Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Hexokinase homolog | 0.0118 | 0.4537 | 0.2359 |
Loa Loa (eye worm) | hexokinase type II | 0.0188 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.285 | 0.285 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0096 | 0.285 | 0.285 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.285 | 0.285 |
Trypanosoma cruzi | hexokinase, putative | 0.0188 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0096 | 0.285 | 0.285 |
Plasmodium vivax | hexokinase, putative | 0.0188 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0188 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0188 | 1 | 1 |
Onchocerca volvulus | 0.0188 | 1 | 1 | |
Echinococcus granulosus | hexokinase type 2 | 0.0188 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0096 | 0.285 | 0.285 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0096 | 0.285 | 0.285 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.5339 | 0.5339 |
Leishmania major | hexokinase, putative | 0.0188 | 1 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0096 | 0.285 | 0.285 |
Onchocerca volvulus | 0.0188 | 1 | 1 | |
Echinococcus multilocularis | hexokinase | 0.0188 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0096 | 0.285 | 0.285 |
Plasmodium falciparum | hexokinase | 0.0188 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0096 | 0.285 | 0.285 |
Loa Loa (eye worm) | hexokinase | 0.0188 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.285 | 0.285 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.285 | 0.285 |
Trypanosoma cruzi | hexokinase, putative | 0.0188 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0096 | 0.285 | 0.285 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0096 | 0.285 | 0.285 |
Brugia malayi | Hexokinase family protein | 0.0188 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0188 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0188 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0188 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0188 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0188 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0188 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.285 | 0.285 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0096 | 0.285 | 0.285 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.285 | 0.285 |
Onchocerca volvulus | 0.0118 | 0.4537 | 0.2359 | |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0096 | 0.285 | 0.285 |
Toxoplasma gondii | hexokinase | 0.0188 | 1 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0096 | 0.285 | 0.285 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0096 | 0.285 | 0.285 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0096 | 0.285 | 0.285 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0096 | 0.285 | 0.285 |
Echinococcus granulosus | hexokinase | 0.0188 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0096 | 0.285 | 0.285 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0096 | 0.285 | 0.285 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0096 | 0.285 | 0.285 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0096 | 0.285 | 0.285 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.285 | 0.285 |
Loa Loa (eye worm) | hexokinase | 0.0118 | 0.4537 | 0.4537 |
Entamoeba histolytica | hexokinase 2 | 0.0188 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0118 | 0.4537 | 0.4537 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0096 | 0.285 | 0.285 |
Echinococcus multilocularis | hexokinase | 0.0188 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0096 | 0.285 | 0.285 |
Onchocerca volvulus | 0.0188 | 1 | 1 | |
Loa Loa (eye worm) | steroid hormone receptor | 0.0096 | 0.285 | 0.285 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0096 | 0.285 | 0.285 |
Echinococcus multilocularis | hexokinase type 2 | 0.0188 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0096 | 0.285 | 0.285 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0096 | 0.285 | 0.285 |
Leishmania major | hexokinase, putative | 0.0188 | 1 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0096 | 0.285 | 0.285 |
Trypanosoma brucei | hexokinase, putative | 0.0188 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0096 | 0.285 | 0.285 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0096 | 0.285 | 0.285 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.285 | 0.285 |
Trypanosoma brucei | hexokinase | 0.0188 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.337 | Induction of apoptosis in human T47D cells | ChEMBL. | 17870538 |
EC50 (functional) | = 0.042 uM | Effective concentration against human breast cancer T47D cell line apoptosis inducing activity was measured by using cell and caspase-based HTS assay | ChEMBL. | 16143530 |
EC50 (functional) | = 0.042 uM | Effective concentration against human breast cancer T47D cell line apoptosis inducing activity was measured by using cell and caspase-based HTS assay | ChEMBL. | 16143530 |
EC50 (functional) | = 0.087 uM | Effective concentration against human non-small cell lung cancer H1299 cells inducing apoptosis, activity was measured by cell and caspase-based HTS assay | ChEMBL. | 16143530 |
EC50 (functional) | = 0.087 uM | Effective concentration against human non-small cell lung cancer H1299 cells inducing apoptosis, activity was measured by cell and caspase-based HTS assay | ChEMBL. | 16143530 |
Log (1/C) (functional) | = 7.38 | Induction of apoptosis in human HL60 B cells | ChEMBL. | 17658263 |
log(1/EC50) (functional) | = 1.337 | Induction of apoptosis in human T47D cells | ChEMBL. | 17870538 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 16143530 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.