TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 354.365 | Formula: C20H14N6O
H donors: 0 H acceptors: 5 LogP: 3.59 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1cc(OCc2ccccc2)cc(c1)n1nnc(n1)c1ccccn1
InChi: 1S/C20H14N6O/c21-13-16-10-17(12-18(11-16)27-14-15-6-2-1-3-7-15)26-24-20(23-25-26)19-8-4-5-9-22-19/h1-12H,14H2
InChiKey: RAZRAFJUUZXUHH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Metabotropic glutamate receptor 5	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	Metabotropic glutamate receptor precursor, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	ko:K04606 glutamate receptor, metabotropic 3, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	Metabotropic glutamate receptor precursor.	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0063	0.3996	0.3716
Schistosoma mansoni	nAChR subunit	0.0137	1	1
Schistosoma mansoni	lipoxygenase	0.0117	0.8371	0.8355
Brugia malayi	jmjC domain containing protein	0.0015	0.0098	0.0098
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0041	0.2194	0.2117
Echinococcus multilocularis	tar DNA binding protein	0.0054	0.3271	0.3204
Schistosoma mansoni	neurotransmitter gated ion channel	0.0063	0.3996	0.3937
Schistosoma mansoni	rab6-interacting	0.002	0.0446	0.0352
Schistosoma mansoni	loxhd1	0.002	0.0446	0.0352
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0137	1	1
Schistosoma mansoni	hypothetical protein	0.002	0.0446	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0137	1	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0057	0.3515	0.3451
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0992	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4859	0.4859
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.3515	0.3451
Echinococcus granulosus	intermediate filament protein	0.0026	0.0992	0.0903
Brugia malayi	jmjC domain containing protein	0.0015	0.0098	0.0098
Brugia malayi	intermediate filament protein	0.0026	0.0992	0.0992
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0137	1	1
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0953	0.0953
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0137	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.3271	0.3204
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0074	0.4859	0.4859
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0063	0.3996	0.3937
Loa Loa (eye worm)	TAR-binding protein	0.0054	0.3271	0.3271
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0063	0.3996	0.3937
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0074	0.4859	0.4859
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4859	0.4859
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0063	0.3996	0.3996
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0137	1	1
Schistosoma mansoni	neurotransmitter gated ion channel	0.0063	0.3996	0.3937
Brugia malayi	Doublecortin family protein	0.002	0.0446	0.0446
Echinococcus granulosus	lamin	0.0026	0.0992	0.0903
Brugia malayi	hypothetical protein	0.0063	0.3996	0.3996
Schistosoma mansoni	lamin	0.0026	0.0992	0.0903
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0063	0.3996	0.3996
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0446	0.0352
Schistosoma mansoni	lipoxygenase	0.0082	0.5508	0.5463
Echinococcus multilocularis	nAChR subunit	0.0137	1	1
Onchocerca volvulus		0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4859	0.4859
Schistosoma mansoni	nAChR subunit	0.0137	1	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0057	0.3515	0.3451
Schistosoma mansoni	hypothetical protein	0.0029	0.1231	0.1144
Echinococcus multilocularis	glycine receptor subunit beta	0.0137	1	1
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0137	1	1
Brugia malayi	hypothetical protein	0.0063	0.3996	0.3996
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0992	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0029	0.1231	0.1231
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0992	0.0992
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0137	1	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0074	0.4859	0.4859
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0137	1	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0137	1	1
Echinococcus granulosus	nAChR subunit	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3996	0.3996
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0063	0.3996	0.3937
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0137	1	1
Echinococcus multilocularis	nAChR subunit	0.0074	0.4859	0.4808
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0137	1	1
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0041	0.2194	0.2117
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0117	0.8371	0.8355
Brugia malayi	jmjC domain containing protein	0.0057	0.3515	0.3515
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0015	0.0098	0.5
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0015	0.0098	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3996	0.3996
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0043	0.233	0.233
Schistosoma mansoni	nAChR subunit	0.0137	1	1
Loa Loa (eye worm)	ACC-1 protein	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3996	0.3996
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0137	1	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0137	1	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3996	0.3996
