TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 457.476 | Formula: C23H27N3O7
H donors: 5 H acceptors: 5 LogP: 1.47 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)[C@@H]1Cc2ccc(cc2)Oc2cc(C[C@H](C(=O)NC(C(=O)N1)[C@H](O)C)N)ccc2O
InChi: 1S/C23H27N3O7/c1-12(27)20-22(30)25-17(23(31)32-2)10-13-3-6-15(7-4-13)33-19-11-14(5-8-18(19)28)9-16(24)21(29)26-20/h3-8,11-12,16-17,20,27-28H,9-10,24H2,1-2H3,(H,25,30)(H,26,29)/t12-,16+,17+,20?/m1/s1
InChiKey: YURORGKOASJSBH-AZASIBJYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0172	0.0359
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0169	0.2171	0.433
Echinococcus multilocularis	neuropeptide receptor	0.0169	0.2171	0.212
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0048	0.0362	0.0754
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0039	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0139	0.0153
Leishmania major	cytochrome p450-like protein	0.0353	0.4928	1
Brugia malayi	follicle stimulating hormone receptor	0.0169	0.2171	0.433
Schistosoma mansoni	neuropeptide receptor	0.0169	0.2171	0.212
Schistosoma mansoni	survival motor neuron protein	0.0048	0.036	0.0297
Brugia malayi	neuropeptide F receptor	0.0169	0.2171	0.433
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0169	0.2171	0.212
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0139	0.0153
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0048	0.0362	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.2171	0.212
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0041	0.0246	0.0512
Onchocerca volvulus		0.0169	0.2171	0.7079
Schistosoma mansoni	hypothetical protein	0.0353	0.4928	0.4895
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0362	0.0612
Onchocerca volvulus		0.0052	0.0419	0.1192
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0311	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0419	0.0729
Onchocerca volvulus		0.0106	0.1227	0.3906
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0169	0.2171	0.212
Brugia malayi	Cytochrome P450 family protein	0.0353	0.4928	1
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0048	0.0362	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0183	0.2387	0.2337
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0048	0.0362	0.0612
Schistosoma mansoni	alpha glucosidase	0.0041	0.0246	0.0183
Brugia malayi	neuropeptide F receptor	0.0169	0.2171	0.433
Onchocerca volvulus		0.0052	0.0419	0.1192
Brugia malayi	Serotonin receptor	0.0169	0.2171	0.433
Onchocerca volvulus		0.0169	0.2171	0.7079
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Echinococcus multilocularis	allatostatin A receptor	0.0169	0.2171	0.212
Brugia malayi	hypothetical protein	0.0052	0.0419	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0419	0.0729
Echinococcus multilocularis	serotonin receptor	0.0169	0.2171	0.212
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0353	0.4928	1
Onchocerca volvulus		0.0169	0.2171	0.7079
Schistosoma mansoni	amine GPCR	0.0169	0.2171	0.212
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Schistosoma mansoni	neuropeptide F-like receptor	0.0169	0.2171	0.212
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Echinococcus granulosus	sodium and chloride dependent glycine	0.0269	0.3662	0.3631
Entamoeba histolytica	hypothetical protein	0.0048	0.0362	0.0255
Schistosoma mansoni	hypothetical protein	0.0169	0.2171	0.212
Plasmodium vivax	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0048	0.0362	0.8394
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0169	0.2171	0.212
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Echinococcus granulosus	hypothetical protein	0.0169	0.2171	0.2132
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0353	0.4928	1
Brugia malayi	putative neuropeptide receptor	0.0169	0.2171	0.433
Echinococcus granulosus	orexin receptor type 2	0.0169	0.2171	0.2132
Echinococcus multilocularis	dro:myosuppressin receptor	0.0169	0.2171	0.212
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0183	0.2387	0.2337
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0169	0.2171	0.433
Loa Loa (eye worm)	cytochrome P450 family protein	0.0353	0.4928	1
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0353	0.4928	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0169	0.2171	0.2132
Schistosoma mansoni	hypothetical protein	0.0169	0.2171	0.212
Brugia malayi	Melatonin receptor type 1A	0.0169	0.2171	0.433
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0345	0.4802	0.9734
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0048	0.0362	0.03
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0362	0.0612
Loa Loa (eye worm)	melatonin receptor type 1A	0.0169	0.2171	0.433
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1226	0.2388
