Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0207 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0022 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activation (binding) | = 21 % | Effective concentration in transactivation assay using a chimeric LXR construct in HEK-293 cells for LXRbeta receptor | ChEMBL. | 16125384 |
Activation (binding) | = 21 % | Effective concentration in transactivation assay using a chimeric LXR construct in HEK-293 cells for LXRbeta receptor | ChEMBL. | 16125384 |
Activation (binding) | = 42 % | Effective concentration in transactivation assay using a chimeric LXR construct in HEK-293 cells for LXRalpha receptor | ChEMBL. | 16125384 |
Activation (binding) | = 42 % | Effective concentration in transactivation assay using a chimeric LXR construct in HEK-293 cells for LXRalpha receptor | ChEMBL. | 16125384 |
EC50 (binding) | = 0.36 uM | Effective concentration in recombinant human LXRalpha ligand binding domain in homogeneous time-resolved fluorescence assay | ChEMBL. | 16125384 |
EC50 (binding) | = 0.36 uM | Effective concentration in recombinant human LXRalpha ligand binding domain in homogeneous time-resolved fluorescence assay | ChEMBL. | 16125384 |
EC50 (binding) | > 50 uM | Effective concentration in recombinant human LXRbeta ligand binding domain in homogeneous time-resolved fluorescence assay | ChEMBL. | 16125384 |
EC50 (binding) | > 50 uM | Effective concentration in recombinant human LXRbeta ligand binding domain in homogeneous time-resolved fluorescence assay | ChEMBL. | 16125384 |
IC50 (binding) | = 0.42 uM | Inhibitory concentration in LXRSPA beta binding assay | ChEMBL. | 16125384 |
IC50 (binding) | = 0.42 uM | Inhibitory concentration in LXRSPA beta binding assay | ChEMBL. | 16125384 |
IC50 (binding) | = 0.49 uM | Inhibitory concentration in LXRSPA alpha binding assay | ChEMBL. | 16125384 |
IC50 (binding) | = 0.49 uM | Inhibitory concentration in LXRSPA alpha binding assay | ChEMBL. | 16125384 |
Induction (binding) | = 5.5 | TA max fold induction against LXR beta | ChEMBL. | 16125384 |
Induction (binding) | = 21.7 | TA max fold induction against LXR alpha | ChEMBL. | 16125384 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.