Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.0418 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0418 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0418 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0418 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0418 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0418 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0418 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0418 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 13.3 uM | Concentration required to reduce the viability of mock-infected human CEM cells | ChEMBL. | 16115762 |
EC50 (functional) | > 13.3 uM | Effective concentration required to inhibit HTLV-III B induced cytopathicity in human CEM cells | ChEMBL. | 16115762 |
Selectivity index (functional) | < 1 | Ratio of CC50 required to reduce the viability of mock-infected human CEM cells to EC50 required to inhibit HTLV-III B induced cytopathicity in that cells | ChEMBL. | 16115762 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.