Detailed information for compound 343872

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 364.319 | Formula: C18H15F3N2O3
  • H donors: 3 H acceptors: 3 LogP: 0.5 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CC(C(=O)O)N)Nc1ccc2c(c1)Cc1c2ccc(c1)C(F)(F)F
  • InChi: 1S/C18H15F3N2O3/c19-18(20,21)11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)23-16(24)8-15(22)17(25)26/h1-4,6-7,15H,5,8,22H2,(H,23,24)(H,25,26)
  • InChiKey: RQMJHVCNUOBABB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0102 0.0995 0.2535
Loa Loa (eye worm) hypothetical protein 0.0035 0.0228 0.045
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0989 0.2522
Onchocerca volvulus 0.0029 0.0167 0.0319
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0052 0.0167
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0193 0.2034 0.4016
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0365 0.093
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0074 0.0678 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0541 0.1549
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0016 0.0032
Echinococcus multilocularis excitatory amino acid transporter 2 0.0457 0.5056 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0549 0.1776
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.033
Entamoeba histolytica hypothetical protein 0.0047 0.0365 0.093
Echinococcus granulosus sodium:dicarboxylate symporter 0.0457 0.5056 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0137 0.0348
Trypanosoma brucei glucose transporter, putative 0.0065 0.0573 0.1642
Plasmodium falciparum DNA topoisomerase 3, putative 0.0015 0.0006 0.0006
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0564 0.0564
Leishmania major mitochondrial DNA topoisomerase II 0.032 0.3491 1
Brugia malayi DNA topoisomerase III beta-1 0.0015 0.0006 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0541 0.1549
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0035 0.0228 0.045
Schistosoma mansoni glucose transport protein 0.0209 0.2226 0.4403
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0549 0.1086
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0228 0.0652
Trypanosoma brucei glucose transporter, putative 0.0065 0.0573 0.1642
Leishmania major glucose transporter, lmgt2 0.0065 0.0573 0.1642
Schistosoma mansoni terminal deoxycytidyl transferase 0.0035 0.0228 0.045
Schistosoma mansoni ap endonuclease 0.0019 0.0052 0.0102
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0457 0.5056 1
Leishmania major DNA polymerase eta, putative 0.0035 0.0228 0.0652
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0541 0.1549
Onchocerca volvulus 0.0029 0.0167 0.0319
Onchocerca volvulus 0.0029 0.0167 0.0319
Loa Loa (eye worm) hypothetical protein 0.0037 0.0255 0.0505
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0167 0.033
Leishmania major hypothetical protein, conserved 0.0029 0.0167 0.0478
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0167 0.0478
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0052 0.0102
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0564 0.1115
Echinococcus granulosus Excitatory amino acid transporter 0.0457 0.5056 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0299 0.0967
Echinococcus multilocularis transient receptor potential ion channel A 0.0097 0.0935 0.1849
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0016 0.0016
Brugia malayi CHE-14 protein 0.0043 0.0328 0.0648
Onchocerca volvulus 0.0029 0.0167 0.0319
Echinococcus granulosus geminin 0.0174 0.1825 0.361
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0167 0.033
Onchocerca volvulus 0.0155 0.1609 0.3174
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0328 0.0648
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1513 0.4334
Onchocerca volvulus 0.0029 0.0167 0.0319
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0668 0.1914
Loa Loa (eye worm) hypothetical protein 0.0155 0.1609 0.3182
Echinococcus granulosus solute carrier family 22 0.0029 0.0167 0.033
Loa Loa (eye worm) hypothetical protein 0.0116 0.1157 0.2288
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0137 0.0207
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.1487 0.294
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.033
Trypanosoma brucei DNA topoisomerase IA, putative 0.0015 0.0006 0.0017
Leishmania major DNA topoisomerase 1A 0.0015 0.0006 0.0017
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0564 0.0564
Trypanosoma brucei glucose transporter, putative 0.0065 0.0573 0.1642
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.033
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0564 0.1115
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.033 0.0946
Schistosoma mansoni protein kinase 0.0064 0.0564 0.1115
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0549 0.1086
Treponema pallidum DNA topoisomerase I (topA) 0.0015 0.0006 0.0028
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0031
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0255 0.0505
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0328 0.0648
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0167 0.0478
Schistosoma mansoni hypothetical protein 0.0042 0.031 0.0612
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0052 0.0131
Onchocerca volvulus 0.0029 0.0167 0.0319
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0231 0.0457
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Echinococcus granulosus dna polymerase kappa 0.0062 0.0541 0.107
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0573 0.1642
