TDR Targets

Basic information

Technical information

TDR Targets ID: 342066
Name: 2,4-dimethoxy-8-(4-methoxyphenyl)quinoline
MW: 295.332 | Formula: C18H17NO3
H donors: 0 H acceptors: 1 LogP: 4.06 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)c1cccc2c1nc(OC)cc2OC
InChi: 1S/C18H17NO3/c1-20-13-9-7-12(8-10-13)14-5-4-6-15-16(21-2)11-17(22-3)19-18(14)15/h4-11H,1-3H3
InChiKey: GKVGKQHUZLAOTH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.1235	0.7604	1
Schistosoma mansoni	hypothetical protein	0.0096	0.0396	0.0511
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0482	0.2841	1
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0068	0.0219	0.0277
Echinococcus multilocularis	laminin	0.0053	0.0123	0.0115
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0057	0.0147	0.0139
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0073	0.0086
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0196	0.1029	0.3569
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0088	0.0105
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0088	0.0105
Brugia malayi	jmjC domain containing protein	0.0057	0.0147	0.0183
Brugia malayi	RNA binding protein	0.0112	0.0499	0.0646
Schistosoma mansoni	tar DNA-binding protein	0.0112	0.0499	0.0646
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0086	0.0334	0.0428
Echinococcus multilocularis	expressed conserved protein	0.0184	0.0954	0.0946
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0008	0.0011
Echinococcus multilocularis	Niemann Pick C1 protein	0.028	0.1561	0.1554
Loa Loa (eye worm)	transcription factor SMAD2	0.0086	0.0335	0.1185
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0187	0.0971	0.1263
Echinococcus granulosus	Niemann Pick C1 protein	0.028	0.1561	0.3847
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0008	0.0011
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.1235	0.7604	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0221	0.1189	0.1564
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.1235	0.7604	1
Brugia malayi	hypothetical protein	0.0037	0.0023	0.002
Onchocerca volvulus		0.0098	0.0412	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0058	0.0159	0.0198
Schistosoma mansoni	hypothetical protein	0.0337	0.1923	0.2521
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0064	0.0196	0.0248
Schistosoma mansoni	tar DNA-binding protein	0.0112	0.0499	0.0646
Schistosoma mansoni	survival motor neuron protein	0.0096	0.0396	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0012	0.0014
Brugia malayi	hypothetical protein	0.0471	0.2767	0.3632
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.0147	0.0183
Loa Loa (eye worm)	TAR-binding protein	0.0112	0.0499	0.1778
Brugia malayi	MH2 domain containing protein	0.0086	0.0335	0.043
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0187	0.0971	0.1268
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0088	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0123	0.0416
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0187	0.0971	1
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0068	0.0219	0.0521
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0088	0.0105
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0084	0.0321	0.1134
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0023	0.002
Brugia malayi	jmjC domain containing protein	0.0057	0.0147	0.0183
Toxoplasma gondii	aldehyde dehydrogenase	0.0058	0.0159	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0334	0.118
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0008	0.0011
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0112	0.0499	0.1778
Schistosoma mansoni	hypothetical protein	0.0081	0.0302	0.0387
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0053	0.0123	0.0151
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0187	0.0971	0.1268
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0123	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0441	0.1568
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0187	0.0971	0.2386
Echinococcus granulosus	lysine specific demethylase 5A	0.0057	0.0147	0.0344
Brugia malayi	Niemann-Pick C1 protein precursor	0.0196	0.1029	0.1344
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0073	0.0086
Schistosoma mansoni	aldehyde dehydrogenase	0.0058	0.0159	0.0198
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0088	0.0105
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.1235	0.7604	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0088	0.0105
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0086	0.0334	0.118
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0058	0.0159	0.0151
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0053	0.0123	0.0416
Echinococcus multilocularis	tumor protein p63	0.0673	0.4044	0.4039
Echinococcus multilocularis	transcription factor Dp 1	0.0039	0.0038	0.003
Onchocerca volvulus		0.0096	0.0396	0.9618
Schistosoma mansoni	tar DNA-binding protein	0.0112	0.0499	0.0646
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0187	0.0971	0.1268
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.1235	0.7604	1
Echinococcus granulosus	microtubule associated protein 2	0.0664	0.3989	0.9863
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.1235	0.7604	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0012	0.0014
Schistosoma mansoni	peptidase Clp (S14 family)	0.0187	0.0971	0.1268
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0073	0.0065
Schistosoma mansoni	jumonji domain containing protein	0.0057	0.0147	0.0183
Schistosoma mansoni	cellular tumor antigen P53	0.0098	0.0412	0.0531
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0073	0.0161
Echinococcus multilocularis	Niemann Pick C1 protein	0.0196	0.1029	0.1021
Schistosoma mansoni	egf-like domain protein	0.0053	0.0123	0.0151
Brugia malayi	TAR-binding protein	0.0112	0.0499	0.0646
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0068	0.0219	0.0211
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0482	0.2841	0.7019
Echinococcus granulosus	Protein patched homolog 1	0.0084	0.0321	0.0775
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0058	0.0159	0.0198
Plasmodium falciparum	dihydroorotate dehydrogenase	0.1235	0.7604	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0073	0.0065
Brugia malayi	Fibulin-1 precursor	0.0053	0.0123	0.0151
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0187	0.0971	0.0964
Loa Loa (eye worm)	hypothetical protein	0.0471	0.2767	1
Schistosoma mansoni	hypothetical protein	0.0037	0.0023	0.002
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0122	0.0564	0.0742
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0088	0.0105
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.1235	0.7604	1
Loa Loa (eye worm)	RNA binding protein	0.0112	0.0499	0.1778
Echinococcus granulosus	Tolloid protein 1	0.0053	0.0123	0.0284
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0012	0.0005
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0482	0.2841	1
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0482	0.2841	0.7019
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0008	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0012	0.0014
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0187	0.0971	0.1268
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0123	0.0416
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0219	0.0277
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0199	0.1048	0.1369
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0023	0.0015
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0073	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.0321	0.1105
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0008	0.0011
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0088	0.0105
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0057	0.0147	0.0344
Schistosoma mansoni	hypothetical protein	0.0081	0.0302	0.0387
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0053	0.0123	0.0416
