Detailed information for compound 343149

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 457.476 | Formula: C23H27N3O7
  • H donors: 5 H acceptors: 5 LogP: 1.47 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)[C@@H]1Cc2ccc(cc2)Oc2cc(C[C@H](C(=O)NC(C(=O)N1)[C@H](O)C)N)ccc2O
  • InChi: 1S/C23H27N3O7/c1-12(27)20-22(30)25-17(23(31)32-2)10-13-3-6-15(7-4-13)33-19-11-14(5-8-18(19)28)9-16(24)21(29)26-20/h3-8,11-12,16-17,20,27-28H,9-10,24H2,1-2H3,(H,25,30)(H,26,29)/t12-,16+,17+,20?/m1/s1
  • InChiKey: YURORGKOASJSBH-AZASIBJYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0345 0.4802 1
Onchocerca volvulus 0.0169 0.2171 0.7079
Onchocerca volvulus 0.0169 0.2171 0.7079
Schistosoma mansoni alpha-1 adrenergic receptor 0.0169 0.2171 0.212
Echinococcus multilocularis rhodopsin orphan GPCR 0.0169 0.2171 0.212
Schistosoma mansoni hypothetical protein 0.0169 0.2171 0.212
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0169 0.2171 0.2132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0169 0.2171 0.212
Giardia lamblia Synaptic glycoprotein SC2 0.0048 0.0362 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0169 0.2171 0.212
Schistosoma mansoni neuropeptide receptor 0.0169 0.2171 0.212
Loa Loa (eye worm) hypothetical protein 0.0073 0.0723 0.1353
Schistosoma mansoni alpha-glucosidase 0.0158 0.2004 0.1952
Echinococcus granulosus tachykinin peptides receptor 99D 0.0169 0.2171 0.2132
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Echinococcus multilocularis allatostatin A receptor 0.0169 0.2171 0.212
Echinococcus multilocularis rhodopsin orphan GPCR 0.0169 0.2171 0.212
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0169 0.2171 0.212
Schistosoma mansoni myosin xvIII 0.0169 0.2171 0.212
Echinococcus multilocularis serotonin transporter 0.0052 0.0419 0.0357
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0345 0.4802 0.9734
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0065 0.0016
Echinococcus multilocularis microtubule associated protein 2 0.0691 1 1
Echinococcus multilocularis neuropeptide receptor 0.0169 0.2171 0.212
Schistosoma mansoni neuropeptide f receptor 76f 0.0169 0.2171 0.212
Echinococcus granulosus synaptic glycoprotein sc2 0.0048 0.0362 0.0315
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0362 0.8394
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0052 0.0419 0.0729
Brugia malayi Melatonin receptor type 1A 0.0169 0.2171 0.433
Brugia malayi hypothetical protein 0.0169 0.2171 0.433
Mycobacterium leprae putative cytochrome p450 0.0353 0.4928 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0139 0.009
Echinococcus granulosus tm gpcr rhodopsin 0.0169 0.2171 0.2132
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0353 0.4928 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0169 0.2171 0.2132
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0353 0.4928 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0052 0.0419 0.0729
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0052 0.0419 0.0357
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0139 0.0153
Schistosoma mansoni histamine h1 receptor 0.0169 0.2171 0.212
Echinococcus granulosus g protein coupled receptor 0.0169 0.2171 0.2132
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0311 0.0142
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0052 0.0419 0.0729
Echinococcus multilocularis neuropeptide s receptor 0.0169 0.2171 0.212
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0353 0.4928 0.5
Echinococcus granulosus fmrfamide receptor 0.0169 0.2171 0.2132
Schistosoma mansoni amine GPCR 0.0169 0.2171 0.212
Echinococcus granulosus dro:myosuppressin receptor 0.0169 0.2171 0.2132
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0353 0.4928 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0212 0.0441
Schistosoma mansoni amine GPCR 0.0169 0.2171 0.212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0138 0.0286
Toxoplasma gondii cytochrome p450 superfamily protein 0.0353 0.4928 1
Onchocerca volvulus 0.0169 0.2171 0.7079
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0169 0.2171 0.2132
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0048 0.0362 0.03
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0246 0.0183
Schistosoma mansoni hypothetical protein 0.0073 0.0723 0.0663
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0353 0.4928 0.5
Echinococcus multilocularis somatostatin receptor 0.0169 0.2171 0.212
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0362 0.0754
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.3187 0.3143
Loa Loa (eye worm) hypothetical protein 0.0052 0.0419 0.0729
Leishmania major cytochrome p450-like protein 0.0353 0.4928 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0169 0.2171 0.212