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0167 0.0478
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0284 0.0562
Giardia lamblia DNA repair protein RAD52 0.0358 0.3923 1
Leishmania major DNA topoisomerase ii 0.027 0.2916 0.8352
Schistosoma mansoni hypothetical protein 0.0209 0.2226 0.4403
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0541 0.1549
Schistosoma mansoni glucose transporter 0.0029 0.0167 0.033
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0549 0.1399
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0061 0.0532 0.2476
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.033
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0052 0.0148
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0564 0.1115
Brugia malayi hypothetical protein 0.0029 0.0167 0.033
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0417 0.0825
Brugia malayi hypothetical protein 0.0155 0.1609 0.3182
Schistosoma mansoni transient receptor potential channel 0.0066 0.0586 0.1159
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0167 0.033
Toxoplasma gondii protein kinase, putative 0.0591 0.66 1
Loa Loa (eye worm) hypothetical protein 0.0193 0.2037 0.4029
Chlamydia trachomatis DNA topoisomerase I 0.0015 0.0006 0.0012
Echinococcus multilocularis General substrate transporter 0.018 0.1889 0.3736
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2226 0.4403
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2226 0.4403
Echinococcus multilocularis solute carrier family 22 0.0029 0.0167 0.033
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0052 0.0102
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0193 0.2034 0.4016
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1513 0.4334
Loa Loa (eye worm) hypothetical protein 0.0039 0.0278 0.055
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0016 0.0046
Plasmodium falciparum DNA gyrase subunit A 0.0061 0.0532 0.0532
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0541 0.1549
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0137 0.0392
Echinococcus multilocularis expressed conserved protein 0.0095 0.0919 0.1817
Loa Loa (eye worm) TOPoisomerase family member 0.0285 0.3092 0.6114
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0167 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.2226 0.7201
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2226 0.4403
Toxoplasma gondii DNA topoisomerase 2, putative 0.0285 0.3092 0.4684
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.0647
Brugia malayi hypothetical protein 0.0037 0.0254 0.0502
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0061 0.0532 0.0805
Loa Loa (eye worm) hypothetical protein 0.0051 0.0414 0.0819
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0457 0.5056 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0167 0.0964
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1236 0.2444
Schistosoma mansoni flap endonuclease-1 0.0024 0.0107 0.0212
Loa Loa (eye worm) hypothetical protein 0.0064 0.0564 0.1115
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0365 0.2107
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0564 0.0855
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0549 0.1086
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0365 0.0553
Plasmodium vivax DNA gyrase subunit B, putative 0.0166 0.1732 0.1732
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0052 0.0102
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0031
Loa Loa (eye worm) hypothetical protein 0.0026 0.0127 0.0251
Toxoplasma gondii exonuclease III APE 0.0019 0.0052 0.0078
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0167 0.0964
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0564 0.0564
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0167 0.054
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0305 0.0604
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0541 0.1549
Schistosoma mansoni sugar transporter 0.0029 0.0167 0.033
Echinococcus multilocularis neutral amino acid transporter A 0.0457 0.5056 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0573 0.1854
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0052 0.024
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0365 0.0722
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.3386 0.97
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0417 0.0825
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0167 0.054
Schistosoma mansoni sugar transporter 0.0029 0.0167 0.033
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0166 0.1732 0.2624
Loa Loa (eye worm) hypothetical protein 0.0047 0.0365 0.0722
Chlamydia trachomatis DNA gyrase subunit A 0.0061 0.0532 0.1051
Echinococcus granulosus transient receptor potential gamma protein 0.01 0.0973 0.1924
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0564 0.0564
Onchocerca volvulus 0.0029 0.0167 0.0319
Brugia malayi Excitatory amino acid transporter 0.0457 0.5056 1
Schistosoma mansoni glucose transport protein 0.0209 0.2226 0.4403
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0137 0.027
Onchocerca volvulus 0.0029 0.0167 0.0319
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0549 0.1086
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2226 0.4403
Echinococcus multilocularis solute carrier family 22 0.0029 0.0167 0.033
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0167 0.033
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0125 0.0248
Echinococcus granulosus GPCR family 2 0.0016 0.0016 0.0031
