protein 0.0102 0.0127 0.4188
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0005 0.0013
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0016 0.0026
Brugia malayi dehydrogenases, short chain protein 9 0.0102 0.0127 0.0208
Echinococcus multilocularis carbonyl reductase 1 0.0102 0.0127 0.0208
Schistosoma mansoni short chain dehydrogenase 0.0102 0.0127 0.0208
Echinococcus granulosus g protein coupled receptor 0.0031 0.0024 0.0039
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0102 0.0127 0.0208
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0207 0.0278 0.0271
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0187 0.025 0.3345
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.0073 0.012
Mycobacterium ulcerans short-chain type oxidoreductase 0.0102 0.0127 0.012
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0102 0.0127 0.0315
Echinococcus multilocularis ecdysone induced protein 78C 0.0101 0.0125 0.0205
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0024 0.0039
Onchocerca volvulus 0.0102 0.0127 0.0654
Echinococcus granulosus neuropeptide receptor A26 0.0424 0.0594 0.0976
Schistosoma mansoni short chain dehydrogenase 0.0102 0.0127 0.0208
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0336 0.0466 0.1151
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Brugia malayi nuclear receptor NHR-67 0.0048 0.0047 0.0077
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0102 0.0127 0.0122
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0077
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Schistosoma mansoni ap endonuclease 0.0022 0.001 0.0016
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0321 0.0444 0.0729
Loa Loa (eye worm) hypothetical protein 0.0053 0.0055 0.0091
Plasmodium falciparum phosphodiesterase gamma, putative 0.0187 0.025 0.0622
Plasmodium vivax amine transporter, putative 0.004 0.0036 0.009
Brugia malayi jmjC domain containing protein 0.0017 0.0003 0.0005
Echinococcus multilocularis neuropeptides capa receptor 0.0031 0.0024 0.0039
Brugia malayi jmjC domain containing protein 0.0017 0.0003 0.0005
Onchocerca volvulus 0.0102 0.0127 0.0654
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0024 0.0039
Brugia malayi thymidylate synthase 0.0768 0.1093 0.1796
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0295 0.0406 0.1009
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0031 0.0024 0.0039
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0061 0.0144
Echinococcus multilocularis peptidase Clp (S14 family) 0.0044 0.0041 0.0068
Plasmodium falciparum transporter, putative 0.004 0.0036 0.009
Loa Loa (eye worm) STAT protein 0.0422 0.0591 0.0971
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0492 0.0693 0.9268
Echinococcus granulosus cpg binding protein 0.003 0.0021 0.0035
Mycobacterium tuberculosis Possible oxidoreductase 0.0102 0.0127 0.0122
Brugia malayi jmjC domain containing protein 0.0065 0.0073 0.012
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0031 0.0024 0.0122
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0169 0.0223 0.0218
Schistosoma mansoni amine GPCR 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Schistosoma mansoni myosin xvIII 0.0031 0.0024 0.0039
Loa Loa (eye worm) transcription factor SMAD2 0.0107 0.0133 0.0218
Brugia malayi diacylglycerol kinase 0.0026 0.0016 0.0026
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0358 0.0497 0.1237
Onchocerca volvulus 0.0768 0.1093 0.5641
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0492 0.0693 0.9268
Trypanosoma brucei short-chain dehydrogenase, putative 0.0102 0.0127 0.0307
Leishmania major 3-keto-dihydrosphingosine reductase 0.0102 0.0127 0.0315
Onchocerca volvulus 0.004 0.0036 0.0187
Echinococcus multilocularis thyroid hormone receptor alpha 0.0101 0.0125 0.0205
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.0036 0.006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0024 0.0039
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0007 0.0002
Echinococcus granulosus neuropeptides capa receptor 0.0031 0.0024 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0114 0.0187
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0031 0.0024 0.0039
Trichomonas vaginalis set domain proteins, putative 0.0216 0.0291 0.3893
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0237 0.0322 0.0529
Loa Loa (eye worm) hypothetical protein 0.0235 0.0319 0.0524
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0026
Echinococcus granulosus sterol regulatory element binding protein 0.0096 0.0117 0.0193
Echinococcus granulosus biogenic amine 5HT receptor 0.0031 0.0024 0.0039
Leishmania major GTP-binding protein, putative 0.0019 0.0005 0.0013
Brugia malayi Dihydrofolate reductase 0.421 0.6088 1
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0026 0.0016 0.0026
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0102 0.0127 0.0315
Loa Loa (eye worm) hypothetical protein 0.0102 0.0127 0.0208
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Brugia malayi G protein-coupled receptor 0.0031 0.0024 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0003 0.0005
