Detailed information for compound 34405

Basic information

Technical information
  • TDR Targets ID: 34405
  • Name: 8-[3-[(5-methoxy-3,4-dihydro-2H-chromen-3-yl) -propylamino]propoxy]-8-azaspiro[4.5]decane-7 ,9-dione
  • MW: 444.564 | Formula: C25H36N2O5
  • H donors: 0 H acceptors: 2 LogP: 4.28 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(C1COc2c(C1)c(OC)ccc2)CCCON1C(=O)CC2(CC1=O)CCCC2
  • InChi: 1S/C25H36N2O5/c1-3-12-26(19-15-20-21(30-2)8-6-9-22(20)31-18-19)13-7-14-32-27-23(28)16-25(17-24(27)29)10-4-5-11-25/h6,8-9,19H,3-5,7,10-18H2,1-2H3
  • InChiKey: AHHHNGSCPKOKHX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-[3-[(5-methoxychroman-3-yl)-propyl-amino]propoxy]-8-azaspiro[4.5]decane-7,9-dione
  • 8-[3-[(5-methoxy-3,4-dihydro-2H-1-benzopyran-3-yl)-propylamino]propoxy]-8-azaspiro[4.5]decane-7,9-dione
  • 8-[3-[(5-methoxy-3,4-dihydro-2H-chromen-3-yl)-propyl-amino]propoxy]-8-azaspiro[4.5]decane-7,9-dione
  • 8-[3-[(5-methoxychroman-3-yl)-propyl-amino]propoxy]-8-azaspiro[4.5]decane-7,9-quinone
  • 8-[3-[(5-methoxychroman-3-yl)-propylamino]propoxy]-8-azaspiro[4.5]decane-7,9-dione
  • 8-[3-[(5-methoxy-3-chromanyl)-propylamino]propoxy]-8-azaspiro[4.5]decane-7,9-dione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0458 0.242 0.3634
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Schistosoma mansoni adenosylhomocysteinase 0.0505 0.2677 0.4705
Echinococcus multilocularis sex peptide receptor 0.0458 0.242 0.242
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0061 0.0138
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0014 0.002
Treponema pallidum heat shock protein 90 0.0034 0.0107 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0458 0.242 0.4251
Echinococcus granulosus heat shock protein 90 0.003 0.0084 0.0123
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0458 0.242 0.242
Echinococcus granulosus high affinity choline transporter 1 0.0395 0.2075 0.3056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0458 0.242 0.4251
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0458 0.242 0.242
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.004 0.0139 0.027
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Onchocerca volvulus 0.0031 0.0094 0.0232
Loa Loa (eye worm) cytochrome P450 family protein 0.0116 0.0558 0.0838
Leishmania major protein kinase A catalytic subunit isoform 2 0.0345 0.1806 0.4108
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.004 0.0055
Brugia malayi Protein kinase domain containing protein 0.0016 0.0011 0.0011
Schistosoma mansoni atypical protein kinase C 0.0016 0.0011 0.0013
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.004 0.0139 0.027
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0218 0.1111 0.1666
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0345 0.1806 0.2711
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0047 0.0181 0.0272
Echinococcus multilocularis neuropeptides capa receptor 0.0458 0.242 0.242
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0065 0.0275 0.0617
Brugia malayi AKH receptor 0.0458 0.242 0.3634
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0016 0.0011 0.0011
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.004 0.0139 0.027
Mycobacterium tuberculosis Probable oxidoreductase 0.0137 0.067 0.1491
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0024 0.0052
Echinococcus multilocularis serine:threonine protein kinase N2 0.0016 0.0011 0.0011
Echinococcus granulosus regulator of G protein signaling 3 0.0065 0.0275 0.0405
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0345 0.1806 0.4128
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0458 0.242 0.8574
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.004 0.0139 0.027
Echinococcus multilocularis musashi 0.003 0.0083 0.0083
Onchocerca volvulus 0.0022 0.0041 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0011 0.0013
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0003 0.0005
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0458 0.242 0.3563
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0016 0.0011 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.004 0.0139 0.027
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0024 0.0021
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.004 0.0139 0.027
Echinococcus multilocularis neuropeptide FF receptor 2 0.0458 0.242 0.242
Onchocerca volvulus 0.0458 0.242 0.8574
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0458 0.242 0.3634
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Echinococcus granulosus g protein coupled receptor 0.0458 0.242 0.3563
Trypanosoma cruzi cytochrome p450-like protein, putative 0.004 0.0139 0.0315
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.004 0.0139 0.027
Trypanosoma cruzi cytochrome P450, putative 0.0067 0.0289 0.0659
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0024 0.0045
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0816 0.4374 1
Schistosoma mansoni hypothetical protein 0.0149 0.0735 0.1287
Onchocerca volvulus 0.0458 0.242 0.8574
Onchocerca volvulus 0.0022 0.0041 0.0042
Echinococcus granulosus NDR protein kinase 0.0016 0.0011 0.0016
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0132 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.013 0.0264
Loa Loa (eye worm) hypothetical protein 0.0345 0.1806 0.2715
Brugia malayi Pre-SET motif family protein 0.0067 0.029 0.0432
Brugia malayi protein kinase C II. 0.0016 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0458 0.242 0.4251
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0016
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0024 0.0045
Echinococcus granulosus low density lipoprotein receptor ldl 0.0022 0.0041 0.006
Schistosoma mansoni Smad4 0.0016 0.0012 0.0016
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0022 0.0041 0.0041
Echinococcus multilocularis lamin 0.003 0.0083 0.0083
Brugia malayi Thioredoxin reductase 0.0054 0.0217 0.0322
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.004 0.0139 0.0282
Echinococcus granulosus ATP dependent DNA helicase Q5 0.003 0.0084 0.0124
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0065 0.0275 0.0275
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0274 0.0411
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Mycobacterium tuberculosis Probable reductase 0.0123 0.0595 0.1318
Echinococcus granulosus sodium:glucose cotransporter 2 0.0044 0.016 0.0235
Brugia malayi intermediate filament protein 0.003 0.0083 0.0121
Loa Loa (eye worm) adenosylhomocysteinase 0.0816 0.4374 0.6576
Brugia malayi Regulator of G protein signaling domain containing protein 0.0065 0.0275 0.0409
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0067 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Echinococcus granulosus protein kinase C gamma type 0.0016 0.0011 0.0016
Echinococcus granulosus biogenic amine 5HT receptor 0.0605 0.3222 0.4745
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.029 0.0505
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0021 0.0044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0032 0.0062
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0273 0.0402
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.004 0.0139 0.0262
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.004 0.004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.004 0.0089
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0069 0.0298 0.0444
Brugia malayi Dopamine receptor 0.0458 0.242 0.3634
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0123 0.0595 0.1142
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.004 0.0139 0.0262
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0458 0.242 0.3563
Brugia malayi cytochrome P450 0.004 0.0139 0.0204
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0418 0.2203 0.3308
Leishmania major cytochrome p450-like protein 0.004 0.0139 0.0282
Schistosoma mansoni neuropeptide receptor 0.0458 0.242 0.4251
Schistosoma mansoni opsin-like receptor 0.0458 0.242 0.4251
Loa Loa (eye worm) AGC/PKA protein kinase 0.0345 0.1806 0.2715
Trypanosoma brucei heat shock protein, putative 0.003 0.0084 0.0157
Onchocerca volvulus 0.003 0.0083 0.0195
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0061
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.013 0.0191
Leishmania major C-8 sterol isomerase-like protein 0.0418 0.2203 0.5018
Echinococcus granulosus 7TM GPCR rhodopsin 0.0458 0.242 0.3563
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.013 0.0224
Loa Loa (eye worm) hypothetical protein 0.0363 0.19 0.2857
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0061
Leishmania major histone-lysine N-methyltransferase, putative 0.0033 0.0101 0.0195
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0458 0.242 0.242
Leishmania major protein kinase A catalytic subunit isoform 1 0.0345 0.1806 0.4108
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0033 0.0049
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0047 0.0181 0.0412
Echinococcus granulosus mitogen activated protein kinase 3 0.0121 0.0582 0.0857
Echinococcus granulosus expressed protein 0.1259 0.679 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0458 0.242 0.3637
Echinococcus multilocularis neuropeptide receptor 0.0458 0.242 0.242
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0261 0.0585
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0084 0.019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0069 0.0298 0.0439