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0353	0.4928	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0169	0.2171	0.212
Onchocerca volvulus		0.0169	0.2171	0.7079
Echinococcus multilocularis	neuropeptides capa receptor	0.0169	0.2171	0.212
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0052	0.0419	0.0729
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0065	0.0016
Echinococcus granulosus	tm gpcr rhodopsin	0.0539	0.7714	0.7703
Schistosoma mansoni	hypothetical protein	0.0034	0.0139	0.0075
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0033	0.0138	0.015
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0353	0.4928	1
Toxoplasma gondii	hypothetical protein	0.0052	0.0419	0.0729
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0353	0.4928	0.5
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0048	0.0362	0.0754
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.2171	0.212
Schistosoma mansoni	biogenic amine receptor	0.0169	0.2171	0.212
Echinococcus granulosus	rhodopsin orphan GPCR	0.0169	0.2171	0.2132
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0045	0.0311	0.0289
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0052	0.0419	0.0729
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0169	0.2171	0.212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0045	0.0311	0.0289
Plasmodium vivax	polyprenol reductase, putative	0.0048	0.0362	0.8394
Echinococcus multilocularis	g-protein coupled receptor	0.0169	0.2171	0.212
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0172	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Trichomonas vaginalis	set domain proteins, putative	0.0227	0.304	0.6331
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0172	0.0359
Brugia malayi	Dopamine receptor protein 1	0.0169	0.2171	0.433
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0052	0.0419	0.0357
Trypanosoma brucei	glucosidase, putative	0.0041	0.0246	0.0154
Schistosoma mansoni	neuropeptide receptor	0.0169	0.2171	0.212
Onchocerca volvulus		0.005	0.0378	0.1055
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0106	0.1226	0.2388
Schistosoma mansoni	biogenic amine receptor	0.0169	0.2171	0.212
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0169	0.2171	0.433
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0353	0.4928	1
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0353	0.4928	1
Brugia malayi	AKH receptor	0.0169	0.2171	0.433
Loa Loa (eye worm)	phosphatidylinositol 3	0.0045	0.0311	0.0506
Schistosoma mansoni	hypothetical protein	0.0034	0.0139	0.0075
Leishmania major	alpha glucosidase II subunit, putative	0.0041	0.0246	0.0154
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0353	0.4928	0.5
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0052	0.0419	0.0357
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0039	0.0081
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0246	0.0154
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0353	0.4928	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0169	0.2171	0.212
Onchocerca volvulus		0.0052	0.0419	0.1192
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0139	0.009
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.0723	0.1353
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0169	0.2171	0.212
Echinococcus granulosus	neuropeptide Y receptor	0.0169	0.2171	0.2132
Echinococcus multilocularis	g protein coupled receptor	0.0169	0.2171	0.212
Echinococcus granulosus	biogenic amine 5HT receptor	0.0169	0.2171	0.2132
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0353	0.4928	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0169	0.2171	0.2132
Onchocerca volvulus		0.0169	0.2171	0.7079
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0138	0.0286
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0138	0.0286
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0169	0.2171	0.2132
Schistosoma mansoni	opsin-like receptor	0.0169	0.2171	0.212
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0052	0.0419	0.0357
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0353	0.4928	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0353	0.4928	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0169	0.2171	0.212
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.0246	0.0512
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0052	0.0419	0.0729
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0169	0.2171	0.2132
Brugia malayi	hypothetical protein	0.0169	0.2171	0.433
Echinococcus granulosus	g-protein coupled receptor	0.0169	0.2171	0.2132
Echinococcus multilocularis	g protein coupled receptor	0.0169	0.2171	0.212
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.3187	0.3143
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0048	0.0362	0.0754
