Detailed information for compound 343560

Basic information

Technical information
  • TDR Targets ID: 343560
  • Name: 2-N-(5-chloro-2-methylphenyl)-5-methyl-7-N-ph enethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2,7- diamine
  • MW: 392.885 | Formula: C21H21ClN6
  • H donors: 2 H acceptors: 3 LogP: 5.64 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)Nc1nn2c(n1)nc(cc2NCCc1ccccc1)C)C
  • InChi: 1S/C21H21ClN6/c1-14-8-9-17(22)13-18(14)25-20-26-21-24-15(2)12-19(28(21)27-20)23-11-10-16-6-4-3-5-7-16/h3-9,12-13,23H,10-11H2,1-2H3,(H,25,27)
  • InChiKey: NHRHUJASDVKCES-UHFFFAOYSA-N  

Network

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Synonyms

  • N2-(5-chloro-2-methyl-phenyl)-5-methyl-N7-phenethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2,7-diamine
  • N2-(5-chloro-2-methylphenyl)-5-methyl-N7-phenethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2,7-diamine
  • [2-(5-chloro-2-methyl-anilino)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-phenethyl-amine
  • N-(5-chloro-2-methylphenyl)-5-methyl-N'-(2-phenylethyl)-[1,2,4]triazolo[5,1-b]pyrimidine-2,7-diamine
  • N-(5-chloro-2-methyl-phenyl)-5-methyl-N'-(2-phenylethyl)-[1,2,4]triazolo[5,1-b]pyrimidine-2,7-diamine
  • [2-[(5-chloro-2-methyl-phenyl)amino]-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-yl]-(2-phenylethyl)amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Pre-SET motif family protein 0.0238 0.0908 0.0908
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0121
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0948 0.3679 0.3679
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0013 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0116 0.0097
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0063 0.0063
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0594 0.0594
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0058 0.0038
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0121 0.0098
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.2567 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0018 0.0018
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0018 0.0018
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0011 0.0023 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0018 0.0018
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0055 0.0196 0.0177
Schistosoma mansoni nuclear hormone receptor 0.001 0.0018 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0018 0.0018
Trypanosoma brucei glucosidase, putative 0.0035 0.0116 0.0093
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0115 0.0115
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.0006
Brugia malayi CXXC zinc finger family protein 0.0029 0.0092 0.0092
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0121 0.0098
Schistosoma mansoni alpha glucosidase 0.0035 0.0116 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0018 0.0018
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0116 0.0361
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0706 0.2737 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0063 0.0044
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0058 0.0058
Schistosoma mansoni glutathione synthetase 0.0706 0.2737 0.2737
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.002
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0121 0.0103
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0058 0.0052
Entamoeba histolytica recQ family DNA helicase 0.001 0.0019 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0018 0.0018
Onchocerca volvulus 0.0036 0.0121 0.1011
Trypanosoma cruzi polyprenyl synthase, putative 0.0948 0.3679 0.3667
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0011 0.0023 0.002
Echinococcus multilocularis bloom syndrome protein 0.002 0.0058 0.0058
Mycobacterium tuberculosis Conserved protein 0.0036 0.0121 0.0098
Loa Loa (eye worm) hypothetical protein 0.0035 0.0115 0.0115
Plasmodium vivax exodeoxyribonuclease III, putative 0.0011 0.0023 0.0006
Schistosoma mansoni hypothetical protein 0.0021 0.0063 0.0063
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0058 0.0034
Onchocerca volvulus 0.0011 0.0023 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0154 0.0154
Schistosoma mansoni neutral sphingomyelinase 0.0011 0.0023 0.0023
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0031 0.0011
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0018 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0115 0.0115
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0706 0.2737 0.2648
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.2567 1 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0055 0.0196 0.0173
Schistosoma mansoni coup transcription factor 0.001 0.0018 0.0018
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0023 0.0023
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0121 0.0098
Loa Loa (eye worm) beta-lactamase 0.0036 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0087 0.0319 0.0319
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.0594 0.0594
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0011 0.0023 0.0004
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0058 0.0034
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0115 0.0115
Brugia malayi CCR4 0.0011 0.0023 0.0023
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0007 0.0007 0.0007
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0018 0.0018
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0018 0.0018
Onchocerca volvulus 0.0029 0.0092 0.0728
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0055 0.0196 0.0654
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0007 0.0007
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0055 0.0196 0.0076
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0025
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0055 0.0196 0.0173
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0121 0.0121
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0075 0.0057
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0018 0.0018
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0018 0.0018
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0011 0.0023 0.0004
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0011 0.0023 0.0018