Plasmodium falciparum adenosylhomocysteinase 0.0816 0.4374 1
Brugia malayi CUB domain containing protein 0.0022 0.0041 0.0057
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.0088 0.0149
Brugia malayi G protein-coupled receptor 0.0458 0.242 0.3634
Echinococcus granulosus somatostatin receptor 0.0458 0.242 0.3563
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.013 0.0286
Brugia malayi MH1 domain containing protein 0.0016 0.0012 0.0013
Brugia malayi hypothetical protein 0.0065 0.0275 0.0409
Echinococcus granulosus allatostatin A receptor 0.0458 0.242 0.3563
Brugia malayi G-protein coupled receptor 0.0458 0.242 0.3634
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Schistosoma mansoni hypothetical protein 0.1057 0.5687 1
Brugia malayi GnHR receptor homolog 0.0458 0.242 0.3634
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.013 0.0286
Leishmania major S-adenosylhomocysteine hydrolase 0.0816 0.4374 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0072 0.0315 0.0709
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0022 0.0041 0.0057
Schistosoma mansoni hypothetical protein 0.0458 0.242 0.4251
Echinococcus granulosus neuropeptide FF receptor 2 0.0458 0.242 0.3563
Loa Loa (eye worm) hypothetical protein 0.0044 0.016 0.024
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0081 0.0361 0.063
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Echinococcus granulosus intermediate filament protein 0.003 0.0083 0.0123
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0458 0.242 0.3634
Schistosoma mansoni opsin-like receptor 0.0458 0.242 0.4251
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.013 0.0264
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0024 0.0054
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Onchocerca volvulus 0.0458 0.242 0.8574
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0061
Echinococcus granulosus alpha 1A adrenergic receptor 0.0458 0.242 0.3563
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0065 0.0275 0.0478
Schistosoma mansoni regulator of G protein signaling 0.0065 0.0275 0.0478
Echinococcus granulosus neuropeptide receptor A26 0.0458 0.242 0.3563
Leishmania major arginine N-methyltransferase-like protein 0.003 0.0088 0.0166
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0033 0.0101 0.0228
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0066 0.0116
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0217 0.0492
Schistosoma mansoni lamin 0.003 0.0083 0.0141
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0274 0.0411
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0957 0.5142 0.7731
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0095 0.0205
Trichomonas vaginalis CMGC family protein kinase 0.0121 0.0582 0.1319
Loa Loa (eye worm) G-protein coupled receptor 0.0458 0.242 0.3637
Echinococcus granulosus cytochrome P450 2K1 0.004 0.0139 0.0204
Onchocerca volvulus 0.0458 0.242 0.8574
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Onchocerca volvulus Neuropeptide F receptor homolog 0.0458 0.242 0.8574
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0021 0.0021
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.004 0.0139 0.0262
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.0076 0.0128
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0022 0.0041 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0166 0.0367
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0458 0.242 0.4251
Loa Loa (eye worm) glutathione reductase 0.0054 0.0217 0.0326
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Entamoeba histolytica hypothetical protein 0.0041 0.0147 0.0331
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.013 0.0252
Schistosoma mansoni neuropeptide F-like receptor 0.0458 0.242 0.4251
Onchocerca volvulus 0.0458 0.242 0.8574
Brugia malayi Bloom's syndrome protein homolog 0.0072 0.0315 0.0469
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0026 0.0065 0.0145
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0071 0.0307 0.0461
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0275 0.0617
Brugia malayi Melatonin receptor type 1A 0.0458 0.242 0.3634
Onchocerca volvulus 0.0458 0.242 0.8574
Brugia malayi Hr1 repeat family protein 0.0016 0.0011 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0458 0.242 0.4251
Echinococcus granulosus G protein coupled receptor 139 0.0458 0.242 0.3563
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.013 0.0192
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.0357 0.0536
Echinococcus multilocularis solute carrier family 5 0.0044 0.016 0.016
Echinococcus multilocularis regulator of G protein signaling 3 0.0065 0.0275 0.0275
Echinococcus granulosus Protein kinase C brain isozyme 0.0016 0.0011 0.0016
Echinococcus multilocularis expressed protein 0.1259 0.679 0.679
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0184 0.041
Echinococcus multilocularis serine:threonine protein kinase 38 0.0016 0.0011 0.0011
Schistosoma mansoni heat shock protein 0.003 0.0084 0.0142
Brugia malayi hypothetical protein 0.0458 0.242 0.3634
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0022 0.0038
Loa Loa (eye worm) hypothetical protein 0.0218 0.1111 0.167
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0022 0.0041 0.006
Loa Loa (eye worm) hypothetical protein 0.0065 0.0275 0.0413
Schistosoma mansoni ap endonuclease 0.0021 0.004 0.0064
Echinococcus multilocularis rho associated protein kinase 0.0312 0.1622 0.1622
Entamoeba histolytica recQ family helicase, putative 0.0038 0.0132 0.0298
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0063 0.0267 0.0599
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0033 0.0101 0.0195
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0417 0.2195 0.2195
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0582 0.1018
Loa Loa (eye worm) neuropeptide F receptor 0.0458 0.242 0.3637
Toxoplasma gondii bicoid-interacting protein BIN3 0.0017 0.0015 0.0024
Loa Loa (eye worm) AGC/PKN protein kinase 0.0016 0.0011 0.0016
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0084 0.019
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Loa Loa (eye worm) RGS-3 protein 0.0065 0.0275 0.0413
Onchocerca volvulus 0.0022 0.0041 0.0042
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0458 0.242 0.4251
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.013 0.0252
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0417 0.2195 0.5
Echinococcus multilocularis mitogen activated protein kinase 0.0121 0.0582 0.0582
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0022 0.0041 0.0041
Brugia malayi hypothetical protein 0.0458 0.242 0.3634
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0024 0.0032
Loa Loa (eye worm) hypothetical protein 0.0065 0.0275 0.0413
Brugia malayi Tachykinin-like peptides receptor 99D 0.0458 0.242 0.3634
Giardia lamblia Kinase, AGC PKA 0.0345 0.1806 1
Echinococcus granulosus basement membrane specific heparan sulfate 0.0022 0.0041 0.006
Leishmania major S-adenosylmethionine decarboxylase 0.0417 0.2195 0.5
Onchocerca volvulus 0.0035 0.0113 0.0302
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0061
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0274 0.0476
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.004 0.0139 0.0262
Trypanosoma brucei heat shock protein, putative 0.003 0.0084 0.0157
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0184 0.041
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Trichomonas vaginalis set domain proteins, putative 0.0531 0.2817 0.6436
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Plasmodium falciparum protein arginine N-methyltransferase 1 0.003 0.0088 0.0188
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0021 0.0036
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0067 0.0289 0.0608
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0003 0.0005
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0024 0.0024
Echinococcus granulosus cpg binding protein 0.0033 0.0104 0.0153
Schistosoma mansoni serine/threonine protein kinase 0.0345 0.1806 0.3172
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0022 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0127
Schistosoma mansoni neuropeptide receptor 0.0458 0.242 0.4251
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0217 0.0451
Schistosoma mansoni regulator of G protein signaling 0.0065 0.0275 0.0478
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0024 0.0044
Entamoeba histolytica protein kinase, putative 0.0016 0.0011 0.0021
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0084 0.0182
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0458 0.242 0.242
Trichomonas vaginalis heat shock protein, putative 0.003 0.0084 0.0179
Trypanosoma brucei heat shock protein, putative 0.003 0.0084 0.0157
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.004 0.0139 0.0315
Echinococcus multilocularis G protein coupled receptor 139 0.0458 0.242 0.242
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.004 0.0139 0.0262
Echinococcus granulosus mitogen activated protein kinase 0.0121 0.0582 0.0857
Toxoplasma gondii AGC kinase 0.0037 0.0122 0.0267
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0417 0.2195 0.3299
Schistosoma mansoni serine/threonine protein kinase 0.0312 0.1622 0.2848
Plasmodium falciparum thioredoxin reductase 0.0054 0.0217 0.0485
Echinococcus multilocularis rhodopsin orphan GPCR 0.0458 0.242 0.242
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.013 0.0264
