Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = -8 % | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring 7-day weight change after intraperitoneal administration of compound at 1 mg/kg | ChEMBL. | 6546949 |
Activity (functional) | = -8 % | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring 7-day weight change after intraperitoneal administration of compound at 2 mg/kg | ChEMBL. | 6546949 |
Activity (functional) | = -8 % | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring 7-day weight change after intraperitoneal administration of compound at 1 mg/kg | ChEMBL. | 6546949 |
Activity (functional) | = -8 % | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring 7-day weight change after intraperitoneal administration of compound at 2 mg/kg | ChEMBL. | 6546949 |
Activity (functional) | = 88 % | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring percent increase in life span after intraperitoneal administration of compound at 0.5 mg/kg | ChEMBL. | 6546949 |
Activity (functional) | = 88 % | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring percent increase in life span after intraperitoneal administration of compound at 0.5 mg/kg | ChEMBL. | 6546949 |
Activity (functional) | = 100 % | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring percent increase in life span after intraperitoneal administration of compound at 1 mg/kg | ChEMBL. | 6546949 |
Activity (functional) | = 100 % | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring percent increase in life span after intraperitoneal administration of compound at 1 mg/kg | ChEMBL. | 6546949 |
Activity (functional) | = 138 % | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring percent increase in life span after intraperitoneal administration of compound at 2 mg/kg | ChEMBL. | 6546949 |
Activity (functional) | = 138 % | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring percent increase in life span after intraperitoneal administration of compound at 2 mg/kg | ChEMBL. | 6546949 |
ID50 (functional) | = 0.031 uM | Compound was evaluated for its cytotoxicity against the L1210 murine leukemia cell culture | ChEMBL. | 6546949 |
ID50 (functional) | = 0.031 uM | Compound was evaluated for its cytotoxicity against the L1210 murine leukemia cell culture | ChEMBL. | 6546949 |
ID50 (functional) | = 0.063 uM | Compound was evaluated for its antitumor activity by the inhibition of L1210 murine leukemia dihydrofolate reductase | ChEMBL. | 6546949 |
ID50 (functional) | = 0.063 uM | Compound was evaluated for its antitumor activity by the inhibition of L1210 murine leukemia dihydrofolate reductase | ChEMBL. | 6546949 |
Inhibition (binding) | = 77 % | Inhibition of Folyl-polyglutamate synthase from mouse liver | ChEMBL. | 3385729 |
Inhibition (binding) | = 77 % | Inhibition of Folyl-polyglutamate synthase from mouse liver | ChEMBL. | 3385729 |
Ki (binding) | = 45 uM | Inhibition of Folyl-polyglutamate synthase from mouse liver | ChEMBL. | 3385729 |
Ki (binding) | = 45 uM | Inhibition of Folyl-polyglutamate synthase from mouse liver | ChEMBL. | 3385729 |
Ki (binding) | = 59 uM | Compound was evaluated for the binding affinity to mouse liver folyl polyglutamate synthetase. | ChEMBL. | 6546949 |
Ki (binding) | = 59 uM | Compound was evaluated for the binding affinity to mouse liver folyl polyglutamate synthetase. | ChEMBL. | 6546949 |
Survival days (functional) | = 13 | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring number of survival days after intraperitoneal administration of compound at 0.5 mg/kg; at a range of 13-16 | ChEMBL. | 6546949 |
Survival days (functional) | = 13 | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring number of survival days after intraperitoneal administration of compound at 1 mg/kg; at a range of 13-17 | ChEMBL. | 6546949 |
Survival days (functional) | = 15 | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring T/C median after intraperitoneal administration of compound at 0.5 mg/kg; T/C median=15/8 | ChEMBL. | 6546949 |
Survival days (functional) | = 16 | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring T/C median after intraperitoneal administration of compound at 1 mg/kg; T/C median=16/8 | ChEMBL. | 6546949 |
Survival days (functional) | = 16 | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring number of survival days after intraperitoneal administration of compound at 2 mg/kg; at a range of 16-20 | ChEMBL. | 6546949 |
Survival days (functional) | = 19 | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring T/C median after intraperitoneal administration of compound at 2 mg/kg; T/C median=19/8 | ChEMBL. | 6546949 |
Weight change (functional) | = -1 % | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring 7-day weight change after intraperitoneal administration of compound at 0.5 mg/kg | ChEMBL. | 6546949 |
Weight change (functional) | = -1 % | In vivo antitumor activity was evaluated against L1210 leukemia implanted mice by measuring 7-day weight change after intraperitoneal administration of compound at 0.5 mg/kg | ChEMBL. | 6546949 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.