Echinococcus granulosus	nAChR subunit	0.0074	0.4859	0.4808
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0137	1	1
Schistosoma mansoni	metabotropic glutamate receptor	0.0041	0.2194	0.2117
Schistosoma mansoni	nAChR subunit	0.0063	0.3996	0.3937
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0044	0.2466	0.2466
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0137	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0063	0.3996	0.3996
Loa Loa (eye worm)	acetylcholine receptor protein	0.0063	0.3996	0.3996
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Brugia malayi	hypothetical protein	0.0063	0.3996	0.3996
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3996	0.3996
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0137	1	1
Brugia malayi	hypothetical protein	0.0063	0.3996	0.3996
Echinococcus granulosus	glycine receptor subunit beta	0.0137	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.3271	0.3204
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0063	0.3996	0.3937
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.0446	0.0352
Brugia malayi	RNA recognition motif domain containing protein	0.0054	0.3271	0.3271
Brugia malayi	jmjC domain containing protein	0.0015	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0098	0.0098
Loa Loa (eye worm)	LGC-31 protein	0.0137	1	1
Brugia malayi	Cation transporter family protein	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3996	0.3996
Brugia malayi	jmjC domain containing protein	0.0057	0.3515	0.3515
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3996	0.3996
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0049	0.2841	0.2841
Echinococcus granulosus	metabotropic glutamate receptor 5	0.006	0.3762	0.37
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3996	0.3996
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0098	0.0098
Onchocerca volvulus		0.0074	0.4859	0.4619
Schistosoma mansoni	nAChR subunit	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4859	0.4859
Onchocerca volvulus		0.0137	1	1
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0063	0.3996	0.3996
Loa Loa (eye worm)	hypothetical protein	0.002	0.0446	0.0446
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.006	0.3762	0.37
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0054	0.3271	0.3271
Echinococcus multilocularis	lamin dm0	0.0026	0.0992	0.0903
Echinococcus granulosus	lamin dm0	0.0026	0.0992	0.0903
Onchocerca volvulus		0.0137	1	1
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0074	0.4859	0.4808
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4859	0.4859
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3996	0.3996
Onchocerca volvulus		0.0137	1	1
Echinococcus multilocularis	lamin	0.0026	0.0992	0.0903
Brugia malayi	metabotropic glutamate receptor type 2	0.0024	0.0798	0.0798
Brugia malayi	TAR-binding protein	0.0054	0.3271	0.3271
Schistosoma mansoni	polycystin 1-related	0.002	0.0446	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3996	0.3996
Schistosoma mansoni	jumonji domain containing protein	0.0057	0.3515	0.3451
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0137	1	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Echinococcus multilocularis	RUN	0.002	0.0446	0.0352
Schistosoma mansoni	neurotransmitter gated ion channel	0.0074	0.4859	0.4808
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4859	0.4859
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0446	0.0352
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0015	0.0098	0.5
Schistosoma mansoni	rab6-interacting	0.002	0.0446	0.0352
Brugia malayi	jmjC domain containing protein	0.0015	0.0098	0.0098
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0117	0.8371	0.8355
Onchocerca volvulus	Putative nachr subunit	0.0137	1	1
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0137	1	1
Brugia malayi	Cation transporter family protein	0.0137	1	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0137	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0137	1	1
Onchocerca volvulus		0.0137	1	1
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0063	0.3996	0.3996
Brugia malayi	Cation transporter family protein	0.0137	1	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0137	1	1
Loa Loa (eye worm)	RNA binding protein	0.0054	0.3271	0.3271
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0043	0.233	0.233
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4859	0.4859
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.3271	0.3204
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0063	0.3996	0.3937
Brugia malayi	hypothetical protein	0.002	0.0446	0.0446
Loa Loa (eye worm)	ACC-1 protein	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.233	0.233
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0015	0.0098	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3996	0.3996
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Schistosoma mansoni	acetylcholine receptor-related	0.0063	0.3996	0.3937
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.3271	0.3204
Brugia malayi	latrophilin 2 splice variant baaae	0.0029	0.1231	0.1231
Loa Loa (eye worm)	GABA receptor subunit	0.0074	0.4859	0.4859
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0137	1	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0446	0.0352
Loa Loa (eye worm)	jmjC domain-containing protein	0.0057	0.3515	0.3515
