Detailed information for compound 34262

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 349.342 | Formula: C15H19N5O5
  • H donors: 4 H acceptors: 6 LogP: -0.51 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(C(C1O)O)n1cnc2c1nc(OCCC#CC)nc2N
  • InChi: 1S/C15H19N5O5/c1-2-3-4-5-24-15-18-12(16)9-13(19-15)20(7-17-9)14-11(23)10(22)8(6-21)25-14/h7-8,10-11,14,21-23H,4-6H2,1H3,(H2,16,18,19)
  • InChiKey: URVQRCGJIKGUGN-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.007 0.0418
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0095 0.0094
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0044 0.005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0152 0.141 0.1582
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0302 0.2976 1
Schistosoma mansoni zinc finger protein 0.0033 0.0175 0.0174
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0152 0.141 0.1574
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0167 0.0243
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0069
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0222 0.214 0.2401
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0185 0.175 0.4209
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0044 0.0049
Trypanosoma cruzi trypanothione reductase, putative 0.0302 0.2976 0.333
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0031 0.0147 0.0971
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0035 0.0027
Trypanosoma cruzi NADH dehydrogenase, putative 0.008 0.0663 0.0732
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2574 0.8644
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.008 0.0663 0.0732
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0044 0.0044
Leishmania major DNA polymerase kappa, putative 0.002 0.0035 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0302 0.2976 0.333
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0302 0.2976 1
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0031 0.0147 0.0458
Brugia malayi exodeoxyribonuclease III family protein 0.0152 0.141 0.1582
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.008 0.0663 0.0743
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2574 0.8644
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0044 0.005
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.0147 0.0165
Brugia malayi glutamate synthase 0.008 0.0663 0.0744
Echinococcus granulosus histone acetyltransferase KAT2B 0.029 0.2851 0.3199
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0035 0.003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0044 0.005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0011 0.0013
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.008 0.0663 0.0743
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0031 0.0147 0.0153
Treponema pallidum oxidoreductase 0.008 0.0663 0.1824
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0035 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0115 0.0352
Trypanosoma cruzi mitochondrial protein 99, putative 0.0031 0.0147 0.0153
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.008 0.0663 0.0732
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2574 0.8644
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0044 0.0049
Mycobacterium ulcerans dehydrogenase 0.008 0.0663 0.2206
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.008 0.0663 0.0743
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0035 0.0169
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0044 0.0037
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0031 0.0147 0.0156
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0031 0.0147 0.0971
Schistosoma mansoni nocturnin 0.0031 0.0147 0.0146
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0031 0.0147 0.0156
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0152 0.141 0.1574
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1629 0.5458
Brugia malayi beta-lactamase family protein 0.0036 0.0206 0.0231
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.008 0.0663 0.0732
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0663 0.0732
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.007 0.0206
Loa Loa (eye worm) hypothetical protein 0.0031 0.0147 0.0156
Mycobacterium tuberculosis Probable reductase 0.0185 0.175 0.1956
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0069
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.008 0.0663 0.2199
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0028 0.0028
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0035 0.0034
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.008 0.0663 0.0744
Trichomonas vaginalis mercuric reductase, putative 0.0302 0.2976 1
Onchocerca volvulus 0.0036 0.0206 0.1019
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0031 0.0147 0.0164
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0302 0.2976 0.333
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0115 0.0352
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.004
Schistosoma mansoni cpg binding protein 0.0131 0.119 0.1189
Onchocerca volvulus 0.0122 0.1098 0.6649
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.008 0.0663 0.0744
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.008 0.0663 0.0732
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0035 0.0027
Echinococcus granulosus tar DNA binding protein 0.0066 0.0513 0.0574
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0031 0.0147 0.0153
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0206 0.0656
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0302 0.2976 0.3332
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0031 0.0147 0.0153
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0031 0.0147 0.0153
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0221
