Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, beta 3 | Starlite/ChEMBL | References |
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, gamma 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131775 | All targets in OG5_131775 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | gamma-aminobutyric acid (GABA) A receptor, gamma 2 | 467 aa | 449 aa | 27.6 % |
Brugia malayi | excitatory GABA receptor EXP-1A | gamma-aminobutyric acid (GABA) A receptor, beta 3 | 473 aa | 441 aa | 29.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0349 | 0.7272 | 1 |
Echinococcus granulosus | peroxidasin | 0.0349 | 0.7272 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0349 | 0.7272 | 0.7272 |
Onchocerca volvulus | 0.0349 | 0.7272 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.7272 | 0.7272 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.7272 | 0.7272 |
Onchocerca volvulus | Peroxidase homolog | 0.0349 | 0.7272 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.7272 | 0.7272 |
Brugia malayi | Animal haem peroxidase family protein | 0.0349 | 0.7272 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.7272 | 0.7272 |
Brugia malayi | Animal haem peroxidase family protein | 0.0349 | 0.7272 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0349 | 0.7272 | 0.7272 |
Onchocerca volvulus | Peroxidasin homolog | 0.0349 | 0.7272 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.7272 | 0.7272 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.7272 | 0.7272 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.7272 | 0.7272 |
Onchocerca volvulus | Dual oxidase homolog | 0.0349 | 0.7272 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0738 | 0.0738 |
Brugia malayi | hypothetical protein | 0.0349 | 0.7272 | 1 |
Schistosoma mansoni | peroxidasin | 0.0349 | 0.7272 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0349 | 0.7272 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.7272 | 0.7272 |
Onchocerca volvulus | 0.0349 | 0.7272 | 0.5 | |
Onchocerca volvulus | 0.0349 | 0.7272 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.7272 | 0.7272 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.7272 | 0.7272 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.7272 | 0.7272 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.7272 | 0.7272 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.7272 | 0.7272 |
Brugia malayi | Animal haem peroxidase family protein | 0.0349 | 0.7272 | 1 |
Brugia malayi | Peroxidasin | 0.0349 | 0.7272 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0349 | 0.7272 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0349 | 0.7272 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0349 | 0.7272 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0349 | 0.7272 | 0.7272 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0349 | 0.7272 | 0.7272 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0349 | 0.7272 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.7272 | 0.7272 |
Schistosoma mansoni | peroxidasin | 0.0349 | 0.7272 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0349 | 0.7272 | 0.7272 |
Onchocerca volvulus | Peroxidasin homolog | 0.0349 | 0.7272 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (functional) | = -5 | Efficacy at GABAA alpha5-beta3-gamma2 receptor expressed in mouse fibroblast L(tk-) cells measured at 300 nM derived from at least three plates/day screened over a minimum of 2 days | ChEMBL. | 16162003 |
Efficacy (functional) | = 43 | Efficacy at GABAA alpha3-beta3-gamma2 receptor expressed in mouse fibroblast L(tk-) cells measured at 300 nM derived from at least three plates/day screened over a minimum of 2 days | ChEMBL. | 16162003 |
Ki (binding) | = 8.5 nM | Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in mouse fibroblast L(tk-) cells (30 min at 24 degrees C, pH 7.4) | ChEMBL. | 16162003 |
Ki (binding) | = 8.5 nM | Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in mouse fibroblast L(tk-) cells (30 min at 24 degrees C, pH 7.4) | ChEMBL. | 16162003 |
Ki (binding) | = 8.8 nM | Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast L(tk-) cells (30 min at 24 degrees C, pH 7.4) | ChEMBL. | 16162003 |
Ki (binding) | = 8.8 nM | Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast L(tk-) cells (30 min at 24 degrees C, pH 7.4) | ChEMBL. | 16162003 |
Ki (binding) | = 10.4 nM | Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast L(tk-) cells (30 min at 24 degrees C, pH 7.4) | ChEMBL. | 16162003 |
Ki (binding) | = 10.4 nM | Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast L(tk-) cells (30 min at 24 degrees C, pH 7.4) | ChEMBL. | 16162003 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.