Detailed information for compound 343590

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 816.936 | Formula: C30H57IN4O8SSi2
  • H donors: 1 H acceptors: 4 LogP: 4.55 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC1=CS(=O)(=O)OC21C(CO[Si](C(C)(C)C)(C)C)OC(C2O[Si](C(C)(C)C)(C)C)n1cc(C)c(=O)n(c1=O)CCC[N+](C)(C)C.[I-]
  • InChi: 1S/C30H57N4O8SSi2.HI/c1-21-18-33(27(36)32(25(21)35)16-15-17-34(8,9)10)26-24(41-45(13,14)29(5,6)7)30(22(31)20-43(37,38)42-30)23(40-26)19-39-44(11,12)28(2,3)4;/h18,20,23-24,26H,15-17,19,31H2,1-14H3;1H/q+1;/p-1
  • InChiKey: KRIOPODBUROFAK-UHFFFAOYSA-M  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.003 0.0029
Brugia malayi G-protein coupled receptor 0.0036 0.003 0.0064
Schistosoma mansoni myosin xvIII 0.0036 0.003 0.0029
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0172 0.0454 0.0453
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0036 0.003 0.0064
Echinococcus granulosus alpha 1A adrenergic receptor 0.0036 0.003 0.0029
Echinococcus granulosus fmrfamide receptor 0.0036 0.003 0.0029
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0036 0.003 0.003
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0067 0.0146
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0172 0.0454 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0036 0.003 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0244 0.0677 0.0677
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Onchocerca volvulus 0.0036 0.003 0.0239
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0172 0.0454 0.0453
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Brugia malayi sulfakinin receptor protein 0.0036 0.003 0.0064
Schistosoma mansoni amine GPCR 0.0036 0.003 0.0029
Echinococcus multilocularis leukotriene A 4 hydrolase 0.3237 1 1
Loa Loa (eye worm) glutamate receptor 0.003 0.001 0.001
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.003 0.0029
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.003 0.0029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.003 0.0029
Toxoplasma gondii aminopeptidase N protein 0.0172 0.0454 1
Brugia malayi hypothetical protein 0.0121 0.0295 0.0646
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Brugia malayi Tachykinin-like peptides receptor 99D 0.0036 0.003 0.0064
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Trypanosoma brucei ingi protein (ORF1) 0.0029 0.0008 0.0058
Echinococcus multilocularis neuropeptide s receptor 0.0494 0.1455 0.1454
Schistosoma mansoni thyroid hormone receptor 0.0135 0.0339 0.0338
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0172 0.0454 0.0453
Trypanosoma brucei ingi protein (ORF1) 0.0029 0.0008 0.0058
Onchocerca volvulus Uncharacterized serine carboxypeptidase homolog 0.042 0.1226 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Echinococcus multilocularis family S10 non peptidase ue (S10 family) 0.0378 0.1097 0.1096
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0002 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.003 0.0029
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0036 0.003 0.0029
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.003 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0122 0.1489
Schistosoma mansoni hypothetical protein 0.0048 0.0067 0.0066
Onchocerca volvulus 0.0036 0.003 0.0239
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.003 0.003
Brugia malayi Peptidase family M1 containing protein 0.0172 0.0454 0.0994
Echinococcus multilocularis G-protein coupled receptor, putative 0.0036 0.003 0.0029
Echinococcus multilocularis g-protein coupled receptor 0.0036 0.003 0.0029
Brugia malayi Peptidase family M1 containing protein 0.0172 0.0454 0.0994
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Echinococcus granulosus insulin receptor 0.0447 0.131 0.1309
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0155 0.2337
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0008 0.0058
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0015 0.0318
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0057 0.0454
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.042 0.1226 1
Plasmodium falciparum GAF domain-related protein, putative 0.0066 0.0122 0.1489
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0172 0.0454 0.3695
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0091 0.0201 0.4424
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0447 0.131 0.1309
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0036 0.003 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.003 0.0029
Schistosoma mansoni neuropeptide receptor 0.0036 0.003 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.003 0.0029
Entamoeba histolytica aminopeptidase, putative 0.0172 0.0454 0.5
Onchocerca volvulus 0.0036 0.003 0.0239
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0036 0.003 0.0064
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.003 0.0029
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.003 0.0029
Onchocerca volvulus 0.0172 0.0454 0.3695
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0315 0.0901 0.0901
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0091 0.0201 0.1635
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0091 0.0201 0.02
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0076 0.0155 0.0339