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0044 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0035 0.0027
Treponema pallidum NADH oxidase 0.0302 0.2976 1
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0206 0.0221
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0031 0.0147 0.0153
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0031 0.0147 0.0153
Leishmania major endonuclease/exonuclease protein-like protein 0.0031 0.0147 0.0153
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0286 0.2808 0.315
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.0147 0.0165
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0035 0.008
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0264 0.2574 0.2881
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0069
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.007 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0035 0.0027
Brugia malayi CXXC zinc finger family protein 0.0122 0.1098 0.1232
Brugia malayi Thioredoxin reductase 0.0872 0.8913 1
Onchocerca volvulus 0.0036 0.0206 0.1019
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1629 0.5458
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.0862 0.0967
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0044 0.005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0302 0.2976 0.333
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0035 0.0027
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0192 0.0215
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0035 0.0027
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0031 0.0147 0.0458
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0206 0.0656
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0373 0.3709 0.4155
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1629 0.5458
Echinococcus multilocularis deoxyribonuclease 1 2 0.0031 0.0147 0.0164
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.007 0.0206
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0206 0.0221
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0028 0.0028
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0129 0.0144
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0206 0.0221
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0513 0.0512
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0044 0.004
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0031 0.0147 0.0458
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0663 0.0732
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0035 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0022
Loa Loa (eye worm) hypothetical protein 0.0037 0.0217 0.0234
Echinococcus multilocularis neutral sphingomyelinase 0.0031 0.0147 0.0164
Leishmania major hypothetical protein, conserved 0.0031 0.0147 0.0153
Schistosoma mansoni hypothetical protein 0.0099 0.0862 0.0861
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.007 0.0206
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0206 0.0665
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0286 0.2808 0.315
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.007 0.0206
Brugia malayi steroid hormone receptor 0.0021 0.0044 0.005
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0302 0.2976 0.3332
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0031 0.0147 0.0153
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0044 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0286 0.2808 0.2807
Schistosoma mansoni DNA polymerase eta 0.002 0.0035 0.0034
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0044 0.0049
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0302 0.2976 0.3332
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0302 0.2976 0.333
Onchocerca volvulus 0.0099 0.0862 0.5157
Loa Loa (eye worm) CXXC zinc finger family protein 0.0122 0.1098 0.1224
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0302 0.2976 0.333
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.008 0.0663 0.0743
Chlamydia trachomatis thioredoxin reductase 0.008 0.0663 0.2206
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0302 0.2976 0.3339
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.008 0.0663 0.2206
Schistosoma mansoni cpg binding protein 0.0122 0.1098 0.1098
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0031 0.0147 0.0971
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0115 0.0352
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0302 0.2976 0.3332
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0235 0.0264
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.008 0.0663 0.0735
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1629 0.5458
Schistosoma mansoni carbon catabolite repressor protein 0.0031 0.0147 0.0146
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0373 0.3709 0.4162
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.008 0.0089
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0031 0.0147 0.0153
Echinococcus granulosus thioredoxin glutathione reductase 0.0872 0.8913 1
Giardia lamblia hypothetical protein 0.0031 0.0147 0.0458
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.009 0.0766 0.0848
Trichomonas vaginalis ap endonuclease, putative 0.0152 0.141 0.472
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0207 0.022
Brugia malayi nuclear hormone receptor 0.0021 0.0044 0.005
Loa Loa (eye worm) hypothetical protein 0.0069 0.0546 0.0603
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0185 0.175 0.1956
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.007 0.0069
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0206 0.0221
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0031 0.0147 0.0458
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0044 0.0049
Onchocerca volvulus 0.0023 0.007 0.0161
