Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | AT19640p | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | 390 aa | 335 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydrofolate reductase | 0.1191 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.075 | 0.5734 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.1191 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1191 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.075 | 0.5734 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.075 | 0.5734 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0235 | 0.0765 | 0.0765 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1191 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.2028 | 0.2028 |
Onchocerca volvulus | 0.0235 | 0.0765 | 0.5 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1191 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0235 | 0.0765 | 0.0765 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.1597 | 0.1597 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.075 | 0.5734 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0235 | 0.0765 | 0.0765 |
Schistosoma mansoni | dihydrofolate reductase | 0.1191 | 1 | 1 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0366 | 0.2028 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.2028 | 0.2028 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1191 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1191 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1191 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0235 | 0.0765 | 0.0765 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.075 | 0.5734 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.075 | 0.5734 | 0.5 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0366 | 0.2028 | 0.2028 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Brain/Blood concentration (ADMET) | = 0.1 | Brain/blood concentration after administration of the compound in rat | ChEMBL. | 16039851 |
CLb (ADMET) | = 48 ml min-1 kg-1 | In vivo clearance after administration of the compound in rat | ChEMBL. | 16039851 |
F (ADMET) | 0 | Oral bioavailability in rat | ChEMBL. | 16039851 |
Ki (binding) | = 8 | Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]-5-HT or [3H]-8-OH-DPAT as the radioligand | ChEMBL. | 16039851 |
Ki (binding) | = 8.2 | Mean binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]-5-HT or [3H]-8-OH-DPAT as the radioligand | ChEMBL. | 16039851 |
Ki (binding) | = 8.3 | Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]-5-HT or [3H]-8-OH-DPAT as the radioligand | ChEMBL. | 16039851 |
Log Ki (binding) | = 8 | Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]-5-HT or [3H]-8-OH-DPAT as the radioligand | ChEMBL. | 16039851 |
Log Ki (binding) | = 8.2 | Mean binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]-5-HT or [3H]-8-OH-DPAT as the radioligand | ChEMBL. | 16039851 |
Log Ki (binding) | = 8.3 | Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]-5-HT or [3H]-8-OH-DPAT as the radioligand | ChEMBL. | 16039851 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.