Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 10 (sodium/bile acid cotransporter), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0572 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0572 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0572 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0572 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0572 | 1 | 1 |
Onchocerca volvulus | 0.0572 | 1 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0572 | 1 | 1 |
Onchocerca volvulus | 0.0572 | 1 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0572 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0572 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0572 | 1 | 1 |
Onchocerca volvulus | 0.0572 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 7.14 % | Amount of the compound (dissolved in aqueous Tween-80) in bile of rat was determined by fecal bile acid content for 45 min in a 37 degree C | ChEMBL. | 16134951 |
Cmax (ADMET) | = 0 ug ml-1 | Maximum biliary concentration of the compound (dissolved in aqueous Tween-80) was determined on intragastric administration at 5-0.04 mg/kg in portal vein of rat gavage model | ChEMBL. | 16134951 |
Cmax (ADMET) | = 0 ug ml-1 | Maximum biliary concentration of the compound (dissolved in aqueous Tween-80) was determined on intragastric administration at 5-0.04 mg/kg in portal artery of rat gavage model | ChEMBL. | 16134951 |
Efficacy (ADMET) | 0 | Efficacy of the compound to increase fecal bile acid excretion; + is more efficacious | ChEMBL. | 16134951 |
IC50 (binding) | = 23 nM | In vitro inhibition of ASBT mediated uptake of [14C]-taurocholate (5 uM) in baby hamster cells expressing human IBAT | ChEMBL. | 16134951 |
IC50 (binding) | = 23 nM | In vitro inhibition of ASBT mediated uptake of [14C]-taurocholate (5 uM) in baby hamster cells expressing human IBAT | ChEMBL. | 16134951 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.