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0011 0.0013
Giardia lamblia DINP protein human, muc B family 0.002 0.0035 0.008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0259 0.2523 0.2522
Onchocerca volvulus 0.0031 0.0147 0.0649
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0302 0.2976 0.333
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.007 0.0066
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0302 0.2976 0.3332
Trichomonas vaginalis esterase, putative 0.0036 0.0206 0.0656
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0031 0.0147 0.0971
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.009 0.0766 0.0848
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0044 0.005
Brugia malayi AMP-binding enzyme family protein 0.0023 0.007 0.0078
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.008 0.0079
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.008 0.0663 0.0732
Schistosoma mansoni synaptojanin 0.0031 0.0147 0.0146
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0206 0.0221
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0347
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.0147 0.0165
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.008 0.0663 0.0735
Brugia malayi hypothetical protein 0.0487 0.4898 0.5496
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0035 0.008
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0115 0.0352
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.008 0.0663 0.0743
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0044 0.0049
Echinococcus granulosus geminin 0.0166 0.1551 0.174
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0513 0.0566
Echinococcus multilocularis glutamate synthase 0.008 0.0663 0.0743
Plasmodium falciparum thioredoxin reductase 0.0302 0.2976 0.3332
Plasmodium falciparum ferrodoxin reductase-like protein 0.008 0.0663 0.0735
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0044 0.0044
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0083 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0035 0.0027
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.0147 0.0165
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.008 0.0663 0.2206
Onchocerca volvulus 0.008 0.0663 0.3905
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0035 0.0027
Trichomonas vaginalis helicase, putative 0.0028 0.0115 0.0352
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0011 0.0012
Echinococcus granulosus traf and tnf receptor associated protein 0.0031 0.0147 0.0164
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0031 0.0147 0.0971
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0302 0.2976 0.333
Toxoplasma gondii FATC domain-containing protein 0.0024 0.008 0.0077
Mycobacterium ulcerans glutamate synthase subunit beta 0.008 0.0663 0.2206
Mycobacterium tuberculosis Conserved protein 0.0036 0.0206 0.0221
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0044 0.0049
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0095 0.0097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.004
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.007 0.0066
Schistosoma mansoni ap endonuclease 0.0152 0.141 0.141
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0028 0.0031
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0302 0.2976 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.008 0.0663 0.2199
Loa Loa (eye worm) hypothetical protein 0.0191 0.1812 0.2025
Echinococcus multilocularis dna polymerase kappa 0.002 0.0035 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0035 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0115 0.0352
Loa Loa (eye worm) hypothetical protein 0.0031 0.0147 0.0156
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0152 0.141 0.1572
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0031 0.0147 0.0153
Loa Loa (eye worm) inositol-1 0.0036 0.0207 0.0223
Loa Loa (eye worm) acetyltransferase 0.0301 0.2963 0.3318
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.004
Loa Loa (eye worm) hypothetical protein 0.0487 0.4898 0.5491
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0035 0.0089
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0207 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0115 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0115 0.0352
Plasmodium vivax glutathione reductase, putative 0.0872 0.8913 1
Leishmania major pantothenate kinase subunit, putative 0.0032 0.0157 0.0164
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0031 0.0147 0.0153
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0031 0.0147 0.0164
Toxoplasma gondii ABC1 family protein 0.0036 0.0206 0.0219
Leishmania major DNA polymerase eta, putative 0.002 0.0035 0.0027
Echinococcus granulosus dna polymerase kappa 0.002 0.0035 0.0038
Entamoeba histolytica glutamate synthase beta subunit, putative 0.008 0.0663 0.4659
Schistosoma mansoni hypothetical protein 0.0031 0.0147 0.0146
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0302 0.2976 0.333
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0044 0.005
Brugia malayi nuclear receptor NHR-88 0.0021 0.0044 0.005
Schistosoma mansoni bromodomain containing protein 0.0018 0.002 0.0019
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0207 0.0231
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0167 0.0178
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0044 0.0044
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0302 0.2976 0.333
Leishmania major hypothetical protein, conserved 0.0036 0.0206 0.0219
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0031 0.0147 0.0156
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0301 0.2963 0.3324
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0206 0.0219
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0037 0.0032
