Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0316 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.9092 | 0.0851 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0316 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0316 | 1 | 0.5 |
Brugia malayi | Peroxidasin | 0.0316 | 1 | 1 |
Onchocerca volvulus | 0.0316 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0316 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1491 | 0.1491 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.1491 | 0.1491 |
Brugia malayi | Animal haem peroxidase family protein | 0.0316 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0316 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Onchocerca volvulus | 0.0316 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0316 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0316 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0316 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0316 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0316 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0312 | 0.9796 | 0.7752 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1491 | 0.1491 |
Echinococcus granulosus | peroxidasin | 0.0316 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0316 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Onchocerca volvulus | 0.0316 | 1 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0316 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.3 nM | Inhibitory concentration against cloned human thyroid hormone receptor beta 1 | ChEMBL. | 16099653 |
IC50 (binding) | = 0.3 nM | Inhibitory concentration against cloned human thyroid hormone receptor beta 1 | ChEMBL. | 16099653 |
IC50 (binding) | = 4.3 nM | Inhibitory concentration against cloned human thyroid hormone receptor alpha 1 | ChEMBL. | 16099653 |
IC50 (binding) | = 4.3 nM | Inhibitory concentration against cloned human thyroid hormone receptor alpha 1 | ChEMBL. | 16099653 |
Selectivity (binding) | = 9 | Ratio of IC50 of thyroid hormone receptor alpha 1 to that of thyroid hormone receptor beta 1 | ChEMBL. | 16099653 |
Selectivity (binding) | = 9 | Ratio of IC50 of thyroid hormone receptor alpha 1 to that of thyroid hormone receptor beta 1 | ChEMBL. | 16099653 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.