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0058 0.0034
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.0006
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0035 0.0035
Entamoeba histolytica recQ family helicase, putative 0.002 0.0058 0.0146
Schistosoma mansoni nocturnin 0.0011 0.0023 0.0023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0154 0.0154
Schistosoma mansoni carbon catabolite repressor protein 0.0011 0.0023 0.0023
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0031 0.0124
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0121 0.0102
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0023 0.0023
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0031 0.0011
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0063 0.0063
Loa Loa (eye worm) polyprenyl synthetase 0.2567 1 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0005 0.000000000032041
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0018 0.0018
Trichomonas vaginalis Phospholipase C precursor, putative 0.0011 0.0023 0.0018
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0023 0.0023
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0116 0.0111
Leishmania major hypothetical protein, conserved 0.0024 0.0075 0.0052
Echinococcus multilocularis shaker cognate 0.0007 0.0007 0.0007
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0018 0.0018
Schistosoma mansoni thyroid hormone receptor 0.001 0.0018 0.0018
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0058 0.0052
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0055 0.0196 0.0196
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0087 0.0319 0.0319
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0018 0.0018
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0031 0.0007
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0058 0.004
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0011 0.0023 0.0023
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0019 0.0002
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0019 0.0019
Trichomonas vaginalis ap endonuclease, putative 0.0055 0.0196 0.0191
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0035 0.0169
Schistosoma mansoni hypothetical protein 0.0164 0.0619 0.0619
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0058 0.004
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.0006
Brugia malayi steroid hormone receptor 0.001 0.0018 0.0018
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0007 0.0007 0.0007
Schistosoma mansoni synaptojanin 0.0011 0.0023 0.0023
Echinococcus granulosus geminin 0.0164 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0706 0.2737 0.2737
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0011 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0018 0.0018
Schistosoma mansoni cpg binding protein 0.003 0.0099 0.0099
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0023 0.0006
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0007 0.0007 0.0007
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0018 0.0018
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0706 0.2737 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0007 0.0007 0.0007
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0007 0.0007
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0121 0.0121
Echinococcus granulosus potassium voltage gated channel protein 0.0087 0.0319 0.0319
Loa Loa (eye worm) histone methyltransferase 0.001 0.0019 0.0019
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.002
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0019 0.0019
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.0006
Brugia malayi Uncoordinated protein 44 0.0014 0.0035 0.0035
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0035 0.0035
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Trypanosoma cruzi mitochondrial protein 99, putative 0.0011 0.0023 0.0004
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0116 0.0361
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0031 0.0025
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0025
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.2567 1 1
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0948 0.3679 0.3679
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0121 0.0121
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0018 0.0018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0409 0.1578 0.1578
Brugia malayi beta-lactamase 0.0036 0.0121 0.0121
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0058 0.0058
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.0897 0.0897
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0031 0.0047
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0058 0.0058
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0075 0.0052
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0036 0.0036
Onchocerca volvulus 0.0271 0.1036 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0055 0.0196 0.0173
Echinococcus granulosus potassium voltage gated channel protein 0.0007 0.0007 0.0007
Echinococcus granulosus voltage gated potassium channel 0.0007 0.0007 0.0007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0075
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0116 0.0116
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0025
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0116 0.0116
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0197 0.018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0115 0.0115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0115 0.0115
Brugia malayi hypothetical protein 0.0016 0.0041 0.0041
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0007 0.0007
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0023 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0121 0.0116
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0011 0.0023 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0018 0.0018
Toxoplasma gondii ABC1 family protein 0.0036 0.0121 0.0103
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0706 0.2737 0.2737
Brugia malayi hypothetical protein 0.0024 0.0075 0.0075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0154 0.0154
Treponema pallidum exodeoxyribonuclease (exoA) 0.0055 0.0196 0.0482
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0706 0.2737 0.272