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0032 0.0157 0.0164
Schistosoma mansoni bromodomain containing protein 0.0076 0.0619 0.0618
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.007 0.0206
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0301 0.2963 0.2962
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.008 0.0663 0.0732
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0031 0.0147 0.0153
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0207 0.022
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0031 0.0147 0.0153
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0031 0.0147 0.0153
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0207 0.066
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0207 0.0231
Echinococcus granulosus histone acetyltransferase KAT2B 0.009 0.0766 0.0859
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0286 0.2808 0.315
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0044 0.0049
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0044 0.0049
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0207 0.0668
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.008 0.0663 0.0735
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.008 0.0663 0.1648
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0207 0.022
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0035 0.0039
Mycobacterium leprae Probable lipase LipE 0.0036 0.0206 0.0341
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0115 0.0352
Brugia malayi Bromodomain containing protein 0.0087 0.0738 0.0828
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0038 0.0221 0.0247
Echinococcus granulosus neutral sphingomyelinase 0.0031 0.0147 0.0164
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0031 0.0147 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0035 0.0027
Echinococcus granulosus serine protein kinase ATM 0.0024 0.008 0.0089
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0044 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0044 0.004
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0031 0.0147 0.0153
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1629 0.5458
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0286 0.2808 0.315
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0207 0.066
Mycobacterium tuberculosis Conserved protein 0.0036 0.0206 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2574 0.8644
Mycobacterium ulcerans NADH dehydrogenase 0.008 0.0663 0.2206
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0035 0.0027
Onchocerca volvulus Glucosylceramidase homolog 0.0173 0.1629 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0115 0.0352
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0286 0.2808 0.315
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0185 0.175 0.1956
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0152 0.141 0.4347
Giardia lamblia Glutamate synthase 0.008 0.0663 0.2199
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.008 0.0663 0.0732
Echinococcus granulosus survival motor neuron protein 1 0.0487 0.4898 0.5495
Schistosoma mansoni glutamate synthase 0.008 0.0663 0.0663
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0302 0.2976 0.2975
Schistosoma mansoni glutamate synthase 0.008 0.0663 0.0663
Loa Loa (eye worm) programmed cell death 8 0.008 0.0663 0.0735
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0302 0.2976 0.3338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0044 0.004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0302 0.2976 0.333
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0035 0.003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0241 0.2335 0.2611
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0044 0.005
Trichomonas vaginalis glutamate synthase, putative 0.008 0.0663 0.2199
Loa Loa (eye worm) hypothetical protein 0.0373 0.3709 0.4156
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.0147 0.0165
Entamoeba histolytica glutamate synthase beta subunit, putative 0.008 0.0663 0.4659
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.008 0.0663 0.1486
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.008 0.0663 0.2206
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0302 0.2976 0.333
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0302 0.2976 0.333
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.008 0.0663 0.1486
Schistosoma mansoni hypothetical protein 0.002 0.0037 0.0036
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0044 0.0044
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0031 0.0147 0.0146
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.008 0.0663 0.0732
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.008 0.0663 0.1648
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0513 0.0512
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0302 0.2976 0.333
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0152 0.141 0.1572
Echinococcus multilocularis synaptojanin 1 0.0031 0.0147 0.0164
Toxoplasma gondii selenide, water dikinase 0.008 0.0663 0.0732
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0407 0.4063 0.4554
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0044 0.005
Schistosoma mansoni hypothetical protein 0.0166 0.1551 0.1551
Echinococcus granulosus glutamate synthase 0.008 0.0663 0.0743
Leishmania major NADH dehydrogenase, putative 0.008 0.0663 0.0732
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0129 0.0128
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0143 0.016
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.008 0.0663 0.0732
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0302 0.2976 0.333
Loa Loa (eye worm) RNA binding protein 0.0066 0.0513 0.0566
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0031 0.0147 0.0153
