Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0039 | 0.0216 | 0.0238 |
Brugia malayi | Pepsin A precursor | 0.0039 | 0.0216 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0216 | 0.0238 |
Echinococcus multilocularis | acetylcholinesterase | 0.0896 | 0.9103 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0896 | 0.9103 | 0.9103 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0151 | 0.1378 | 0.1378 |
Brugia malayi | hypothetical protein | 0.0151 | 0.1378 | 0.1513 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0039 | 0.0216 | 0.0238 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0039 | 0.0216 | 0.0216 |
Plasmodium vivax | aspartyl protease, putative | 0.0039 | 0.0216 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0151 | 0.1378 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0896 | 0.9103 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0185 | 0.1729 | 1 |
Schistosoma mansoni | gliotactin | 0.0151 | 0.1378 | 0.1378 |
Plasmodium falciparum | plasmepsin V | 0.0039 | 0.0216 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0151 | 0.1378 | 0.1513 |
Plasmodium vivax | aspartyl protease, putative | 0.0039 | 0.0216 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0151 | 0.1378 | 0.1513 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0151 | 0.1378 | 0.1513 |
Brugia malayi | Carboxylesterase family protein | 0.0151 | 0.1378 | 0.1513 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0151 | 0.1378 | 0.1513 |
Plasmodium falciparum | plasmepsin VI | 0.0039 | 0.0216 | 0.5 |
Onchocerca volvulus | 0.0039 | 0.0216 | 0.1251 | |
Plasmodium falciparum | plasmepsin VII | 0.0039 | 0.0216 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0151 | 0.1378 | 0.1378 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0039 | 0.0216 | 0.0238 |
Loa Loa (eye worm) | carboxylesterase | 0.0151 | 0.1378 | 0.1513 |
Brugia malayi | Protein kinase domain containing protein | 0.0185 | 0.1729 | 0.1899 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1378 | 0.1513 |
Brugia malayi | Carboxylesterase family protein | 0.0896 | 0.9103 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0896 | 0.9103 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0151 | 0.1378 | 0.1513 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0151 | 0.1378 | 0.1378 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0039 | 0.0216 | 0.0216 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0039 | 0.0216 | 0.5 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0039 | 0.0216 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0151 | 0.1378 | 0.1513 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0185 | 0.1729 | 0.1899 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0039 | 0.0216 | 0.0216 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0185 | 0.1729 | 0.1899 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0039 | 0.0216 | 0.0238 |
Onchocerca volvulus | 0.0151 | 0.1378 | 0.7969 | |
Onchocerca volvulus | 0.0039 | 0.0216 | 0.1251 | |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0039 | 0.0216 | 0.0216 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0216 | 0.0238 |
Loa Loa (eye worm) | carboxylesterase | 0.0896 | 0.9103 | 1 |
Onchocerca volvulus | 0.0151 | 0.1378 | 0.7969 | |
Plasmodium falciparum | plasmepsin II | 0.0039 | 0.0216 | 0.5 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0039 | 0.0216 | 0.5 |
Onchocerca volvulus | 0.0151 | 0.1378 | 0.7969 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0151 | 0.1378 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0185 | 0.1729 | 0.1729 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 0.9103 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1378 | 0.1513 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0185 | 0.1729 | 0.1899 |
Plasmodium vivax | plasmepsin V, putative | 0.0039 | 0.0216 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0896 | 0.9103 | 1 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0039 | 0.0216 | 0.0238 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0151 | 0.1378 | 0.1513 |
Echinococcus granulosus | acetylcholinesterase | 0.0896 | 0.9103 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0151 | 0.1378 | 0.1378 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0151 | 0.1378 | 0.1513 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1378 | 0.1513 |
Brugia malayi | Carboxylesterase family protein | 0.0151 | 0.1378 | 0.1513 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0185 | 0.1729 | 0.1899 |
Schistosoma mansoni | acetylcholinesterase | 0.0151 | 0.1378 | 0.1378 |
Brugia malayi | Carboxylesterase family protein | 0.0151 | 0.1378 | 0.1513 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 0.9103 | 1 |
Plasmodium falciparum | plasmepsin I | 0.0039 | 0.0216 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0039 | 0.0216 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0039 | 0.0216 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1378 | 0.1513 |
Plasmodium vivax | aspartyl protease, putative | 0.0039 | 0.0216 | 0.5 |
Onchocerca volvulus | 0.0151 | 0.1378 | 0.7969 | |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1378 | 0.1513 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0039 | 0.0216 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0216 | 0.0238 |
Plasmodium falciparum | plasmepsin III | 0.0039 | 0.0216 | 0.5 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.0039 | 0.0216 | 0.5 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0185 | 0.1729 | 0.1899 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0039 | 0.0216 | 0.0216 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0039 | 0.0216 | 0.0216 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0151 | 0.1378 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0151 | 0.1378 | 1 |
Plasmodium vivax | plasmepsin IV, putative | 0.0039 | 0.0216 | 0.5 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0039 | 0.0216 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1378 | 0.1513 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0216 | 0.0238 |
Onchocerca volvulus | 0.0151 | 0.1378 | 0.7969 | |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0039 | 0.0216 | 0.0216 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0896 | 0.9103 | 1 |
Plasmodium falciparum | plasmepsin X | 0.0039 | 0.0216 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0151 | 0.1378 | 0.1513 |
Echinococcus granulosus | acetylcholinesterase | 0.0896 | 0.9103 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0896 | 0.9103 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0151 | 0.1378 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0151 | 0.1378 | 0.1378 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0039 | 0.0216 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0039 | 0.0216 | 0.0216 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0039 | 0.0216 | 0.0216 |
Brugia malayi | Carboxylesterase family protein | 0.0151 | 0.1378 | 0.1513 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0216 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1378 | 0.1513 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0039 | 0.0216 | 0.0216 |
Toxoplasma gondii | aspartyl protease | 0.0039 | 0.0216 | 0.5 |
Plasmodium falciparum | plasmepsin IV | 0.0039 | 0.0216 | 0.5 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0039 | 0.0216 | 0.0238 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0151 | 0.1378 | 0.5 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0039 | 0.0216 | 0.0238 |
Plasmodium falciparum | plasmepsin IX | 0.0039 | 0.0216 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T/C (functional) | = 110 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 25 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 110 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 25 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 112 % | Antitumor activity against P-388 Leukemia in female BDF1 mice expressed as percent T/C at dose 50 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 112 % | Antitumor activity against P-388 Leukemia in female BDF1 mice expressed as percent T/C at dose 50 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 116 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 100 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 116 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 100 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 169 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 200 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 169 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 200 mg/kg i.p. | ChEMBL. | 7452684 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.