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0018 0.0018
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0013 0.0013
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0007 0.0007 0.0007
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.2567 1 1
Echinococcus granulosus synaptojanin 1 0.0011 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0058
Schistosoma mansoni cpg binding protein 0.0029 0.0092 0.0092
Echinococcus multilocularis voltage gated potassium channel 0.0007 0.0007 0.0007
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0055 0.0196 0.0178
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000032041
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0063 0.004
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0116 0.0098
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0018 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0116 0.0097
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0001 0.0001
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.2567 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000032041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0018 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0115 0.0115
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0075 0.0057
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0018 0.0018
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0035 0.0035
Brugia malayi Pre-SET motif family protein 0.0035 0.0115 0.0115
Echinococcus granulosus bloom syndrome protein 0.002 0.0058 0.0058
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0007 0.0007 0.0007
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0948 0.3679 0.3679
Echinococcus granulosus Ankyrin 0.0014 0.0036 0.0036
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0263 0.0263
Brugia malayi ecdysteroid receptor 0.001 0.0018 0.0018
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0058 0.0034
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0055 0.0196 0.0173
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0087 0.0319 0.0319
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0121 0.0098
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0055 0.0196 0.0196
Echinococcus multilocularis Ankyrin 0.0014 0.0036 0.0036
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0121 0.0098
Echinococcus multilocularis potassium voltage gated channel protein 0.0007 0.0007 0.0007
Echinococcus granulosus FTZ F1 alpha 0.001 0.0018 0.0018
Loa Loa (eye worm) polyprenyl synthetase 0.0706 0.2737 0.2737
Plasmodium vivax SET domain protein, putative 0.0035 0.0115 0.0097
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0023 0.002
Echinococcus granulosus traf and tnf receptor associated protein 0.0011 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0121
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0058 0.0058
Schistosoma mansoni synaptojanin 0.0011 0.0023 0.0023
Brugia malayi beta-lactamase family protein 0.0036 0.0121 0.0121
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0007 0.0007 0.0007
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0023 0.0006
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0031 0.0025
Brugia malayi Kringle domain containing protein 0.0021 0.0063 0.0063
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0154 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0018 0.0018
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0706 0.2737 0.272
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Schistosoma mansoni thyroid hormone receptor 0.001 0.0018 0.0018
Mycobacterium tuberculosis Conserved protein 0.0036 0.0121 0.0098
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Echinococcus granulosus farnesyl pyrophosphate synthase 0.2567 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0018 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0121 0.0116
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0706 0.2737 0.2737
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0011 0.0023 0.0023
Schistosoma mansoni vesicular amine transporter 0.0007 0.0007 0.0007
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0706 0.2737 0.2723
Echinococcus granulosus neutral sphingomyelinase 0.0011 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0164 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0019
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0011 0.0023 0.0023
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0121 0.0116
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0023 0.0006
Toxoplasma gondii exonuclease III APE 0.0055 0.0196 0.0178
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0083 0.0304 0.0304
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0011 0.0023 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0706 0.2737 0.272
Schistosoma mansoni farnesyl pyrophosphate synthase 0.2567 1 1
Echinococcus granulosus dnaJ subfamily B 0.0409 0.1578 0.1578
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.002
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0063 0.0045
Echinococcus multilocularis synaptojanin 1 0.0011 0.0023 0.0023
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0031 0.0031
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0948 0.3679 0.3679
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0063 0.0045
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0116 0.0111
Brugia malayi Protein kinase domain containing protein 0.0021 0.0063 0.0063
Onchocerca volvulus 0.0035 0.0115 0.0954
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0007 0.0007
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0075 0.0056
Echinococcus multilocularis cpg binding protein 0.003 0.0099 0.0099
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0058 0.0058
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0023 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0121
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0035 0.0035
Schistosoma mansoni cpg binding protein 0.003 0.0099 0.0099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000032041
Loa Loa (eye worm) voltage-gated potassium channel 0.0007 0.0007 0.0007
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0018 0.0018
Echinococcus granulosus shaker cognate 0.0007 0.0007 0.0007
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0023 0.0023