Brugia malayi putative neuropeptide receptor 0.0036 0.003 0.0064
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.042 0.1226 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.042 0.1226 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Echinococcus granulosus epidermal growth factor receptor 0.0203 0.0551 0.055
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0155 0.2337
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0122 0.2681
Brugia malayi Protein kinase domain containing protein 0.0247 0.0688 0.1509
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0091 0.0201 0.4424
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0091 0.0201 0.02
Brugia malayi Serine carboxypeptidase F41C3.5 precursor 0.042 0.1226 0.2691
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.003 0.0029
Echinococcus multilocularis neuropeptide receptor A26 0.0494 0.1455 0.1454
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0172 0.0454 0.3695
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.065 0.0649
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0064 0.0064
Loa Loa (eye worm) peptidase family M1 containing protein 0.0172 0.0454 0.0454
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0172 0.0454 0.3695
Mycobacterium ulcerans aminopeptidase N PepN 0.0172 0.0454 1
Echinococcus multilocularis aminopeptidase N 0.0172 0.0454 0.0453
Loa Loa (eye worm) hypothetical protein 0.0027 0.0002 0.0002
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0172 0.0454 0.3695
Echinococcus granulosus aminopeptidase N 0.0172 0.0454 0.0453
Trypanosoma brucei aminopeptidase, putative 0.0172 0.0454 0.3695
Onchocerca volvulus 0.0036 0.003 0.0239
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Echinococcus granulosus g protein coupled receptor 0.0036 0.003 0.0029
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0036 0.003 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.003 0.0029
Loa Loa (eye worm) glutathione reductase 0.0047 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0036 0.003 0.0029
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Echinococcus multilocularis metabotropic glutamate receptor 5 0.003 0.001 0.0009
Echinococcus multilocularis somatostatin receptor 0.0036 0.003 0.0029
Echinococcus granulosus neuropeptide receptor 0.0036 0.003 0.0029
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0172 0.0454 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0091 0.0201 0.4424
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.003 0.0029
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Brugia malayi neuropeptide F receptor 0.0036 0.003 0.0064
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0036 0.003 0.0029
Loa Loa (eye worm) TK/EGFR protein kinase 0.0203 0.0551 0.0551
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0036 0.003 0.0029
Schistosoma mansoni amine GPCR 0.0036 0.003 0.0029
Schistosoma mansoni tyrosine kinase 0.0203 0.0551 0.055
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Treponema pallidum ribonuclease H (rnhA) 0.0027 0.0001 0.5
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0091 0.0201 0.02
Brugia malayi hypothetical protein 0.0235 0.065 0.1427
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0252 0.0702 0.1539
Onchocerca volvulus Neuropeptide F receptor homolog 0.0036 0.003 0.0239
Schistosoma mansoni histamine h1 receptor 0.0036 0.003 0.0029
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.003 0.0029
Trypanosoma cruzi aminopeptidase, putative 0.0172 0.0454 0.3695
Echinococcus multilocularis neuropeptide receptor 0.0036 0.003 0.0029
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0091 0.0201 0.1635
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.003 0.0029
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0252 0.8342
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0036 0.003 0.0029
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0252 0.7767
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0308 0.0307
Brugia malayi ORL1-like opioid receptor 0.0036 0.003 0.0064
Echinococcus multilocularis allatostatin A receptor 0.0036 0.003 0.0029
Schistosoma mansoni lysosomal protective protein precursor (cathepsin A) (carboxypeptidase 0.0042 0.0047 0.0046
Echinococcus granulosus dna polymerase eta 0.0045 0.0057 0.0056
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0172 0.0454 0.3695
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0172 0.0454 0.0453
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Echinococcus granulosus neuropeptide receptor 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Brugia malayi Dopamine receptor protein 1 0.0036 0.003 0.0064
Brugia malayi hypothetical protein 0.0036 0.003 0.0064
Toxoplasma gondii hypothetical protein 0.0066 0.0122 0.2681
Echinococcus multilocularis dna polymerase eta 0.0045 0.0057 0.0056
Toxoplasma gondii aminopeptidase N, putative 0.0172 0.0454 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.003 0.0029
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0091 0.0201 0.1635
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0057 0.0454
Loa Loa (eye worm) TATA binding protein associated factor 0.0172 0.0454 0.0454
Onchocerca volvulus 0.0048 0.0067 0.0542