Echinococcus multilocularis GPCR, family 2 0.0016 0.0016 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0127 0.0127
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0052 0.0052
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0285 0.3092 0.6114
Onchocerca volvulus 0.0029 0.0167 0.0319
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0365 0.0722
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0016 0.0032
Schistosoma mansoni transient receptor potential channel 4 0.01 0.0973 0.1924
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0084 0.0166
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0549 0.1399
Onchocerca volvulus 0.0029 0.0167 0.0319
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0439 0.1259
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0365 0.118
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0137 0.0392
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Giardia lamblia DNA topoisomerase III 0.0015 0.0006 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0267 0.0764
Chlamydia trachomatis DNA gyrase subunit B 0.0166 0.1732 0.3425
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0193 0.2034 0.4016
Onchocerca volvulus 0.0029 0.0167 0.0319
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0989 0.1956
Echinococcus granulosus General substrate transporter 0.018 0.1889 0.3736
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0031
Treponema pallidum glutamate transporter 0.0202 0.2147 1
Trypanosoma brucei glucose transporter 1E 0.0065 0.0573 0.1642
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0564 0.0855
Brugia malayi hypothetical protein 0.0026 0.0127 0.0251
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0328 0.0648
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0015 0.0006 0.0009
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0365 0.1045
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0541 0.1549
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0328 0.1059
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0062 0.0541 0.1749
Schistosoma mansoni hypothetical protein 0.0174 0.1825 0.361
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.033
Echinococcus granulosus expressed conserved protein 0.0095 0.0919 0.1817
Echinococcus granulosus solute carrier family 22 0.0029 0.0167 0.033
Plasmodium falciparum proline--tRNA ligase 0.0073 0.0668 0.0668
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0167 0.033
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.0647
Trypanosoma cruzi DNA topoisomerase III, putative 0.0015 0.0006 0.0017
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.033 0.0946
Plasmodium vivax proline--tRNA ligase, putative 0.0073 0.0668 0.0668
Entamoeba histolytica hypothetical protein 0.0102 0.0995 0.2535
Onchocerca volvulus 0.0029 0.0167 0.0319
Mycobacterium ulcerans DNA gyrase subunit A 0.0061 0.0532 0.3069
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0285 0.3092 0.6114
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0166 0.1732 0.3425
Trypanosoma brucei unspecified product 0.0055 0.0463 0.1327
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0518 0.1025
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0573 0.1642
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0016 0.0032
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0564 0.1115
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0016 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0305 0.0875
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0668 0.1914
Leishmania major glucose transporter, lmgt3 0.0065 0.0573 0.1642
Schistosoma mansoni transient receptor potential channel 0.0066 0.0586 0.1159
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0429
Loa Loa (eye worm) sugar transporter 0.0029 0.0167 0.033
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0016 0.0032
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0016 0.0032
Toxoplasma gondii sugar transporter ST1 0.0029 0.0167 0.0253
Plasmodium falciparum hexose transporter 0.0209 0.2226 0.2226
Leishmania major DNA topoisomerase III, putative 0.0015 0.0006 0.0017
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0015 0.0006 0.0017
Plasmodium falciparum flap endonuclease 1 0.0027 0.0137 0.0137
Echinococcus granulosus transient receptor potential ion channel A 0.0097 0.0935 0.1849
Brugia malayi Probable DNA topoisomerase II 0.0285 0.3092 0.6114
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0031
Brugia malayi Sugar transporter family protein 0.0029 0.0167 0.033
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0457 0.5056 1
Plasmodium falciparum protein kinase 7 0.0591 0.66 0.66
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0573 0.1854
Entamoeba histolytica DNA topoisomerase II, putative 0.0285 0.3092 0.788
Loa Loa (eye worm) hypothetical protein 0.0063 0.0548 0.1083
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.1703 0.3368
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0586 0.1159
Loa Loa (eye worm) hypothetical protein 0.0063 0.0549 0.1086
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0167 0.054
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0166 0.1732 0.8068
Chlamydia trachomatis neutral amino acid transporter 0.0202 0.2147 0.4245
Schistosoma mansoni hypothetical protein 0.0042 0.031 0.0612
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0209 0.2226 0.4403
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0061 0.0532 0.1051
