Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0239 | 0.022 |
Mycobacterium ulcerans | L-lactate dehydrogenase (cytochrome) LldD2 | 0.0182 | 0.3837 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0245 | 0.5394 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0432 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0366 | 0.0366 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0835 | 0.1386 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0366 | 0.0462 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0366 | 0.05 |
Treponema pallidum | hypothetical protein | 0.0182 | 0.3837 | 0.5 |
Echinococcus granulosus | DNA repair protein complementing XP G cells | 0.0036 | 0.0239 | 0.0272 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0031 | 0.0123 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.4381 | 1 |
Entamoeba histolytica | isopentenyl-diphosphate delta-isomerase, putative | 0.0065 | 0.096 | 1 |
Mycobacterium leprae | POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2 | 0.0182 | 0.3837 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.5394 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0835 | 0.1352 |
Mycobacterium tuberculosis | Possible L-lactate dehydrogenase (cytochrome) LldD2 | 0.0182 | 0.3837 | 0.5 |
Echinococcus multilocularis | DNA repair protein complementing XP G cells | 0.0036 | 0.0239 | 0.0272 |
Entamoeba histolytica | DNA-repair protein, putative | 0.0036 | 0.0239 | 0.1386 |
Leishmania major | isopentenyl-diphosphate delta-isomerase, putative,isomerase, putative | 0.0065 | 0.096 | 1 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0036 | 0.0239 | 1 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0031 | 0.0123 | 0.5 |
Brugia malayi | Flap endonuclease-1 | 0.0031 | 0.0123 | 0.004 |
Plasmodium vivax | DNA repair protein RAD2, putative | 0.0036 | 0.0239 | 1 |
Trypanosoma brucei | isopentenyl-diphosphate delta-isomerase (type II) | 0.0065 | 0.096 | 0.0848 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.4381 | 1 |
Plasmodium falciparum | DNA repair protein RAD2, putative | 0.0036 | 0.0239 | 1 |
Schistosoma mansoni | xp-G/rad2 DNA repair endonuclease family | 0.0036 | 0.0239 | 0.0239 |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0036 | 0.0239 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -8.1 | Binding affinity for human corticotropin releasing factor receptor 1 expressed in LtK- cells using [125I]-sauvagine | ChEMBL. | 16134945 |
Log Ki (binding) | = 8.1 | Binding affinity for human corticotropin releasing factor receptor 1 expressed in LtK- cells using [125I]-sauvagine | ChEMBL. | 16134945 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.