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Brugia malayi neuropeptide F receptor 0.0036 0.003 0.0064
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.013 0.0324 0.0324
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0172 0.0454 1
Echinococcus multilocularis epidermal growth factor receptor 0.0203 0.0551 0.055
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.065 0.0649
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0172 0.0454 0.0453
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0172 0.0454 0.0453
Schistosoma mansoni opsin-like receptor 0.0036 0.003 0.0029
Loa Loa (eye worm) melatonin receptor type 1A 0.0036 0.003 0.003
Toxoplasma gondii aminopeptidase n, putative 0.0172 0.0454 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0289 1
Schistosoma mansoni neuropeptide receptor 0.0036 0.003 0.0029
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0289 1
Echinococcus multilocularis epidermal growth factor receptor 0.0203 0.0551 0.055
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0091 0.0201 0.1635
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0036 0.003 0.0029
Echinococcus granulosus somatostatin receptor 0.0036 0.003 0.0029
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0036 0.003 0.0029
Loa Loa (eye worm) aminopeptidase N 0.0172 0.0454 0.0454
Schistosoma mansoni hypothetical protein 0.0036 0.003 0.0029
Echinococcus multilocularis neuropeptide FF receptor 2 0.0036 0.003 0.0029
Echinococcus granulosus g-protein coupled receptor 0.0036 0.003 0.0029
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0091 0.0201 0.1635
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0172 0.0454 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.243 0.2429
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.042 0.1226 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0172 0.0454 0.0453
Brugia malayi GnHR receptor homolog 0.0036 0.003 0.0064
Loa Loa (eye worm) hypothetical protein 0.0235 0.065 0.065
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0036 0.003 0.0029
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.003 0.003
Trypanosoma brucei Aminopeptidase M1, putative 0.0172 0.0454 0.3695
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0064 0.0063
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0036 0.003 0.003
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0002 0.0001
Schistosoma mansoni tyrosine kinase 0.0203 0.0551 0.055
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0036 0.003 0.0029
Echinococcus granulosus orexin receptor type 2 0.0036 0.003 0.0029
Schistosoma mansoni tyrosine kinase 0.0447 0.131 0.1309
Brugia malayi Melatonin receptor type 1A 0.0036 0.003 0.0064
Loa Loa (eye worm) hypothetical protein 0.0172 0.0454 0.0454
Brugia malayi follicle stimulating hormone receptor 0.0036 0.003 0.0064
Echinococcus multilocularis 0.0058 0.01 0.0099
Mycobacterium tuberculosis Probable reductase 0.0107 0.0252 0.8342
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0203 0.0551 0.055
Echinococcus granulosus lysosomal protective protein 0.042 0.1226 0.1225
Chlamydia trachomatis endonuclease IV 0.0076 0.0155 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.042 0.1226 0.1226
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0252 0.8342
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0252 0.8342
Schistosoma mansoni tyrosine kinase 0.02 0.054 0.0539
Loa Loa (eye worm) hypothetical protein 0.0172 0.0454 0.0454
Schistosoma mansoni neuropeptide receptor 0.0036 0.003 0.0029
Schistosoma mansoni hypothetical protein 0.01 0.0229 0.0228
Brugia malayi RE15519p 0.0036 0.003 0.0064
Echinococcus granulosus family S10 non peptidase ue S10 family 0.0378 0.1097 0.1096
Echinococcus multilocularis g protein coupled receptor 0.0036 0.003 0.0029
Schistosoma mansoni biogenic amine receptor 0.0036 0.003 0.0029
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0036 0.003 0.0029
Brugia malayi metabotropic glutamate receptor type 2 0.003 0.001 0.002
Brugia malayi hypothetical protein 0.0036 0.003 0.0064
Brugia malayi hypothetical protein 0.0172 0.0454 0.0994
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.003 0.0029
Echinococcus multilocularis fmrfamide receptor 0.0036 0.003 0.0029
Brugia malayi Serotonin receptor 0.0036 0.003 0.0064
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.003 0.0029
Trypanosoma brucei Aminopeptidase M1, putative 0.0172 0.0454 0.3695
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0091 0.0201 0.4424
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0782 0.2355 0.2355
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0252 0.8342
Schistosoma mansoni family S10 unassigned peptidase (S10 family) 0.042 0.1226 0.1225
Schistosoma mansoni amine GPCR 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.003 0.0029
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.042 0.1226 1
Schistosoma mansoni opsin-like receptor 0.0036 0.003 0.0029
Brugia malayi G-protein coupled receptor 0.0036 0.003 0.0064
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0036 0.003 0.0064
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0172 0.0454 0.0453
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0172 0.0454 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.003 0.0029