Brugia malayi Protein kinase domain containing protein 0.0016 0.0011 0.0011
Treponema pallidum NADH oxidase 0.0019 0.0024 0.1908
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0307 0.0534
Giardia lamblia Heat shock protein HSP 90-alpha 0.003 0.0084 0.0332
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0816 0.4374 1
Echinococcus granulosus fmrfamide receptor 0.0458 0.242 0.3563
Schistosoma mansoni hypothetical protein 0.0069 0.0298 0.0519
Trichomonas vaginalis DNA helicase recq, putative 0.0038 0.0132 0.029
Brugia malayi Calcium binding EGF domain containing protein 0.0022 0.0041 0.0057
Schistosoma mansoni ap endonuclease 0.0021 0.004 0.0064
Echinococcus granulosus hypothetical protein 0.0458 0.242 0.3563
Trypanosoma brucei unspecified product 0.0038 0.013 0.0264
Trypanosoma brucei heat shock protein 84, putative 0.002 0.0029 0.0031
Mycobacterium leprae putative cytochrome p450 0.004 0.0139 0.0073
Schistosoma mansoni adenosylhomocysteinase 0.0505 0.2677 0.4705
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0121 0.0582 0.132
Echinococcus granulosus dro:myosuppressin receptor 0.0458 0.242 0.3563
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0024 0.0054
Echinococcus granulosus chromobox protein 1 0.008 0.0357 0.0525
Schistosoma mansoni neuropeptide F-like receptor 0.0458 0.242 0.4251
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0024 0.0054
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0026 0.0065 0.0137
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.004 0.0139 0.0262
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.003 0.0088 0.0196
Echinococcus granulosus regulator of G protein signaling 7 0.0065 0.0275 0.0405
Echinococcus granulosus solute carrier family 5 0.0044 0.016 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0275 0.0617
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.004 0.0139 0.027
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0022 0.0041 0.006
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.013 0.0264
Brugia malayi Cytochrome P450 family protein 0.0067 0.0289 0.043
Onchocerca volvulus 0.0458 0.242 0.8574
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.013 0.0224
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0731 0.3906 0.6867
Mycobacterium tuberculosis Probable dehydrogenase 0.0123 0.0595 0.1318
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0016 0.0011 0.0016
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0012 0.0016
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.004 0.0139 0.027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0032 0.0062
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.004 0.0139 0.0262
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0026 0.0065 0.0147
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.013 0.0264
Echinococcus granulosus rhodopsin orphan GPCR 0.0458 0.242 0.3563
Echinococcus granulosus histone lysine methyltransferase setb 0.0067 0.029 0.0428
Echinococcus granulosus dna polymerase eta 0.0038 0.013 0.0192
Echinococcus multilocularis g protein coupled receptor 0.0458 0.242 0.242
Schistosoma mansoni endoplasmin 0.003 0.0084 0.0142
Loa Loa (eye worm) CYP4Cod1 0.0067 0.0289 0.0434
Echinococcus granulosus neuropeptides capa receptor 0.0458 0.242 0.3563
Loa Loa (eye worm) hypothetical protein 0.0605 0.3222 0.4843
Brugia malayi latrophilin 2 splice variant baaae 0.0149 0.0735 0.1101
Echinococcus multilocularis Smad4 0.0016 0.0012 0.0012
Brugia malayi Regulator of G protein signaling domain containing protein 0.0065 0.0275 0.0409
Leishmania major hypothetical protein, conserved 0.0033 0.0101 0.0195
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0458 0.242 0.242
Schistosoma mansoni biogenic amine receptor 0.0458 0.242 0.4251
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0345 0.1806 0.4126
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0123 0.0595 0.1318
Echinococcus multilocularis axis inhibition protein axin 0.0065 0.0275 0.0275
Brugia malayi hypothetical protein 0.0065 0.0275 0.0409
Schistosoma mansoni adenosylhomocysteinase 0.0816 0.4374 0.7691
Loa Loa (eye worm) hypothetical protein 0.0067 0.029 0.0437
Brugia malayi regulator of G-protein signaling rgs-7 0.0065 0.0275 0.0409
Leishmania major heat shock protein, putative 0.002 0.0029 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0345 0.1806 0.3172
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.004 0.0139 0.027
Entamoeba histolytica protein kinase, putative 0.0039 0.0133 0.0299
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.004 0.0139 0.0262
Trypanosoma cruzi Heat shock protein 83, putative 0.003 0.0084 0.019
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0458 0.242 0.3563
Echinococcus multilocularis heat shock protein 90 0.003 0.0084 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0275 0.0617
Echinococcus granulosus g protein coupled receptor 0.0458 0.242 0.3563
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0048 0.0185 0.0411
Entamoeba histolytica protein kinase, putative 0.0039 0.0133 0.0299
Onchocerca volvulus 0.0312 0.1622 0.5712
Loa Loa (eye worm) PXA domain-containing protein 0.0065 0.0275 0.0413
Leishmania major DNA polymerase kappa, putative 0.0038 0.013 0.0264
Loa Loa (eye worm) endoplasmin 0.003 0.0084 0.0126
Onchocerca volvulus 0.003 0.0083 0.0195
Entamoeba histolytica hypothetical protein 0.0047 0.0181 0.0409
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.013 0.0196
Echinococcus multilocularis histone h3 methyltransferase 0.0257 0.1326 0.1326
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0458 0.242 0.3634
Echinococcus multilocularis g protein coupled receptor 0.0458 0.242 0.242
Brugia malayi p70 ribosomal S6 kinase beta 0.0037 0.0122 0.0178
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0017 0.0015 0.0023
Brugia malayi Protein kinase domain containing protein 0.0957 0.5142 0.7729
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0021 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.013 0.0264
Brugia malayi Heterochromatin protein 1 0.008 0.0357 0.0532
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0017 0.0015 0.0023
Brugia malayi hypothetical protein 0.0458 0.242 0.3634
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0069 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0061
Loa Loa (eye worm) hypothetical protein 0.0395 0.2075 0.312
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0065 0.0275 0.0405
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0011 0.0013
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0417 0.2195 0.3296
Loa Loa (eye worm) hypothetical protein 0.0065 0.0275 0.0413
Schistosoma mansoni heat shock protein 0.003 0.0084 0.0142
Schistosoma mansoni hypothetical protein 0.0069 0.0298 0.0519
Echinococcus multilocularis dna polymerase kappa 0.0038 0.013 0.013
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0458 0.242 0.3634
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.013 0.0264
Giardia lamblia Sgs1 DNA helicase, putative 0.003 0.0084 0.0336
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0816 0.4374 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.004 0.0139 0.027
Onchocerca volvulus 0.0022 0.0041 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.004 0.0139 0.027
Trypanosoma brucei protein kinase, putative 0.0121 0.0582 0.1299
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0217 0.0495
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0458 0.242 0.4251
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0132 0.0268
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.013 0.0244
Brugia malayi Carm1-pending protein 0.0017 0.0015 0.0018
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Onchocerca volvulus 0.0458 0.242 0.8574
Loa Loa (eye worm) latrophilin receptor protein 2 0.0069 0.0298 0.0449
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.003 0.0084 0.0123
Schistosoma mansoni axis inhibition protein axin 0.0065 0.0275 0.0478
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0021 0.0046
Toxoplasma gondii adenosylhomocysteinase, putative 0.0816 0.4374 1
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Echinococcus granulosus sodium:glucose cotransporter 0.0044 0.016 0.0235
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0014 0.002
Giardia lamblia DINP protein human, muc B family 0.0038 0.013 0.0595
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0121 0.0582 0.1329
Schistosoma mansoni cpg binding protein 0.0033 0.0104 0.0177
Trichomonas vaginalis chromobox protein, putative 0.008 0.0357 0.0804
Brugia malayi hypothetical protein 0.0025 0.0061 0.0087
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0458 0.242 0.3637
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0011 0.0014
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0021 0.0012
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0022 0.0041 0.0061
Giardia lamblia Grp94/Hsp90 0.0034 0.0107 0.0466
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0121 0.0582 0.1299
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0024 0.0008
Schistosoma mansoni inositol transporter 0.0044 0.016 0.0275
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0345 0.1806 0.4121
Echinococcus multilocularis bloom syndrome protein 0.0072 0.0315 0.0315
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0024 0.0054
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0069 0.0298 0.0298
Entamoeba histolytica hypothetical protein 0.0041 0.0147 0.0331