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.032 0.3491 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.033 0.0946
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0167 0.054
Schistosoma mansoni patched 1 0.0043 0.0328 0.0648
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0052 0.0102
Plasmodium vivax sugar transporter, putative 0.0029 0.0167 0.0167
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0052 0.0148
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Treponema pallidum glutamate/aspartate transporter 0.0202 0.2147 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.033
Trypanosoma brucei glucose transporter, putative 0.0065 0.0573 0.1642
Loa Loa (eye worm) hypothetical protein 0.0116 0.1157 0.2288
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0586 0.1159
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0989 0.1956
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0084 0.0485
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0564 0.1115
Echinococcus granulosus excitatory amino acid transporter 2 0.0457 0.5056 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0365 0.1045
Schistosoma mansoni hypothetical protein 0.0042 0.031 0.0612
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0541 0.3123
Brugia malayi major facilitator superfamily protein 0.0029 0.0167 0.033
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0167 0.033
Trypanosoma brucei glucose transporter 2A 0.0065 0.0573 0.1642
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0031
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0016 0.0032
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1236 0.2444
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0015 0.0006 0.0012
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0016 0.0046
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0573 0.1642
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0365 0.0722
Echinococcus granulosus excitatory amino acid transporter 2 0.0457 0.5056 1
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0015 0.0006 0.0012
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 0.3386 0.97
Schistosoma mansoni glucose transport protein 0.0209 0.2226 0.4403
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.033
Leishmania major DNA topoisomerase III, putative 0.0015 0.0006 0.0017
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0457 0.5056 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0209 0.2226 0.3373
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0015 0.0006 0.0012
Trypanosoma cruzi DNA topoisomerase II, putative 0.027 0.2916 0.8352
Trypanosoma brucei DNA topoisomerase II beta, putative 0.027 0.2916 0.8352
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0573 0.1854
Schistosoma mansoni hypothetical protein 0.0037 0.0254 0.0502
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0541 0.1549
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Loa Loa (eye worm) hypothetical protein 0.0039 0.0278 0.055
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Brugia malayi DNA topoisomerase III 0.0015 0.0006 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0564 0.1115
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0202 0.2147 0.4245
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0063 0.0549 0.1086
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0267 0.0764
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Trypanosoma brucei sugar transporter, putative 0.0029 0.0167 0.0478
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0541 0.1549
Entamoeba histolytica protein kinase, putative 0.0064 0.0564 0.1437
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Loa Loa (eye worm) sugar transporter 0.0209 0.2226 0.4403
Echinococcus multilocularis dna polymerase kappa 0.0062 0.0541 0.107
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0668 0.1914
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0255 0.0505
Plasmodium vivax DNA gyrase subunit A, putative 0.0061 0.0532 0.0532
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0254 0.0502
Echinococcus multilocularis excitatory amino acid transporter 2 0.0457 0.5056 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0417 0.0825
Echinococcus granulosus excitatory amino acid transporter 3 0.0457 0.5056 1
Brugia malayi Sugar transporter family protein 0.0209 0.2226 0.4403
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0167 0.033
Giardia lamblia Sugar-proton symporter 0.0029 0.0167 0.0426
Mycobacterium ulcerans sugar transporter 0.0029 0.0167 0.0964
Brugia malayi Cam kinase protein 1 0.0064 0.0564 0.1115
Echinococcus multilocularis Excitatory amino acid transporter 0.0457 0.5056 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0564 0.1115
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0365 0.2107
Echinococcus multilocularis geminin 0.0174 0.1825 0.361
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0015 0.0006 0.0012
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0052 0.0102
Schistosoma mansoni protein kinase 0.0064 0.0564 0.1115
Chlamydia trachomatis glutamate symporter 0.0457 0.5056 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0167 0.033
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0182 0.0521
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0564 0.1115
Entamoeba histolytica deoxycytidyl transferase, putative 0.0035 0.0228 0.058
Brugia malayi Sugar transporter family protein 0.0029 0.0167 0.033
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.0647
Trypanosoma brucei DNA topoisomerase III, putative 0.0015 0.0006 0.0017