Schistosoma mansoni	aldehyde dehydrogenase	0.0058	0.0159	0.0198
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0058	0.0159	0.0198
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0058	0.0159	0.0198
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0187	0.0971	1
Echinococcus granulosus	transcription factor Dp 1	0.0039	0.0038	0.0073
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0122	0.0564	0.0556
Brugia malayi	Probable ClpP-like protease	0.0187	0.0971	0.1268
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0412	0.1463
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0012	0.0016
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0122	0.0564	0.0742
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0088	0.0105
Loa Loa (eye worm)	MH2 domain-containing protein	0.0086	0.0335	0.1185
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0088	0.0105
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0482	0.2841	1
Schistosoma mansoni	hypothetical protein	0.0081	0.0302	0.0387
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0088	0.0229
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0482	0.2841	0.2835
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0088	0.0105
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0008	0.0011
Echinococcus granulosus	Niemann Pick C1 protein	0.0196	0.1029	0.2529
Schistosoma mansoni	patched 1	0.0084	0.0321	0.0412
Schistosoma mansoni	hypothetical protein	0.0059	0.0161	0.0202
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0219	0.0277
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0058	0.0159	0.0209
Schistosoma mansoni	hypothetical protein	0.0081	0.0302	0.0387
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0068	0.0219	0.0277
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.1235	0.7604	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0073	0.0161
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0068	0.0219	0.0763
Echinococcus multilocularis	microtubule associated protein 2	0.0664	0.3989	0.3984
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0012	0.0005
Echinococcus granulosus	survival motor neuron protein 1	0.0471	0.2767	0.6835
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0321	0.1134
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0068	0.0219	0.0694
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0008	0.0011
Schistosoma mansoni	hypothetical protein	0.0337	0.1923	0.2521
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0088	0.0229
Echinococcus multilocularis	fibrillin 1	0.0053	0.0123	0.0115
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0482	0.2841	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0059	0.0161	0.0202
Schistosoma mansoni	microtubule-associated protein tau	0.0664	0.3989	0.524
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0088	0.0105
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0023	0.0037
Echinococcus granulosus	sterol regulatory element binding protein	0.0084	0.0321	0.0775
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0096	0.0396	0.0511
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0086	0.0334	0.0428
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0053	0.0123	0.0416
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0088	0.0105
Echinococcus multilocularis	lysine specific demethylase 5A	0.0057	0.0147	0.0139
Brugia malayi	Calcium binding EGF domain containing protein	0.0053	0.0123	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0088	0.0288
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0482	0.2841	0.2835
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0123	0.0416
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0482	0.2841	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0008	0.0011
Brugia malayi	Zinc finger, C2H2 type family protein	0.0482	0.2841	0.3729
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0088	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0088	0.0288
Schistosoma mansoni	tar DNA-binding protein	0.0112	0.0499	0.0646
Echinococcus multilocularis	Tolloid protein 1	0.0053	0.0123	0.0115
Echinococcus multilocularis	sterol regulatory element binding protein	0.0084	0.0321	0.0313
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.1235	0.7604	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0482	0.2841	1
Schistosoma mansoni	dihydroorotate dehydrogenase	0.1235	0.7604	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.0147	0.0183
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0088	0.0105
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0058	0.0159	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0088	0.0288
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0008	0.0011
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0122	0.0564	0.0732
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.1235	0.7604	1
Brugia malayi	RNA recognition motif domain containing protein	0.0112	0.0499	0.0646
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0073	0.0086
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0187	0.0971	0.1268
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0012	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0196	0.1029	0.37
Onchocerca volvulus		0.0047	0.0088	0.1968
Echinococcus multilocularis	geminin	0.0337	0.1923	0.1916
Echinococcus granulosus	laminin	0.0053	0.0123	0.0284
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0088	0.0105
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0053	0.0123	0.0151
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0088	0.0105
Schistosoma mansoni	amine GPCR	0.0719	0.4339	0.5701
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0187	0.0971	0.1268
Brugia malayi	CHE-14 protein	0.0084	0.0321	0.0412
Echinococcus multilocularis	protein dispatched 1	0.0096	0.0396	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0123	0.0416
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0088	0.0229
Onchocerca volvulus	Arrow homolog	0.0053	0.0123	0.2842
Echinococcus granulosus	expressed conserved protein	0.0184	0.0954	0.2343
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0161	0.0555
Leishmania major	dihydroorotate dehydrogenase	0.1235	0.7604	1
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0053	0.0123	0.0151
Echinococcus granulosus	peptidase Clp S14 family	0.0122	0.0564	0.1377
Echinococcus granulosus	geminin	0.0337	0.1923	0.4744
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.1235	0.7604	1
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0482	0.2841	0.3729
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0053	0.0123	0.0151
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0088	0.0105
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0068	0.0219	0.0277
Echinococcus multilocularis	survival motor neuron protein 1	0.0471	0.2767	0.2761
Echinococcus granulosus	tumor protein p63	0.0673	0.4044	1
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.1235	0.7604	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0073	0.0236
Echinococcus multilocularis	protein patched	0.0084	0.0321	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0012	0.0014
Echinococcus granulosus	tar DNA binding protein	0.0112	0.0499	0.1215
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0008	0.0011
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0064	0.0196	0.0248
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0187	0.0971	1
Echinococcus multilocularis	tar DNA binding protein	0.0112	0.0499	0.0491
Schistosoma mansoni	tar DNA-binding protein	0.0112	0.0499	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0971	0.3491
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0482	0.2841	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0057	0.0147	0.0503
Toxoplasma gondii	hypothetical protein	0.0064	0.0196	0.0248
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0219	0.0277
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0064	0.0196	0.0243