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0024 0.0039
Schistosoma mansoni hypothetical protein 0.0032 0.0024 0.0039
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0101 0.0125 0.0205
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0024 0.0039
Brugia malayi Serotonin receptor 0.0031 0.0024 0.0039
Loa Loa (eye worm) oxidoreductase 0.0102 0.0127 0.0208
Onchocerca volvulus 0.0048 0.0048 0.0245
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0024 0.0039
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0067 0.0075 0.5577
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.053 0.0747 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0102 0.0127 0.0315
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0101 0.0125 0.0205
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0101 0.0125 0.0205
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0019 0.0005 0.0009
Schistosoma mansoni hypothetical protein 0.0022 0.001 0.0017
Schistosoma mansoni steroid dehydrogenase 0.0102 0.0127 0.0208
Brugia malayi hypothetical protein 0.0235 0.0319 0.0524
Echinococcus multilocularis Niemann Pick C1 protein 0.032 0.0442 0.0726
Giardia lamblia Short-chain dehydrogenase, putative 0.0102 0.0127 0.1707
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.004 0.0036 0.006
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0315
Echinococcus granulosus FTZ F1 alpha 0.0101 0.0125 0.0205
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Brugia malayi hypothetical protein 0.0048 0.0047 0.0077
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0102 0.0127 0.0315
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0031 0.0024 0.0039
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0321 0.0444 0.0729
Loa Loa (eye worm) raf kinase 0.0748 0.1064 0.1748
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0187 0.025 0.3345
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0016 0.0026
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0036 0.0059
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0102 0.0127 0.1695
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0102 0.0127 0.012
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0508 0.0716 0.1175
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.0047 0.0077
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.0036 0.006
Echinococcus multilocularis neuropeptides capa receptor 0.0031 0.0024 0.0039
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.004 0.0036 0.006
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0036 0.006
Schistosoma mansoni atypical protein kinase C 0.0026 0.0016 0.0026
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Loa Loa (eye worm) hypothetical protein 0.0102 0.0127 0.0208
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0031 0.0024 0.0039
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0047 0.0116
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0187 0.025 0.0411
Trypanosoma cruzi short chain dehydrogenase, putative 0.0102 0.0127 0.0315
Loa Loa (eye worm) hypothetical protein 0.0053 0.0055 0.0091
Echinococcus multilocularis carbonyl reductase 1 0.0102 0.0127 0.0208
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0225 0.0305 0.4078
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0067 0.0075 0.0123
Schistosoma mansoni protein kinase C mu 0.0026 0.0016 0.0026
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.001 0.0024
Schistosoma mansoni neuropeptide receptor 0.0031 0.0024 0.0039
Brugia malayi neuropeptide F receptor 0.0031 0.0024 0.0039
Leishmania major importin beta-1 subunit, putative 0.0021 0.0008 0.002
Echinococcus multilocularis steroid dehydrogenase 0.0102 0.0127 0.0208
Leishmania major short chain dehydrogenase/reductase, putative 0.0102 0.0127 0.0315
Echinococcus granulosus serotonin transporter 0.0237 0.0322 0.0529
Loa Loa (eye worm) hypothetical protein 0.0102 0.0127 0.0208
Onchocerca volvulus 0.0186 0.0248 0.1279
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.004 0.0036 0.006
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.001 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0016 0.0026
Onchocerca volvulus 0.0048 0.0047 0.0243
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0027
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0122 0.0201
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0024 0.0039
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Onchocerca volvulus 0.0026 0.0016 0.0083
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0102 0.0127 0.4188
Loa Loa (eye worm) hypothetical protein 0.0032 0.0024 0.0039
Schistosoma mansoni short chain dehydrogenase 0.0102 0.0127 0.0208
Onchocerca volvulus 0.0101 0.0125 0.0643
Leishmania major short chain dehydrogenase, putative 0.0102 0.0127 0.0315
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0003 0.0005
Brugia malayi hypothetical protein 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0026
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0492 0.0693 0.9268
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0102 0.0127 0.1695
