TDR Targets

Basic information

Technical information

TDR Targets ID: 343513
Name: (3Z)-5-(2,2-dimethylpropoxymethyl)-5-(hydroxy methyl)-3-[5-methyl-3-(2-methylpropyl)hexylid ene]oxolan-2-one
MW: 368.551 | Formula: C22H40O4
H donors: 1 H acceptors: 2 LogP: 5.66 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: OCC1(COCC(C)(C)C)OC(=O)/C(=C\CC(CC(C)C)CC(C)C)/C1
InChi: 1S/C22H40O4/c1-16(2)10-18(11-17(3)4)8-9-19-12-22(13-23,26-20(19)24)15-25-14-21(5,6)7/h9,16-18,23H,8,10-15H2,1-7H3/b19-9-
InChiKey: OEXHUZRSQNHBKQ-OCKHKDLRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3Z)-5-(2,2-dimethylpropoxymethyl)-5-(hydroxymethyl)-3-(3-isobutyl-5-methyl-hexylidene)tetrahydrofuran-2-one
(3Z)-5-(2,2-dimethylpropoxymethyl)-5-(hydroxymethyl)-3-(3-isobutyl-5-methylhexylidene)-2-tetrahydrofuranone
(3Z)-3-(3-isobutyl-5-methyl-hexylidene)-5-methylol-5-(neopentyloxymethyl)tetrahydrofuran-2-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase C, alpha	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, delta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Onchocerca volvulus		Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Brugia malayi	Protein kinase c protein 2	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Schistosoma japonicum	Protein kinase C gamma type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	Protein kinase C, brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	Protein kinase C brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	telomerase reverse transcriptase subunit	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	protein kinase C gamma type	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Calcium-dependent protein kinase C, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	serine threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	follicle stimulating hormone receptor	0.0025	0.0099	0.0385
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0119	0.574	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0025	0.0099	0.0251
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.0099	0.0251
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0099	0.013
Schistosoma mansoni	hypothetical protein	0.0025	0.0099	0.013
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Schistosoma mansoni	myosin xvIII	0.0025	0.0099	0.013
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0099	0.013
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0099	0.0251
Brugia malayi	hypothetical protein	0.0025	0.0099	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Echinococcus multilocularis	protein kinase c epsilon type	0.0041	0.1076	0.2736
Brugia malayi	Dopamine receptor protein 1	0.0025	0.0099	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Schistosoma mansoni	serine/threonine protein kinase	0.0041	0.1076	0.142
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0107	0.5024	0.8342
Schistosoma mansoni	amine GPCR	0.0025	0.0099	0.013
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0099	0.013
Echinococcus multilocularis	sex peptide receptor	0.0025	0.0099	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0099	0.0251
Entamoeba histolytica	hypothetical protein	0.0036	0.0747	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0099	0.013
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0747	0.1899
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0025	0.0099	0.0099
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0025	0.0099	0.0385
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.0099	0.0251
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0099	0.0251
Brugia malayi	G-protein coupled receptor	0.0025	0.0099	0.0385
Schistosoma mansoni	hypothetical protein	0.0025	0.0099	0.013
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0099	0.0251
Echinococcus granulosus	allatostatin A receptor	0.0025	0.0099	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Brugia malayi	protein kinase C II.	0.0041	0.1076	0.4188
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Brugia malayi	hypothetical protein	0.0025	0.0099	0.0385
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0025	0.0099	0.013
Trichomonas vaginalis	AGC family protein kinase	0.0023	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0099	0.0251
Schistosoma mansoni	serine/threonine protein kinase	0.0089	0.3934	0.519
Brugia malayi	putative neuropeptide receptor	0.0025	0.0099	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Brugia malayi	Melatonin receptor type 1A	0.0025	0.0099	0.0385
Schistosoma mansoni	hypothetical protein	0.0036	0.0747	0.0986
Loa Loa (eye worm)	hypothetical protein	0.0167	0.8606	0.8606
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0025	0.0099	0.0099
Brugia malayi	Serotonin receptor	0.0025	0.0099	0.0385
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0107	0.5024	0.8342
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0025	0.0099	0.0251
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0099	0.0251
Brugia malayi	Protein kinase c protein 2	0.0066	0.257	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0025	0.0099	0.0251