Activities

Activity type	Activity value	Assay description	Source	Reference
LD99 (functional)	= 3.1 ug ml-1	Lethal dose against Haemonchus contortus Lawes ( levamisole andbenzimidazole resistant) using NemaTox assay	ChEMBL.	16165359
LD99 (functional)	= 3.1 ug ml-1	Lethal dose against Haemonchus contortus CAVR (ivermectin resistant) using NemaTox assay	ChEMBL.	16165359
LD99 (functional)	= 3.1 ug ml-1	Lethal dose against Ostertagia circumcincta using NemaTox assay	ChEMBL.	16165359
LD99 (functional)	= 6.3 ug ml-1	Lethal dose against Haemonchus contortus (susceptible) using NemaTox assay	ChEMBL.	16165359
LD99 (functional)	= 6.3 ug ml-1	Lethal dose against Haemonchus contortus VSRG (benzimidazole resistant) using NemaTox assay	ChEMBL.	16165359
LD99 (functional)	= 6.3 ug ml-1	Lethal dose against Trichostrongylus colubriformis using NemaTox assay	ChEMBL.	16165359
LD99 (functional)	= 12.5 ug ml-1	Lethal dose against Haemonchus contortus using NemaTox assay	ChEMBL.	16165359

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL196068
PubChem: 9944003

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 342066