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0016 0.0031
Giardia lamblia DINP protein human, muc B family 0.0042 0.0305 0.0778
Schistosoma mansoni hypothetical protein 0.0174 0.1825 0.361
Echinococcus granulosus flap endonuclease 1 0.0027 0.0137 0.027
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0052 0.0131
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.1513 0.4334
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0084 0.0391
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0127 0.0192
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0254 0.0502
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.3386 0.97
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0236 0.0677
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Loa Loa (eye worm) hypothetical protein 0.0038 0.0267 0.0527
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0202 0.2147 0.4245
Echinococcus multilocularis excitatory amino acid transporter 3 0.0457 0.5056 1
Echinococcus granulosus neutral amino acid transporter 0.0457 0.5056 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0016 0.0046
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0016 0.0024
Trypanosoma brucei DNA topoisomerase III, putative 0.0015 0.0006 0.0017
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0365 0.1045
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Echinococcus granulosus neutral amino acid transporter A 0.0457 0.5056 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0035 0.0228 0.045
Plasmodium falciparum mitogen-activated protein kinase 2 0.0338 0.3702 0.3702
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0586 0.1159
Leishmania major DNA polymerase kappa, putative 0.0042 0.0305 0.0875
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0127 0.0363
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0016 0.0046
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0052 0.0298
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0365 0.0722
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0573 0.1854
Brugia malayi GRF zinc finger family protein 0.0015 0.0006 0.0012
Trypanosoma brucei DNA polymerase eta, putative 0.0035 0.0228 0.0652
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.033
Loa Loa (eye worm) hypothetical protein 0.0035 0.0231 0.0457
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0016 0.0032
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2226 0.4403
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0031
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0127 0.0363
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0061 0.0532 0.1051
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0457 0.5056 1
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0167 0.054
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0167 0.0964
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0052 0.0148
Schistosoma mansoni ap endonuclease 0.0019 0.0052 0.0102
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.033
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0073 0.0668 0.1012
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0167 0.033
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0284 0.0562
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Onchocerca volvulus 0.0029 0.0167 0.0319
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0564 0.1824
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0989 0.1956
Echinococcus multilocularis Excitatory amino acid transporter 0.0457 0.5056 1
Plasmodium vivax DNA topoisomerase 3, putative 0.0015 0.0006 0.0006
Mycobacterium ulcerans hypothetical protein 0.0164 0.1703 0.9833
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0573 0.1642
Trypanosoma cruzi DNA topoisomerase III, putative 0.0015 0.0006 0.0017
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0015 0.0006 0.0012
Echinococcus multilocularis neutral amino acid transporter A 0.0457 0.5056 1
Echinococcus multilocularis solute carrier family 22 0.0029 0.0167 0.033
Trypanosoma brucei DNA polymerase IV, putative 0.0055 0.0463 0.1327
Schistosoma mansoni protein kinase 0.0064 0.0564 0.1115
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0564 0.0564
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0052 0.0052
Brugia malayi MH2 domain containing protein 0.0123 0.1236 0.2444
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0564 0.1115
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0564 0.1115
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0573 0.1854
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0127 0.0127
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0228 0.045
Echinococcus multilocularis rho GTPase activating protein 20 0.0015 0.0006 0.0012
Schistosoma mansoni DNA topoisomerase II 0.0285 0.3092 0.6114
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0358 0.3923 1
Loa Loa (eye worm) hypothetical protein 0.0193 0.2037 0.4029
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.033
Schistosoma mansoni sugar transporter 0.0029 0.0167 0.033
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0167 0.033
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0541 0.3123
Trypanosoma brucei glucose transporter, putative 0.0065 0.0573 0.1642
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0202 0.2147 0.4245
Echinococcus multilocularis neutral amino acid transporter A 0.0457 0.5056 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0137 0.0442
Toxoplasma gondii hypothetical protein 0.005 0.0404 0.0612
Giardia lamblia DNA topoisomerase II 0.027 0.2922 0.7447