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0286 0.2808 0.2807
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0031 0.0147 0.0164
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0031 0.0147 0.0156
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0206 0.0219
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0031 0.0147 0.0458
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0031 0.0147 0.0156
Trichomonas vaginalis disulfide oxidoreductase, putative 0.008 0.0663 0.2199
Mycobacterium tuberculosis Probable dehydrogenase 0.0185 0.175 0.1956
Echinococcus granulosus zinc finger protein 0.0033 0.0175 0.0196
Mycobacterium tuberculosis Conserved protein 0.0036 0.0206 0.0221
Brugia malayi CCR4 0.0031 0.0147 0.0165
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.008 0.0663 0.0744
Plasmodium falciparum thioredoxin reductase 0.0872 0.8913 1
Trypanosoma brucei RNA editing exonuclease 2 0.0031 0.0147 0.0153
Plasmodium vivax ferrodoxin reductase, putative 0.008 0.0663 0.0735
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0582 0.0653
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0031 0.0147 0.0971
Schistosoma mansoni survival motor neuron protein 0.0099 0.0862 0.0861
Trichomonas vaginalis disulfide oxidoreductase, putative 0.008 0.0663 0.2199
Schistosoma mansoni hypothetical protein 0.008 0.0663 0.0663
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0031 0.0147 0.0156
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0031 0.0147 0.0153
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0302 0.2976 0.333
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0206 0.0219
Leishmania major hypothetical protein, conserved 0.0026 0.0095 0.0094
Brugia malayi RNA binding protein 0.0066 0.0513 0.0575
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.008 0.0663 0.2199
Plasmodium vivax exodeoxyribonuclease III, putative 0.0031 0.0147 0.0156
Brugia malayi ecdysteroid receptor 0.0021 0.0044 0.005
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0302 0.2976 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0147 0.0156
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.007 0.0206
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.008 0.0663 0.0735
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0115 0.0352
Onchocerca volvulus Putative neutral sphingomyelinase 0.0031 0.0147 0.0649
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0147 0.0156
Leishmania major hypothetical protein, conserved 0.0031 0.0147 0.0153
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0115 0.0352
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0115 0.0352
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0207 0.1397
Leishmania major RNA-editing complex protein MP100, putative 0.0031 0.0147 0.0153
Leishmania major hypothetical protein, conserved 0.008 0.0663 0.0732
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0152 0.141 0.1574
Brugia malayi glutathione reductase 0.0872 0.8913 1
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0031 0.0147 0.0164
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0031 0.0147 0.0156
Trichomonas vaginalis ap endonuclease, putative 0.0152 0.141 0.472
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0044 0.0044
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.008 0.0663 0.0732
Mycobacterium ulcerans beta-lactamase 0.0036 0.0206 0.0665
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0206 0.023
Entamoeba histolytica hypothetical protein 0.0024 0.008 0.049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0286 0.2808 0.2807
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0031 0.0147 0.0156
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0152 0.141 1
Schistosoma mansoni sulfide quinone reductase 0.008 0.0663 0.0663
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0222 0.214 0.2401
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0035 0.0038
Schistosoma mansoni coup transcription factor 0.0021 0.0044 0.0044
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0011 0.0012
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0035 0.0027
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0095 0.0097
Loa Loa (eye worm) hypothetical protein 0.0056 0.0409 0.045
Echinococcus granulosus dna polymerase eta 0.002 0.0035 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1629 0.5458
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0872 0.8913 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0302 0.2976 0.333
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.004
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.008 0.0077
Brugia malayi Inositol-1 0.0036 0.0207 0.0232
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.008 0.0089
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0152 0.141 0.1574
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0035 0.0027
Entamoeba histolytica acetyltransferase, GNAT family 0.0081 0.0666 0.4681
Leishmania major hypothetical protein, conserved 0.008 0.0663 0.0732
Mycobacterium ulcerans hypothetical protein 0.0036 0.0206 0.0665
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0031 0.0147 0.0971
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0031 0.0147 0.0153
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0031 0.0147 0.0156
Trypanosoma cruzi NADH dehydrogenase, putative 0.008 0.0663 0.0732
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0031 0.0147 0.0153
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0221
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0129 0.0144
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0513 0.0566
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0582 0.0653
Entamoeba histolytica disulphide oxidoreductase, putative 0.008 0.0663 0.4659