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0022 0.0041 0.0066
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.002 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0458 0.242 0.242
Onchocerca volvulus 0.0458 0.242 0.8574
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0458 0.242 0.242
Schistosoma mansoni neuropeptide receptor 0.0458 0.242 0.4251
Schistosoma mansoni biogenic amine (5HT) receptor 0.0605 0.3222 0.5662
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0458 0.242 0.4251
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0184 0.0557
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.004 0.0139 0.0262
Schistosoma mansoni histamine h1 receptor 0.0458 0.242 0.4251
Mycobacterium ulcerans heat shock protein 90 0.0034 0.0107 0.0191
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0022 0.0041 0.0057
Echinococcus multilocularis adenosylhomocysteinase 0.0816 0.4374 0.4374
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0345 0.1806 0.1806
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.004 0.3381
Onchocerca volvulus 0.0458 0.242 0.8574
Brugia malayi MH2 domain containing protein 0.0016 0.0012 0.0013
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0061 0.0128
Schistosoma mansoni hypothetical protein 0.0458 0.242 0.4251
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0203 0.1029 0.2343
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0458 0.242 0.3637
Brugia malayi neuropeptide F receptor 0.0458 0.242 0.3634
Brugia malayi Latrophilin receptor protein 2 0.0069 0.0298 0.0444
Echinococcus multilocularis GPCR, family 2 0.0069 0.0298 0.0298
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0024 0.0036
Echinococcus multilocularis fmrfamide receptor 0.0458 0.242 0.242
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0458 0.242 0.242
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0011 0.0013
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.124 0.1864
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.004 0.0059
Schistosoma mansoni alpha-1 adrenergic receptor 0.0458 0.242 0.4251
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.004 0.0078
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0022 0.0041 0.0061
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.004 0.0139 0.0262
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0021 0.0012
Echinococcus multilocularis neuropeptide Y receptor 0.0458 0.242 0.242
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.003 0.0084 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0275 0.0617
Toxoplasma gondii AGC kinase 0.0345 0.1806 0.4122
Echinococcus granulosus peptide allatostatin:somatostatin 0.0458 0.242 0.3563
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0345 0.1806 0.1806
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0458 0.242 0.4251
Echinococcus granulosus rhodopsin orphan GPCR 0.0458 0.242 0.3563
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Leishmania major hypothetical protein, conserved 0.0033 0.0101 0.0195
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0345 0.1806 0.4128
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0084 0.019
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.004 0.0139 0.0315
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0138 0.0674 0.0993
Trypanosoma brucei heat shock protein 90, putative 0.003 0.0084 0.0157
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0217 0.032
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0256 0.132 0.3009
Echinococcus granulosus sodium:myo inositol cotransporter 0.0044 0.016 0.0235
Echinococcus multilocularis rhodopsin orphan GPCR 0.0458 0.242 0.242
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0133 0.0291
Echinococcus multilocularis lamin dm0 0.003 0.0083 0.0083
Leishmania major hypothetical protein, conserved 0.0025 0.0061 0.0105
Trichomonas vaginalis chromobox protein, putative 0.008 0.0357 0.0804
Echinococcus multilocularis chromobox protein 1 0.008 0.0357 0.0357
Brugia malayi neuropeptide F receptor 0.0458 0.242 0.3634
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0022 0.0041 0.0041
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0067 0.029 0.029
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0084 0.0122
Echinococcus multilocularis Regulator of G protein signaling 20 0.0065 0.0275 0.0275
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0017 0.0015 0.0015
Echinococcus multilocularis protein kinase c iota type 0.0016 0.0011 0.0011
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0024 0.0054
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.004 0.0058
Echinococcus multilocularis smad 0.0016 0.0012 0.0012
Trichomonas vaginalis heat shock protein, putative 0.003 0.0084 0.0179
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0458 0.242 0.3563
Echinococcus multilocularis protein kinase c epsilon type 0.0016 0.0011 0.0011
Plasmodium falciparum glutathione reductase 0.0054 0.0217 0.0485
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0133 0.0291
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0032 0.0062
Brugia malayi Smad1 0.0016 0.0012 0.0013
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0033 0.0101 0.0195
Echinococcus granulosus axis inhibition protein axin 0.0065 0.0275 0.0405
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0816 0.4374 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0137 0.067 0.1318
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0458 0.242 0.242
Echinococcus granulosus tm gpcr rhodopsin 0.0458 0.242 0.3563
Echinococcus multilocularis neuropeptide receptor 0.0458 0.242 0.242
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0021 0.0031
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.004 0.0139 0.0262
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0816 0.4374 1
Trypanosoma brucei C-8 sterol isomerase, putative 0.0418 0.2203 0.5018
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0069 0.0298 0.0439
Loa Loa (eye worm) heat shock protein 90 0.003 0.0084 0.0126
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0345 0.1806 0.4128
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.004 0.0139 0.0262
Schistosoma mansoni hypothetical protein 0.0017 0.0015 0.0022
Echinococcus multilocularis serotonin receptor 0.0605 0.3222 0.3222
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0024 0.0021
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.013 0.0297
Schistosoma mansoni myosin xvIII 0.0458 0.242 0.4251
Echinococcus multilocularis high affinity choline transporter 1 0.0395 0.2075 0.2075
Entamoeba histolytica heat shock protein 90, putative 0.003 0.0084 0.0187
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.004 0.0078
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0345 0.1806 0.266
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.003 0.0084 0.0084
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.004 0.0139 0.0262
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0458 0.242 0.242
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0138 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.0257 0.1326 0.1994
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0345 0.1806 0.4108
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0007
Echinococcus granulosus 7tm_1 domain containing protein 0.0458 0.242 0.3563
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0166 0.0367
Brugia malayi chromobox protein homolog 3 0.0045 0.0166 0.0245
Leishmania major DNA polymerase eta, putative 0.0038 0.013 0.0264
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.013 0.0191
Echinococcus granulosus neuropeptide Y receptor 0.0458 0.242 0.3563
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0033 0.0033
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0044 0.016 0.016
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0345 0.1806 0.4108
Schistosoma mansoni DNA helicase recq5 0.003 0.0084 0.0143
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0274 0.0476
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0061 0.0105
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0458 0.242 0.4251
Brugia malayi G-protein coupled receptor 0.0458 0.242 0.3634
Echinococcus granulosus protein arginine N methyltransferase 7 0.0017 0.0015 0.0023
Trypanosoma brucei heat shock protein 90, putative 0.003 0.0084 0.0157
Schistosoma mansoni biogenic amine (5HT) receptor 0.0458 0.242 0.4251
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0084 0.0122
Schistosoma mansoni biogenic amine receptor 0.0458 0.242 0.4251
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0021 0.0046
Plasmodium vivax heat shock protein, putative 0.002 0.0029 0.0062
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0458 0.242 0.3634
Trypanosoma brucei trypanothione reductase 0.0054 0.0217 0.0463
Schistosoma mansoni histone J3 methyltransferase 0.0257 0.1326 0.2328
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0017 0.0015 0.0024
Echinococcus multilocularis orexin receptor type 2 0.0458 0.242 0.242
Echinococcus granulosus rhodopsin orphan GPCR 0.0458 0.242 0.3563
Brugia malayi Cytochrome P450 family protein 0.0067 0.0289 0.043
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0731 0.3906 0.3906
Echinococcus granulosus methyltransferase protein 5 0.0017 0.0015 0.0023
Schistosoma mansoni DNA helicase recq1 0.003 0.0084 0.0143
Onchocerca volvulus 0.0044 0.016 0.0469
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0022 0.0041 0.0057