Loa Loa (eye worm) cytochrome P450 family protein 0.0353 0.4928 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0052 0.0419 0.0357
Echinococcus granulosus rhodopsin orphan GPCR 0.0169 0.2171 0.2132
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0353 0.4928 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0169 0.2171 0.2132
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0246 0.0512
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0183 0.2387 0.4775
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Loa Loa (eye worm) cytochrome P450 family protein 0.0353 0.4928 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0311 0.0647
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0035 0.0073
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0048 0.0362 0.0255
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0353 0.4928 0.5
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Onchocerca volvulus 0.0169 0.2171 0.7079
Echinococcus multilocularis serotonin receptor 0.0169 0.2171 0.212
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0353 0.4928 1
Schistosoma mansoni adenoreceptor 0.0169 0.2171 0.212
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0139 0.0153
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0169 0.2171 0.212
Loa Loa (eye worm) cytochrome P450 family protein 0.0353 0.4928 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Loa Loa (eye worm) hypothetical protein 0.0052 0.0419 0.0729
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2171 0.212
Schistosoma mansoni biogenic amine receptor 0.0169 0.2171 0.212
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0345 0.4802 0.9734
Schistosoma mansoni sodium-dependent amino acid transporter 0.0052 0.0419 0.0357
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0353 0.4928 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0169 0.2171 0.2132
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0246 0.0512
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0048 0.0362 0.0255
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0246 0.0512
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0139 0.009
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Mycobacterium leprae Conserved hypothetical protein 0.0353 0.4928 0.5
Onchocerca volvulus 0.0052 0.0419 0.1192
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Entamoeba histolytica hypothetical protein 0.0048 0.0362 0.0255
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0311 0.0289
Loa Loa (eye worm) hypothetical protein 0.0034 0.0139 0.0153
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0353 0.4928 0.5
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0353 0.4928 1
Plasmodium vivax amine transporter, putative 0.0052 0.0419 1
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0048 0.0362 0.03
Loa Loa (eye worm) hypothetical protein 0.0237 0.3187 0.642
Loa Loa (eye worm) hypothetical protein 0.0052 0.0419 0.0729
Echinococcus multilocularis g protein coupled receptor 0.0169 0.2171 0.212
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0246 0.0154
Schistosoma mansoni sodium/chloride dependent transporter 0.0269 0.3662 0.3621
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0048 0.0362 0.03
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0169 0.2171 0.433
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0169 0.2171 0.212
Onchocerca volvulus 0.0052 0.0419 0.1192
Brugia malayi neuropeptide F receptor 0.0169 0.2171 0.433
Brugia malayi Glycosyl hydrolases family 31 protein 0.0183 0.2387 0.4775
Schistosoma mansoni amine GPCR 0.0169 0.2171 0.212
Echinococcus granulosus sodium and chloride dependent glycine 0.0269 0.3662 0.3631
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0311 0.0289
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0246 0.0512
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Brugia malayi Cytochrome P450 family protein 0.0353 0.4928 1
Plasmodium falciparum transporter, putative 0.0052 0.0419 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0353 0.4928 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0169 0.2171 0.212
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0246 0.0512
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0052 0.0419 0.0372
Onchocerca volvulus 0.0169 0.2171 0.7079
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0048 0.0362 0.0754
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0345 0.4802 0.974
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0311 0.0289
Onchocerca volvulus 0.0052 0.0419 0.1192
Echinococcus multilocularis sex peptide receptor 0.0169 0.2171 0.212
Onchocerca volvulus 0.0169 0.2171 0.7079
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0353 0.4928 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0169 0.2171 0.433
