Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0014 | 0.0088 | 0.1604 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0484 | 0.1214 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0014 | 0.0088 | 0.6864 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0033 | 0.0484 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0033 | 0.0484 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0033 | 0.0484 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0195 | 0.3901 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0012 | 0.0001 |
Onchocerca volvulus | 0.0033 | 0.0484 | 1 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0033 | 0.0484 | 1 |
Onchocerca volvulus | 0.0029 | 0.0412 | 0.8182 | |
Schistosoma mansoni | gliotactin | 0.0033 | 0.0484 | 0.1214 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0033 | 0.0484 | 0.1171 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0033 | 0.0484 | 0.0473 |
Brugia malayi | Carboxylesterase family protein | 0.0033 | 0.0484 | 0.1214 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0014 | 0.0088 | 0.1604 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0011 | 0.0012 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0484 | 0.1214 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0014 | 0.0088 | 0.1604 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0033 | 0.0484 | 0.1214 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0014 | 0.0088 | 0.6864 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0484 | 0.1214 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0011 | 0.0012 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0011 | 0.0012 | 0.0246 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0122 | 0.0284 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0016 | 0.0122 | 0.0284 |
Echinococcus multilocularis | acetylcholinesterase | 0.0195 | 0.3901 | 0.3894 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0011 | 0.0012 | 0.0246 |
Brugia malayi | AMP-binding enzyme family protein | 0.0014 | 0.0088 | 0.0195 |
Schistosoma mansoni | acetylcholinesterase | 0.0033 | 0.0484 | 0.1214 |
Echinococcus multilocularis | neuroligin | 0.0033 | 0.0484 | 0.0473 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0029 | 0.0412 | 0.1028 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0014 | 0.0088 | 0.1604 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0011 | 0.0012 | 0.0246 |
Trypanosoma brucei | cytochrome P450, putative | 0.0016 | 0.0122 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0033 | 0.0484 | 0.0473 |
Echinococcus multilocularis | acetylcholinesterase | 0.0195 | 0.3901 | 0.3894 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0195 | 0.3901 | 0.3894 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0033 | 0.0484 | 0.1214 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0011 | 0.0012 | 0.0246 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0011 | 0.0012 | 0.0246 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0014 | 0.0088 | 0.1604 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0011 | 0.0012 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0195 | 0.3901 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0195 | 0.3901 | 0.9646 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0014 | 0.0088 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0033 | 0.0484 | 0.1214 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0484 | 0.1214 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0014 | 0.0088 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0033 | 0.0484 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0011 | 0.0012 | 0.0246 |
Loa Loa (eye worm) | carboxylesterase | 0.0033 | 0.0484 | 0.1214 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0412 | 0.1028 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0014 | 0.0088 | 0.1811 |
Leishmania major | cytochrome p450-like protein | 0.0016 | 0.0122 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0195 | 0.3901 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0011 | 0.0012 | 0.0252 |
Brugia malayi | Carboxylesterase family protein | 0.0033 | 0.0484 | 0.1214 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0011 | 0.0012 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0484 | 0.1214 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.0492 | 0.1235 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0484 | 0.1214 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0011 | 0.0012 | 0.0246 |
Echinococcus multilocularis | tumor protein p63 | 0.0201 | 0.4044 | 0.4037 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0033 | 0.0484 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0122 | 0.0284 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0011 | 0.0012 | 0.0246 |
Brugia malayi | Carboxylesterase family protein | 0.0033 | 0.0484 | 0.1214 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0011 | 0.0012 | 0.0246 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0016 | 0.0122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0484 | 0.1214 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0033 | 0.0484 | 0.1171 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0011 | 0.0012 | 0.0246 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0011 | 0.0012 | 0.0246 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0014 | 0.0088 | 0.1604 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0011 | 0.0012 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0012 | 0.0001 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0011 | 0.0012 | 0.0246 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0011 | 0.0012 | 0.0246 |
Brugia malayi | AMP-binding enzyme family protein | 0.0014 | 0.0088 | 0.0195 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0014 | 0.0088 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0122 | 0.0284 |
Onchocerca volvulus | 0.0033 | 0.0484 | 1 | |
Echinococcus granulosus | neuroligin | 0.0033 | 0.0484 | 0.1171 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0016 | 0.0122 | 0.2337 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0122 | 0.0284 |
Onchocerca volvulus | 0.0033 | 0.0484 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0012 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0088 | 0.0195 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0014 | 0.0088 | 0.1604 |
Echinococcus granulosus | tumor protein p63 | 0.0201 | 0.4044 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0011 | 0.0012 | 0.0005 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0033 | 0.0484 | 0.1214 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0033 | 0.0484 | 0.1171 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0011 | 0.0012 | 0.0246 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0033 | 0.0484 | 0.0473 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0484 | 0.1214 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0011 | 0.0012 | 0.0246 |
Onchocerca volvulus | 0.0033 | 0.0484 | 1 | |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0014 | 0.0088 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0014 | 0.0088 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0012 | 0.0001 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.0088 | 0.1811 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0011 | 0.0012 | 0.0246 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0011 | 0.0012 | 0.0246 |
Brugia malayi | AMP-binding enzyme family protein | 0.0014 | 0.0088 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0088 | 0.0195 |
Mycobacterium ulcerans | hypothetical protein | 0.0014 | 0.0088 | 0.1604 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.3901 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0033 | 0.0484 | 0.1214 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0016 | 0.0122 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0033 | 0.0484 | 0.1214 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0014 | 0.0088 | 0.6864 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0011 | 0.0012 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0088 | 0.0195 |
Loa Loa (eye worm) | carboxylesterase | 0.0033 | 0.0484 | 0.1214 |
Onchocerca volvulus | 0.0033 | 0.0484 | 1 | |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0011 | 0.0012 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.3901 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0195 | 0.3901 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0195 | 0.3901 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0195 | 0.3901 | 0.9646 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0012 | 0.0001 |
Echinococcus granulosus | carboxylesterase 5A | 0.0195 | 0.3901 | 0.9646 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.0492 | 0.1235 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K ass (binding) | = 4600000 l mol-1 | Binding affinity as apparent association constant for human coagulation factor X | ChEMBL. | 16140530 |
K ass (binding) | = 4600000 l mol-1 | Binding affinity as apparent association constant for human coagulation factor X | ChEMBL. | 16140530 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.