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0254 0.0502
Giardia lamblia Hexose transporter 0.0029 0.0167 0.0426
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0285 0.3092 0.6114
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0228 0.045
Toxoplasma gondii sugar transporter ST3 0.0029 0.0167 0.0253
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.033
Echinococcus granulosus Excitatory amino acid transporter 0.0457 0.5056 1
Giardia lamblia DNA topoisomerase III 0.0015 0.0006 0.0015
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0015 0.0006 0.0012
Echinococcus granulosus solute carrier family 22 0.0029 0.0167 0.033
Plasmodium falciparum DNA gyrase subunit B 0.0166 0.1732 0.1732
Leishmania major glucose transporter, lmgt1 0.0065 0.0573 0.1642
Echinococcus granulosus neutral amino acid transporter A 0.0457 0.5056 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0167 0.054
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0031
Trypanosoma brucei unspecified product 0.0024 0.0104 0.0299
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0167 0.033
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0573 0.1854
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0541 0.1549
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0564 0.0564
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0016 0.0032
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2226 0.4403
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0167 0.033
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0549 0.1086
Mycobacterium ulcerans DNA topoisomerase I 0.0015 0.0006 0.0035
Entamoeba histolytica protein kinase, putative 0.0064 0.0564 0.1437
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0015 0.0006 0.0017
Leishmania major hypothetical protein, conserved 0.0026 0.0127 0.0363
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0564 0.1115
Loa Loa (eye worm) hypothetical protein 0.0039 0.0278 0.055
Schistosoma mansoni sugar transporter 0.0029 0.0167 0.033
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0668 0.1914
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0365 0.5386
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0457 0.5056 1
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0031
Entamoeba histolytica DNA topoisomerase III, putative 0.0015 0.0006 0.0015
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0228 0.045
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0182 0.0521
Echinococcus multilocularis transient receptor potential gamma protein 0.01 0.0973 0.1924
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.1007 0.1992
Chlamydia trachomatis DNA gyrase subunit B 0.0131 0.1333 0.2636
Trypanosoma cruzi DNA topoisomerase II, putative 0.027 0.2916 0.8352
Toxoplasma gondii sugar transporter ST2 0.0029 0.0167 0.0253
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.033
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0586 0.1159
Onchocerca volvulus 0.0029 0.0167 0.0319
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0541 0.1549
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0564 0.1615
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.033
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0016 0.0032
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0305 0.0875
Loa Loa (eye worm) hypothetical protein 0.0101 0.0989 0.1956
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0015 0.0006 0.0012
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0573 0.1854
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0573 0.1642
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0137 0.0392
Echinococcus multilocularis dna polymerase eta 0.0035 0.0228 0.045
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.033
Trichomonas vaginalis DNA polymerase eta, putative 0.0062 0.0541 0.1749
Leishmania major mitochondrial DNA polymerase beta 0.0311 0.3386 0.97
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2226 0.4403
Loa Loa (eye worm) excitatory amino acid transporter 0.0457 0.5056 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0284 0.4196
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0338 0.3702 0.3702
Chlamydia trachomatis DNA gyrase subunit A 0.0061 0.0532 0.1051
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0255 0.0505
Loa Loa (eye worm) hypothetical protein 0.01 0.0973 0.1924
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0137 0.027
Loa Loa (eye worm) hypothetical protein 0.0051 0.0417 0.0825
Trypanosoma brucei unspecified product 0.0024 0.0104 0.0299
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0035 0.0228 0.045
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0285 0.3092 0.6114
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0328 0.0648
Onchocerca volvulus Putative transporter 0.0029 0.0167 0.0319
Plasmodium falciparum DNA topoisomerase 2 0.0285 0.3092 0.3092
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0668 0.1914
Brugia malayi polk-prov protein 0.0038 0.0267 0.0527
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0167 0.033
Toxoplasma gondii DNA topoisomerase family protein 0.0015 0.0006 0.0009
Echinococcus multilocularis protein patched 0.0043 0.0328 0.0648
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0016 0.0024
Echinococcus multilocularis solute carrier family 22 0.0029 0.0167 0.033
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0541 0.1549
Brugia malayi hypothetical protein 0.0029 0.0167 0.033
Entamoeba histolytica DNA topoisomerase III, putative 0.0015 0.0006 0.0015