Trypanosoma cruzi short chain dehydrogenase, putative 0.0102 0.0127 0.0315
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0187 0.025 0.0411
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0102 0.0127 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0062 0.0146
Brugia malayi hypothetical protein 0.004 0.0036 0.0059
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0508 0.0716 0.1175
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.001 0.0024
Loa Loa (eye worm) dehydrogenase 0.0102 0.0127 0.0208
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0016 0.004
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.019 0.0253 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.042 0.5627
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0379 0.0528 0.0866
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0018 0.0045
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0062 0.0154
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0102 0.0127 0.0122
Echinococcus granulosus serotonin receptor 0.0031 0.0024 0.0039
Giardia lamblia Hypothetical protein 0.0102 0.0127 0.1707
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.0127 0.0122
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0047 0.0108
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0225 0.0305 0.4078
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.0047 0.0077
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Plasmodium falciparum steroid dehydrogenase, putative 0.0102 0.0127 0.0315
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0031 0.0024 0.0039
Leishmania major short chain dehydrogenase/reductase, putative 0.0102 0.0127 0.0315
Leishmania major quinonoid dihydropteridine reductase 0.0102 0.0127 0.0315
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0031 0.0024 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0752 0.1069 0.1756
Schistosoma mansoni patched 1 0.0096 0.0117 0.0193
Entamoeba histolytica diacylglycerol kinase, putative 0.0026 0.0016 0.0529
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0102 0.0127 0.0315
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0003 0.0005
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0077 0.0126
Brugia malayi AKH receptor 0.0031 0.0024 0.0039
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0101 0.0125 0.0205
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0492 0.0693 0.9268
Brugia malayi Dopamine receptor 0.0031 0.0024 0.0039
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0102 0.0127 0.0122
Loa Loa (eye worm) hypothetical protein 0.0101 0.0125 0.0205
Leishmania major quinonoid dihydropteridine reductase 0.0102 0.0127 0.0315
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Loa Loa (eye worm) oxidoreductase 0.0102 0.0127 0.0208
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0187 0.025 0.3345
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0036 0.006
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0034 0.0028 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0101 0.0125 0.0205
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.2785 0.402 1
Mycobacterium ulcerans dehydrogenase 0.0102 0.0127 0.012
Leishmania major short chain dehydrogenase, putative 0.0102 0.0127 0.0315
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0018 0.003
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0031 0.0024 0.0039
Brugia malayi putative neuropeptide receptor 0.0031 0.0024 0.0039
Echinococcus multilocularis carbonyl reductase 1 0.0102 0.0127 0.0208
Onchocerca volvulus 0.0102 0.0127 0.0654
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0187 0.025 0.0411
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.004 0.0036 0.006
Toxoplasma gondii hypothetical protein 0.004 0.0036 0.009
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0492 0.0693 0.1723
Echinococcus granulosus somatostatin receptor 0.0031 0.0024 0.0039
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0102 0.0127 0.012
Toxoplasma gondii diacylglycerol kinase, putative 0.0026 0.0016 0.004
Brugia malayi hypothetical protein 0.004 0.0036 0.006
Entamoeba histolytica hypothetical protein 0.004 0.0036 0.1192
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.2785 0.402 1
Schistosoma mansoni hypothetical protein 0.0031 0.0024 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0024 0.0039
Schistosoma mansoni hypothetical protein 0.0032 0.0024 0.0039
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0038 0.0033 0.0081
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0027
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0102 0.0127 0.0315
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0492 0.0693 0.1716
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0102 0.0127 0.0315
Schistosoma mansoni short chain dehydrogenase 0.0102 0.0127 0.0208
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0114 0.0187
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0036 0.006
Schistosoma mansoni cpg binding protein 0.003 0.0021 0.0035
Schistosoma mansoni nuclear receptor nhr-48 0.0048 0.0047 0.0077
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Schistosoma mansoni hypothetical protein 0.0092 0.0112 0.0184