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Echinococcus granulosus	G protein coupled receptor 139	0.0169	0.2171	0.2132
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0169	0.2171	0.212
Plasmodium vivax	hypothetical protein, conserved	0.0052	0.0419	1
Echinococcus granulosus	allatostatin A receptor	0.0169	0.2171	0.2132
Schistosoma mansoni	amine GPCR	0.0169	0.2171	0.212
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0169	0.2171	0.212
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.2171	0.212
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0169	0.2171	0.212
Echinococcus multilocularis	g protein coupled receptor	0.0169	0.2171	0.212
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0353	0.4928	0.5
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0419	0.0729
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0169	0.2171	0.433
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0353	0.4928	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0169	0.2171	0.433
Echinococcus granulosus	fmrfamide receptor	0.0169	0.2171	0.2132
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0048	0.0362	0.03
Onchocerca volvulus		0.0169	0.2171	0.7079
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0353	0.4928	1
Brugia malayi	hypothetical protein	0.0169	0.2171	0.433
Echinococcus granulosus	lysosomal alpha glucosidase	0.0183	0.2387	0.2349
Onchocerca volvulus		0.0169	0.2171	0.7079
Onchocerca volvulus		0.0169	0.2171	0.7079
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0353	0.4928	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0169	0.2171	0.2132
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0169	0.2171	0.212
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0311	0.0647
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0169	0.2171	0.212
Schistosoma mansoni	neuropeptide f receptor 76f	0.0169	0.2171	0.212
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0353	0.4928	0.5
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0041	0.0246	0.0183
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0139	0.0075
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0353	0.4928	1
Onchocerca volvulus		0.0169	0.2171	0.7079
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0353	0.4928	0.5
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Schistosoma mansoni	sodium/chloride dependent transporter	0.0052	0.0419	0.0357
Brugia malayi	hypothetical protein	0.0169	0.2171	0.433
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0353	0.4928	0.5
Echinococcus granulosus	g protein coupled receptor	0.0169	0.2171	0.2132
Brugia malayi	sulfakinin receptor protein	0.0169	0.2171	0.433
Echinococcus granulosus	neuropeptides capa receptor	0.0169	0.2171	0.2132
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0169	0.2171	0.212
Schistosoma mansoni	amine GPCR	0.0169	0.2171	0.212
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0169	0.2171	0.212
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0353	0.4928	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0169	0.2171	0.2132
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0353	0.4928	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0169	0.2171	0.212
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0345	0.4802	0.974
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.3187	0.3154
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0169	0.2171	0.212
Schistosoma mansoni	neuropeptide receptor	0.0169	0.2171	0.212
Loa Loa (eye worm)	norepinephrine transporter	0.0052	0.0419	0.0729
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0169	0.2171	0.212
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0169	0.2171	0.433
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Brugia malayi	GnHR receptor homolog	0.0169	0.2171	0.433
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0169	0.2171	0.2132
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0353	0.4928	0.5
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0269	0.3662	0.7396
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0045	0.0311	0.0142
Brugia malayi	Dopamine receptor protein 2	0.0169	0.2171	0.433
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0139	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0419	0.0729
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0169	0.2171	0.212
Echinococcus granulosus	7tm_1 domain containing protein	0.0169	0.2171	0.2132
Echinococcus multilocularis	serotonin transporter	0.0052	0.0419	0.0357
Onchocerca volvulus		0.0227	0.304	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0169	0.2171	0.212
Echinococcus granulosus	rhodopsin orphan GPCR	0.0169	0.2171	0.2132
Schistosoma mansoni	hypothetical protein	0.0034	0.0139	0.0075
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0045	0.0311	0.0289