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0338 0.3702 0.5609
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0127 0.0363
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0573 0.1642
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0202 0.2147 0.4245
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0541 0.1549
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.027 0.2916 0.8352
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0564 0.0564
Mycobacterium ulcerans DNA gyrase subunit B 0.0166 0.1732 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0564 0.0564
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0052 0.0167
Plasmodium vivax DNA topoisomerase II, putative 0.0285 0.3092 0.3092
Brugia malayi Flap endonuclease-1 0.0027 0.0137 0.027
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0137 0.0137
Trypanosoma brucei DNA topoisomerase ii 0.032 0.3491 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0035 0.0228 0.045
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0564 0.1115
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0573 0.1642
Schistosoma mansoni DNA polymerase eta 0.0035 0.0228 0.045
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0365 0.0722
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0167 0.054
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0016 0.0031
Trypanosoma cruzi hexose transporter 0.0065 0.0573 0.1642
Loa Loa (eye worm) hypothetical protein 0.0043 0.0328 0.0648
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0564 0.0564
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Trypanosoma brucei glucose transporter, putative 0.0065 0.0573 0.1642
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0166 0.1732 0.3425
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0549 0.8102
Trypanosoma brucei glucose transporter, putative 0.0065 0.0573 0.1642
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0167 0.0478
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.032 0.3491 1
Schistosoma mansoni hypothetical protein 0.0035 0.0231 0.0457
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0518 0.1025
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0182 0.0521
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.033
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0015 0.0006 0.009
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0052 0.0102
Plasmodium vivax hexose transporter 0.0209 0.2226 0.2226
Echinococcus granulosus solute carrier family 22 0.0029 0.0167 0.033
Brugia malayi major facilitator superfamily protein 0.0029 0.0167 0.033
Brugia malayi hypothetical protein 0.0017 0.0022 0.0043
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0015 0.0006 0.002
Brugia malayi isocitrate dehydrogenase 0.0016 0.0016 0.0032
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0167 0.0478
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0365 0.0722
Trichomonas vaginalis DNA topoisomerase II, putative 0.0285 0.3092 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0564 0.0855
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0016 0.0032
Trypanosoma cruzi DNA topoisomerase III, putative 0.0015 0.0006 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0541 0.1549
Trypanosoma brucei glucose transporter, putative 0.0065 0.0573 0.1642
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.0647
Echinococcus multilocularis protein dispatched 1 0.005 0.0398 0.0787
Onchocerca volvulus 0.0029 0.0167 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0167 0.054
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0016 0.0016
Plasmodium vivax CDK-related protein kinase 6, putative 0.0889 1 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Brugia malayi hypothetical protein 0.0029 0.0167 0.033
Leishmania major protein kinase, putative 0.0064 0.0564 0.1615
Loa Loa (eye worm) hypothetical protein 0.0053 0.0439 0.0869
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0031
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0052 0.0148
Onchocerca volvulus 0.0029 0.0167 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Schistosoma mansoni hypothetical protein 0.0042 0.031 0.0612
Echinococcus granulosus dna polymerase eta 0.0035 0.0228 0.045
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0127 0.0127
Schistosoma mansoni transient receptor potential channel 0.01 0.0973 0.1924
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0031 0.0047
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0365 0.0365
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.1487 0.294
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0016 0.0031
Loa Loa (eye worm) DNA topoisomerase III 0.0015 0.0006 0.0012
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0015 0.0006 0.002
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0549 0.1086
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.033 0.0946
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0541 0.1549
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0167 0.054
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0137 0.0348

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.1 uM Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2 ChEMBL. 16165356
IC50 (binding) = 2.4 uM Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3 ChEMBL. 16165356
IC50 (binding) = 3.8 uM Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1 ChEMBL. 16165356

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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