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0102 0.0127 0.0208
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0101 0.0125 0.0205
Echinococcus granulosus dnaJ subfamily B 0.04 0.0558 0.0917
Schistosoma mansoni rac gtpase activating protein 0.0026 0.0016 0.0026
Loa Loa (eye worm) hypothetical protein 0.0101 0.0125 0.0205
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0358 0.0497 0.1237
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0031 0.0024 0.0039
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0019 0.0005 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0024 0.0039
Schistosoma mansoni hypothetical protein 0.0032 0.0024 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0024 0.0039
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0003 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.053 0.0747 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0101 0.0125 0.0205
Brugia malayi RhoGAP domain containing protein 0.0026 0.0016 0.0026
Loa Loa (eye worm) oxidoreductase 0.0102 0.0127 0.0208
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0018 0.003
Leishmania major hypothetical protein, conserved 0.0038 0.0033 0.0081
Trypanosoma cruzi cruzipain precursor, putative 0.0058 0.0062 0.0154
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0023 0.0011 0.0057
Schistosoma mansoni alpha-1 adrenergic receptor 0.0031 0.0024 0.0039
Echinococcus granulosus steroid dehydrogenase 0.0102 0.0127 0.0208
Plasmodium vivax hypothetical protein, conserved 0.004 0.0036 0.009
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0492 0.0693 0.9268
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0031 0.0024 0.0039
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0187 0.025 0.0614
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0102 0.0127 0.0315
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0031 0.0024 0.0039
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0102 0.0127 0.0208
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Loa Loa (eye worm) hypothetical protein 0.0102 0.0127 0.0208
Toxoplasma gondii carbonyl reductase 1, putative 0.0102 0.0127 0.0315
Schistosoma mansoni amine GPCR 0.0031 0.0024 0.0039
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.005 0.0124
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.2785 0.402 1
Onchocerca volvulus 0.0031 0.0024 0.0122
Schistosoma mansoni nuclear hormone receptor 0.0101 0.0125 0.0205
Leishmania major hypothetical protein, conserved 0.0102 0.0127 0.0315
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0492 0.0693 0.1716
Trypanosoma cruzi hypothetical protein, conserved 0.0102 0.0127 0.0315
Loa Loa (eye worm) RasGEF domain-containing protein 0.0026 0.0016 0.0026
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0566 0.08 0.1313
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0053 0.0055 0.0091
Mycobacterium ulcerans hypothetical protein 0.0026 0.0016 0.001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0101 0.0125 0.0205
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0003 0.0005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0053 0.0055 0.0091
Giardia lamblia Hypothetical protein 0.0057 0.006 0.0769
Brugia malayi hypothetical protein 0.0102 0.0127 0.0208
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0101 0.0125 0.0205
Loa Loa (eye worm) hypothetical protein 0.0102 0.0127 0.0208
Brugia malayi CHE-14 protein 0.0096 0.0117 0.0193
Echinococcus multilocularis retinol dehydrogenase 11 0.0102 0.0127 0.0208
Brugia malayi Nuclear hormone receptor-like 1 0.0053 0.0055 0.0091
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.005 0.0116
Onchocerca volvulus 0.0031 0.0024 0.0122
Brugia malayi tailless protein 0.0048 0.0047 0.0077
Brugia malayi Probable ClpP-like protease 0.0067 0.0075 0.0123
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0102 0.0127 0.012
Echinococcus granulosus thyroid hormone receptor alpha 0.0048 0.0047 0.0077
Brugia malayi oxidoreductase 0.0102 0.0127 0.0208
Echinococcus granulosus neuropeptide receptor 0.0031 0.0024 0.0039
Schistosoma mansoni hypothetical protein 0.0026 0.0016 0.0026
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0019 0.0005 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0016 0.0026
Loa Loa (eye worm) hypothetical protein 0.1249 0.1791 0.2942
Loa Loa (eye worm) steroid hormone receptor 0.0101 0.0125 0.0205
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0024 0.0039
Trypanosoma cruzi UNC119 0.0057 0.006 0.0149
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0031 0.0024 0.0039
Echinococcus multilocularis dnaJ subfamily B 0.04 0.0558 0.0917
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0067 0.0075 0.0186
Onchocerca volvulus 0.0237 0.0322 0.166
Loa Loa (eye worm) melatonin receptor type 1A 0.0031 0.0024 0.0039
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0186 0.0248 0.3318
Onchocerca volvulus 0.0031 0.0024 0.0122
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.025 0.0622
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0044 0.0041 0.0037