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0035	0.0073
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0052	0.0419	0.0372
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0353	0.4928	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0052	0.0419	0.0372
Trypanosoma cruzi	cytochrome P450, putative	0.0353	0.4928	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0106	0.1226	0.2388
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0045	0.0311	0.0142
Echinococcus multilocularis	neuropeptide Y receptor	0.0169	0.2171	0.212
Brugia malayi	G-protein coupled receptor	0.0169	0.2171	0.433
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.0246	0.0512
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0169	0.2171	0.212
Onchocerca volvulus		0.0169	0.2171	0.7079
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0052	0.0419	0.0729
Brugia malayi	G protein-coupled receptor	0.0169	0.2171	0.433
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.2171	0.212
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.2171	0.212
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0169	0.2171	0.433
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0052	0.0419	0.0357
Echinococcus granulosus	neuropeptide Y receptor	0.0169	0.2171	0.2132
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0212	0.0441
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0353	0.4928	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0169	0.2171	0.212
Brugia malayi	putative neuropeptide receptor NPR1	0.0169	0.2171	0.433
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0045	0.0311	0.0506
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0353	0.4928	1
Brugia malayi	hypothetical protein	0.0169	0.2171	0.433
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0183	0.2387	0.4775
Loa Loa (eye worm)	G-protein coupled receptor	0.0169	0.2171	0.433
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0311	0.0647
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0048	0.0362	0.0398
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0169	0.2171	0.2132
Loa Loa (eye worm)	serotonin transporter b	0.0052	0.0419	0.0729
Brugia malayi	Cytochrome P450 family protein	0.0353	0.4928	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0169	0.2171	0.212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0045	0.0311	0.0263
Loa Loa (eye worm)	cytochrome P450 family protein	0.0353	0.4928	1
Schistosoma mansoni	myosin xvIII	0.0169	0.2171	0.212
Loa Loa (eye worm)	TYRA-2 protein	0.0169	0.2171	0.433
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0353	0.4928	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0052	0.0419	0.0357
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.2171	0.212
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0041	0.0246	0.0512
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0045	0.0311	0.0248
Echinococcus multilocularis	serotonin receptor	0.0169	0.2171	0.212
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Leishmania major	cytochrome p450-like protein	0.0353	0.4928	1
Toxoplasma gondii	hypothetical protein	0.0052	0.0419	0.0729
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0106	0.1226	0.2388
Echinococcus granulosus	neuropeptides capa receptor	0.0169	0.2171	0.2132
Onchocerca volvulus		0.0048	0.036	0.0993
Echinococcus multilocularis	somatostatin receptor	0.0169	0.2171	0.212
Echinococcus granulosus	dro:myosuppressin receptor	0.0169	0.2171	0.2132
Giardia lamblia	Synaptic glycoprotein SC2	0.0048	0.0362	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0045	0.0311	0.0289
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0353	0.4928	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0183	0.2387	0.4775
Echinococcus granulosus	somatostatin receptor	0.0169	0.2171	0.2132
Brugia malayi	G protein-coupled receptor F59B2.13	0.0169	0.2171	0.433
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0052	0.0419	0.0729
Echinococcus multilocularis	microtubule associated protein 2	0.0691	1	1
Onchocerca volvulus		0.0169	0.2171	0.7079
Echinococcus granulosus	neuropeptide FF receptor 2	0.0169	0.2171	0.2132
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0169	0.2171	0.212
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0169	0.2171	0.433
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.2171	0.212
Schistosoma mansoni	amine GPCR	0.0169	0.2171	0.212
Onchocerca volvulus		0.0169	0.2171	0.7079
Brugia malayi	larval opioid receptor	0.0169	0.2171	0.433
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0169	0.2171	0.212
Brugia malayi	hypothetical protein	0.0169	0.2171	0.433
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0169	0.2171	0.2132
Onchocerca volvulus		0.0169	0.2171	0.7079
Loa Loa (eye worm)	cytochrome P450	0.0353	0.4928	1
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0353	0.4928	0.5