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0289 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0447 0.131 0.131
Echinococcus granulosus tachykinin peptides receptor 99D 0.0036 0.003 0.0029
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0172 0.0454 0.0453
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.003 0.0029
Schistosoma mansoni adenoreceptor 0.0036 0.003 0.0029
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0172 0.0454 0.0453
Onchocerca volvulus 0.0036 0.003 0.0239
Echinococcus granulosus microtubule associated protein 2 0.0686 0.2055 0.2055
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0036 0.003 0.0029
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.003 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0122 0.2681
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.003 0.0029
Schistosoma mansoni amine GPCR 0.1492 0.4565 0.4564
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Echinococcus multilocularis lysosomal protective protein 0.042 0.1226 0.1225
Onchocerca volvulus 0.0036 0.003 0.0239
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Schistosoma mansoni survival motor neuron protein 0.0048 0.0067 0.0066
Loa Loa (eye worm) hypothetical protein 0.0076 0.0155 0.0155
Brugia malayi G protein-coupled receptor 0.0036 0.003 0.0064
Echinococcus multilocularis microtubule associated protein 2 0.0686 0.2055 0.2055
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.003 0.0029
Leishmania major DNA polymerase eta, putative 0.0031 0.0015 0.0118
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0091 0.0201 0.4424
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0066 0.0122 0.2576
Echinococcus multilocularis neuropeptide receptor 0.0036 0.003 0.0029
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0808 0.2434 0.5345
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0066 0.0122 0.2576
Trypanosoma cruzi aminopeptidase, putative 0.0172 0.0454 0.3695
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0172 0.0454 0.3695
Loa Loa (eye worm) TYRA-2 protein 0.0036 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0289 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0036 0.003 0.0029
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0036 0.003 0.003
Toxoplasma gondii endonuclease IV APN 0.0076 0.0155 0.3411
Brugia malayi intermediate filament protein 0.0027 0.0002 0.0001
Brugia malayi hypothetical protein 0.0036 0.003 0.0064
Schistosoma mansoni neuropeptide receptor 0.0036 0.003 0.0029
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0172 0.0454 0.0453
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0201 0.4424
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0029 0.0008 0.0058
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Brugia malayi hypothetical protein 0.0036 0.003 0.0064
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.003 0.0029
Echinococcus granulosus sex peptide receptor 0.0036 0.003 0.0029
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.003 0.0029
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Toxoplasma gondii thioredoxin reductase 0.0047 0.0064 0.1401
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Echinococcus multilocularis insulin receptor 0.0447 0.131 0.1309
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0091 0.0201 0.4424
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0808 0.2434 0.2433
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0172 0.0454 0.0453
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0252 0.8342
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0036 0.003 0.0064
Echinococcus granulosus serotonin receptor 0.0036 0.003 0.0029
Brugia malayi Peptidase family M1 containing protein 0.0172 0.0454 0.0994
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0027 0.0001 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0091 0.0201 0.4424
Echinococcus granulosus epidermal growth factor receptor 0.0203 0.0551 0.055
Echinococcus granulosus neuropeptide s receptor 0.0494 0.1455 0.1454
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0262 0.0735 0.0735
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.0057
Brugia malayi hypothetical protein 0.0036 0.003 0.0064
Onchocerca volvulus 0.0036 0.003 0.0239
Schistosoma mansoni tyrosine kinase 0.02 0.054 0.0539
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Echinococcus multilocularis g protein coupled receptor 0.0036 0.003 0.0029
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0172 0.0454 0.0453
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.003 0.0029
Echinococcus granulosus 7TM GPCR rhodopsin 0.0036 0.003 0.0029
Schistosoma mansoni microtubule-associated protein tau 0.0686 0.2055 0.2055
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.003 0.0029
Echinococcus multilocularis dro:myosuppressin receptor 0.0036 0.003 0.0029
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0091 0.0201 0.4424
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.003 0.0029
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0447 0.131 0.1309
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0036 0.003 0.0029
Echinococcus granulosus neuropeptide FF receptor 2 0.0036 0.003 0.0029
Brugia malayi G protein-coupled receptor F59B2.13 0.0036 0.003 0.0064
Toxoplasma gondii hypothetical protein 0.0066 0.0122 0.2681