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0187 0.025 0.3345
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0102 0.0127 0.0315
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0102 0.0127 0.0315
Brugia malayi STAT protein, DNA binding domain containing protein 0.0422 0.0591 0.0971
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Trichomonas vaginalis ran, putative 0.0019 0.0005 0.0073
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0023 0.0011 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0101 0.0125 0.0205
Brugia malayi hypothetical protein 0.0053 0.0055 0.0091
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0187 0.025 0.0411
Brugia malayi Protein kinase domain containing protein 0.0026 0.0016 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0062 0.0146
Plasmodium vivax hypothetical protein, conserved 0.0102 0.0127 0.0315
Entamoeba histolytica hypothetical protein, conserved 0.0054 0.0057 0.1868
Echinococcus granulosus WW domain containing oxidoreductase 0.0102 0.0127 0.0208
Echinococcus granulosus thymidylate synthase 0.0768 0.1093 0.1796
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0024 0.0039
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0366 0.0509 0.1265
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0102 0.0127 0.0122
Loa Loa (eye worm) hypothetical protein 0.0224 0.0302 0.0497
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0067 0.0075 0.0186
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0024 0.0039
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0129 0.0165 0.016
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0187 0.025 0.0622
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Leishmania major cathepsin L-like protease 0.0058 0.0062 0.0154
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.0073 0.012
Echinococcus multilocularis neuropeptide Y receptor 0.0031 0.0024 0.0039
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1006 0.1438 0.2361
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0018 0.003
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0102 0.0127 0.4188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0101 0.0125 0.0205
Schistosoma mansoni steroid dehydrogenase 0.0102 0.0127 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0101 0.0125 0.0205
Schistosoma mansoni neuropeptide f receptor 76f 0.0031 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0072 0.0083 0.0136
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0066 0.0108
Brugia malayi hypothetical protein 0.0031 0.0024 0.0039
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0031 0.0024 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0062 0.0146
Brugia malayi nuclear hormone receptor 0.0101 0.0125 0.0205
Echinococcus granulosus Protein patched homolog 1 0.0096 0.0117 0.0193
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0048 0.0047 0.0077
Entamoeba histolytica hypothetical protein 0.004 0.0036 0.1192
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.0036 0.006
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0492 0.0693 0.9268
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0186 0.0248 0.0407
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0492 0.0693 0.9268
Leishmania major hypothetical protein, conserved 0.0049 0.005 0.0124
Brugia malayi Pre-SET motif family protein 0.0028 0.0018 0.003
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0102 0.0127 0.012
Echinococcus granulosus protein kinase c epsilon type 0.0026 0.0016 0.0026
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0077
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.0127 0.0122
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0492 0.0693 0.9268
Onchocerca volvulus 0.004 0.0036 0.0187
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0062 0.0146
Echinococcus granulosus hypothetical protein 0.0102 0.0127 0.0208
Brugia malayi dihydrofolate reductase family protein 0.421 0.6088 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.0127 0.0122
Schistosoma mansoni opsin-like receptor 0.0031 0.0024 0.0039
Loa Loa (eye worm) oxidoreductase 0.0102 0.0127 0.0208
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0024 0.0039
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0102 0.0127 0.019
Echinococcus granulosus dro:myosuppressin receptor 0.0031 0.0024 0.0039
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.004 0.0036 0.006
Loa Loa (eye worm) neuropeptide F receptor 0.0031 0.0024 0.0039
Leishmania major hypothetical protein, conserved 0.0017 0.0003 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0101 0.0125 0.0205
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0492 0.0693 0.9268
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0077
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0102 0.0127 0.0315
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0018 0.003
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Echinococcus granulosus sex peptide receptor 0.0031 0.0024 0.0039
Schistosoma mansoni short chain dehydrogenase 0.0102 0.0127 0.0208
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Leishmania major hypothetical protein, unknown function 0.0054 0.0057 0.0141