Trichomonas vaginalis	AGC family protein kinase	0.0023	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0023	0	0.5
Trypanosoma brucei	trypanothione reductase	0.0047	0.142	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Brugia malayi	larval opioid receptor	0.0025	0.0099	0.0385
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.005	0.1584	0.1584
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0025	0.0099	0.0385
Trichomonas vaginalis	AGC family protein kinase	0.0023	0	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0025	0.0099	0.0385
Schistosoma mansoni	adenoreceptor	0.0025	0.0099	0.013
Echinococcus multilocularis	somatostatin receptor	0.0025	0.0099	0.0251
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0025	0.0099	0.0251
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.0099	0.013
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0099	0.0099
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0025	0.0099	0.0251
Brugia malayi	hypothetical protein	0.0025	0.0099	0.0385
Brugia malayi	hypothetical protein	0.0025	0.0099	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0099	0.0251
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.0099	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Brugia malayi	hypothetical protein	0.0025	0.0099	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0099	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0099	0.0099
Trichomonas vaginalis	AGC family protein kinase	0.0023	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0099	0.0251
Brugia malayi	Dopamine receptor protein 2	0.0025	0.0099	0.0385
Echinococcus multilocularis	protein kinase c iota type	0.004	0.0985	0.2505
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0099	0.0251
Brugia malayi	neuropeptide F receptor	0.0025	0.0099	0.0385
Leishmania major	trypanothione reductase	0.0047	0.142	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0025	0.0099	0.0251
Trichomonas vaginalis	AGC family protein kinase	0.0023	0	0.5
Brugia malayi	Dopamine receptor	0.0025	0.0099	0.0385
Brugia malayi	glutathione reductase	0.0047	0.142	0.5524
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0025	0.0099	0.013
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.0099	0.0251
Schistosoma mansoni	opsin-like receptor	0.0025	0.0099	0.013
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0025	0.0099	0.013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0099	0.013
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0099	0.0251
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0025	0.0099	0.0251
Loa Loa (eye worm)	glutathione reductase	0.0047	0.142	0.142
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0025	0.0099	0.013
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0025	0.0099	0.013
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0025	0.0099	0.0251
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0099	0.0251
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0099	0.013
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1463	0.1463
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0025	0.0099	0.0251
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0747	0.1899
Brugia malayi	G-protein coupled receptor	0.0025	0.0099	0.0385
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.0099	0.0251
Trichomonas vaginalis	AGC family protein kinase	0.0023	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0099	0.013
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0099	0.013
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0025	0.0099	0.013
Echinococcus granulosus	Protein kinase C brain isozyme	0.0089	0.3934	1
Brugia malayi	Thioredoxin reductase	0.0047	0.142	0.5524
Trichomonas vaginalis	AGC family protein kinase	0.0023	0	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0025	0.0099	0.0251
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.0099	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Entamoeba histolytica	hypothetical protein	0.0036	0.0747	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0025	0.0099	0.0251
Trichomonas vaginalis	AGC family protein kinase	0.0023	0	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0025	0.0099	0.0385
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.142	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0099	0.013
Echinococcus multilocularis	serotonin receptor	0.0025	0.0099	0.0251
Mycobacterium tuberculosis	Probable reductase	0.0107	0.5024	0.8342
Onchocerca volvulus		0.0167	0.8606	1
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0089	0.3934	1
Brugia malayi	RE15519p	0.0025	0.0099	0.0385
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0099	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0747	0.0986
Echinococcus granulosus	somatostatin receptor	0.0025	0.0099	0.0251
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0099	0.0251
Schistosoma mansoni	atypical protein kinase C	0.004	0.0985	0.13
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.142	0.142