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0169	0.2171	0.7079
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0353	0.4928	0.5
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0353	0.4928	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0246	0.0154
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0353	0.4928	0.5
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0041	0.0246	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Mycobacterium leprae	putative cytochrome p450	0.0353	0.4928	0.5
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.036	0.0607
Brugia malayi	3-oxo-5-alpha-steroid 4-dehydrogenase 1	0.0345	0.4802	0.974
Echinococcus granulosus	g protein coupled receptor	0.0169	0.2171	0.2132
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Onchocerca volvulus		0.0048	0.0362	0.1
Loa Loa (eye worm)	hypothetical protein	0.0237	0.3187	0.642
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0378	0.0316
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0345	0.4802	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0169	0.2171	0.212
Trypanosoma brucei	cytochrome P450, putative	0.0353	0.4928	1
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0345	0.4802	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0052	0.0419	0.5
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3662	0.7396
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0052	0.0419	0.0372
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0539	0.7714	0.7699
Echinococcus multilocularis	sex peptide receptor	0.0169	0.2171	0.212
Echinococcus granulosus	neutral alpha glucosidase AB	0.0041	0.0246	0.0198
Brugia malayi	Dopamine receptor	0.0169	0.2171	0.433
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.0246	0.0512
Echinococcus multilocularis	orexin receptor type 2	0.0169	0.2171	0.212
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.0246	0.0512
Plasmodium falciparum	transporter, putative	0.0052	0.0419	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0035	0.0073
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0169	0.2171	0.212
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0169	0.2171	0.212
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0052	0.0419	0.0357
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0052	0.0419	0.0357
Brugia malayi	hypothetical protein	0.0169	0.2171	0.433
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0269	0.3662	0.3621
Echinococcus multilocularis	neuropeptides capa receptor	0.0169	0.2171	0.212
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0345	0.4802	0.9734
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0169	0.2171	0.212
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0353	0.4928	0.5
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0353	0.4928	1
Schistosoma mansoni	hypothetical protein	0.0073	0.0723	0.0663
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0169	0.2171	0.212
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0269	0.3662	0.7396
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0169	0.2171	0.212
Echinococcus granulosus	synaptic glycoprotein sc2	0.0048	0.0362	0.0315
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0139	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Echinococcus granulosus	sex peptide receptor	0.0169	0.2171	0.2132
Brugia malayi	hypothetical protein	0.0169	0.2171	0.433
Schistosoma mansoni	opsin-like receptor	0.0169	0.2171	0.212
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0052	0.0419	0.0729
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.2171	0.212
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0172	0.0359
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0353	0.4928	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.2171	0.212
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative	0.0345	0.4802	0.9734
Plasmodium vivax	amine transporter, putative	0.0052	0.0419	1
Echinococcus granulosus	tumor protein p63	0.0338	0.471	0.4685
Loa Loa (eye worm)	G-protein coupled receptor	0.0169	0.2171	0.433
Onchocerca volvulus		0.0169	0.2171	0.7079
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0052	0.0419	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0139	0.009
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0169	0.2171	0.433
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3662	0.7396
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0041	0.0246	0.0373
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0169	0.2171	0.212
Schistosoma mansoni	neuropeptide receptor	0.0169	0.2171	0.212
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0353	0.4928	0.5
Schistosoma mansoni	adenoreceptor	0.0169	0.2171	0.212
Echinococcus multilocularis		0.0353	0.4928	0.4895