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0036 0.003 0.0029
Leishmania major trypanothione reductase 0.0047 0.0064 0.0518
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0091 0.0201 0.4424
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.003 0.0029
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0015 0.0118
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0076 0.0155 0.1977
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Brugia malayi Serotonin receptor 0.0036 0.003 0.0064
Onchocerca volvulus 0.0036 0.003 0.0239
Onchocerca volvulus 0.0036 0.003 0.0239
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0308 0.0307
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.003 0.0029
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0172 0.0454 0.0453
Toxoplasma gondii GAF domain-containing protein 0.0066 0.0122 0.2681
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0122 0.2681
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.003 0.0029
Brugia malayi Thioredoxin reductase 0.0047 0.0064 0.0139
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0036 0.003 0.0029
Echinococcus granulosus metabotropic glutamate receptor 5 0.003 0.001 0.0009
Brugia malayi hypothetical protein 0.1488 0.4553 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.003 0.0029
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0091 0.0201 0.4424
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0057 0.0122
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Onchocerca volvulus 0.0027 0.0002 0.0004
Echinococcus granulosus allatostatin A receptor 0.0036 0.003 0.0029
Brugia malayi hypothetical protein 0.0036 0.003 0.0064
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.003 0.0029
Schistosoma mansoni growth hormone secretagogue receptor 0.0036 0.003 0.0029
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0172 0.0454 0.0453
Echinococcus granulosus peptide allatostatin:somatostatin 0.0036 0.003 0.0029
Schistosoma mansoni amine GPCR 0.0036 0.003 0.0029
Echinococcus multilocularis sex peptide receptor 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.003 0.0029
Echinococcus granulosus G protein coupled receptor 139 0.0036 0.003 0.0029
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0172 0.0454 0.3695
Mycobacterium ulcerans endonuclease IV 0.0076 0.0155 0.0996
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Schistosoma mansoni metabotropic glutamate receptor 0.003 0.001 0.0009
Onchocerca volvulus 0.0036 0.003 0.0239
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.003 0.0029
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.003 0.0029
Schistosoma mansoni neuropeptide f receptor 76f 0.0036 0.003 0.0029
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.3237 1 1
Brugia malayi hypothetical protein 0.0172 0.0454 0.0994
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Schistosoma mansoni tyrosine kinase 0.02 0.054 0.0539
Schistosoma mansoni aminopeptidase A (M01 family) 0.0172 0.0454 0.0453
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Trypanosoma cruzi Aminopeptidase M1, putative 0.0172 0.0454 0.3695
Loa Loa (eye worm) hypothetical protein 0.0172 0.0454 0.0454
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.003 0.0029
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Brugia malayi Receptor family ligand binding region containing protein 0.013 0.0324 0.0709
Echinococcus granulosus dro:myosuppressin receptor 0.0036 0.003 0.0029
Brugia malayi hypothetical protein 0.0036 0.003 0.0064
Brugia malayi TATA binding protein associated factor 0.0172 0.0454 0.0994
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0808 0.2434 0.2433
Onchocerca volvulus 0.0027 0.0002 0.0004
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.003 0.0029
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0064 0.0518
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.042 0.1226 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.003 0.0029
Brugia malayi Metabotropic glutamate receptor precursor. 0.003 0.001 0.002
Trypanosoma brucei unspecified product 0.0029 0.0008 0.0058
Schistosoma mansoni alpha-1 adrenergic receptor 0.0036 0.003 0.0029
Echinococcus granulosus g protein coupled receptor 0.0036 0.003 0.0029
Schistosoma mansoni biogenic amine receptor 0.0036 0.003 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Brugia malayi hypothetical protein 0.0036 0.003 0.0064
Onchocerca volvulus 0.0036 0.003 0.0239
Trypanosoma brucei RNA helicase, putative 0.01 0.0229 0.1865
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0036 0.003 0.003
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Echinococcus multilocularis orexin receptor type 2 0.0036 0.003 0.0029
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 0.042 0.1226 1
Brugia malayi Dopamine receptor 0.0036 0.003 0.0064
Echinococcus granulosus hypothetical protein 0.0036 0.003 0.0029
Onchocerca volvulus 0.0036 0.003 0.0239
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Mycobacterium ulcerans aminopeptidase N PepN 0.0172 0.0454 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.003 0.0029
Schistosoma mansoni hypothetical protein 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Brugia malayi AKH receptor 0.0036 0.003 0.0064