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.002
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.0594 0.0594
Schistosoma mansoni hypothetical protein 0.0011 0.0023 0.0023
Echinococcus granulosus cpg binding protein 0.003 0.0099 0.0099
Schistosoma mansoni alpha-glucosidase 0.0135 0.0509 0.0509
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0058 0.0052
Leishmania major hypothetical protein, conserved 0.0021 0.0063 0.004
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0018 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0121 0.0116
Brugia malayi Death domain containing protein 0.0014 0.0035 0.0035
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Trichomonas vaginalis set domain proteins, putative 0.0271 0.1036 0.1031
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0023 0.0004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0031
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0023 0.002
Onchocerca volvulus 0.0091 0.0335 0.3115
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Echinococcus multilocularis potassium voltage gated channel protein 0.0007 0.0007 0.0007
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.2567 1 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0121
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0011 0.0023 0.0018
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0111
Echinococcus granulosus potassium voltage gated channel protein 0.0007 0.0007 0.0007
Loa Loa (eye worm) RecQ helicase 0.002 0.0058 0.0058
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0023 0.0023
Treponema pallidum octaprenyl-diphosphate synthase 0.0948 0.3679 1
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0011 0.0023 0.0023
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.002
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0108 0.0108
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.0006
Leishmania major hypothetical protein, conserved 0.0036 0.0121 0.0098
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0018 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0154 0.0154
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0706 0.2737 0.2724
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0011 0.0023 0.0023
Brugia malayi follicle stimulating hormone receptor 0.0235 0.0897 0.0897
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0111
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0018 0.0018
Schistosoma mansoni voltage-gated potassium channel 0.0087 0.0319 0.0319
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0063 0.0063
Schistosoma mansoni cript-related 0.0011 0.0023 0.0023
Schistosoma mansoni voltage-gated potassium channel 0.0087 0.0319 0.0319
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000032041
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Onchocerca volvulus 0.0036 0.0121 0.1011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0036 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0018 0.0018
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0706 0.2737 0.5
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0011 0.0023 0.0018
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0019 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0025
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0121 0.0116
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.0881 0.086
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0121 0.0098
Schistosoma mansoni hypothetical protein 0.0014 0.0035 0.0035
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.2567 1 1
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0706 0.2737 0.2648
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0116 0.0116
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0111
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0031 0.0025
Trypanosoma cruzi mitochondrial protein 99, putative 0.0011 0.0023 0.0004
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0058 0.0058
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0121 0.0098
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0023 0.0023
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0007 0.0007
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0116 0.0111
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0018 0.0018
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0055 0.0196 0.0196
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0018 0.0018
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0023 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0018 0.0018
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0007 0.0007
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0121
Echinococcus multilocularis traf and tnf receptor associated protein 0.0011 0.0023 0.0023
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0116 0.0093
Echinococcus multilocularis deoxyribonuclease 1 2 0.0011 0.0023 0.0023
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0023 0.0023
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000032041
Brugia malayi Protein kinase domain containing protein 0.0014 0.0035 0.0035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0154 0.0154
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0223 0.0223
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0018 0.0018
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.2567 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0121 0.0102
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0005 0.000000000032041
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0058 0.0058
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0011 0.0023 0.002
Treponema pallidum hypothetical protein 0.0011 0.0023 0.0011
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0706 0.2737 1
Schistosoma mansoni trans-prenyltransferase 0.0706 0.2737 0.2737
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0007
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0011 0.0023 0.0018
Schistosoma mansoni alpha-glucosidase 0.0135 0.0509 0.0509
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0018 0.0018
Echinococcus multilocularis neutral sphingomyelinase 0.0011 0.0023 0.0023
Onchocerca volvulus 0.0036 0.0121 0.1011
Brugia malayi exodeoxyribonuclease III family protein 0.0055 0.0196 0.0196
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0035 0.0035
