Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 10 (sodium/bile acid cotransporter), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.1482 | 0.0319 |
Schistosoma mansoni | dihydrofolate reductase | 0.0823 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0823 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0823 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.1482 | 0.0319 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0601 | 0.6706 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0601 | 0.6706 | 0.5 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.1482 | 0.0319 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0823 | 1 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.1482 | 0.0319 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0823 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0601 | 0.6706 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0823 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0823 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0601 | 0.6706 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0823 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0228 | 0.1201 | 0.1201 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.1482 | 0.0319 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0601 | 0.6706 | 0.5 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.1482 | 0.0319 |
Brugia malayi | Sodium Bile acid symporter family protein | 0.0247 | 0.1482 | 0.0319 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0601 | 0.6706 | 0.5 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.1482 | 0.0319 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0247 | 0.1482 | 0.1482 |
Echinococcus granulosus | dihydrofolate reductase | 0.0823 | 1 | 1 |
Onchocerca volvulus | 0.0247 | 0.1482 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 nM | In vitro inhibition of ASBT mediated uptake of [14C]-taurocholate (5 uM) in baby hamster cells expressing human IBAT | ChEMBL. | 16134951 |
IC50 (binding) | = 5 nM | In vitro inhibition of ASBT mediated uptake of [14C]-taurocholate (5 uM) in baby hamster cells expressing human IBAT | ChEMBL. | 16134951 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.