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0024 0.0039
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.0127 0.0122
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0358 0.0497 0.1237
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Loa Loa (eye worm) hypothetical protein 0.004 0.0036 0.006
Schistosoma mansoni hypothetical protein 0.0495 0.0696 0.1143
Schistosoma mansoni neuropeptide receptor 0.0031 0.0024 0.0039
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.0047 0.0243
Echinococcus granulosus g-protein coupled receptor 0.0031 0.0024 0.0039
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0031 0.0024 0.0039
Onchocerca volvulus 0.0048 0.0047 0.0243
Echinococcus multilocularis orexin receptor type 2 0.0031 0.0024 0.0039
Onchocerca volvulus 0.0031 0.0024 0.0122
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0492 0.0693 0.9268
Trichomonas vaginalis conserved hypothetical protein 0.0188 0.0251 0.336
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0102 0.0127 0.4188
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0492 0.0693 0.9268
Toxoplasma gondii aldehyde dehydrogenase 0.0107 0.0133 0.0332
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Schistosoma mansoni peptidase Clp (S14 family) 0.0067 0.0075 0.0123
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.025 0.0622
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0102 0.0127 0.1695
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0016 0.0027
Brugia malayi steroid hormone receptor 0.0101 0.0125 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.042 0.5627
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0237 0.0322 0.0529
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0003 0.0005
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0008 0.011
Leishmania major hypothetical protein, conserved 0.0057 0.0061 0.0152
Loa Loa (eye worm) TYRA-2 protein 0.0031 0.0024 0.0039
Entamoeba histolytica hypothetical protein 0.0021 0.0008 0.0272
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0315
Echinococcus granulosus dihydrofolate reductase 0.421 0.6088 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Brugia malayi Dopamine receptor protein 1 0.0031 0.0024 0.0039
Brugia malayi nuclear receptor NHR-88 0.0048 0.0047 0.0077
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0028 0.0045
Leishmania major cAMP-specific phosphodiesterase, putative 0.0187 0.025 0.0622
Schistosoma mansoni carbonyl reductase 0.0102 0.0127 0.0208
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0492 0.0693 0.9268
Schistosoma mansoni hypothetical protein 0.004 0.0036 0.0059
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0127 0.0208
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0003 0.0005
Echinococcus granulosus carbonyl reductase 1 0.0102 0.0127 0.0208
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0039
Schistosoma mansoni ran 0.0019 0.0005 0.0009
Schistosoma mansoni ap endonuclease 0.0022 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0026
Echinococcus multilocularis protein kinase c iota type 0.0026 0.0016 0.0026
Schistosoma mansoni retinoic acid receptor RXR 0.0489 0.0688 0.1131
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.025 0.0622
Mycobacterium ulcerans short chain dehydrogenase 0.0102 0.0127 0.012
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0036 0.006
Trypanosoma brucei UNC119 0.0057 0.006 0.0141
Brugia malayi Raf kinase 0.0726 0.1031 0.1694
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0186 0.0248 0.0407
Leishmania major hypothetical protein, conserved 0.0187 0.025 0.0622
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0038 0.0033 0.0073
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0931 0.133 0.2184
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0101 0.0125 0.0205
Plasmodium falciparum amino acid transporter, putative 0.004 0.0036 0.009
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0053 0.0055 0.0136
Schistosoma mansoni hypothetical protein 0.0031 0.0024 0.0039
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0031 0.0024 0.0039
Echinococcus multilocularis Rac GTPase activating protein 1 0.0026 0.0016 0.0026
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0007 0.0016
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0492 0.0693 0.9268
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0492 0.0693 0.9268
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0031 0.0024 0.0039
Trypanosoma brucei short-chain dehydrogenase, putative 0.0102 0.0127 0.0307
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0034 0.0028 0.0045
Schistosoma mansoni retinal rod rhodopsin-sensitive cgmp 3'5'-cyclic phosphodiesterase 0.028 0.0385 0.0632

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.882 uM Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay ChEMBL. 16220982
IC50 (binding) = 0.882 uM Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay ChEMBL. 16220982

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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