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0992	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0043	0.233	0.233
Onchocerca volvulus		0.0063	0.3996	0.3716
Schistosoma mansoni	lamin	0.0026	0.0992	0.0903
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0063	0.3996	0.3996
Loa Loa (eye worm)	doublecortin family protein	0.002	0.0446	0.0446
Schistosoma mansoni	nAChR subunit	0.0137	1	1
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0137	1	1
Loa Loa (eye worm)	glutamate receptor	0.0049	0.2841	0.2841
Plasmodium falciparum	LCCL domain-containing protein	0.002	0.0446	1
Brugia malayi	hypothetical protein	0.0063	0.3996	0.3996
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0137	1	1
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.0446	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3996	0.3996
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0098	0.0098
Onchocerca volvulus		0.0074	0.4859	0.4619
Plasmodium vivax	multidomain scavenger receptor, putative	0.002	0.0446	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0137	1	1
Echinococcus granulosus	glycine receptor subunit beta	0.0137	1	1
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0063	0.3996	0.3937
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0074	0.4859	0.4859
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Onchocerca volvulus		0.0026	0.0992	0.0571
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.3271	0.3204
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0098	0.0098
Entamoeba histolytica	hypothetical protein	0.0074	0.4859	0.5
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0056	0.3387	0.3322
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0074	0.4859	0.4808
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3996	0.3996
Schistosoma mansoni	metabotropic glutamate receptor	0.0024	0.0798	0.0707
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0137	1	1
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0137	1	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0137	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0063	0.3996	0.3996
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0446	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4859	0.4859
Loa Loa (eye worm)	hypothetical protein	0.006	0.3762	0.3762
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0446	0.0352
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0137	1	1
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0137	1	1
Brugia malayi	RNA binding protein	0.0054	0.3271	0.3271
Schistosoma mansoni	nAChR subunit	0.0137	1	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0137	1	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0137	1	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0057	0.3515	0.3451
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0137	1	1
Schistosoma mansoni	nAChR subunit	0.0063	0.3996	0.3937
Echinococcus granulosus	tar DNA binding protein	0.0054	0.3271	0.3204
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4859	0.4859
Onchocerca volvulus		0.0026	0.0992	0.0571
Schistosoma mansoni	nAChR subunit	0.0137	1	1
Echinococcus granulosus	RUN	0.002	0.0446	0.0352
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0137	1	1
Onchocerca volvulus		0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0137	1	1
Brugia malayi	hypothetical protein	0.002	0.0446	0.0446
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0137	1	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0057	0.3515	0.3451
Leishmania major	hypothetical protein, conserved	0.0015	0.0098	0.5
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0137	1	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.3515	0.3451
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3996	0.3996
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0992	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0137	1	1
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0063	0.3996	0.3996
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0137	1	1
Loa Loa (eye worm)	glutamate receptor	0.0019	0.0423	0.0423
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0098	0.0098
Onchocerca volvulus		0.0063	0.3996	0.3716
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3996	0.3996
Echinococcus multilocularis	musashi	0.0026	0.0992	0.0903
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0015	0.0098	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0098	0.0098

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 1000 nM	In vitro functional activity measured by changes in cytosolic [Ca2+] concentrations against rat metabotropic glutamate receptor 5	ChEMBL.	16183275
IC50 (functional)	> 1000 nM	In vitro functional activity measured by changes in cytosolic [Ca2+] concentrations against rat metabotropic glutamate receptor 5	ChEMBL.	16183275
Ki (binding)	> 600 nM	Ability to displace [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from binding to metabotropic glutamate receptor 5 in rat cortical membranes	ChEMBL.	16183275
Ki (binding)	> 600 nM	Ability to displace [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from binding to metabotropic glutamate receptor 5 in rat cortical membranes	ChEMBL.	16183275

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL381683

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 344750