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0353 0.4928 0.5
Brugia malayi RE15519p 0.0169 0.2171 0.433
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Brugia malayi GnHR receptor homolog 0.0169 0.2171 0.433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0172 0.0359
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0052 0.0419 0.0372
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0169 0.2171 0.212
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0088 0.0184
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0353 0.4928 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0311 0.0506
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0311 0.0506
Echinococcus granulosus tumor protein p63 0.0338 0.471 0.4685
Onchocerca volvulus 0.0169 0.2171 0.7079
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0353 0.4928 0.5
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0362 0.0398
Loa Loa (eye worm) G-protein coupled receptor 0.0169 0.2171 0.433
Toxoplasma gondii hypothetical protein 0.0052 0.0419 0.0729
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2171 0.212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2171 0.212
Schistosoma mansoni biogenic amine (5HT) receptor 0.0169 0.2171 0.212
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0353 0.4928 0.5
Brugia malayi hypothetical protein 0.0237 0.3187 0.642
Brugia malayi Dopamine receptor protein 1 0.0169 0.2171 0.433
Onchocerca volvulus 0.0169 0.2171 0.7079
Echinococcus granulosus sodium and chloride dependent glycine 0.0269 0.3662 0.3631
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0246 0.0373
Echinococcus granulosus neuropeptide receptor A26 0.0169 0.2171 0.2132
Brugia malayi Cytochrome P450 family protein 0.0353 0.4928 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0353 0.4928 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0169 0.2171 0.2132
Loa Loa (eye worm) hypothetical protein 0.0106 0.1226 0.2388
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0169 0.2171 0.212
Trypanosoma cruzi cytochrome P450, putative 0.0353 0.4928 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0169 0.2171 0.212
Echinococcus granulosus serotonin receptor 0.0169 0.2171 0.2132
Schistosoma mansoni hypothetical protein 0.0034 0.0139 0.0075
Echinococcus granulosus biogenic amine 5HT receptor 0.0169 0.2171 0.2132
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0169 0.2171 0.2132
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0311 0.0248
Schistosoma mansoni neuropeptide receptor 0.0169 0.2171 0.212
Onchocerca volvulus 0.0169 0.2171 0.7079
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0378 0.0316
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.2387 0.2337
Plasmodium falciparum amino acid transporter, putative 0.0052 0.0419 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0378 0.0645
Echinococcus multilocularis neuropeptide Y receptor 0.0169 0.2171 0.212
Brugia malayi G-protein coupled receptor 0.0169 0.2171 0.433
Onchocerca volvulus 0.0169 0.2171 0.7079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0169 0.2171 0.212
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0169 0.2171 0.212
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0246 0.0512
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0052 0.0419 0.0357
Echinococcus granulosus g protein coupled receptor 0.0169 0.2171 0.2132
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0419 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0169 0.2171 0.2132
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Echinococcus granulosus peptide allatostatin:somatostatin 0.0169 0.2171 0.2132
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0311 0.0142
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0246 0.0154
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0169 0.2171 0.212
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0048 0.0362 0.0612
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0052 0.0419 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0362 0.0754
Echinococcus granulosus tm gpcr rhodopsin 0.0539 0.7714 0.7703
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0169 0.2171 0.212
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0169 0.2171 0.212
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0052 0.0419 0.0357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0172 0.0359
Schistosoma mansoni hypothetical protein 0.0034 0.0139 0.0075
Leishmania major cytochrome p450-like protein 0.0353 0.4928 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0169 0.2171 0.433
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0269 0.3662 0.7396
Schistosoma mansoni hypothetical protein 0.0169 0.2171 0.212