Entamoeba histolytica	trans-2,3-enoyl-CoA reductase, putative	0.0048	0.0362	0.0255
Loa Loa (eye worm)	neuropeptide F receptor	0.0169	0.2171	0.433
Schistosoma mansoni	histamine h1 receptor	0.0169	0.2171	0.212
Echinococcus granulosus	3 oxo 5 alpha steroid 4 dehydrogenase C terminal	0.0048	0.0362	0.0315
Schistosoma mansoni	sodium/chloride dependent transporter	0.0269	0.3662	0.3621
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0052	0.0419	0.0357
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0041	0.0246	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0723	0.1353
Echinococcus granulosus	neuropeptide receptor A26	0.0169	0.2171	0.2132
Brugia malayi	hypothetical protein	0.0237	0.3187	0.642
Schistosoma mansoni	cytochrome P450	0.0353	0.4928	0.4895
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0048	0.0362	0.0754
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0045	0.0311	0.0248
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0169	0.2171	0.212
Loa Loa (eye worm)	CYP4Cod1	0.0353	0.4928	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0169	0.2171	0.433
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0169	0.2171	0.212
Echinococcus granulosus	biogenic amine 5HT receptor	0.0169	0.2171	0.2132
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0353	0.4928	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0052	0.0419	0.0357
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0345	0.4802	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0074	0.0154
Echinococcus multilocularis	neuropeptide receptor A26	0.0169	0.2171	0.212
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0169	0.2171	0.212
Loa Loa (eye worm)	hypothetical protein	0.0345	0.4802	0.974
Echinococcus granulosus	rhodopsin orphan GPCR	0.0169	0.2171	0.2132
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0045	0.0311	0.0289
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0169	0.2171	0.2132
Brugia malayi	hypothetical protein	0.0169	0.2171	0.433
Echinococcus granulosus	sodium and chloride dependent glycine	0.0269	0.3662	0.3631
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0353	0.4928	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0138	0.0286
Echinococcus granulosus	g protein coupled receptor	0.0169	0.2171	0.2132
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0139	0.0075
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0362	0.0754
Echinococcus multilocularis	fmrfamide receptor	0.0169	0.2171	0.212
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0052	0.0419	0.0372
Leishmania major	cytochrome p450-like protein	0.0353	0.4928	1
Echinococcus multilocularis	fmrfamide receptor	0.0169	0.2171	0.212
Schistosoma mansoni	hypothetical protein	0.0034	0.0139	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0169	0.2171	0.7079
Brugia malayi	Serotonin receptor	0.0169	0.2171	0.433
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0045	0.0311	0.0289
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.0246	0.0512
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0169	0.2171	0.212
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0353	0.4928	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0169	0.2171	0.212
Brugia malayi	G-protein coupled receptor	0.0169	0.2171	0.433
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0353	0.4928	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0041	0.0246	0.0512
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0169	0.2171	0.2132
Echinococcus granulosus	rhodopsin orphan GPCR	0.0169	0.2171	0.2132
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Echinococcus granulosus	serotonin transporter	0.0052	0.0419	0.0372
Brugia malayi	hypothetical protein	0.0169	0.2171	0.433
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0169	0.2171	0.433
Echinococcus granulosus	rhodopsin orphan GPCR	0.0169	0.2171	0.2132
Schistosoma mansoni	hypothetical protein	0.0169	0.2171	0.212
Echinococcus multilocularis	tumor protein p63	0.0338	0.471	0.4676
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0052	0.0419	0.0357
Brugia malayi	hypothetical protein	0.0169	0.2171	0.433
Echinococcus multilocularis	neuropeptide receptor	0.0169	0.2171	0.212
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0138	0.0286
Echinococcus granulosus	neuropeptide receptor	0.0169	0.2171	0.2132
Schistosoma mansoni	biogenic amine receptor	0.0169	0.2171	0.212
Schistosoma mansoni	hypothetical protein	0.0169	0.2171	0.212
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0169	0.2171	0.2132
Echinococcus multilocularis	synaptic glycoprotein sc2	0.0048	0.0362	0.03
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0169	0.2171	0.212
Loa Loa (eye worm)	cytochrome P450 family protein	0.0353	0.4928	1
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0353	0.4928	1