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0031 0.0147 0.0153
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0044 0.0049
Echinococcus multilocularis zinc finger protein 0.0033 0.0175 0.0196
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1629 0.5458
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0031 0.0147 0.0156
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.008 0.0663 0.0743
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0044 0.0049
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0031 0.0147 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0035 0.0027
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0302 0.2976 0.333
Trypanosoma cruzi trypanothione reductase, putative 0.0872 0.8913 1
Schistosoma mansoni hypothetical protein 0.0166 0.1551 0.1551
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0221
Schistosoma mansoni glutamate synthase 0.008 0.0663 0.0663
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0207 0.022
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0221
Trichomonas vaginalis disulfide oxidoreductase, putative 0.008 0.0663 0.2199
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.007 0.0418
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.004
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0513 0.0575
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0407 0.4063 0.4554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.008 0.0231
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.0147 0.0165
Trichomonas vaginalis apoptosis inducing factor, putative 0.008 0.0663 0.2199
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0031 0.0147 0.0971
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0031 0.0147 0.0458
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.008 0.0663 0.0743
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0302 0.2976 0.3338
Schistosoma mansoni ap endonuclease 0.0152 0.141 0.141
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1726 0.5786
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0044 0.004
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0095 0.0094
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.008 0.0663 0.4659
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0044 0.005
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0206 0.023
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0044 0.0044
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0206 0.0341
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0011 0.0003
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0044 0.0044
Toxoplasma gondii exonuclease III APE 0.0152 0.141 0.1572
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0044 0.0049
Trichomonas vaginalis disulfide oxidoreductase, putative 0.008 0.0663 0.2199
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.008 0.0663 0.0735
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0152 0.141 0.1582
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0035 0.003
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0095 0.0094
Toxoplasma gondii NADPH-glutathione reductase 0.0302 0.2976 0.333
Treponema pallidum exodeoxyribonuclease (exoA) 0.0152 0.141 0.4466
Trypanosoma cruzi mitochondrial protein 99, putative 0.0031 0.0147 0.0153
Brugia malayi AMP-binding enzyme family protein 0.0023 0.007 0.0078
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0044 0.0044
Giardia lamblia NADH oxidase lateral transfer candidate 0.0302 0.2976 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0081 0.0666 0.0739
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0206 0.0656
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0031 0.0147 0.0153
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0031 0.0147 0.0153
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0152 0.141 0.4725
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0207 0.066
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0115 0.0352
Giardia lamblia Histone acetyltransferase GCN5 0.0081 0.0666 0.2209
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0206 0.0221
Plasmodium falciparum glutathione reductase 0.0872 0.8913 1
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0663 0.0732
Schistosoma mansoni inositol monophosphatase 0.0036 0.0207 0.0206
Brugia malayi AMP-binding enzyme family protein 0.0023 0.007 0.0078
Loa Loa (eye worm) histone methyltransferase 0.0038 0.0221 0.0238
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.008 0.0663 0.0743
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0206 0.0205
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0031 0.0147 0.0971
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.008 0.0663 0.0735
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2574 0.8644
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0044 0.005
Brugia malayi PHD-finger family protein 0.0039 0.0229 0.0257
Mycobacterium ulcerans lipase LipD 0.0036 0.0206 0.0665
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.008 0.0663 0.2206
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0407 0.4063 1
Plasmodium falciparum DNase I-like protein, putative 0.0031 0.0147 0.0156
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0152 0.141 0.1572
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.008 0.0663 0.0732
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0035 0.0027
Schistosoma mansoni sulfide quinone reductase 0.008 0.0663 0.0663
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0035 0.0027
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0031 0.0147 0.0153
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.008 0.0663 0.2206
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0035 0.0027
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0028 0.0031
