Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) | Human herpesvirus 5 chemokine receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0045 | 0.0279 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0045 | 0.0279 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0045 | 0.0279 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0163 | 0.3814 | 1 |
Brugia malayi | Hr1 repeat family protein | 0.0045 | 0.0279 | 0.0451 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0045 | 0.0279 | 0.0451 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 0.9603 | 0.9592 |
Schistosoma mansoni | serine/threonine protein kinase | 0.008 | 0.1326 | 0.1771 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0045 | 0.0279 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0045 | 0.0279 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0045 | 0.0279 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0048 | 0.0368 | 0.015 |
Trichomonas vaginalis | AGC family protein kinase | 0.0045 | 0.0279 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0077 | 0.1237 | 0.1622 |
Echinococcus multilocularis | protein kinase c iota type | 0.0077 | 0.1237 | 0.1622 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0048 | 0.0368 | 0.015 |
Trichomonas vaginalis | AGC family protein kinase | 0.0045 | 0.0279 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0045 | 0.0279 | 0.0451 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.008 | 0.1326 | 0.1771 |
Trichomonas vaginalis | AGC family protein kinase | 0.0045 | 0.0279 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.8645 | 0.8606 |
Brugia malayi | Protein kinase domain containing protein | 0.0045 | 0.0279 | 0.0451 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0242 | 0.6186 | 1 |
Toxoplasma gondii | AGC kinase | 0.0045 | 0.0279 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0207 | 0.514 | 0.8229 |
Brugia malayi | Protein kinase domain containing protein | 0.0045 | 0.0279 | 0.0451 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.008 | 0.1326 | 0.1771 |
Trichomonas vaginalis | AGC family protein kinase | 0.0045 | 0.0279 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.008 | 0.1326 | 0.1771 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0163 | 0.3814 | 0.5984 |
Brugia malayi | protein kinase C II. | 0.0242 | 0.6186 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.8645 | 0.8606 |
Trichomonas vaginalis | AGC family protein kinase | 0.0045 | 0.0279 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0242 | 0.6186 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0242 | 0.6186 | 0.6076 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0242 | 0.6186 | 1 |
Onchocerca volvulus | 0.0324 | 0.8645 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.8645 | 0.8606 |
Trichomonas vaginalis | AGC family protein kinase | 0.0045 | 0.0279 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0077 | 0.1237 | 0.1622 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | uM | Effective concentration against US28-mediated inositol phosphate production in COS-7 cells; Not determined | ChEMBL. | 16190772 |
EC50 (functional) | 0 uM | Effective concentration against US28-mediated inositol phosphate production in COS-7 cells; Not determined | ChEMBL. | 16190772 |
IC50 (binding) | = 19.5 uM | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 | ChEMBL. | 16190772 |
IC50 (binding) | = 19.5 uM | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 | ChEMBL. | 16190772 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.