Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Flap structure-specific endonuclease | 0.0033 | 0.0101 | 0.5 |
Brugia malayi | Flap endonuclease-1 | 0.0033 | 0.0101 | 1 |
Mycobacterium tuberculosis | Possible L-lactate dehydrogenase (cytochrome) LldD2 | 0.0176 | 0.288 | 0.5 |
Echinococcus multilocularis | DNA repair protein complementing XP G cells | 0.0038 | 0.0196 | 1 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0033 | 0.0101 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0544 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0196 | 1 |
Entamoeba histolytica | isopentenyl-diphosphate delta-isomerase, putative | 0.0063 | 0.0692 | 1 |
Trypanosoma brucei | isopentenyl-diphosphate delta-isomerase (type II) | 0.0063 | 0.0692 | 0.0597 |
Leishmania major | isopentenyl-diphosphate delta-isomerase, putative,isomerase, putative | 0.0063 | 0.0692 | 1 |
Plasmodium vivax | DNA repair protein RAD2, putative | 0.0038 | 0.0196 | 1 |
Mycobacterium ulcerans | L-lactate dehydrogenase (cytochrome) LldD2 | 0.0176 | 0.288 | 1 |
Treponema pallidum | hypothetical protein | 0.0176 | 0.288 | 0.5 |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0038 | 0.0196 | 1 |
Echinococcus granulosus | DNA repair protein complementing XP G cells | 0.0038 | 0.0196 | 1 |
Schistosoma mansoni | xp-G/rad2 DNA repair endonuclease family | 0.0038 | 0.0196 | 0.0196 |
Plasmodium falciparum | DNA repair protein RAD2, putative | 0.0038 | 0.0196 | 1 |
Mycobacterium leprae | POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2 | 0.0176 | 0.288 | 0.5 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0038 | 0.0196 | 1 |
Entamoeba histolytica | DNA-repair protein, putative | 0.0038 | 0.0196 | 0.1608 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 40 % | Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells at 10 uM | ChEMBL. | 16134937 |
Inhibition (binding) | = 40 % | Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells at 10 uM | ChEMBL. | 16134937 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.