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0099	0.0251
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0099	0.0251
Echinococcus granulosus	neuropeptide FF receptor 2	0.0025	0.0099	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Echinococcus granulosus	protein kinase c epsilon type	0.0041	0.1076	0.2736
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0025	0.0099	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0167	0.8606	0.8606
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0025	0.0099	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Brugia malayi	hypothetical protein	0.0025	0.0099	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Echinococcus granulosus	7tm_1 domain containing protein	0.0025	0.0099	0.0251
Brugia malayi	AKH receptor	0.0025	0.0099	0.0385
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.142	0.3609
Plasmodium falciparum	thioredoxin reductase	0.0047	0.142	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0099	0.0099
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0025	0.0099	0.0251
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0099	0.0251
Brugia malayi	Serotonin receptor	0.0025	0.0099	0.0385
Echinococcus multilocularis	dro:myosuppressin receptor	0.0025	0.0099	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.0099	0.013
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0099	0.0251
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0099	0.013
Loa Loa (eye worm)	TYRA-2 protein	0.0025	0.0099	0.0099
Schistosoma mansoni	histamine h1 receptor	0.0025	0.0099	0.013
Echinococcus granulosus	hypothetical protein	0.0025	0.0099	0.0251
Schistosoma mansoni	neuropeptide f receptor 76f	0.0025	0.0099	0.013
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0025	0.0099	0.0099
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0107	0.5024	0.8342
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0099	0.0251
Schistosoma mansoni	amine GPCR	0.0025	0.0099	0.013
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Schistosoma mansoni	amine GPCR	0.0025	0.0099	0.013
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0025	0.0099	0.0385
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0119	0.574	1
Echinococcus multilocularis	serine threonine protein kinase	0.0072	0.2948	0.7495
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0099	0.013
Entamoeba histolytica	hypothetical protein	0.0036	0.0747	1
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.0099	0.0251
Echinococcus granulosus	protein kinase c iota type	0.004	0.0985	0.2505
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0099	0.0251
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0099	0.0251
Brugia malayi	neuropeptide F receptor	0.0025	0.0099	0.0385
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0099	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0099	0.0251
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0099	0.013
Mycobacterium tuberculosis	Probable oxidoreductase	0.0119	0.574	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Brugia malayi	hypothetical protein	0.0025	0.0099	0.0385
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0048	0.1463	0.372
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.0099	0.013
Schistosoma mansoni	hypothetical protein	0.0025	0.0099	0.013
Echinococcus multilocularis	serotonin receptor	0.0025	0.0099	0.0251
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0041	0.1076	0.1076
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0099	0.0251
Brugia malayi	hypothetical protein	0.0025	0.0099	0.0385
Entamoeba histolytica	hypothetical protein	0.0036	0.0747	1
Brugia malayi	sulfakinin receptor protein	0.0025	0.0099	0.0385
Trichomonas vaginalis	AGC family protein kinase	0.0023	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0099	0.013
Echinococcus multilocularis	G protein coupled receptor 139	0.0025	0.0099	0.0251
Echinococcus granulosus	neuropeptide receptor A26	0.0025	0.0099	0.0251
Echinococcus granulosus	G protein coupled receptor 139	0.0025	0.0099	0.0251
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0099	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Schistosoma mansoni	amine GPCR	0.0025	0.0099	0.013
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0025	0.0099	0.013
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0099	0.0251
Echinococcus granulosus	RNA directed DNA polymerase	0.0048	0.1463	0.372
Echinococcus granulosus	fmrfamide receptor	0.0025	0.0099	0.0251
Brugia malayi	hypothetical protein	0.0025	0.0099	0.0385
Schistosoma mansoni	growth hormone secretagogue receptor	0.0025	0.0099	0.013
Plasmodium vivax	glutathione reductase, putative	0.0047	0.142	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0025	0.0099	0.0251
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0025	0.0099	0.0099
Echinococcus granulosus	serotonin receptor	0.0025	0.0099	0.0251
Echinococcus granulosus	g-protein coupled receptor	0.0025	0.0099	0.0251
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.0099	0.013
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0025	0.0099	0.0251