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0345 0.4802 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0169 0.2171 0.2132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0172 0.0359
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0169 0.2171 0.212
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0353 0.4928 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0169 0.2171 0.433
Brugia malayi Pre-SET motif family protein 0.0199 0.2626 0.5268
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0353 0.4928 1
Echinococcus multilocularis synaptic glycoprotein sc2 0.0048 0.0362 0.03
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Toxoplasma gondii hypothetical protein 0.0052 0.0419 0.0729
Loa Loa (eye worm) hypothetical protein 0.0269 0.3662 0.7396
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0353 0.4928 1
Schistosoma mansoni opsin-like receptor 0.0169 0.2171 0.212
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.2387 0.2337
Echinococcus granulosus g protein coupled receptor 0.0169 0.2171 0.2132
Leishmania major cytochrome p450-like protein 0.0353 0.4928 1
Echinococcus multilocularis fmrfamide receptor 0.0169 0.2171 0.212
Onchocerca volvulus 0.0048 0.036 0.0993
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0169 0.2171 0.212
Echinococcus granulosus neuropeptide receptor 0.0169 0.2171 0.2132
Echinococcus multilocularis sodium and chloride dependent glycine 0.0269 0.3662 0.3621
Echinococcus multilocularis neuropeptide receptor 0.0169 0.2171 0.212
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Echinococcus multilocularis orexin receptor type 2 0.0169 0.2171 0.212
Echinococcus granulosus cytochrome P450 2K1 0.0353 0.4928 0.4903
Echinococcus granulosus G protein coupled receptor 139 0.0169 0.2171 0.2132
Echinococcus granulosus rhodopsin orphan GPCR 0.0169 0.2171 0.2132
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0169 0.2171 0.433
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0052 0.0419 0.0357
Onchocerca volvulus 0.005 0.0378 0.1055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0138 0.0286
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0353 0.4928 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0138 0.0286
Schistosoma mansoni neuropeptide F-like receptor 0.0169 0.2171 0.212
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0345 0.4802 1
Brugia malayi hypothetical protein 0.0169 0.2171 0.433
Schistosoma mansoni cytochrome P450 0.0353 0.4928 0.4895
Loa Loa (eye worm) hypothetical protein 0.0052 0.0419 0.0729
Echinococcus granulosus allatostatin A receptor 0.0169 0.2171 0.2132
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0039 0.0081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2171 0.212
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0311 0.0289
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0353 0.4928 1
Brugia malayi putative neuropeptide receptor NPR1 0.0169 0.2171 0.433
Echinococcus multilocularis rhodopsin orphan GPCR 0.0169 0.2171 0.212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0138 0.0286
Schistosoma mansoni neuropeptide receptor 0.0169 0.2171 0.212
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.1226 0.2388
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0052 0.0419 0.0357
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0169 0.2171 0.212
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0048 0.0362 0.0315
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0362 0.0754
Schistosoma mansoni hypothetical protein 0.0034 0.0139 0.0075
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0169 0.2171 0.433
Echinococcus granulosus somatostatin receptor 0.0169 0.2171 0.2132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0169 0.2171 0.212
Echinococcus multilocularis tumor protein p63 0.0338 0.471 0.4676
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0169 0.2171 0.212
Schistosoma mansoni hypothetical protein 0.0169 0.2171 0.212
Echinococcus granulosus rhodopsin orphan GPCR 0.0169 0.2171 0.2132
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0052 0.0419 0.0372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0138 0.0286
Echinococcus multilocularis dro:myosuppressin receptor 0.0169 0.2171 0.212
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0353 0.4928 1
Schistosoma mansoni neuropeptide receptor 0.0169 0.2171 0.212
Echinococcus granulosus g-protein coupled receptor 0.0169 0.2171 0.2132
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0353 0.4928 0.5
Brugia malayi hypothetical protein 0.0169 0.2171 0.433
Schistosoma mansoni amine GPCR 0.0169 0.2171 0.212
Brugia malayi ORL1-like opioid receptor 0.0169 0.2171 0.433
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0169 0.2171 0.212
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Brugia malayi hypothetical protein 0.0169 0.2171 0.433