Leishmania major lanosterol 14-alpha-demethylase, putative 0.004 0.0139 0.0282
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Entamoeba histolytica hypothetical protein 0.0065 0.0275 0.0625
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Echinococcus granulosus rhodopsin orphan GPCR 0.0458 0.242 0.3563
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0017 0.0015 0.0034
Schistosoma mansoni amine GPCR 0.0458 0.242 0.4251
Trypanosoma cruzi Protein kinase B 0.0028 0.0076 0.0173
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0009 0.0008
Echinococcus multilocularis protein arginine methyltransferase 0.003 0.0088 0.0088
Echinococcus granulosus Smad4 0.0016 0.0012 0.0018
Brugia malayi RE15519p 0.0458 0.242 0.3634
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0022 0.0041 0.0041
Schistosoma mansoni blooms syndrome DNA helicase 0.0057 0.0232 0.0403
Onchocerca volvulus 0.0458 0.242 0.8574
Brugia malayi hypothetical protein 0.0047 0.0181 0.0267
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0034 0.0107 0.0211
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0417 0.2195 0.5
Echinococcus granulosus dna polymerase kappa 0.0038 0.013 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.013 0.0264
Schistosoma mansoni smad1 5 8 and 0.0016 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0149 0.0735 0.1105
Echinococcus multilocularis heat shock protein 0.003 0.0084 0.0084
Schistosoma mansoni amine GPCR 0.0458 0.242 0.4251
Loa Loa (eye worm) AGC/AKT protein kinase 0.0039 0.0133 0.0199
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0012 0.0018
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0017 0.0015 0.0023
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0022 0.0041 0.0066
Echinococcus granulosus chromobox protein 1 0.008 0.0357 0.0525
Giardia lamblia Kinase, CMGC MAPK 0.0121 0.0582 0.3128
Schistosoma mansoni adenoreceptor 0.0458 0.242 0.4251
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0147 0.0216
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0084 0.019
Echinococcus granulosus protein kinase c iota type 0.0016 0.0011 0.0016
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0021 0.0021
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0071 0.0307 0.0461
Echinococcus multilocularis serine:threonine protein kinase N2 0.0016 0.0011 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.004 0.0078
Echinococcus granulosus serine/threonine protein kinase 0.0028 0.0076 0.0112
Echinococcus granulosus tar DNA binding protein 0.0064 0.0274 0.0403
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0021 0.0031
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0024 0.0052
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0028 0.0076 0.0173
Brugia malayi sulfakinin receptor protein 0.0458 0.242 0.3634
Echinococcus granulosus low density lipoprotein receptor protein 0.0022 0.0041 0.006
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Echinococcus multilocularis mitogen activated protein kinase 3 0.0121 0.0582 0.0582
Echinococcus granulosus endoplasmin 0.0034 0.0107 0.0158
Echinococcus granulosus regulator of G protein signaling 3 0.0065 0.0275 0.0405
Schistosoma mansoni z-protein (S1r protein) 0.0065 0.0275 0.0478
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0458 0.242 0.4251
Loa Loa (eye worm) hypothetical protein 0.0418 0.2203 0.3312
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0458 0.242 0.4251
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0032 0.0062
Echinococcus granulosus geminin 0.1057 0.5687 0.8376
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0071 0.0307 0.0457
Schistosoma mansoni smad1 5 8 and 0.0016 0.0012 0.0016
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0016 0.0011 0.0016
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0011 0.0012
Echinococcus granulosus neuropeptide receptor 0.0458 0.242 0.3563
Echinococcus granulosus tm gpcr rhodopsin 0.0458 0.242 0.3563
Loa Loa (eye worm) cytochrome P450 0.004 0.0139 0.0208
Schistosoma mansoni neuropeptide f receptor 76f 0.0458 0.242 0.4251
Brugia malayi PXA domain containing protein 0.0065 0.0275 0.0409
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0016 0.0011 0.0016
Echinococcus multilocularis beta adrenergic receptor kinase 0.0071 0.0307 0.0307
Schistosoma mansoni neuropeptide receptor 0.0458 0.242 0.4251
Trichomonas vaginalis CMGC family protein kinase 0.0121 0.0582 0.1319
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0022 0.0041 0.0057
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0022 0.0041 0.0041
Trypanosoma brucei heat shock protein, putative 0.003 0.0084 0.0157
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.004 0.0139 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0066 0.0116
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0024 0.5
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0084 0.019
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0816 0.4374 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0061
Loa Loa (eye worm) neuropeptide F receptor 0.0458 0.242 0.3637
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0466 0.2466 0.3708
Echinococcus multilocularis g-protein coupled receptor 0.0458 0.242 0.242
Brugia malayi basement membrane proteoglycan precursor 0.0022 0.0041 0.0057
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0047 0.0181 0.0379
Echinococcus granulosus biogenic amine 5HT receptor 0.0458 0.242 0.3563
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0022 0.0041 0.0042
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0345 0.1806 0.266
Schistosoma mansoni amine GPCR 0.0458 0.242 0.4251
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0016 0.0011 0.0016
Brugia malayi Dopamine receptor protein 1 0.0458 0.242 0.3634
Echinococcus multilocularis rhodopsin orphan GPCR 0.0458 0.242 0.242
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0123 0.0595 0.1318
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0458 0.242 0.242
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Giardia lamblia Kinase, AGC PKA 0.0026 0.0065 0.0228
Echinococcus granulosus rhodopsin orphan GPCR 0.0458 0.242 0.3563
Schistosoma mansoni smad 0.0016 0.0012 0.0016
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0034 0.0107 0.0199
Schistosoma mansoni amine GPCR 0.0458 0.242 0.4251
Brugia malayi Sodium:solute symporter family protein 0.0044 0.016 0.0235
Schistosoma mansoni biogenic amine receptor 0.0458 0.242 0.4251
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0203 0.1029 0.2349
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0012 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0307 0.0534
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0289 0.0434
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0084 0.019
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0731 0.3906 0.5753
Schistosoma mansoni cpg binding protein 0.0031 0.0094 0.0159
Echinococcus multilocularis neuropeptide Y receptor 0.0458 0.242 0.242
Leishmania major cytochrome p450-like protein 0.004 0.0139 0.0282
Brugia malayi Endoplasmin precursor 0.003 0.0084 0.0121
Echinococcus multilocularis rhodopsin orphan GPCR 0.0458 0.242 0.242
Onchocerca volvulus 0.0458 0.242 0.8574
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0034 0.0107 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0458 0.242 0.3637
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0458 0.242 0.4251
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0345 0.1806 0.4122
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0133 0.0291
Entamoeba histolytica adenosylhomocysteinase, putative 0.0816 0.4374 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0065 0.0275 0.0478
Trypanosoma brucei Heat shock protein 83, putative 0.003 0.0084 0.0157
Toxoplasma gondii hypothetical protein 0.0033 0.0101 0.0219
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0011 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.013 0.0297
Brugia malayi Cytochrome P450 family protein 0.004 0.0139 0.0204
Echinococcus multilocularis serine threonine protein kinase 0.0016 0.0011 0.0011
Brugia malayi CXXC zinc finger family protein 0.0031 0.0094 0.0136
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0032 0.0062
Schistosoma mansoni cpg binding protein 0.0033 0.0104 0.0177
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0024 0.0054
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.013 0.013
Schistosoma mansoni hypothetical protein 0.004 0.0139 0.0238
Schistosoma mansoni hypothetical protein 0.0069 0.0298 0.0519
Loa Loa (eye worm) intermediate filament protein 0.003 0.0083 0.0125
Loa Loa (eye worm) RNA binding protein 0.0064 0.0274 0.0411
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.0088 0.0149
Brugia malayi Serotonin receptor 0.0458 0.242 0.3634
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0022 0.0041 0.0057
Echinococcus multilocularis neuropeptide receptor A26 0.0458 0.242 0.242
Brugia malayi Serotonin receptor 0.0458 0.242 0.3634
Echinococcus granulosus heat shock protein 0.003 0.0084 0.0123
Echinococcus granulosus basement membrane specific heparan sulfate 0.0022 0.0041 0.006
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0121 0.0582 0.1329
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.004 0.0055
Echinococcus multilocularis regulator of G protein signaling 3 0.0065 0.0275 0.0275
Echinococcus multilocularis nervana 2 0.002 0.0033 0.0033
Brugia malayi follicle stimulating hormone receptor 0.1234 0.6652 1