Leishmania major hypothetical protein, conserved 0.0031 0.0147 0.0153
Echinococcus multilocularis cpg binding protein 0.0131 0.119 0.1335
Plasmodium vivax thioredoxin reductase, putative 0.0872 0.8913 1
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.008 0.0663 0.4659
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0513 0.0512
Brugia malayi acetyltransferase, GNAT family protein 0.0301 0.2963 0.3324
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0221
Giardia lamblia Inositol 5-phosphatase 4 0.0031 0.0147 0.0458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0044 0.004
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.0143 0.016
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0031 0.0147 0.0458
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.008 0.0663 0.1486
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0206 0.0665
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0115 0.0352
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0044 0.005
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.0147 0.0165
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.0143 0.016
Trypanosoma brucei C-8 sterol isomerase, putative 0.0373 0.3709 0.4155
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.001 0.0009
Echinococcus granulosus sulfide:quinone oxidoreductase 0.008 0.0663 0.0743
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.008 0.0663 0.0735
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0513 0.0512
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0011 0.001
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.008 0.0663 0.2199
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.004
Schistosoma mansoni cpg binding protein 0.0131 0.119 0.1189
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0031 0.0147 0.0971
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0206 0.0221
Echinococcus multilocularis geminin 0.0166 0.1551 0.174
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0031 0.0147 0.0156
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.2244 0.251
Schistosoma mansoni neutral sphingomyelinase 0.0031 0.0147 0.0146
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.007 0.0066
Mycobacterium ulcerans hypothetical protein 0.008 0.0663 0.2206
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0115 0.0352
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0044 0.005
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0044 0.0044
Trypanosoma brucei NADH dehydrogenase 0.008 0.0663 0.0732
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0044 0.0044
Trypanosoma brucei trypanothione reductase 0.0872 0.8913 1
Brugia malayi Bromodomain containing protein 0.0045 0.0293 0.0328
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0011 0.001
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.008 0.0663 0.2206
Schistosoma mansoni disulfide oxidoreductase 0.008 0.0663 0.0663
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0035 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1726 0.5786
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.008 0.0663 0.2206
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0206 0.0231
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0302 0.2976 1
Brugia malayi beta-lactamase family protein 0.0036 0.0206 0.0231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0044 0.004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0143 0.0142
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.009 0.0766 0.2548
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0038 0.0221 0.0247
Onchocerca volvulus 0.0031 0.0147 0.0649
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.008 0.0663 0.1486
Echinococcus multilocularis thioredoxin glutathione reductase 0.0872 0.8913 1
Loa Loa (eye worm) thioredoxin reductase 0.0872 0.8913 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0185 0.175 0.1956
Trichomonas vaginalis glutamate synthase, putative 0.008 0.0663 0.2199
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.008 0.0663 0.0732
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0031 0.0147 0.0971
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0206 0.0205
Loa Loa (eye worm) glutathione reductase 0.0872 0.8913 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0206 0.0221
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0206 0.0656
Mycobacterium ulcerans ferredoxin reductase 0.008 0.0663 0.2206
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0035 0.0089
Schistosoma mansoni cript-related 0.0031 0.0147 0.0146
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0206 0.0656
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0044 0.005
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0095 0.0094
Echinococcus granulosus cpg binding protein 0.0131 0.119 0.1335
Loa Loa (eye worm) hypothetical protein 0.0026 0.0095 0.0097
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.008 0.0663 0.0735
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0035 0.0027
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0185 0.175 0.1956
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0031 0.0147 0.0153
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.007 0.0069
Leishmania major C-8 sterol isomerase-like protein 0.0373 0.3709 0.4155
Mycobacterium ulcerans hypothetical protein 0.0023 0.007 0.0206
Schistosoma mansoni inositol monophosphatase 0.0036 0.0207 0.0206
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0192 0.0215
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.0147 0.0165
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0095 0.0097
Echinococcus granulosus synaptojanin 1 0.0031 0.0147 0.0164
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0044 0.004
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0031 0.0147 0.0164
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2574 0.8644