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Trypanosoma brucei cytochrome P450, putative 0.0353 0.4928 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0353 0.4928 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0139 0.0075
Echinococcus multilocularis neuropeptides capa receptor 0.0169 0.2171 0.212
Brugia malayi putative neuropeptide receptor 0.0169 0.2171 0.433
Brugia malayi cytochrome P450 0.0353 0.4928 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0052 0.0419 0.0357
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0169 0.2171 0.433
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0353 0.4928 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0169 0.2171 0.212
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0269 0.3662 0.7396
Onchocerca volvulus 0.0106 0.1227 0.3906
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0246 0.0373
Echinococcus multilocularis 0.0353 0.4928 0.4895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0311 0.0647
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0199 0.2626 0.5268
Schistosoma mansoni amine GPCR 0.0169 0.2171 0.212
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0246 0.0373
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0353 0.4928 1
Echinococcus granulosus orexin receptor type 2 0.0169 0.2171 0.2132
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0169 0.2171 0.433
Loa Loa (eye worm) serotonin transporter b 0.0052 0.0419 0.0729
Onchocerca volvulus 0.0048 0.0362 0.1
Loa Loa (eye worm) CYP4Cod1 0.0353 0.4928 1
Echinococcus multilocularis g protein coupled receptor 0.0169 0.2171 0.212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2171 0.212
Echinococcus granulosus GPCR family 2 0.0034 0.0139 0.009
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0353 0.4928 1
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0048 0.0362 0.0754
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0169 0.2171 0.212
Schistosoma mansoni hypothetical protein 0.0169 0.2171 0.212
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0138 0.0286
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Schistosoma mansoni hypothetical protein 0.0048 0.036 0.0297
Schistosoma mansoni microtubule-associated protein tau 0.0691 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0169 0.2171 0.433
Schistosoma mansoni sodium/chloride dependent transporter 0.0269 0.3662 0.3621
Echinococcus multilocularis fmrfamide receptor 0.0169 0.2171 0.212
Loa Loa (eye worm) cytochrome P450 0.0353 0.4928 1
Onchocerca volvulus 0.0169 0.2171 0.7079
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0246 0.0512
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0353 0.4928 0.5
Trichomonas vaginalis set domain proteins, putative 0.0227 0.304 0.6331
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0169 0.2171 0.433
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0311 0.0263
Trypanosoma brucei glucosidase, putative 0.0041 0.0246 0.0154
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0345 0.4802 0.9734
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.3187 0.3154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0039 0.0081
Schistosoma mansoni hypothetical protein 0.0353 0.4928 0.4895
Brugia malayi Tachykinin-like peptides receptor 99D 0.0169 0.2171 0.433
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Echinococcus granulosus lysosomal alpha glucosidase 0.0183 0.2387 0.2349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0172 0.0359
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.1226 0.2388
Schistosoma mansoni alpha-glucosidase 0.0158 0.2004 0.1952
Brugia malayi hypothetical protein 0.0052 0.0419 0.0729
Echinococcus multilocularis neuropeptides capa receptor 0.0169 0.2171 0.212
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Loa Loa (eye worm) hypothetical protein 0.0048 0.0362 0.0612
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0353 0.4928 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0169 0.2171 0.212
Loa Loa (eye worm) norepinephrine transporter 0.0052 0.0419 0.0729
Loa Loa (eye worm) hypothetical protein 0.0052 0.0419 0.0729
Onchocerca volvulus 0.0052 0.0419 0.1192
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0035 0.0073
Brugia malayi Dopamine receptor protein 2 0.0169 0.2171 0.433
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0246 0.0512
Brugia malayi hypothetical protein 0.0169 0.2171 0.433
Echinococcus granulosus neuropeptides capa receptor 0.0169 0.2171 0.2132
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0052 0.0419 0.0729
Schistosoma mansoni biogenic amine receptor 0.0169 0.2171 0.212
Loa Loa (eye worm) G-protein coupled receptor 0.0169 0.2171 0.433
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0353 0.4928 0.5