Toxoplasma gondii AGC kinase 0.0345 0.1806 0.4122
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0061
Plasmodium falciparum heat shock protein 90 0.003 0.0084 0.0179
Brugia malayi regulator of G-protein signaling egl-10 0.0065 0.0275 0.0409
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0458 0.242 0.4251
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0121 0.0582 0.1329
Entamoeba histolytica hypothetical protein 0.0041 0.0147 0.0331
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0137 0.067 0.1491
Echinococcus granulosus protein kinase c epsilon type 0.0016 0.0011 0.0016
Brugia malayi Calcitonin receptor-like protein seb-1 0.0218 0.1111 0.1666
Brugia malayi larval opioid receptor 0.0458 0.242 0.3634
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0016 0.0011 0.0016
Echinococcus multilocularis low density lipoprotein receptor protein 0.0022 0.0041 0.0041
Onchocerca volvulus 0.0022 0.0041 0.0042
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0021 0.0031
Echinococcus granulosus GPCR family 2 0.0069 0.0298 0.0439
Schistosoma mansoni smad1 5 8 and 0.0016 0.0012 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.013 0.0264
Echinococcus granulosus ATP dependent DNA helicase Q1 0.003 0.0084 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0066 0.0116
Echinococcus granulosus beta-adrenergic receptor kinase 0.0071 0.0307 0.0452
Schistosoma mansoni DNA polymerase eta 0.0038 0.013 0.0224
Entamoeba histolytica recQ family DNA helicase 0.0015 0.0005 0.0007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0458 0.242 0.4251
Brugia malayi Protein kinase domain containing protein 0.0039 0.0133 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.013 0.0264
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0458 0.242 0.4251
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0061
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Loa Loa (eye worm) hypothetical protein 0.0065 0.0275 0.0413
Brugia malayi hypothetical protein 0.0458 0.242 0.3634
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.004 0.0139 0.0262
Plasmodium falciparum glutathione reductase 0.0019 0.0024 0.0044
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0024 0.0021
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.004 0.0043
Echinococcus granulosus bloom syndrome protein 0.0072 0.0315 0.0464
Plasmodium falciparum thioredoxin reductase 0.0019 0.0024 0.0044
Echinococcus multilocularis regulator of G protein signaling 0.0065 0.0275 0.0275
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0121 0.0582 0.1329
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0011 0.0013
Leishmania major cytochrome p450-like protein 0.0067 0.0289 0.0628
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0218 0.1111 0.167
Brugia malayi PXA domain containing protein 0.0065 0.0275 0.0409
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0061 0.0135
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0458 0.242 0.4251
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0024 0.0054
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.004 0.0139 0.0262
Echinococcus granulosus serine:threonine protein kinase N2 0.0016 0.0011 0.0016
Schistosoma mansoni intermediate filament proteins 0.003 0.0083 0.0141
Brugia malayi hypothetical protein 0.0458 0.242 0.3634
Echinococcus multilocularis thyroid hormone receptor alpha 0.0149 0.0734 0.0734
Brugia malayi hypothetical protein 0.0458 0.242 0.3634
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.004 0.0139 0.0262
Echinococcus granulosus rho-associated protein kinase 1 0.0312 0.1622 0.2389
Brugia malayi Adenosylhomocysteinase 0.0816 0.4374 0.6575
Schistosoma mansoni endoplasmin 0.003 0.0084 0.0142
Toxoplasma gondii thioredoxin reductase 0.0054 0.0217 0.0486
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0121 0.0582 0.1299
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.003 0.0088 0.0188
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0037 0.0122 0.0183
Echinococcus granulosus lamin 0.003 0.0083 0.0123
Brugia malayi heat shock protein 90 0.003 0.0084 0.0121
Schistosoma mansoni lamin 0.003 0.0083 0.0141
Schistosoma mansoni sodium/solute symporter 0.0044 0.016 0.0275
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.004 0.0139 0.027
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.013 0.0297
Echinococcus multilocularis axis inhibition protein axin 0.0065 0.0275 0.0275
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0083 0.0121
Loa Loa (eye worm) AGC/NDR protein kinase 0.0016 0.0011 0.0016
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Trichomonas vaginalis CMGC family protein kinase 0.0121 0.0582 0.1319
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0017 0.0015 0.0023
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0133 0.0291
Echinococcus granulosus adenosylhomocysteinase 0.0816 0.4374 0.6442
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0017 0.0015 0.0034
Entamoeba histolytica hypothetical protein 0.0065 0.0275 0.0625
Schistosoma mansoni growth hormone secretagogue receptor 0.0458 0.242 0.4251
Echinococcus granulosus nervana 2 0.002 0.0033 0.0049
Onchocerca volvulus 0.0306 0.159 0.5598
Plasmodium vivax SET domain protein, putative 0.0067 0.029 0.066
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.013 0.0264
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.004 0.182
Echinococcus granulosus tachykinin peptides receptor 99D 0.0458 0.242 0.3563
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0458 0.242 0.4251
Brugia malayi hypothetical protein 0.0016 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0275 0.0617
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0012 0.0018
Brugia malayi G protein-coupled receptor F59B2.13 0.0458 0.242 0.3634
Trypanosoma brucei unspecified product 0.0026 0.0066 0.0116
Trypanosoma cruzi cytochrome P450, putative 0.0067 0.0289 0.0659
Echinococcus multilocularis cpg binding protein 0.0033 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.0138 0.0674 0.118
Echinococcus multilocularis neuropeptides capa receptor 0.0458 0.242 0.242
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0016 0.0011 0.0011
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0458 0.242 0.3637
Loa Loa (eye worm) hypothetical protein 0.0029 0.008 0.0121
Loa Loa (eye worm) hypothetical protein 0.0045 0.0166 0.0249
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0076 0.017
Schistosoma mansoni regulator of G protein signaling 0.0065 0.0275 0.0478
Entamoeba histolytica hypothetical protein 0.0041 0.0147 0.0331
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0345 0.1806 0.4108
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0016 0.0011 0.0011
Schistosoma mansoni protein arginine n-methyltransferase 0.0017 0.0015 0.0022
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0123 0.0595 0.1318
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.013 0.0297
Echinococcus multilocularis serotonin receptor 0.0605 0.3222 0.3222
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.034 0.1774 0.1774
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.124 0.1864
Brugia malayi GH02984p 0.0395 0.2075 0.3116
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.004 0.0139 0.027
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0345 0.1806 0.4128
Entamoeba histolytica 90 kDa heat shock protein, putative 0.002 0.0029 0.0062
Schistosoma mansoni opsin-like receptor 0.0458 0.242 0.4251
Echinococcus multilocularis dna polymerase eta 0.0038 0.013 0.013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0032 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.013 0.0264
Loa Loa (eye worm) hypothetical protein 0.0025 0.0061 0.0092
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0458 0.242 0.242
Loa Loa (eye worm) hypothetical protein 0.0065 0.0275 0.0413
Echinococcus granulosus histone h3 methyltransferase 0.0257 0.1326 0.1953
Plasmodium vivax glutathione reductase, putative 0.0054 0.0217 0.0492
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.034 0.1774 0.2613
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.004 0.0085
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0816 0.4374 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0274 0.0476
Toxoplasma gondii cytochrome p450 superfamily protein 0.004 0.0139 0.0306
Onchocerca volvulus 0.0022 0.0041 0.0042
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0816 0.4374 1
Echinococcus granulosus low density lipoprotein receptor ldl 0.0022 0.0041 0.006
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0217 0.0217
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0026 0.0065 0.0065
Brugia malayi Dopamine receptor protein 2 0.0458 0.242 0.3634
Loa Loa (eye worm) Carm1-pending protein 0.0017 0.0015 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.004 0.0139 0.027
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0022 0.0041 0.0057
Echinococcus multilocularis g protein coupled receptor 0.0458 0.242 0.242
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0061 0.0138
Plasmodium falciparum heat shock protein 90, putative 0.002 0.0029 0.0054
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0044 0.016 0.016
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0022 0.0041 0.0042
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0016 0.0011 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0032 0.0062
Brugia malayi hypothetical protein 0.0139 0.0681 0.102