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.008 0.0663 0.0732
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.008 0.0663 0.0743
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0044 0.005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0044 0.0049
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0011 0.0012
Entamoeba histolytica thioredoxin reductase, putative 0.008 0.0663 0.4659
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.004
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.008 0.0663 0.1648
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0044 0.005
Plasmodium vivax histone acetyltransferase GCN5, putative 0.009 0.0766 0.0851
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0035 0.0034
Mycobacterium tuberculosis Probable exported protein 0.0031 0.0147 0.0156
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0031 0.0147 0.0458
Leishmania major hypothetical protein, conserved 0.008 0.0663 0.0732
Treponema pallidum thioredoxin reductase (trxB) 0.008 0.0663 0.1824
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.008 0.0663 0.0735
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0031 0.0147 0.0153
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0286 0.2808 0.3144
Mycobacterium ulcerans monoxygenase 0.008 0.0663 0.2206
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0152 0.141 0.472
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0044 0.0044
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0206 0.0221
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0513 0.0512
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0115 0.0352
Leishmania major trypanothione reductase 0.0872 0.8913 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0044 0.0049
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.008 0.0663 0.0732
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0143 0.016
Trichomonas vaginalis disulfide oxidoreductase, putative 0.008 0.0663 0.2199
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0221
Schistosoma mansoni synaptojanin 0.0031 0.0147 0.0146
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.008 0.0663 0.0732
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0031 0.0147 0.0153
Trichomonas vaginalis Phospholipase C precursor, putative 0.0031 0.0147 0.0458
Loa Loa (eye worm) hypothetical protein 0.008 0.0663 0.0735
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0513 0.0574
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.007 0.0418
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.008 0.0663 0.0735
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0035 0.0027
Brugia malayi beta-lactamase 0.0036 0.0206 0.0231
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0011 0.0012
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.008 0.0663 0.0735
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.008 0.0663 0.4659
Echinococcus multilocularis dna polymerase eta 0.002 0.0035 0.0038
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0031 0.0147 0.0153
Onchocerca volvulus 0.0036 0.0206 0.1019
Echinococcus multilocularis traf and tnf receptor associated protein 0.0031 0.0147 0.0164
Toxoplasma gondii thioredoxin reductase 0.0872 0.8913 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0264 0.2574 0.2888
Mycobacterium tuberculosis Probable oxidoreductase 0.0407 0.4063 0.4554
Brugia malayi TAR-binding protein 0.0066 0.0513 0.0575
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0044 0.005
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0044 0.004
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.008 0.0663 0.0743
Trichomonas vaginalis bromodomain-containing protein, putative 0.009 0.0766 0.2548
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0031 0.0147 0.0164
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.008 0.0077
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0206 0.0221
Trichomonas vaginalis disulfide oxidoreductase, putative 0.008 0.0663 0.2199
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0044 0.0049
Loa Loa (eye worm) hypothetical protein 0.0031 0.0147 0.0156
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.008 0.0663 0.2199
Giardia lamblia Thioredoxin reductase 0.008 0.0663 0.2199
Plasmodium falciparum glutathione reductase 0.0302 0.2976 0.3332
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0115 0.0352
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0152 0.141 0.1572
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0044 0.0049
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.0147 0.0165
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.008 0.0663 0.0743
Brugia malayi hypothetical protein 0.0026 0.0095 0.0106
Trichomonas vaginalis glutathione reductase, putative 0.0302 0.2976 1
Echinococcus multilocularis survival motor neuron protein 1 0.0487 0.4898 0.5495
Trypanosoma brucei unspecified product 0.002 0.0035 0.0027
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0302 0.2976 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0011 0.0003
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.008 0.0663 0.0732

Activities

Activity type Activity value Assay description Source Reference
-Log EC50 (functional) = 4.2 M Prolongation of the stimulus-QRS interval by 50% of the maximum response at the Adenosine A1 receptor in langendorff guinea pig heart preparation ChEMBL. 2016707
-Log EC50 (functional) = 7.56 M Coronary arteries vasodilation at the Adenosine A2 receptor in langendorff guinea pig heart preparation ChEMBL. 2016707
Ratio (functional) = 2800 Ratio of EC50 stim-QRS (conduction block) and EC50 for vasodilation of coronary arteries ChEMBL. 2016707

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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