Onchocerca volvulus 0.0169 0.2171 0.7079
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0169 0.2171 0.2132
Echinococcus granulosus sex peptide receptor 0.0169 0.2171 0.2132
Schistosoma mansoni growth hormone secretagogue receptor 0.0169 0.2171 0.212
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0052 0.0419 0.0729
Brugia malayi follicle stimulating hormone receptor 0.0169 0.2171 0.433
Loa Loa (eye worm) neuropeptide F receptor 0.0169 0.2171 0.433
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0311 0.0289
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Echinococcus multilocularis g protein coupled receptor 0.0169 0.2171 0.212
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0169 0.2171 0.212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0039 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0311 0.0647
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0052 0.0419 0.0729
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0052 0.0419 0.0372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0074 0.0154
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2171 0.212
Echinococcus granulosus neuropeptide FF receptor 2 0.0169 0.2171 0.2132
Treponema pallidum sodium- and chloride- dependent transporter 0.0052 0.0419 0.5
Echinococcus multilocularis GPCR, family 2 0.0034 0.0139 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2171 0.212
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0169 0.2171 0.212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0311 0.0248
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0138 0.0286
Echinococcus granulosus rhodopsin orphan GPCR 0.0169 0.2171 0.2132
Onchocerca volvulus 0.0169 0.2171 0.7079
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0353 0.4928 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0169 0.2171 0.2132
Onchocerca volvulus 0.0227 0.304 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0052 0.0419 0.0357
Echinococcus multilocularis G-protein coupled receptor, putative 0.0169 0.2171 0.212
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0353 0.4928 1
Brugia malayi Serotonin receptor 0.0169 0.2171 0.433
Loa Loa (eye worm) neuropeptide F receptor 0.0169 0.2171 0.433
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0353 0.4928 0.5
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Onchocerca volvulus 0.0169 0.2171 0.7079
Onchocerca volvulus 0.0169 0.2171 0.7079
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0139 0.0075
Brugia malayi hypothetical protein 0.0169 0.2171 0.433
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0052 0.0419 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0169 0.2171 0.212
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0052 0.0419 0.0357
Echinococcus multilocularis sodium and chloride dependent glycine 0.0269 0.3662 0.3621
Schistosoma mansoni hypothetical protein 0.0034 0.0139 0.0075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0169 0.2171 0.212
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0246 0.0512
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0353 0.4928 0.5
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0353 0.4928 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0052 0.0419 0.0729
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.1226 0.2388
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Brugia malayi Serotonin receptor 0.0169 0.2171 0.433
Brugia malayi hypothetical protein 0.0169 0.2171 0.433
Echinococcus granulosus rhodopsin orphan GPCR 0.0169 0.2171 0.2132
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Echinococcus granulosus neuropeptide s receptor 0.0169 0.2171 0.2132
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0353 0.4928 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0169 0.2171 0.7079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0172 0.0359
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0362 0.0398
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0169 0.2171 0.433
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0169 0.2171 0.212
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0353 0.4928 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0419 0.0729
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Loa Loa (eye worm) hypothetical protein 0.0052 0.0419 0.0729
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0311 0.0289
Echinococcus granulosus hypothetical protein 0.0169 0.2171 0.2132
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0169 0.2171 0.7079
Echinococcus granulosus rhodopsin orphan GPCR 0.0169 0.2171 0.2132
Brugia malayi AKH receptor 0.0169 0.2171 0.433
Schistosoma mansoni opsin-like receptor 0.0169 0.2171 0.212
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0048 0.0362 0.0612
