Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0052 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0052 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 61 uM | Cytotoxicity against MT4 cells by MTT method | ChEMBL. | 16335924 |
CC50 (functional) | > 61 uM | Cytotoxicity against MT4 cells by MTT method | ChEMBL. | 16335924 |
EC50 (functional) | = 0.15 uM | Antiviral activity against wild type HIV1 NL4-3 infected MT4 cells by MTT method | ChEMBL. | 16335924 |
EC50 (functional) | = 2.2 uM | Antiviral activity against HIV1 IRLL98 mutant strain infected MT4 cells by MTT method | ChEMBL. | 16335924 |
EC50 (functional) | > 61 uM | Antiviral activity against HIV1 K103N mutant strain infected MT4 cells by MTT method | ChEMBL. | 16335924 |
EC50 (functional) | > 61 uM | Antiviral activity against HIV1 Y188L mutant strain infected MT4 cells by MTT method | ChEMBL. | 16335924 |
ID50 (binding) | 0 | Inhibition of Y181I mutant HIV1 reverse transcriptase by [3H]-dTTP poly(rA)/oligo(dT) incorporation at 400 uM | ChEMBL. | 16335924 |
ID50 (binding) | = 2 uM | Inhibition of wild type HIV1 reverse transcriptase by [3H]-dTTP poly(rA)/oligo(dT) incorporation | ChEMBL. | 16335924 |
ID50 (binding) | = 2 uM | Inhibition of wild type HIV1 reverse transcriptase by [3H]-dTTP poly(rA)/oligo(dT) incorporation | ChEMBL. | 16335924 |
ID50 (binding) | = 35 uM | Inhibition of K103N mutant HIV1 reverse transcriptase by [3H]-dTTP poly(rA)/oligo(dT) incorporation | ChEMBL. | 16335924 |
ID50 (binding) | = 35 uM | Inhibition of K103N mutant HIV1 reverse transcriptase by [3H]-dTTP poly(rA)/oligo(dT) incorporation | ChEMBL. | 16335924 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.