Echinococcus multilocularis regulator of G protein signaling 7 0.0065 0.0275 0.0275
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1234 0.6652 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0017 0.0015 0.0023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.013 0.0297
Brugia malayi ORL1-like opioid receptor 0.0458 0.242 0.3634
Entamoeba histolytica protein kinase, putative 0.0037 0.0122 0.0274
Loa Loa (eye worm) hypothetical protein 0.0065 0.0275 0.0413
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.0076 0.0128
Loa Loa (eye worm) heat shock protein 75 0.002 0.0029 0.0044
Onchocerca volvulus Arrow homolog 0.0022 0.0041 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.004 0.0139 0.027
Echinococcus granulosus Regulator of G protein signaling 20 0.0065 0.0275 0.0405
Echinococcus granulosus g protein coupled receptor 0.0458 0.242 0.3563
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Loa Loa (eye worm) hypothetical protein 0.0069 0.0298 0.0449
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.004 0.0139 0.0262
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.004 0.0139 0.027
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0137 0.067 0.1491
Onchocerca volvulus 0.0531 0.2817 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0458 0.242 0.242
Echinococcus granulosus rhodopsin orphan GPCR 0.0458 0.242 0.3563
Echinococcus granulosus heat shock protein 90 0.003 0.0084 0.0123
Trichomonas vaginalis DNA helicase recq, putative 0.0072 0.0315 0.0709
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0005 0.0003
Echinococcus multilocularis 0.004 0.0139 0.0139
Echinococcus granulosus regulator of G protein signaling 7 0.0065 0.0275 0.0405
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0011 0.0013
Onchocerca volvulus 0.0081 0.0361 0.1192
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0022 0.0041 0.0057
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0061
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.003 0.0088 0.0188
Entamoeba histolytica hypothetical protein 0.0065 0.0275 0.0625
Leishmania major trypanothione reductase 0.0054 0.0217 0.0463
Brugia malayi hypothetical protein 0.0458 0.242 0.3634
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0041 0.0066
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Brugia malayi hypothetical protein 0.0041 0.0147 0.0216
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0107 0.0234
Echinococcus multilocularis dro:myosuppressin receptor 0.0458 0.242 0.242
Schistosoma mansoni thyroid hormone receptor 0.0149 0.0734 0.1286
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0084 0.0182
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0109
Schistosoma mansoni serine/threonine kinase 0.0016 0.0011 0.0013
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0274 0.0407
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0121 0.0582 0.1299
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0061 0.0127
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0022 0.0041 0.0066
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0061
Onchocerca volvulus 0.0458 0.242 0.8574
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0458 0.242 0.3563
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0065 0.0275 0.0413
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0345 0.1806 0.1806
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.002 0.0029 0.0043
Schistosoma mansoni inositol transporter 0.0044 0.016 0.0275
Schistosoma mansoni axis inhibition protein axin 0.0065 0.0275 0.0478
Brugia malayi MAP kinase sur-1 0.0121 0.0582 0.087
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.013 0.0264
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0076 0.017
Plasmodium vivax heat shock protein 90, putative 0.002 0.0029 0.0062
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Toxoplasma gondii heat shock protein 75, putative 0.002 0.0029 0.0055
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0033 0.0101 0.0228
Echinococcus granulosus neuropeptide Y receptor 0.0458 0.242 0.3563
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0017 0.0015 0.0034
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0017 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0069 0.0298 0.0519
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0022 0.0041 0.0041
Echinococcus multilocularis G-protein coupled receptor, putative 0.0458 0.242 0.242
Trypanosoma brucei rac serine-threonine kinase, putative 0.0039 0.0133 0.0269
Echinococcus multilocularis endoplasmin 0.0034 0.0107 0.0107
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.004 0.0086
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0418 0.2203 0.5035
Echinococcus multilocularis regulator of G protein signaling 7 0.0065 0.0275 0.0275
Echinococcus granulosus axis inhibition protein axin 0.0065 0.0275 0.0405
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0016 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0044 0.016 0.0235
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0121 0.0582 0.0875
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0289 0.0434
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0299 0.0521
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0021 0.0021
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0065 0.0275 0.0478
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0032 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0274 0.0476
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0024 0.0037
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Loa Loa (eye worm) hypothetical protein 0.0038 0.013 0.0196
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.003 0.0084 0.0084
Trypanosoma brucei heat shock protein, putative 0.003 0.0084 0.0157
Trypanosoma brucei cytochrome P450, putative 0.0067 0.0289 0.0628
Echinococcus granulosus neuropeptides capa receptor 0.0458 0.242 0.3563
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0011 0.0012
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0458 0.242 0.4251
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.004 0.0139 0.027
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.013 0.0264
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.004 0.0055
Schistosoma mansoni thyroid hormone receptor 0.0149 0.0734 0.1286
Echinococcus multilocularis neuropeptide s receptor 0.0458 0.242 0.242
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0033 0.0101 0.0228
Brugia malayi glutathione reductase 0.0054 0.0217 0.0322
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0017 0.0015 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.004 0.0139 0.027
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0816 0.4374 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0061 0.0127
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Echinococcus granulosus neuropeptide receptor 0.0458 0.242 0.3563
Plasmodium vivax endoplasmin, putative 0.003 0.0084 0.0187
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0011 0.0013
Loa Loa (eye worm) ATP-dependent DNA helicase 0.003 0.0084 0.0127
Entamoeba histolytica PH domain containing protein kinase, putative 0.0347 0.1817 0.4151
Onchocerca volvulus 0.0458 0.242 0.8574
Echinococcus granulosus smad 0.0016 0.0012 0.0018
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0021 0.0036
Leishmania major protein kinase A catalytic subunit 0.0345 0.1806 0.4108
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0033 0.0101 0.0228
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0458 0.242 0.4251
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0458 0.242 0.4251
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0026 0.0065 0.0096
Trypanosoma brucei unspecified product 0.0026 0.0066 0.0116
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0024 0.0021
Echinococcus granulosus serotonin receptor 0.0458 0.242 0.3563
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0345 0.1806 0.1806
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0345 0.1806 0.266
Brugia malayi putative neuropeptide receptor NPR1 0.0458 0.242 0.3634
Loa Loa (eye worm) hypothetical protein 0.0605 0.3222 0.4843
Schistosoma mansoni amine GPCR 0.0458 0.242 0.4251
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0417 0.2195 0.5016
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0024 0.0054
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Echinococcus granulosus tm gpcr rhodopsin 0.0458 0.242 0.3563
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0021 0.0012
Brugia malayi SET domain containing protein 0.0016 0.0011 0.0011
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.013 0.0294
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.013 0.0264
Schistosoma mansoni hypothetical protein 0.0022 0.0041 0.0066
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0003 0.0003
Echinococcus multilocularis heat shock protein 90 0.003 0.0084 0.0084
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0012 0.0012
Echinococcus granulosus serine threonine protein kinase nrc 0.0026 0.0065 0.0096
Schistosoma mansoni adenosylhomocysteinase 0.0505 0.2677 0.4705
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Toxoplasma gondii heat shock protein 90, putative 0.003 0.0084 0.018
Brugia malayi hypothetical protein 0.0458 0.242 0.3634
Trypanosoma brucei heat shock protein, putative 0.003 0.0084 0.0157
Toxoplasma gondii Hsp90 domain-containing protein 0.002 0.0029 0.0055
Brugia malayi Pre-SET motif family protein 0.0466 0.2466 0.3705
Echinococcus granulosus lamin dm0 0.003 0.0083 0.0123