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2171 0.212
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0345 0.4802 0.9734
Brugia malayi G protein-coupled receptor 0.0169 0.2171 0.433
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.036 0.0607
Schistosoma mansoni alpha glucosidase 0.0041 0.0246 0.0183
Echinococcus multilocularis serotonin receptor 0.0169 0.2171 0.212
Brugia malayi sulfakinin receptor protein 0.0169 0.2171 0.433
Loa Loa (eye worm) TYRA-2 protein 0.0169 0.2171 0.433
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0052 0.0419 0.0729
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0052 0.0419 0.0729
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0052 0.0419 0.0357
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0353 0.4928 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0169 0.2171 0.433
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0052 0.0419 0.0357
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0048 0.0362 0.0754
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0353 0.4928 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0353 0.4928 1
Echinococcus multilocularis neuropeptide receptor A26 0.0169 0.2171 0.212
Brugia malayi Synaptic glycoprotein SC2 0.0048 0.0362 0.0612
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0353 0.4928 0.5
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0353 0.4928 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0169 0.2171 0.2132
Trypanosoma cruzi cytochrome P450, putative 0.0353 0.4928 1
Echinococcus multilocularis G protein coupled receptor 139 0.0169 0.2171 0.212
Brugia malayi hypothetical protein 0.0169 0.2171 0.433
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2171 0.212
Schistosoma mansoni biogenic amine receptor 0.0169 0.2171 0.212
Loa Loa (eye worm) hypothetical protein 0.0052 0.0419 0.0729
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0539 0.7714 0.7699
Brugia malayi Cytochrome P450 family protein 0.0353 0.4928 1
Brugia malayi G-protein coupled receptor 0.0169 0.2171 0.433
Echinococcus multilocularis neuropeptide Y receptor 0.0169 0.2171 0.212
Brugia malayi hypothetical protein 0.0169 0.2171 0.433
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0052 0.0419 0.0357
Loa Loa (eye worm) hypothetical protein 0.0345 0.4802 0.974
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0723 0.1353
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0169 0.2171 0.212
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0246 0.0154
Brugia malayi Dopamine receptor 0.0169 0.2171 0.433
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0345 0.4802 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0139 0.0153
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0169 0.2171 0.2132
Echinococcus granulosus neuropeptide receptor 0.0169 0.2171 0.2132
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0169 0.2171 0.212
Schistosoma mansoni biogenic amine (5HT) receptor 0.0169 0.2171 0.212
Brugia malayi neuropeptide F receptor 0.0169 0.2171 0.433
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0169 0.2171 0.212
Echinococcus multilocularis g-protein coupled receptor 0.0169 0.2171 0.212
Echinococcus granulosus neuropeptides capa receptor 0.0169 0.2171 0.2132
Echinococcus granulosus neuropeptide Y receptor 0.0169 0.2171 0.2132
Brugia malayi hypothetical protein 0.0169 0.2171 0.433
Plasmodium vivax polyprenol reductase, putative 0.0048 0.0362 0.8394
Loa Loa (eye worm) hypothetical protein 0.0269 0.3662 0.7396
Schistosoma mansoni survival motor neuron protein 0.0048 0.036 0.0297
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0353 0.4928 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433
Echinococcus granulosus serotonin transporter 0.0052 0.0419 0.0372
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0138 0.015
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0353 0.4928 0.5
Schistosoma mansoni opsin-like receptor 0.0169 0.2171 0.212
Onchocerca volvulus 0.0169 0.2171 0.7079
Brugia malayi Cytochrome P450 family protein 0.0353 0.4928 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0169 0.2171 0.212
Brugia malayi larval opioid receptor 0.0169 0.2171 0.433
Loa Loa (eye worm) hypothetical protein 0.0048 0.0362 0.0612
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0345 0.4802 0.974
Onchocerca volvulus 0.0169 0.2171 0.7079
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0246 0.0198
Loa Loa (eye worm) hypothetical protein 0.0169 0.2171 0.433

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 13.5 uM Inhibition of lipid droplets accumulation in mouse peritoneal macrophages as a model of macrophage-derived foam-cell formation ChEMBL. 16054812

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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