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0706 0.2737 0.2723
Trypanosoma cruzi polyprenyl synthase, putative 0.0948 0.3679 0.3667
Brugia malayi nuclear hormone receptor 0.001 0.0018 0.0018
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0706 0.2737 0.272
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0055 0.0196 0.0177
Leishmania major polyprenyl synthase, putative 0.0948 0.3679 0.3664
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.2567 1 1
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0075 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0018 0.0018
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0706 0.2737 0.2723
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.2567 1 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.002
Trichomonas vaginalis esterase, putative 0.0036 0.0121 0.0116
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0075 0.0052
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0018 0.0018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0121 0.0098
Onchocerca volvulus Putative neutral sphingomyelinase 0.0011 0.0023 0.0054
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0706 0.2737 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Schistosoma mansoni DNA helicase recq5 0.002 0.0058 0.0058
Giardia lamblia Farnesyl diphosphate synthase 0.2567 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0092 0.0092
Brugia malayi beta-lactamase family protein 0.0036 0.0121 0.0121
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0013 0.0013
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0115 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0018 0.0018
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0706 0.2737 0.2737
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0018 0.0018
Echinococcus multilocularis potassium voltage gated channel protein 0.0087 0.0319 0.0319
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0111
Brugia malayi nuclear receptor NHR-88 0.001 0.0018 0.0018
Echinococcus multilocularis transfer RNA-Gly 0.0007 0.0007 0.0007
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000032041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0018 0.0018
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0011 0.0023 0.0004
Schistosoma mansoni DNA helicase recq1 0.002 0.0058 0.0058
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0058 0.0058
Trypanosoma brucei farnesyl pyrophosphate synthase 0.2567 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0018 0.0018
Leishmania major farnesyl pyrophosphate synthase 0.2567 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0075 0.0056
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0007 0.0007 0.0007
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0018 0.0018
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0011 0.0023 0.0004
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0031 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.0063
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0121 0.0121
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0011 0.0023 0.0004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0018 0.0018
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0011 0.0023 0.002
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0011 0.0023 0.0018
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0116 0.0111
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0055 0.0196 0.0173
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.2567 1 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0121 0.0098
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0018 0.0018
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.1578 0.1578
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0007 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0706 0.2737 1
Onchocerca volvulus 0.0021 0.0063 0.0441
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0948 0.3679 0.3679
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.0594 0.0594
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0018 0.0018
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0121 0.0121
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0011 0.0023 0.0018
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0023 0.0023
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0706 0.2737 0.272
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0011 0.0023 0.0023
Brugia malayi Polyprenyl synthetase family protein 0.0706 0.2737 0.2737
Trichomonas vaginalis ap endonuclease, putative 0.0055 0.0196 0.0191
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0018 0.0018
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0023 0.0004
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0058 0.0034
Onchocerca volvulus 0.0011 0.0023 0.0054
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0263 0.0263
Leishmania major solanesyl-diphosphate synthase, putative 0.0706 0.2737 0.272
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0018 0.0018
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0706 0.2737 1
Echinococcus multilocularis geminin 0.0164 0.0619 0.0619
Schistosoma mansoni ap endonuclease 0.0055 0.0196 0.0196
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.2567 1 1
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0011 0.0023 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0121
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0035 0.0035
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0121 0.0121
Echinococcus granulosus death domain containing protein 0.0014 0.0035 0.0035
Schistosoma mansoni ap endonuclease 0.0055 0.0196 0.0196
Schistosoma mansoni netrin receptor unc5 0.0014 0.0035 0.0035
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0023 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0018 0.0018
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0111
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.0908 0.0908
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0706 0.2737 0.2724
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 290 nM Inhibitory constant against thrombin ChEMBL. 16137886
Ki (binding) = 290 nM Inhibitory constant against thrombin ChEMBL. 16137886

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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