Schistosoma mansoni	hypothetical protein	0.0048	0.036	0.0297
Echinococcus granulosus	rhodopsin orphan GPCR	0.0169	0.2171	0.2132
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0419	0.0729
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0199	0.2626	0.5268
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0172	0.0359
Echinococcus granulosus	cytochrome P450 2K1	0.0353	0.4928	0.4903
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0169	0.2171	0.212
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0353	0.4928	1
Plasmodium falciparum	amino acid transporter, putative	0.0052	0.0419	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0169	0.2171	0.212
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0353	0.4928	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0419	0.0729
Mycobacterium leprae	Conserved hypothetical protein	0.0353	0.4928	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0169	0.2171	0.2132
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0353	0.4928	0.5
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0052	0.0419	0.0729
Brugia malayi	RE15519p	0.0169	0.2171	0.433
Brugia malayi	Synaptic glycoprotein SC2	0.0048	0.0362	0.0612
Schistosoma mansoni	amine GPCR	0.0169	0.2171	0.212
Onchocerca volvulus		0.0169	0.2171	0.7079
Entamoeba histolytica	3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein	0.0048	0.0362	0.0255
Onchocerca volvulus		0.0169	0.2171	0.7079
Echinococcus granulosus	neuropeptide receptor	0.0169	0.2171	0.2132
Schistosoma mansoni	sodium/chloride dependent transporter	0.0269	0.3662	0.3621
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0169	0.2171	0.212
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0052	0.0419	0.0357
Brugia malayi	Pre-SET motif family protein	0.0199	0.2626	0.5268
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0169	0.2171	0.212
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0353	0.4928	0.5
Echinococcus multilocularis	3 oxo 5 alpha steroid 4 dehydrogenase, C terminal	0.0048	0.0362	0.03
Leishmania major	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	0.0345	0.4802	0.9734
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0139	0.0153
Schistosoma mansoni	opsin-like receptor	0.0169	0.2171	0.212
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Echinococcus granulosus	GPCR family 2	0.0034	0.0139	0.009
Schistosoma mansoni	microtubule-associated protein tau	0.0691	1	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0041	0.0246	0.0373
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0269	0.3662	0.3621
Echinococcus multilocularis	neuropeptide s receptor	0.0169	0.2171	0.212
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0039	0.0081
Treponema pallidum	sodium- and chloride- dependent transporter	0.0052	0.0419	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0138	0.0286
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0362	0.0754
Schistosoma mansoni	alpha-glucosidase	0.0158	0.2004	0.1952
Loa Loa (eye worm)	hypothetical protein	0.005	0.0378	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0419	0.0729
Brugia malayi	Cytochrome P450 family protein	0.0353	0.4928	1
Schistosoma mansoni	alpha-glucosidase	0.0158	0.2004	0.1952
Entamoeba histolytica	steroid 5-alpha reductase, putative	0.0345	0.4802	1
Echinococcus granulosus	serotonin receptor	0.0169	0.2171	0.2132
Brugia malayi	Cytochrome P450 family protein	0.0353	0.4928	1
Onchocerca volvulus		0.0052	0.0419	0.1192
Trypanosoma cruzi	cytochrome P450, putative	0.0353	0.4928	1
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0052	0.0419	0.0357
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0088	0.0184
Echinococcus multilocularis	G protein coupled receptor 139	0.0169	0.2171	0.212
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0052	0.0419	0.0729
Brugia malayi	ORL1-like opioid receptor	0.0169	0.2171	0.433
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0138	0.0286
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0052	0.0419	0.0729
Echinococcus granulosus	tm gpcr rhodopsin	0.0169	0.2171	0.2132
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0353	0.4928	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0169	0.2171	0.433
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0419	0.0729
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0138	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2171	0.433
Brugia malayi	cytochrome P450	0.0353	0.4928	1
Onchocerca volvulus		0.0169	0.2171	0.7079

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 13.5 uM	Inhibition of lipid droplets accumulation in mouse peritoneal macrophages as a model of macrophage-derived foam-cell formation	ChEMBL.	16054812

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 427655

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 343149