Schistosoma mansoni opsin-like receptor 0.0036 0.003 0.0029
Loa Loa (eye worm) leukotriene A4 hydrolase 0.3237 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0091 0.0201 0.4424
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.003 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0122 0.2681
Brugia malayi Protein kinase domain containing protein 0.0447 0.131 0.2875
Brugia malayi larval opioid receptor 0.0036 0.003 0.0064
Echinococcus multilocularis serotonin receptor 0.0036 0.003 0.0029
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0172 0.0454 1
Echinococcus multilocularis fmrfamide receptor 0.0036 0.003 0.0029
Trypanosoma brucei trypanothione reductase 0.0047 0.0064 0.0518
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0036 0.003 0.0064
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0076 0.0155 0.4044
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0091 0.0201 0.02
Onchocerca volvulus 0.0172 0.0454 0.3695
Toxoplasma gondii hypothetical protein 0.0066 0.0122 0.2681
Onchocerca volvulus 0.0036 0.003 0.0239
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.003 0.0029
Schistosoma mansoni biogenic amine receptor 0.0036 0.003 0.0029
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0064 0.0063
Brugia malayi hypothetical protein 0.0036 0.003 0.0064
Onchocerca volvulus 0.0036 0.003 0.0239
Brugia malayi putative neuropeptide receptor NPR1 0.0036 0.003 0.0064
Loa Loa (eye worm) hypothetical protein 0.0717 0.2151 0.2151
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0091 0.0201 0.4424
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0036 0.003 0.0029
Echinococcus multilocularis serotonin receptor 0.0036 0.003 0.0029
Giardia lamblia Ribonuclease H 0.0027 0.0001 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0036 0.003 0.0239
Schistosoma mansoni hypothetical protein 0.0125 0.0308 0.0307
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0172 0.0454 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0036 0.003 0.0029
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.042 0.1226 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0002 0.0002
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.0339 0.0338
Brugia malayi Furin-like cysteine rich region family protein 0.0203 0.0551 0.1208
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0091 0.0201 0.4424
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0172 0.0454 0.3695
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0172 0.0454 0.3695
Onchocerca volvulus 0.0036 0.003 0.0239
Brugia malayi glutathione reductase 0.0047 0.0064 0.0139
Echinococcus multilocularis G protein coupled receptor 139 0.0036 0.003 0.0029
Echinococcus multilocularis g protein coupled receptor 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Brugia malayi hypothetical protein 0.0036 0.003 0.0064
Schistosoma mansoni thyroid hormone receptor 0.0135 0.0339 0.0338
Leishmania major DNA polymerase eta, putative 0.0045 0.0057 0.0454
Schistosoma mansoni tyrosine kinase 0.0203 0.0551 0.055
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0091 0.0201 0.044
Onchocerca volvulus 0.0036 0.003 0.0239
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Onchocerca volvulus 0.0172 0.0454 0.3695
Schistosoma mansoni family S10 non-peptidase homologue (S10 family) 0.042 0.1226 0.1225
Echinococcus granulosus neuropeptide receptor A26 0.0494 0.1455 0.1454
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Schistosoma mansoni tyrosine kinase 0.0447 0.131 0.1309
Onchocerca volvulus 0.0036 0.003 0.0239
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0036 0.003 0.0029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.003 0.0029
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0172 0.0454 0.3695
Echinococcus granulosus 7tm_1 domain containing protein 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0091 0.0201 0.0201
Echinococcus granulosus g protein coupled receptor 0.0036 0.003 0.0029
Schistosoma mansoni DNA polymerase eta 0.0045 0.0057 0.0056
Brugia malayi Dopamine receptor protein 2 0.0036 0.003 0.0064

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 110 uM Cytostatic concentration required to inhibitcell proliferation in human CEM cell line ChEMBL. 16220981
EC50 (functional) = 4.9 uM Effective concentration required to inhibit HIV-1 induced cytopathicity in human MT-4 cell line ChEMBL. 16220981
EC50 (functional) = 5 uM Effective concentration required to inhibit HIV-1 induced cytopathicity in human CEM cell line ChEMBL. 16220981
EC50 (functional) > 25 uM Effective concentration required to inhibit HIV-2 induced cytopathicity in human MT-4 cell line ChEMBL. 16220981
EC50 (functional) > 25 uM Effective concentration required to inhibit HIV-2 induced cytopathicity in human CEM cell line ChEMBL. 16220981
EC50 (functional) > 25 uM Effective concentration required to inhibit HIV-1/138K induced cytopathicity in human CEM cell line ChEMBL. 16220981
IC50 (binding) = 11 uM Inhibitory concentration required to inhibit recombinant HIV-1 reverse transcriptase ChEMBL. 16220981
SI (functional) = 22 Ratio of cytostatic concentration to effective concentration in human CEM cell line ChEMBL. 16220981

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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