Onchocerca volvulus 0.0458 0.242 0.8574
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.004 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.029 0.0505
Entamoeba histolytica PH domain containing protein kinase, putative 0.0347 0.1817 0.4151
Loa Loa (eye worm) Smad1 0.0016 0.0012 0.0018
Echinococcus granulosus orexin receptor type 2 0.0458 0.242 0.3563
Brugia malayi RNA binding protein 0.0064 0.0274 0.0407
Echinococcus multilocularis geminin 0.1057 0.5687 0.5687
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.004 0.0139 0.0262
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0061
Schistosoma mansoni chromobox protein 0.008 0.0357 0.0622
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0021 0.0027
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Schistosoma mansoni high-affinity choline transporter 0.0395 0.2075 0.3645
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0458 0.242 0.4251
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0024 0.0044
Echinococcus granulosus neuropeptide s receptor 0.0458 0.242 0.3563
Schistosoma mansoni hypothetical protein 0.0022 0.0041 0.0066
Echinococcus multilocularis protein arginine N methyltransferase 8 0.003 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.003 0.0083 0.0125
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0024 0.0044
Echinococcus multilocularis chromobox protein 1 0.008 0.0357 0.0357
Schistosoma mansoni heat shock protein 0.002 0.0029 0.0046
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0022 0.0041 0.0061
Trypanosoma cruzi heat shock protein, putative 0.002 0.0029 0.0065
Brugia malayi enteropeptidase precursor 0.0022 0.0041 0.0057
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0275 0.0617
Brugia malayi isocitrate dehydrogenase 0.0018 0.0021 0.0027
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0033 0.0033
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0017 0.0015 0.0031
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0022 0.0041 0.0061
Loa Loa (eye worm) hypothetical protein 0.0214 0.1088 0.1635
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.029 0.0505
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0047 0.0181 0.0412
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.003 0.0088 0.0189
Echinococcus multilocularis rac serine:threonine kinase 0.0028 0.0076 0.0076
Trypanosoma brucei heat shock protein, putative 0.003 0.0084 0.0157
Loa Loa (eye worm) G-protein coupled receptor 0.0458 0.242 0.3637
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0005 0.001
Brugia malayi putative neuropeptide receptor 0.0458 0.242 0.3634
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0012 0.0018
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.0088 0.0149
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0022 0.0041 0.0061
Toxoplasma gondii exonuclease III APE 0.0021 0.004 0.0079
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0017 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Schistosoma mansoni regulator of G protein signaling 0.0065 0.0275 0.0478
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Trichomonas vaginalis CMGC family protein kinase 0.0121 0.0582 0.1319
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0061
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0417 0.2195 0.5
Trypanosoma brucei histone-lysine n-methyltransferase 0.0033 0.0101 0.0195
Entamoeba histolytica heat shock protein 90, putative 0.003 0.0084 0.0187
Echinococcus multilocularis somatostatin receptor 0.0458 0.242 0.242
Echinococcus multilocularis allatostatin A receptor 0.0458 0.242 0.242
Trichomonas vaginalis AGC family protein kinase 0.0345 0.1806 0.4121
Echinococcus granulosus protein arginine methyltransferase 0.003 0.0088 0.0129
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0012 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0345 0.1806 0.3172
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.004 0.0086
Echinococcus granulosus sex peptide receptor 0.0458 0.242 0.3563
Schistosoma mansoni chromobox protein 0.008 0.0357 0.0622
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0024 0.0021
Brugia malayi Hsp90 protein 0.002 0.0029 0.0039
Schistosoma mansoni hypothetical protein 0.0458 0.242 0.4251
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0147 0.0252
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0217 0.0326
Brugia malayi A-kinase anchor protein 10, precursor 0.0065 0.0275 0.0409
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0021 0.0035
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0417 0.2195 0.5016
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0166 0.049
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0107 0.0234
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0067 0.029 0.0653
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0133 0.0291
Mycobacterium leprae Conserved hypothetical protein 0.004 0.0139 0.0073
Onchocerca volvulus 0.0458 0.242 0.8574
Echinococcus multilocularis fmrfamide receptor 0.0458 0.242 0.242
Giardia lamblia Heat shock protein HSP 90-alpha 0.003 0.0084 0.0332
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0083 0.0125
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.004 0.0089
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0047 0.0181 0.0409
Brugia malayi Protein arginine N-methyltransferase 0.0017 0.0015 0.0018
Trypanosoma brucei heat shock protein, putative 0.003 0.0084 0.0157
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0033 0.0049
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0022 0.0041 0.0057
Brugia malayi MH1 domain containing protein 0.0016 0.0012 0.0013
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0024 0.0044
Echinococcus granulosus g-protein coupled receptor 0.0458 0.242 0.3563
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0307 0.0534
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.013 0.0244
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0024 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0458 0.242 0.242
Brugia malayi Cytochrome P450 family protein 0.0116 0.0558 0.0834
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0044 0.016 0.016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0458 0.242 0.242
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0095 0.0205
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0094 0.0141
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0458 0.242 0.242
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0274 0.0274
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.0257 0.1326 0.199
Loa Loa (eye worm) RecQ helicase 0.0072 0.0315 0.0473
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0816 0.4374 1
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.003 0.0088 0.0188
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0005 0.001
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0133 0.0291
Loa Loa (eye worm) TYRA-2 protein 0.0458 0.242 0.3637
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0274 0.0476
Entamoeba histolytica protein kinase 2, putative 0.0026 0.0065 0.0145
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.004 0.0139 0.0262
Echinococcus granulosus rhodopsin orphan GPCR 0.0458 0.242 0.3563
Echinococcus multilocularis nervana 2 0.002 0.0033 0.0033
Loa Loa (eye worm) AGC/PKA protein kinase 0.0345 0.1806 0.2715
Toxoplasma gondii heat shock protein HSP90 0.003 0.0084 0.018
Plasmodium vivax heat shock protein 86, putative 0.003 0.0084 0.0187
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Loa Loa (eye worm) hypothetical protein 0.0458 0.242 0.3637
Echinococcus granulosus protein arginine N methyltransferase 8 0.003 0.0088 0.0129
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0123 0.0595 0.1318
Loa Loa (eye worm) hypothetical protein 0.0057 0.0235 0.0354
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0024 0.0054
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0417 0.2195 0.3232
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.004 0.0139 0.027
Schistosoma mansoni adenosylhomocysteinase 0.0505 0.2677 0.4705
Schistosoma mansoni hypothetical protein 0.1057 0.5687 1
Leishmania major heat shock protein 83-1 0.003 0.0084 0.0157
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0021 0.0021
Schistosoma mansoni regulator of G protein signaling 0.0065 0.0275 0.0478
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0044 0.016 0.0354
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0132 0.03
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0458 0.242 0.242
Onchocerca volvulus 0.0458 0.242 0.8574
Echinococcus granulosus nervana 2 0.002 0.0033 0.0049
Schistosoma mansoni hypothetical protein 0.0041 0.0147 0.0252
Brugia malayi TAR-binding protein 0.0064 0.0274 0.0407
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0133 0.0291
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0049 0.0188 0.0425
Schistosoma mansoni cytochrome P450 0.004 0.0139 0.0238
Brugia malayi MH2 domain containing protein 0.0016 0.0012 0.0013
Brugia malayi hypothetical protein 0.0458 0.242 0.3634
Brugia malayi MH2 domain containing protein 0.0242 0.124 0.186

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = -9.3 Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement ChEMBL. 8568799
Log Ki (binding) = 9.3 Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement ChEMBL. 8568799

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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