Echinococcus granulosus	neuropeptide s receptor	0.0025	0.0099	0.0251
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0099	0.0251
Schistosoma mansoni	serine/threonine protein kinase	0.0089	0.3934	0.519
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0099	0.0251
Brugia malayi	G protein-coupled receptor F59B2.13	0.0025	0.0099	0.0385
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0099	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0183	0.9592	0.9592
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0099	0.0251
Echinococcus granulosus	orexin receptor type 2	0.0025	0.0099	0.0251
Echinococcus granulosus	sex peptide receptor	0.0025	0.0099	0.0251
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0099	0.013
Echinococcus granulosus	protein kinase C gamma type	0.0072	0.2948	0.7495
Echinococcus multilocularis	neuropeptide s receptor	0.0025	0.0099	0.0251
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.0099	0.0251
Toxoplasma gondii	thioredoxin reductase	0.0047	0.142	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.0099	0.0251
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0099	0.0251
Brugia malayi	ORL1-like opioid receptor	0.0025	0.0099	0.0385
Echinococcus granulosus	dro:myosuppressin receptor	0.0025	0.0099	0.0251
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0099	0.0251
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0099	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0099	0.0251
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0099	0.0251
Echinococcus multilocularis	allatostatin A receptor	0.0025	0.0099	0.0251
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.0099	0.013
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0025	0.0099	0.0099
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0025	0.0099	0.0251
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0107	0.5024	0.8342
Echinococcus multilocularis	RNA directed DNA polymerase	0.0048	0.1463	0.372
Loa Loa (eye worm)	hypothetical protein	0.0064	0.2449	0.2449
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.0099	0.0251
Brugia malayi	GnHR receptor homolog	0.0025	0.0099	0.0385
Schistosoma mansoni	hypothetical protein	0.0025	0.0099	0.013
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0119	0.574	1
Brugia malayi	G protein-coupled receptor	0.0025	0.0099	0.0385
Brugia malayi	putative neuropeptide receptor NPR1	0.0025	0.0099	0.0385
Brugia malayi	hypothetical protein	0.0036	0.0747	0.2906
Mycobacterium tuberculosis	Probable dehydrogenase	0.0107	0.5024	0.8342
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0099	0.013
Echinococcus granulosus	7TM GPCR rhodopsin	0.0025	0.0099	0.0251
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0099	0.013
Schistosoma mansoni	amine GPCR	0.0025	0.0099	0.013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0099	0.013
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0099	0.013
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0025	0.0099	0.013
Schistosoma mansoni	opsin-like receptor	0.0025	0.0099	0.013
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0099	0.013
Loa Loa (eye worm)	hypothetical protein	0.0167	0.8606	0.8606
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0025	0.0099	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.0099	0.013
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0025	0.0099	0.0251
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.142	0.3609
Plasmodium falciparum	glutathione reductase	0.0047	0.142	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0099	0.0251
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0099	0.0251
Brugia malayi	hypothetical protein	0.0025	0.0099	0.0385
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.142	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0023	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0099	0.0251
Echinococcus multilocularis	g-protein coupled receptor	0.0025	0.0099	0.0251
Schistosoma mansoni	opsin-like receptor	0.0025	0.0099	0.013
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0099	0.0251
Loa Loa (eye worm)	melatonin receptor type 1A	0.0025	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0099	0.0099
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0025	0.0099	0.013

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 2140 nM	Inhibition of [3H]-PDBu binding to C1b domain of protein kinase C delta with phosphatidylserine	ChEMBL.	16134942
Ki (binding)	= 2140 nM	Inhibition of [3H]-PDBu binding to C1b domain of protein kinase C delta with phosphatidylserine	ChEMBL.	16134942
Ki (binding)	= 5874 nM	Inhibition of [3H]-PDBu binding to recombinant protein kinase C alpha was determined at pH 7.4, 37 degree C for 5 min	ChEMBL.	16134942
Ki (binding)	= 5874 nM	Inhibition of [3H]-PDBu binding to recombinant protein kinase C alpha was determined at pH 7.4, 37 degree C for 5 min	ChEMBL.	16134942

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL194357
PubChem: 11574218

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 343513