Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dynamin 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dynamin, putative | 0.0026 | 0.0864 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0116 | 0.6906 | 0.8837 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.254 | 1 |
Trichomonas vaginalis | dynamin, putative | 0.0026 | 0.0864 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0313 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0018 | 0.0313 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0313 | 0.1234 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.254 | 1 |
Schistosoma mansoni | dynamin | 0.0028 | 0.0997 | 0.0706 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.1725 | 0.6341 |
Trypanosoma brucei | dynamin-1-like protein | 0.0026 | 0.0864 | 0.2471 |
Echinococcus granulosus | dynamin 1 protein | 0.0026 | 0.0864 | 0.2471 |
Trichomonas vaginalis | interferon-induced GTP-binding protein mx, putative | 0.0026 | 0.0864 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0313 | 0.5 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0018 | 0.0313 | 0.0177 |
Schistosoma mansoni | dynamin | 0.0028 | 0.0997 | 0.0706 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.254 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1725 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0018 | 0.0313 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0018 | 0.0313 | 0.5 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0018 | 0.0313 | 0.0177 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0129 | 0.7773 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.254 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0018 | 0.0313 | 0.5 |
Trypanosoma brucei | dynamin-1-like protein | 0.0026 | 0.0864 | 0.2471 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0116 | 0.6906 | 0.8837 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.254 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1725 | 1 |
Trichomonas vaginalis | dynamin, putative | 0.0026 | 0.0864 | 1 |
Plasmodium falciparum | dynamin-like protein | 0.0026 | 0.0864 | 0.2471 |
Echinococcus granulosus | dynamin 1 | 0.0028 | 0.0997 | 0.307 |
Giardia lamblia | Dynamin | 0.0026 | 0.0864 | 1 |
Leishmania major | trypanothione reductase | 0.0051 | 0.254 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.254 | 1 |
Schistosoma mansoni | dynamin | 0.0026 | 0.0864 | 0.0568 |
Toxoplasma gondii | dynamin-related protein DRPA | 0.0026 | 0.0864 | 0.2605 |
Echinococcus multilocularis | dynamin | 0.0026 | 0.0864 | 0.2471 |
Mycobacterium tuberculosis | Probable reductase | 0.0116 | 0.6906 | 0.8837 |
Brugia malayi | Dynamin | 0.0028 | 0.0997 | 0.3925 |
Trichomonas vaginalis | mgm1, putative | 0.0026 | 0.0864 | 1 |
Plasmodium falciparum | dynamin-like protein | 0.0026 | 0.0864 | 0.2471 |
Brugia malayi | hypothetical protein | 0.0039 | 0.1725 | 0.6792 |
Trichomonas vaginalis | dynamin, putative | 0.0026 | 0.0864 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0997 | 0.0795 |
Toxoplasma gondii | dynamin-related protein DRPB | 0.0026 | 0.0864 | 0.2605 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.254 | 1 |
Echinococcus multilocularis | dynamin 1 protein | 0.0026 | 0.0864 | 0.2471 |
Echinococcus multilocularis | dynamin 1 | 0.0028 | 0.0997 | 0.307 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.254 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0116 | 0.6906 | 0.8837 |
Plasmodium vivax | dynamin protein, putative | 0.0026 | 0.0864 | 0.2471 |
Leishmania major | GTP-binding protein, putative | 0.0026 | 0.0864 | 0.2471 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0129 | 0.7773 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0116 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0129 | 0.7773 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.254 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.1725 | 0.6341 |
Echinococcus granulosus | dynamin | 0.0026 | 0.0864 | 0.2471 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.1725 | 0.1458 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0129 | 0.7773 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0018 | 0.0313 | 0.5 |
Plasmodium vivax | dynamin-like protein, putative | 0.0026 | 0.0864 | 0.2471 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1725 | 1 |
Brugia malayi | Dynamin | 0.0028 | 0.0997 | 0.3925 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0116 | 0.6906 | 0.8837 |
Trichomonas vaginalis | dynamin, putative | 0.0026 | 0.0864 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.254 | 0.2985 |
Trichomonas vaginalis | dynamin, putative | 0.0026 | 0.0864 | 1 |
Brugia malayi | glutathione reductase | 0.0051 | 0.254 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.254 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1725 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1725 | 0.1458 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.254 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.254 | 1 |
Brugia malayi | Dynamin central region family protein | 0.0026 | 0.0864 | 0.34 |
Trypanosoma cruzi | dynamin-1-like protein | 0.0026 | 0.0864 | 0.2471 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.